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Genetic study on dental attrition in mice

Research Project

Project/Area Number 19592368
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNihon University

Principal Investigator

MAEDA Takahide  Nihon University, 松戸歯学部, 教授 (70130599)

Co-Investigator(Kenkyū-buntansha) OGAWA Kei  日本大学, 松戸歯学部, 助教 (20453889)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords咬耗 / 連鎖解析 / 候補遺伝子 / マウス / 遺伝要因 / 感受性 / 原因遺伝子 / 近交系マウス / pool DNA / mapping / 下顎角
Research Abstract

The aim of this study was to identify the chromosomes harboring candidate causative gene(s) for dental attrition using pools of DNA from two strains mice with different susceptibilities to attrition. Attrition scores in F2 mice aged 260 days obtained by genetic crossing of C3H and B6 mice ranged from low to high. DNA from four F2 mice with high attrition scores and four F2 mice with low attrition scores was pooled. The 53 Mit markers used in this study were determined as informative markers, being polymorphisms between C3H and B6, and were distributed among all auto chromosomes in mice. This suggests that the candidate chromosomes harboring causative gene(s) for attrition are linked with D4Mit13 and D13Mit9, which were identified as homozygous alleles of C3H in Pool High DNA and homozygous alleles of B6 in Pool Low DNA.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (17 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (13 results)

  • [Journal Article] Mapping of affected Genes to Dental Attrition Susceptibility Using pool DNA in Mice2011

    • Author(s)
      Kei Ogawa, Chiaki Tatsumi, Elif Bahar Tuna, Takahide Maeda
    • Journal Title

      International J of Oral-Medical Science 10

      Pages: 51-56

    • Related Report
      2010 Final Research Report
  • [Journal Article] SMXA Recombinant 近交系マウスを用いた下顎角の大きさを規定する遺伝子の量的形質遺伝解析2010

    • Author(s)
      成島順子, ら
    • Journal Title

      小児歯誌 47

      Pages: 746-751

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] SMXA Recombinant 近交系マウスを用いた下顎角の大きさを規定する遺伝子の量的形質遺伝解析2010

    • Author(s)
      成島順子
    • Journal Title

      小児歯誌 47

      Pages: 746-751

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 各種イオン飲料の飲用によるエナメル質への影響2009

    • Author(s)
      横屋知恵子, 清水邦彦
    • Journal Title

      小児歯誌 47

      Pages: 615-620

    • Related Report
      2009 Annual Research Report 2009 Self-evaluation Report
  • [Presentation] 近交系マウス系統間における下顎角の大きさの比較および遺伝要因の検討2011

    • Author(s)
      小川京、辰巳千明、清水邦彦、前田隆秀
    • Organizer
      第48回 日本小児歯科学会大会 発表
    • Place of Presentation
      愛知(名古屋国際会議場)
    • Year and Date
      2011-05-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 咬合の不均衡によって生じる身体能力と高次脳機能の変化2010

    • Author(s)
      高橋昌嗣, 他
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      愛知(名古屋国際会議場)
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経線維腫症I型における原因遺伝子の欠失と変異2010

    • Author(s)
      小林亮介, 他
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      愛知(名古屋国際会議場)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 鶴蝕感受性に関与する遺伝子の探索2010

    • Author(s)
      折野大輔, 他
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      愛知(名古屋国際会議場)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 近交系マウス系統間における下顎角の大きさの比較および遺伝要因の検討2010

    • Author(s)
      小川京, 他
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      愛知(名古屋国際会議場)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] NOD/SCID.E2f1-/-マウスを用いた齪蝕高感受性モデル動物の確立2010

    • Author(s)
      伊藤龍朗, 他
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      愛知(名古屋国際会議場)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 乳歯列期後方交叉咬合児における上下顎咬合模型の分析2010

    • Author(s)
      臼井朗, 他
    • Organizer
      第48回日本小児歯科学会大会
    • Place of Presentation
      愛知(名古屋国際会議場)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] SMXA Recombinant近交系マウスを用いた下顎角の大きさを規定する遺伝子の量的形質遺伝解析2010

    • Author(s)
      小川京、成島順子、清水武彦、清水邦彦、前田隆秀
    • Organizer
      第47回 日本小児歯科学会大会 発表
    • Place of Presentation
      大阪(大阪大学コンベンションセンター)
    • Year and Date
      2010-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 近交系マウス系統間における下顎角の大きさの比較および遺伝要因の検討2010

    • Author(s)
      小川京, 辰巳千明, 清水邦彦, 前田隆査
    • Organizer
      日本小児歯科学会にて
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] The effect of dietary restriction in growing mice-mandibular angle : IADR meeting2010

    • Place of Presentation
      Barcelona Spain
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 近交系マウス系統間における下顎角の大きさの比較および遺伝要因の検討2009

    • Author(s)
      小川京, 辰巳千明, 清水邦彦, 前田隆秀
    • Organizer
      第48回日本小児歯科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-05-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] SMXA Recombinant 近交系マウスを用いた下顎角の大きさを規定する遺伝子の量的形質遺伝解析2009

    • Author(s)
      小川京, 成島順子, 清水武彦, 清水邦彦, 前田隆秀
    • Organizer
      第47回日本小児歯科学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] SMXA Recombinant 近交系マウスを用いた下顎角の大きさを規定する遺伝子の量的形質遺伝解析2009

    • Author(s)
      小川京, 成島順子, 清水武彦, 清水邦彦, 前田隆秀
    • Organizer
      小児歯科学雑誌
    • Related Report
      2009 Self-evaluation Report

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Published: 2007-04-01   Modified: 2016-04-21  

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