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Role of Hedgehog-Patched1 signaling pathway on orthodontic tooth movement and bone remodeling

Research Project

Project/Area Number 19592346
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionThe University of Tokyo

Principal Investigator

MASAKO Matsuzaki  The University of Tokyo, 医学部・附属病院, 助教 (80313154)

Co-Investigator(Kenkyū-buntansha) TAKASHI Susami  東京大学, 医学部・附属病院, 准教授 (80179184)
UNG-IL Chung  東京大学, 大学院・工学系研究科, 教授 (30345053)
KAZUMI Ohkubo  東京大学, 医学部・附属病院, 助教 (10396715)
CHIKAZU Daichi  東京大学, 医学部・附属病院, 助教 (30343122)
OKI Meiko  東京大学, 医学部・附属病院, 講師 (10345225)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords顎顔面骨 / 歯科矯正治療 / Patched1 / Patched 1 / Scleraxis / Tenomodulin / サイクロパミン / Hhシグナル / 骨芽細胞・破骨細胞
Research Abstract

HhシグナルのレセプターであるPatched1(Ptch1)haploinsuficient(+/-)マウスを用いて解析を行った。結果、顎顔面骨・長管骨において高代謝回転型の骨リモデリングが行われている事が確認された。さらにin vitro での解析からPtch1+/-の骨芽細胞では細胞増殖ではなく、分化能が、また破骨細胞支持能が亢進している事がわかった。このことから、成体の骨組織の恒常性維持にHhシグナリングが関与する事が明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (16 results)

All 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (3 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Selection of highly osteogenic and chondrogenic cells from bone marrow stromal cells in biocompatible polymer-coted plates2009

    • Author(s)
      Liu G, Iwata K, Ogasawara T, Watanabe J, Fukazawa K, Ishihara k, Asawa Y, Fujihara Y, Chung UI, Moro T, Takatori Y, Takato T, Nakamura K, Kawaguchi H, Hoshi K
    • Journal Title

      J Biomed Mater Res A (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selection of highly osteogenic and chondrogenic cells from bone marrow stromal cells in biocompatible polymer-coated plates.2009

    • Author(s)
      Liu G et al.
    • Journal Title

      J Biomed Mater Res A (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity2008

    • Author(s)
      Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung UI
    • Journal Title

      Developmental Cell 14

      Pages: 689-69

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Patchedl haploinsufHciency increases adult bone mass and modulates Gli3 repressor activity.2008

    • Author(s)
      Ohba, S et al.
    • Journal Title

      Dev Cell 14

      Pages: 689-69

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraoral reconstructionon of the-soft palate following tumor resection using a mucoperiosteal flap supplied by the greater palatine vessels.2008

    • Author(s)
      Chikazu. D et al.
    • Journal Title

      J Oral Maxillofac Surg 19

      Pages: 203-206

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secondary correction of bilateral cleft lip and nasal deformity by simultaneous placement of an Abbe flap, septal cartilage graft, and cantilevered iliac bone graft.2008

    • Author(s)
      Yoshiyuki Yonehara
    • Journal Title

      Journal of Oral and Maxillofacial Surgery 66

      Pages: 581-588

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of tumoural calcinosis in the temporomandibular joint associated with systemic sclerosis.2008

    • Author(s)
      Daichi Chikazu
    • Journal Title

      International journal of Oral and Maxillofacial Surgery 37

      Pages: 190-193

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-2 activity is essential for the osseointegration of dental implants.2007

    • Author(s)
      Daichi Chikazu
    • Journal Title

      International journal of Oral and Maxillofacial Surgery 36

      Pages: 441-446

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 上下顎骨切り術後に早期プレート抜去・ゴム牽引を行ったApert症候群の1例2008

    • Author(s)
      須佐美 隆史
    • Organizer
      第26回日本頭蓋顎顔面外科学会学術集会
    • Place of Presentation
      盛岡
    • Related Report
      2008 Final Research Report
  • [Presentation] 上下顎骨切り術後に早期プレート抜去・ゴム牽引を行ったAbert 症候群の1例2008

    • Author(s)
      須佐美隆史
    • Organizer
      第26回日本頭蓋顎顔面外科学会学術集会
    • Place of Presentation
      盛岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] Patched1機能不全によるHedgehogシグナルの活性化は、Runx2のDNA結合・転写活性を競合阻害している抑制型Gli3産生を低下させることによって骨量を増加させる2007

    • Author(s)
      大庭 伸介
    • Organizer
      第25回 日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-19
    • Related Report
      2007 Annual Research Report
  • [Book] 鰓弓由来の症候群口と歯の事典(高戸毅, ほか)2008

    • Author(s)
      須佐美 隆史
    • Publisher
      朝倉書店
    • Related Report
      2008 Final Research Report
  • [Book] 鰓弓由来の症候群.口と歯の事典(高戸毅ほか編集)2008

    • Author(s)
      須佐美隆史
    • Publisher
      朝倉書店
    • Related Report
      2008 Annual Research Report
  • [Book] 口と歯の事典2008

    • Author(s)
      高戸 毅
    • Total Pages
      436
    • Publisher
      朝倉書店
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/~oralsurg/index.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/%7Eoralsurg/archive.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2018-11-16  

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