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Molecular regulation in craniofacial patterning and development at chick embryo

Research Project

Project/Area Number 19592362
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNara Medical University

Principal Investigator

KAWAKAMI Masayoshi  Nara Medical University, 医学部, 講師 (20244717)

Co-Investigator(Kenkyū-buntansha) WANAKA Akio  奈良県立医科大学, 医学部, 教授 (90210989)
Research Collaborator M.JOY Richman  University of British Columbia, Department of Oral Health Sciences, Life Sciences Institute, Associate professor
FUJII Ryosuke  奈良県立医科大学, 医学部, 研究生
OKUDA Hiroaki  奈良県立医科大学, 医学部, 助教 (40453162)
TATSUMI Tatsumi  奈良県立医科大学, 医学部, 講師 (90208033)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords歯科矯正学 / 形態発生 / 遺伝子 / 細胞・組織 / 歯学 / 発生・分化 / 国際情報交換 / chick embryo / L3 / Lhx8 / FGF / siRNA / retinoic acid
Research Abstract

顎顔面は複雑な構造から成り、その形成パターンも複雑であり、不明な点も多い。しかし顎顔面の先天異常の治療を行っていくうえで、顎顔面の形成メカニズムを理解することは必要である。L3/Lhx8は、LIM homeobox のtranscription factorであり、個体発生のボディプランとされている。本研究では、Chick embryo を用いて、L3/Lhx8 遺伝子発現を制御する生体のシグナル応答について検討したものである。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (1 results)

  • [Journal Article] Disk position and temporomandibular joint structure associated with mandibular setback in mandibular asymmetry patients2009

    • Author(s)
      Kawakami M, Yamamoto K, Inoue T, Kajihara A, Fujimoto M Kirita T
    • Journal Title

      Angle Orthodontist 79

      Pages: 521-527

    • Related Report
      2008 Final Research Report
  • [Journal Article] Panoramic findings for predicting eruption of mandibular premolars associated with dentigerous cyst after marsupialization2008

    • Author(s)
      Fujii R, Kawakami M, Hyomoto M, Ishida J, Kirita T
    • Journal Title

      Journal of Oral and Maxillofacial Surgery 66

      Pages: 272-276

    • Related Report
      2008 Final Research Report
  • [Journal Article] Knockdown of the L3/Lhx8 gene suppresses cholinergic differentiation of murine embryomic stem cell-derived spheres2008

    • Author(s)
      Manabe T, Tatsumi K, Inoue M, Matsuyoshi H, Makinodan M, Yamauchi T, Makinodan E, Yokoyama S, Sakumura R, Wanaka A
    • Journal Title

      International Journal of Developmental Neuroscience 26

      Pages: 249-252

    • Related Report
      2008 Final Research Report
  • [Journal Article] Knockdown of the L3/Lhx8 gene suppresses cholinergic differentiation of murine embryonic stem cell-derived spheres.2008

    • Author(s)
      Manabe T, Tatsumi K, Inoue M, Matsuyoshi H, Makinodan M, Yamauchi T, Makinodan E, Yokoyama S, Sakumura R, Okuda H, Wanaka A
    • Journal Title

      International Journal of Developmental Neurosciences 26

      Pages: 249-252

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Panoramic findings for predicting eruption of mandibular premolars associated with dentigerous cyst after marsupialization2008

    • Author(s)
      Fujii R, Kawakami M, Hyomoto M, Ishida J, Kirita T.
    • Journal Title

      Journal of Oral and Maxillofacial Surgery 66

      Pages: 272-276

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] L3/Lhx8 is a pivotal factor for cholinergic differentiation of murine embryonic stem cells2007

    • Author(s)
      Manabe T, Tatsumi K, Inoue M, Makinodan M, Yamauchi T, Makinodan E, Yokoyama S, Sakumura R, Wanaka A
    • Journal Title

      Cell Death Differentiation 14

      Pages: 1080-1085

    • Related Report
      2008 Final Research Report
  • [Journal Article] An association between the MICA-A5.1 allele and an increased susceptibility to oral squamous cell carcinoma in Japanese patients.2007

    • Author(s)
      Tamaki S, Sanefuji N, Ohgi K, Imai Y, Kawakami M, Yamamoto K, Ishitani A, Hatake K, Kirita T
    • Journal Title

      Journal of Oral Pathology and Medicine. 36

      Pages: 351-356

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] L3/Lhx8 is a pivotal factor for cholinergic differentiation of murine embryonic stem cells2007

    • Author(s)
      Manabe T, Tatsumi K, Inoue M, Makinodan M, Yamauchi T, Makinodann E, Yokoyama S, Sakumura R, Wanaka A
    • Journal Title

      Gell Death and Differentiation 14

      Pages: 1080-1085

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Noonan症候群患者の顎顔面形態の特徴2008

    • Author(s)
      川上正良, 大槻楽人, 山本一彦, 川上哲司, 藤井亮介, 桐田忠昭
    • Organizer
      第67回日本矯正歯科学会大会
    • Place of Presentation
      千葉・幕張メッセ
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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