Periodontal regeneration after implantation BMP and teeth with cells on the root planed surface populating from periodontal ligament in vitro

• Project/Area Number: 19592379
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Hokkaido University
• Principal Investigator: SAITO Akira Hokkaido University, 大学院・歯学研究科, 助教 (20301913)
• Co-Investigator(Kenkyū-buntansha): SAITO Emiko 北海道大学, 大学院・歯学研究科, 助教 (80374528) ; YOSHIMURA Yoshitaka 北海道大学, 大学院・歯学研究科, 助教 (30230816)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 歯根膜 / 組織培養 / BMP / 歯周組織再生 / 歯根膜細胞

Research Abstract

The width of residual bone was one of the clinical host factors which affected bone regeneration following BMP-implantation. However, it did not affect connective tissue attachment, cementum regeneration and downgrowth of junctional epithelium. PDL cells that recognize and attach to dentin, don't form connective tissue attachment always. BMP also increased by the addition of connective tissue attachment may occur is suggested.

Research Products

• [Journal Article] Ectopic bone formation after implantation of themoreversible gelation polymer as a acarrier of bone morphogenetic protein-2 (2009)
  • Author(s): Saito E, Saito A, Takahashi S, Yamamoto T, Honma Y, Kawanami M
  • Journal Title: Connect Tissue Res Pages: 349-420
  • Peer Reviewed
• [Journal Article] Influence of residual bone on recombinant human bone morphogenetic protein-2-induced periodontal regeneration in experimental periodontitis in dogs (2009)
  • Author(s): Saito A, Saito E, Handa R, Honma Y, Kawanami M
  • Journal Title: Journal of periodontology. Pages: 961-968
  • Peer Reviewed
• [Journal Article] Influence of residual bone on recombinant human bone morphogenetic protein-2-in duced periodontal regeneration in experimental periodontitis in dogs (2009)
  • Author(s): Saito, A., Saito, F., Handa, R., Honma, Y., Kawanami, M.
  • Journal Title: Journal of periodontology 80(6) Pages: 961-968
  • Peer Reviewed
• [Journal Article] 半月状歯肉弁歯冠側移動術後治癒の組織学的評価 (2008)
  • Author(s): 半田良平, 齋藤彰, 齋藤恵美子, 本間義幸, 川浪雅光
  • Journal Title: 日歯保存誌 Pages: 670-680
  • NAID: 110007026973
  • Peer Reviewed
• [Journal Article] 歯周組織再生療法の臨床研究の現況 (2008)
  • Author(s): 川浪雅光, 齋藤彰, 加藤熈, 齋藤恵美子, 他3名
  • Journal Title: 歯科臨床研究 Pages: 71-81
  • Peer Reviewed
• [Journal Article] BMPを用いた歯周組織再生療法の開発 (2008)
  • Author(s): 宮治裕史, 菅谷勉, 齋藤彰, 齋藤恵美子, 他3名
  • Journal Title: 日本歯科評論 Pages: 39-40
• [Presentation] 人工ECMの幾何学:ハニカム型からランダム・トンネル型幾何構造のTCPの創製と骨・血管誘導 (2010)
  • Author(s): 久保木芳徳, 浦本洋一, 滝田裕子, 斎藤彰, 他5名
  • Organizer: 第22回代用臓器再生学研究会
  • Place of Presentation: 北海道大学学術交流会館札幌
  • Year and Date: 2010-01-23
• [Presentation] 人工ECMの幾何学 : ハニカム型からランダム・トンネル型幾何構造のTCPの創製と骨・血管誘導 (2010)
  • Author(s): 久保木芳徳, 浦本洋一, 滝田裕子, 斎藤彰, 他4名
  • Organizer: 第21年度・第22回代用臓器再生学研究会
• [Presentation] 歯周組織再生療法後のブラッシング開始時期の検討 (2009)
  • Author(s): 高橋大郎, 齋藤恵美子, 原橋宏幸, 齋藤彰, 他5名
  • Organizer: 第52回日本歯周病学会秋季学術大会
  • Place of Presentation: 宮崎観光ホテル宮崎
  • Year and Date: 2009-10-11
• [Presentation] Ectopic bone formation after implantation of themoreversible gelation polymer as a acarrier of bone morphogenetic protein-2 (2009)
  • Author(s): Saito E, Saito A, Takahashi S, 他3名
  • Organizer: Yokosuka Science Festa 2009 Program & Proceedings
• [Presentation] 人工マトリックスの幾何学的特性を利用した歯根膜・セメント質・骨組織再建の原理について (2009)
  • Author(s): 久保木芳徳, 滝田裕子, 斎藤彰
  • Organizer: 第27回日本骨代謝学会
• [Presentation] 歯周組織再生療法後のブラッシング開始時期の検討 (2009)
  • Author(s): 高橋大郎, 江崎光恵, 半田良平, 齋藤恵美子, 原橋宏幸, 齋藤彰, 他3名
  • Organizer: 第52回日本歯周病学会秋季学術大会
• [Presentation] Ectopic bone formation after implantation of themoreversible gelation polymer a s a acarrier of bone morphogenetic protein-2 (2009)
  • Author(s): Saito, E., Saito, A., Takahashi, S., Yamamoto, T., Honma, Y., Kawanami, M.
  • Organizer: 41ST ANNUAL MEETING OF THE JAPANESE SOCIETY FOR CONNECTIVE TISSUE RESEARCH (JSCTR)
  • Place of Presentation: Shonan Village Center YOKOSUKA
• [Presentation] Periodontal healing after transplantation of teeth cultured with EMD (2008)
  • Author(s): 齋藤彰
  • Organizer: 米国歯周病学会
  • Place of Presentation: シアトル
  • Year and Date: 2008-09-08
• [Presentation] Ryohei Handa, Yoshiyuki Honma, Masamitsu Kawanami (2008)
  • Author(s): Akira Saito, Emiko Saito
  • Organizer: Periodontal healing after transplantation of teeth cultured with EMD, AAP
• [Presentation] 半月状歯肉弁歯冠側移動術後治癒の組織学的評価 (2008)
  • Author(s): 半田良平, 齋藤彰, 齋藤恵美子, 原橋宏幸, 本間義幸, 川浪雅光
  • Organizer: 日歯保存誌 (プログラム及び講演抄録集)
• [Presentation] in vitroで歯根膜細胞を増殖させた歯の移植後の治癒に与えるエムドゲインの影響 (2007)
  • Author(s): 齋藤 彰
  • Organizer: 日本歯周病学会
  • Place of Presentation: 横須賀芸術劇場・横須賀市
  • Year and Date: 2007-05-19
• [Presentation] 新規組織接着剤による象牙質と軟組織との接着 (2007)
  • Author(s): 堀川元, 半田良平, 原橋宏幸, 齋藤恵美子, 齋藤彰, 川浪雅光
  • Organizer: 日歯保存誌50 (秋季特別号)
• [Presentation] in vitro で歯根膜細胞を増殖させた歯の移植後の治癒に与えるエムドゲインの影響 (2007)
  • Author(s): 齋藤彰, 齋藤恵美子, 原橋宏幸, 半田良平, 他4名
  • Organizer: 日歯周誌49 (春季特別号)