Gene expression profile of the cartilage of mandible and the growth palate of tibia during growth period

• Project/Area Number: 19592373
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Tsurumi University
• Principal Investigator: NAKAMURA Yoshiki Tsurumi University, 歯学部, 教授 (10097321)
• Co-Investigator(Kenkyū-buntansha): 野田 晃司 鶴見大学, 歯学部, 講師 (10148059) ; 及川 崇 鶴見大学, 歯学部, 助教 (60386919)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 下顎頭軟骨 / 脛骨骨端軟骨 / 遺伝子解析 / 網羅的解析 / 成長期 / 骨端軟骨 / 軟骨性成長 / 遺伝子発現 / 静止層 / 増殖層 / 肥大層 / 下顎頭軟骨組織 / 骨端軟骨組織 / 発現遺伝子 / maicroarray

Research Abstract

今回、我々は下顎頭軟骨と長管骨の骨端軟骨には本質的な違いがあるのかを明らかにするために、両軟骨組織に発現している遺伝子を解析することを目的とした。すなわち、成長期にある下顎頭軟骨と長管骨骨端軟骨の発現遺伝子を網羅的に解析し、それぞれの発現遺伝子の違いを検討した。

Research Products

• [Journal Article] Orthodontic Treatment for Oral Rehabilitation after Multiple Maxillofacial Bone Fracture (2008)
  • Author(s): Nakamura Y, Ogino T, Hirashita A
  • Journal Title: Amer J Orthod & Dentofac Orthop 134 Pages: 447-455
  • Peer Reviewed
• [Journal Article] Time-lapse observation of rat periodontal ligament during function and tooth movement using micro-computed tomography (2008)
  • Author(s): Nakamura Y, Noda K, Shimoda S, Oikawa T, Arai C, Nomura Y and Kawasaki K
  • Journal Title: European J Orthod 30 Pages: 320-326
  • Peer Reviewed
• [Journal Article] Evaluation of risk factors for dental caries from 6 to 8 years old children (2008)
  • Author(s): Katsumura S, Nishikawara F, Tamaki Y, Yamada H, Nakamura Y, Sato K, Tsuge S, Nomura Y , Hanada N
  • Journal Title: Pediatlic Dental Journal Vol.18, No.1
  • NAID: 10024180134
  • Peer Reviewed
• [Journal Article] Time-lapse observation of rat periodontal ligament during function and tooth movement using micro-computed tomography (2008)
  • Author(s): Nakamura Y, Noda K, Shimoda S, Oikawa T, et al.
  • Journal Title: European J Orthodontics 30 Pages: 320-326
  • Peer Reviewed
• [Journal Article] A randomized controlled trial by the 3DS dental caries (2007)
  • Author(s): Katsumura S, Nishikawara F, Tamaki Y, Nakamura Y, Sato K, Nomura Y, Hanada N
  • Journal Title: ediatric Dental Journal 17 Pages: 1-7
  • Peer Reviewed
• [Journal Article] 骨格性下顎前突症のおける外科的矯正治療後の軟組織側貌の予測 (2007)
  • Author(s): 飛田康平、関谷利子、常盤肇、中村芳樹
  • Journal Title: Orthodontic wave-Japanese Edition 66 Pages: 72-80
  • Peer Reviewed
• [Journal Article] A new idea and method of tooth movement using a ratchet bracket (2007)
  • Author(s): Noda K, Nakamura Y, Shimpo S, Oikawa T
  • Journal Title: European J Orthod 29 Pages: 225-231
  • Peer Reviewed
• [Journal Article] Laser capture microdissection of rat periodontal ligament for gene analysis (2007)
  • Author(s): Y Nakamau, Y Nomura, et. al.
  • Journal Title: Biotechnic and Histochemistry 82 Pages: 295-300
  • Peer Reviewed
• [Journal Article] Elimination of transverse dental compensation is critical for treatment of patients with severe facial asymmetry
  • Author(s): Sekiya T, Nakamura Y, Oikawa T, et.al.
  • Journal Title: Amer J Orthod & Dentofac Orthop (In press)
  • Peer Reviewed
• [Journal Article] Evaluation of asymmetry of lip in orthognathic surgery patients
  • Author(s): Yamashita Y, Nakamura Y, et.al.
  • Journal Title: Amer J Orthod Dentfac Orthop (In press)
  • Peer Reviewed
• [Journal Article] Laser capture microdissection of rat periodontal ligament for gene analysis
  • Author(s): Yoshiki Nakamura, Yoshiaki Nomura, Chihiro Arai, Koji Noda, Takashi Oikawa, Kyotaro Kogure, Tadafumi Kawamoto, Nobuhiro Hanada
  • Journal Title: Biotechnic and Histochemistry (In press)
  • Peer Reviewed
• [Journal Article] Morphological changes in the rat periodontal ligament and its vascularity after experimental tooth movement using super elastic forces
  • Author(s): Noda K, Nakamura Y, Kogure K, Nomura Y
  • Journal Title: European J Orthodontics (In press)
  • Peer Reviewed
• [Journal Article] Evaluation of asymmetry of lip in orthognathic surgery patient
  • Author(s): Yamashita Y, Nakamura Y, Shimada T, Hirashita A
  • Journal Title: American J orthodontics and dentofacial orthopedics (In press)
  • Peer Reviewed
• [Journal Article] Time・lapse observation of rat periodontal ligament during function and tooth movement using micro・computed tomography
  • Author(s): Y Nakamura, K Noda, et. al.
  • Journal Title: European Journal of Orthodontics (In press)
  • Peer Reviewed
• [Journal Article] Evaluation of asymmetry of lip in orthognathic surgery patients
  • Author(s): Y Yamashita, Y Nakamura, et. al.
  • Journal Title: America Journal of Orthodontists (In press)
  • Peer Reviewed
• [Presentation] 成長期における下顎頭軟骨と脛骨骨端軟骨の発現遺伝子の網羅的解析 (2008)
  • Author(s): 宮本豊, 中村芳樹, 新井千博, 及川 崇, 野田晃司, 野村義明, 花田信弘
  • Organizer: 日本矯正歯科学会
  • Place of Presentation: 千 葉 市
  • Year and Date: 2008-09-16
• [Presentation] Time-lapse observation of rat PDL during tooth movement with micro-CT (2008)
  • Author(s): Nakamura Y, Arai C., et.al.
  • Organizer: 84 Congress of the European Orthodontic Society
  • Place of Presentation: Lisbon, Portogal
• [Presentation] Changes in rat periodontal ligamentand its vascularity by super elastic force (2008)
  • Author(s): Noda K, Nakamura Y, et.al.
  • Organizer: 84 Congress of the European Orthodontic Society
  • Place of Presentation: Lisbon, Portogal Lisbon, Portogal
• [Presentation] Gene expression profile of periodontal ligament and gingival connective tissue (2008)
  • Author(s): Oikawa T, Nakamura Y, et.al.
  • Organizer: 84 Congress of the European Orthodontic Society
  • Place of Presentation: Lisbon, Portogal Lisbon, Portogal
• [Presentation] Microarray analysis of the PDL during tooth movement (2008)
  • Author(s): Arai C, Nakamura Y, et.al.
  • Organizer: 84 Congress of the European Orthodontic Society
  • Place of Presentation: Lisbon, Portogal Lisbon, Portogal
• [Presentation] 成長期における下顎頭軟骨と脛骨骨端軟骨の発現遺伝子の網羅的解析 (2008)
  • Author(s): 宮本豊、中村芳樹, 他
  • Organizer: 第67回日本矯正歯科学会大会
  • Place of Presentation: 千葉
• [Presentation] ラット歯根膜および歯肉の結合組織の遺伝子発現の比較検討 (2008)
  • Author(s): 及川崇、中村芳樹、他
  • Organizer: 第67回日本矯正歯科学会大会
  • Place of Presentation: 千葉
• [Presentation] 断続的な矯正力を繰り返し用いたさいのラット歯根膜組織の形態的変化の観察 (2008)
  • Author(s): 小暮杏太郎、野田晃司、中村芳樹, 他
  • Organizer: 第67回日本矯正歯科学会
  • Place of Presentation: 千葉
• [Presentation] ラット歯根膜細胞のlaser microdissectionによるm-RNAの解析 (2007)
  • Author(s): 中村芳樹、及川崇、野田晃司、平下斐雄
  • Organizer: 第46回歯科基礎医学会
  • Place of Presentation: 広島
• [Presentation] 歯を移動した際の発現遺伝子の解析、その1圧迫側歯根膜 (2007)
  • Author(s): 及川崇、中村芳樹, その他
  • Organizer: 第66回日本矯正歯科学会
  • Place of Presentation: 大阪
• [Presentation] 歯を移動した際の発現遺伝子の解析、その2牽引側歯根膜 (2007)
  • Author(s): 新井千博、中村芳樹、その他
  • Organizer: 第66回日本矯正歯科学会
  • Place of Presentation: 大阪
• [Presentation] Microarray analisis of the PDL during tooth movement in rat (2007)
  • Author(s): C Arai, Y Nakamura, et. al.
  • Organizer: Japanese Association for Dental Research
  • Place of Presentation: 横浜市
• [Presentation] Microarray analysis of the PDL during tooth movement in rat, Japanese association for Dental Research
  • Author(s): Arai T, Nakamura Y., et.al.
  • Organizer: 55^<th> annual meeting