Regulation of cementoblast differenciation by transcriptional factors and periodontal regeneration

• Project/Area Number: 19592381
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Kagoshima University
• Principal Investigator: NOGUCHI Kazuyuki Kagoshima University, 大学院・歯学総合研究科, 教授 (90218298)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Hiroaki 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (50396967)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: セメント芽細胞 / 転写因子 / 石灰化 / 歯周組織再生 / 成長因子 / エムドゲインゲル / bFGF / PDGF / FK-506 / 歯根膜細胞 / PGE_2 / VEGF / PI-3キナーゼ

Research Abstract

セメント芽細胞はPGE_2によって石灰化の抑制が認められたのに対し、FK-506およびBMP-2の添加によりalkaline phosphatase活性の上昇、転写因子osterixの発現亢進が認められ、NFATの関与が示唆された。イヌの歯周組織欠損では、bFGFやPDGFによって良好な歯周組織再生が認められ、これらの因子に関連する転写因子に関して今後解析が必要である。

Research Products

• [Journal Article] Surface properties and biocompatibility of acid-etched titanium (2008)
  • Author(s): Iwaya Y, Machigashira M, Kanbara K, Miyamoto M, Noguchi K, Izumi Y, Ban S
  • Journal Title: Dent Mater J 27 Pages: 415-421
  • NAID: 110006742425
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 inhibits mineralization and enhances matrix metalloproteinase-13 in mature cementoblasts mainly via the EP4 pathway (2008)
  • Author(s): Oka H, Miyauchi M, Sakamoto K, Kitagawa M, Noguchi K, Somerman MJ, Takata T
  • Journal Title: Arch Oral Biol 53 Pages: 243-249
  • NAID: 120001192641
  • Peer Reviewed
• [Journal Article] Internal prostaglandin synthesis augments osteoprotegerin production in human gingival fibroblasts stimulated by lipopolysaccharide (2007)
  • Author(s): Kiji M, Nagasawa T, Hormdee D, Yashiro R, Kobayashi H, Noguchi K, Nitta H, Izumi Y, Ishikawa I
  • Journal Title: Clin Exp Immunol 149 Pages: 327-334
  • Peer Reviewed
• [Journal Article] PGE2 activates cementoclastogenesis by cementoblasts via EP4 (2007)
  • Author(s): Oka H, et. al.
  • Journal Title: J Dent Res 86 Pages: 974-979
  • Peer Reviewed
• [Journal Article] Prostaglandin E_2 inhibits mineralization and enhances matrix metallo-Proteinase-13 in mature cementoblasts mainly via the EP4 pathway (2007)
  • Author(s): Oka H, et. al.
  • Journal Title: Arch Oral Biol 53 Pages: 243-249
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin- 1alpha-stimulated human periodontal ligament cells
  • Author(s): Bando Y, Noguchi K, Kobayashi H, Yoshida N, Ishikawa I, Izumi Y.
  • Journal Title: J Periodontal Res (in press)
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-lalpha-stimulated human periodontal ligament cells.
  • Author(s): Bando Y, et al.
  • Journal Title: J Periodont Res (In press)
  • Peer Reviewed
• [Journal Article] Effect of syrface roughness on initial responses of ostoblastic-like cells on two types of zirconia
  • Author(s): Yamashita D, et al.
  • Journal Title: Dental Materials Journal (In press)
  • Peer Reviewed
• [Presentation] 歯根膜細胞におけるPGE2によるVEGF産生に関する研究 (2008)
  • Author(s): 坂東由記子、野口和行、小林宏明、和泉雄一
  • Organizer: 日本歯科保存学会2008年秋季学術大会(第129回)
  • Place of Presentation: 富山国際会議場(富山市)
  • Year and Date: 2008-11-07
• [Presentation] 歯根膜細胞におけるPGE_2によるVEGF産生に関する研究 (2008)
  • Author(s): 坂東由記子
  • Organizer: 日本歯科保存学会2008年秋季学術大会(第129回)
  • Place of Presentation: 富山国際会議場(富山市)
  • Year and Date: 2008-11-07
• [Presentation] Effect of PGE_2 on VEGF production in IL-1・-stimulated human periodontal ligament cells (2007)
  • Author(s): Bando Y, Noguchi K, Kobayashi H, Izu mi Y
  • Organizer: The 7th International M eeting of Asian Pacific, Society of Per iodontology
  • Place of Presentation: Beijin
  • Year and Date: 2007-09-21
• [Presentation] Effect of PGE_2 on VEGF production in IL-1α-stimulated human periodontal ligament cells (2007)
  • Author(s): Bando Y, et. al.
  • Organizer: The 7th International Meeting of Asian Pacific Society of Periodontology
  • Place of Presentation: Beijin
  • Year and Date: 2007-09-21