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Study of mechanical tensile stress effects on the synthesis of osteoprotegerin in microvascular endothelium

Research Project

Project/Area Number 19592364
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

ISOGAI Emiko  Health Sciences University of Hokkaido, 歯学部, 講師 (80113570)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Michiyo  北海道医療大学, 歯学部, 助手 (80316265)
ARAKAWA Toshiya  北海道医療大学, 歯学部, 講師 (40306254)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsオステオプロテゲリン / マトリックス / 血管内皮細胞 / 伸展刺激 / TNFα / オステオプロテグリン(OPG) / インテグリン / IL-6 / 血管新生
Research Abstract

矯正力により歯を移動させる際に、歯根膜に豊富に存在する微小血管は骨や歯根膜のリモデリングに重要な役割を果たす。我々は破骨細胞活性化抑制因子 (OPG)の血管内皮細胞に及ぼす作用と伸展刺激に伴うOPGの発現動態について検討を行った。OPGにより、血管新生能の亢進および血管内皮細細胞の著しい伸展や微小管の伸長が観察された。しかし、TNFα刺激下、血管内皮細胞において、24時間持続的伸展刺激によるOPG産生量の変化は認められなかった。本研究結果より、機械的刺激による歯周組織のOPG濃度の変化に応じて血管の再構築などに作用している可能性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (32 results)

All 2009 2008 2007

All Journal Article (18 results) (of which Peer Reviewed: 17 results) Presentation (14 results)

  • [Journal Article] Antimicrobial activity of three tick defensins and four mammalian cathelicidin-derived synthetic peptides against Lyme disease spirochetes and bacteria isolated from the midgut2009

    • Author(s)
      Isogai, E., Isogai, H., Takahashi, K., Kobayashi-Sakamoto, M. & Okumura, K.
    • Journal Title

      Exp Appl Acarol

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] P. B. Ceragenin CSA-13 exhibits antimicrobial activity against cariogenic and periodontopathic bacteria.2009

    • Author(s)
      Isogai, E., Isogai, H., Takahashi, K., Okumura, K. & Savage
    • Journal Title

      Oral Microbiol Immunol 24

      Pages: 170-172

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of alphav integrin in osteoprotegerin-induced endothelial cell migration and proliferation2008

    • Author(s)
      Kobayashi-Sakamoto, M., Isogai, E., Hirose, K. & Chiba, I.
    • Journal Title

      Microvasc Res 76

      Pages: 139-144

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Negative regulation of quorum-sensing systems in Pseudomonas aeruginosa by ATP-dependent Lon protease2008

    • Author(s)
      Takaya, A., Tabuchi, F., Tsuchiya, H., Isogai, E. & Yamamoto, T
    • Journal Title

      J Bacteriol 190

      Pages: 4181-4188

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of streptococcal hypersensitivity in the pathogenesis of Behcet's Disease2008

    • Author(s)
      Kaneko, F., Oyama, N., Yanagihori, H., Isogai, E., et al
    • Journal Title

      Eur J Dermatol 18

      Pages: 489-498

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of catechin diet on gingivitis in cats2008

    • Author(s)
      Isogai, H., Isogai, E., Takahashi, K. & Kurebayashi, Y
    • Journal Title

      Int J Applres Vet M 6

      Pages: 82-86

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tick biology and tick-borne infections2008

    • Author(s)
      Isogai E, Isogai H, Hayashi S
    • Journal Title

      Current Trend in Microbiology in press

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of differentially expressed genes in porcine epithelial cells derived from periodontal ligament and gingiva by DNA microarray2008

    • Author(s)
      Kurashige, Y., Saitoh, M., Nishimura, M., Noro, D., Kaku, T., Igarashi, S., Takuma, T., Arakawa, T., Inoue, T., and Abiko, Y
    • Journal Title

      Arch Oral Biol 53

      Pages: 473-442

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two distinct pathways for cyclooxygenase-2 protein degradation2008

    • Author(s)
      Mbonye, U.R., Yuan, C., Harris, C.E., Sidhu, R.S., Song, I., Arakawa, T., and Smith, W.L
    • Journal Title

      J Biol Chem 283

      Pages: 8611-623

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of alpha(v) integrin in osteoprotegrin-induced endothelial cell migration and proliferation2008

    • Author(s)
      Kobayashi-Sakamoto M
    • Journal Title

      Microvasc Res 76

      Pages: 139-144

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of catechin diet on gingivitis in cats2008

    • Author(s)
      Isogai H
    • Journal Title

      Int J Appl Res Vet Med 6

      Pages: 82-86

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative regulation of quorum-sensing systems in Pseudomonas aeruginosa by ATP-dependent Lon protease2008

    • Author(s)
      Takaya A
    • Journal Title

      J Bacteriol 190

      Pages: 4181-4188

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of streptococcal hypersensitivity in the pathogenesis of Behcet's disease2008

    • Author(s)
      Kaneko F
    • Journal Title

      Eur J Dermatol 18

      Pages: 489-498

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tick biology and tick-borne infections2008

    • Author(s)
      Isogai E
    • Journal Title

      Current Trend in Microbiology 4

      Pages: 1-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of differentially expressed genes in porcine epithelial cells derived from periodontal ligament and gingiva by DNA microarray2008

    • Author(s)
      Kurashige Y
    • Journal Title

      Arch Oral Biol 53

      Pages: 437-442

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two distinct pathways for cyclooxygenase-2 protein degradation2008

    • Author(s)
      Mbonye UR
    • Journal Title

      J Biol Chem 283

      Pages: 8611-8623

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯科病院環境の真菌学的検討-病院環境におけるStachybotrys chartarum, Aspergillus niger, Chaetomium funicolaの分離2007

    • Author(s)
      磯貝恵美子、小林美智代、奥村一彦、磯貝 浩、榑林陽一、林 俊治
    • Journal Title

      環境感染 22(4)

      Pages: 260-265

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 自然免疫における抗菌ペプチドの機能2007

    • Author(s)
      磯貝 恵美子、磯貝 浩
    • Journal Title

      ダニ研究 2

      Pages: 1-3

    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of αV integrin in osteoprotegerin-induced endothelial cell migration and proliferation2009

    • Author(s)
      小林 美智代
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Osteoprotegerin-mediated cytoskeletal reorganization in microvascular endothelium2009

    • Author(s)
      Kobayashi-Sakamoto M, Isogai, E, Hirose, K, Reid P, Chiba I, and Holen I
    • Organizer
      IADR/AADR/CADR 87th General Session and Exhibition
    • Place of Presentation
      Miami,USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Osteoprotegerin promotes proliferation and migration of human microvascular endothelial cells2008

    • Author(s)
      小林 美智代, 磯貝恵美子
    • Organizer
      第57回日本口腔衛生学会総会,
    • Place of Presentation
      大宮
    • Year and Date
      2008-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Osteoprotegerin promotes proliferation and migration of human microvascular endothelial cells2008

    • Author(s)
      小林 美智代
    • Organizer
      第57回日本口腔衛生学会総会
    • Place of Presentation
      大宮
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pathogenesis of skin lesions in Lyme disese2008

    • Author(s)
      Isogai E, Isogai H, Takahashi K, Kobayashi-Sakamoto M,
    • Organizer
      11^<th> International Conference on Lyme Borreliosis and other tick-borne diseases
    • Place of Presentation
      Irvine, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Savage PBFunctional properties of cationic antimicrobial compounds on the neutrophils and endothelial cells2008

    • Author(s)
      Isogai E ,Isogai H, Okumura K, Kobayashi-Salkamoto M, Kaneko F, Ohgami K, Ohno S
    • Organizer
      13^<th> Int Conf for Behcet's disease
    • Place of Presentation
      Klagenfult
    • Related Report
      2008 Final Research Report
  • [Presentation] Protective effects of antimicrobial steroid (CSA-13) against bacterial infection with ocular manifestations2008

    • Author(s)
      Isogai H, Isogai E
    • Organizer
      13^<th> Int Conf for Behcet's disease
    • Place of Presentation
      Klagenfult
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Functional properties of cationic antimicrobial compounds on the neutrophils and endothelial cells2008

    • Author(s)
      Isogai E
    • Organizer
      13^<th> Int Conf for Behcet's disease
    • Place of Presentation
      Klagenfult
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pathogenesis of skin lesions in Lyme disese2008

    • Author(s)
      Isogai E
    • Organizer
      11^<th> International Conference on Lyme Borreliosis and other tick-borne diseases
    • Place of Presentation
      Irvine
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gingival damages and oxidative stress in canine periodontitis2007

    • Author(s)
      Isogai H, Isogai E
    • Organizer
      ASM General 107^<th> Meeting, ASM General 107^<th> Meeting
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression of hCAP18 is resistant factor against hCAP18-induced apoptosis2007

    • Author(s)
      Okumura K, Sawada N, Muraoka.K, Isogai E, Hosokawa Y, Shibata T, Isogai H
    • Organizer
      42th annual meeting IADR, Sep
    • Place of Presentation
      Greece, Thessaloniki
    • Related Report
      2008 Final Research Report
  • [Presentation] Osteoprotegerin promotes integrin αvβ3-dependnent endothelial cell migration2007

    • Author(s)
      Kobayashi-Sakamoto M, Isogai E, Hirose K, Chiba I,
    • Place of Presentation
      Glasgow, UK
    • Related Report
      2008 Final Research Report
  • [Presentation] Gingival damages and oxidative stress in canine periodontitis2007

    • Author(s)
      Isogai H, Isogai E
    • Organizer
      ASM General 107^<th> Meeting
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2007 Annual Research Report
  • [Presentation] Expression of hCAP18 is resistant factor against hCAPI8-induced apoptosis2007

    • Author(s)
      Okumura K, SawadaN, Muraoka.K, Isogai E, Hosokawa Y, Shibata T, lsogaiH
    • Organizer
      42th annual meeting IADR
    • Place of Presentation
      Greece, Thessaloxiiki
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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