• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the mechanism of new retinoid X receptor ligand action in the enhancement of bone volume in vivo.

Research Project

Project/Area Number 19592375
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

NAKAMURA Midori  Matsumoto Dental University, 歯学部, 講師 (90278177)

Co-Investigator(Kenkyū-buntansha) MIYAZAWA Hiroo  松本歯科大学, 大学院歯学独立研究科, 教授 (90147637)
NAKAMURA Hiroshi  松本歯科大学, 総合歯科医学研究所, 講師 (00278178)
NINOMIYA Tadashi  松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
UEHARA Shunsuke  松本歯科大学, 歯学部, 助教 (90434480)
UDAGAWA Nobuyuki  松本歯科大学, 歯学部, 教授 (70245801)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsレチノイド X 受容体(RXR) / RXR アンタゴニスト / RXR アゴニスト / ビスフォスフォネート / 骨吸収 / 骨形成 / 破骨細胞 / 受容体Xレチノイド / 骨代謝 / OPG遺伝子欠損マウス / 卵巣摘出術 / RXRアンタゴニスト / RXRアゴニスト / 骨芽細胞 / 脂肪細胞 / 骨量増加 / レチノイドX受容体 / 骨粗鬆症 / 卵巣摘出
Research Abstract

OPG遺伝子欠損マウス(14週齢雄)に対して、HX531を混和(0.03%)した飼料を1匹当たり毎日3g、30日間与える実験を行った。その結果、HX531の投与は大腿骨皮質骨部における著明な骨量増加作用が認められた。この効果は、我々が、既に報告したビスフォスフォネート(骨吸収阻害薬)の皮下注射実験と同様の強いものであった。一方、RXRアゴニスト作用が報告されているHX630とPA024の投与においても、骨量増加作用が認められた。以上の結果から、新規レチノイドX受容体(RXR)アンタゴニスト・アゴニスト共に、in vivoにおける破骨細胞による骨吸収を阻害することにより、強い骨量増加作用を示すことが明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (21 results)

All 2009 2008 2007

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (3 results) Book (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.2009

    • Author(s)
      Mizoguchi T, Muto A, Udagawa N et al.
    • Journal Title

      J Cell Biol 184

      Pages: 541-554

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling.2009

    • Author(s)
      Koide M, Kinugawa S, Udagawa N et al.
    • Journal Title

      J Bone Miner Res in press

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function.2009

    • Author(s)
      Narita N, Kobayashi Y, Udagawa N et al.
    • Journal Title

      Nano Lett 9

      Pages: 1406-1413

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.2009

    • Author(s)
      Mizoguchi T, et al.
    • Journal Title

      J Cell Biol 184

      Pages: 541-554

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function.2009

    • Author(s)
      Narita N, et al.
    • Journal Title

      Nano Lett 9

      Pages: 1406-1413

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MKK6-p38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts.2008

    • Author(s)
      Yamashita T, Kobayashi Y, Udagawa N et al.
    • Journal Title

      Biochem Biophys Res Commun 365

      Pages: 252-257

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of heat treatment of hydroxyapatite on osteoblast differentiation.2008

    • Author(s)
      Asami A, Nakamura M, Nakamura H, Udagawa N, Miyazawa H et al.
    • Journal Title

      J Hard Tissue Biol 17

      Pages: 37-46

    • NAID

      130004480472

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and structure-activity relationships of 16-ene-22-thia-1α, 25-dihydroxy-26,27-dimethyl-19-norvitamin D_3 analogs having side chains of different sizes.2008

    • Author(s)
      Takaku H, Miyamoto Y, Udagawa N et al.
    • Journal Title

      Bioorg Med Chem 16

      Pages: 1796-1815

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The murine glucagon-like peptide-1 receptor is essential for control of bone resorption.2008

    • Author(s)
      Yamada C, Yamada Y, Udagawa N et al.
    • Journal Title

      Endocrinology 149

      Pages: 574-579

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MKK6-p38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts.2008

    • Author(s)
      Yamashita T, et al.
    • Journal Title

      Biochem Biophys Res Commun 365

      Pages: 252-257

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signal transduction of lipopolysaccharide- induced osteoclast differentiation.2007

    • Author(s)
      Udagawa N, Sato N et al.
    • Journal Title

      Periodontology 2000 43

      Pages: 56-64

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoblasts play important roles in osteoclastogenesis through offering the critical microecvironment for the action of RANKL.2007

    • Author(s)
      Udagawa N, et. al.
    • Journal Title

      Dentistry in Japan 43

      Pages: 195-200

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoprotegerin reduces the serum level of receptor activator of NF-kB ligand derived from osteoblasts.2007

    • Author(s)
      Udagawa N, et. al.
    • Journal Title

      J Immunol 178

      Pages: 192-200

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signal transduction of lipopolysaccharide-induced osteoclast differenti-ation2007

    • Author(s)
      Udagawa N, et. al.
    • Journal Title

      Periodontology 43

      Pages: 56-64

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Regulation of RANK ligand production and its signaling in osteoclast formation.2008

    • Author(s)
      Udagawa N
    • Organizer
      13^<th>International Congress of Endocrinology
    • Place of Presentation
      Rio de Janeiro
    • Year and Date
      2008-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulation of RANK ligand production and its signaling in osteoclast formation.2008

    • Author(s)
      Udagawa N
    • Organizer
      13^<th>International Congress of Endocrinology
    • Place of Presentation
      Rio de Janeiroブラジル(Rio centro)
    • Year and Date
      2008-11-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 重力負荷は卵巣摘出による骨密度低下を是正する2007

    • Author(s)
      中村美どり, 他
    • Organizer
      歯科基礎医学会学術大会(第49回)
    • Place of Presentation
      札幌
    • Year and Date
      2007-08-31
    • Related Report
      2007 Annual Research Report
  • [Book] Principles of Bone Biology2009

    • Author(s)
      Takahashi N, Udagawa N et al.
    • Publisher
      Third Edition in press
    • Related Report
      2008 Final Research Report
  • [Book] Principles of Bone Biology, Third Edition2009

    • Author(s)
      Takahashi N, et al.
    • Publisher
      Academic Press(In press)
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] レチノイドX受容体関連化合物を用いた骨粗鬆症の治療剤2007

    • Inventor(s)
      宇田川信之、中村美どり、影近弘之
    • Industrial Property Rights Holder
      松本歯科大学
    • Filing Date
      2007-03-15
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] レチノイドX受容体関連化合物を用いた骨粗鬆症の治療剤2007

    • Inventor(s)
      宇田川信之, 中村美どり, 影近弘之
    • Industrial Property Rights Holder
      松本歯科大学
    • Filing Date
      2007-03-15
    • Related Report
      2008 Annual Research Report
    • Overseas

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi