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Study of perlodontitis prevention viewed from robustness of periodontal tissues

Research Project

Project/Area Number 19592388
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

KIDO Junichi  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (10195315)

Co-Investigator(Kenkyū-buntansha) KATAOK Masatoshi  産業技術総合研究所, 健康工学研究センター, 主任研究員 (20224438)
BANDO Mika  徳島大学, 大学院・ヘルスバイオサイエンス(HBS)研究部, 技術補佐員 (10510000)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords抗菌ペプチド / ロバストネス / 歯周病予防 / 歯学 / 歯周病予防法 / マイクロアレイ
Research Abstract

本研究では, 歯周病の予防について歯周組織の感染に対する頑健性(ロバストネス)を抗菌ペプチドの発現に注目して検討を行った。その結果, 口腔上皮細胞では通常時で高発現を示すものと外的刺激により発現上昇する抗菌ペプチドが認められた。抗菌ペプチドを介したロバストネス強化因子としてInterleukin-1α(IL・1α)と小柴胡湯の効果を調べた結果, 7つの抗菌ペプチドの発現上昇が認められた。また, Calprotectinの発現については, 上皮細胞と線維芽細胞の間でIL-1αとKeratinocyte growth factor(KGF)によってその発現が調節されていることが判明した。これらの結果は, ロバストネスに視点をおいた歯周病予防の研究の基盤となると考えられる。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2009 2008 2007 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (17 results)

  • [Journal Article] Shosaikoto increases calprotectin expression in human oral epithelial cells2009

    • Author(s)
      Hiroshima Y, et al.
    • Journal Title

      J Periodont Res (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of calprotectin expression in human keratinocytes in vitro2007

    • Author(s)
      Hiroshima Y, Bando M, Kataoka M, Nagata T, Kido J
    • Journal Title

      日歯周誌 49

      Pages: 224-232

    • NAID

      10027094494

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Shosaikoto increases calprotectin expression in human oral epithelial cells

    • Author(s)
      Hiroshima Y, Bando M, Kataoka M, Shinohara Y, Herzberg MC, Ross KF, Inagaki Y, Nagata T, Kido J
    • Journal Title

      J Periodont Res (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Interleukin-1αによるS100A9遺伝子の転写調節2008

    • Author(s)
      板東美香, 廣島佑香, 木戸淳一, 片岡正俊, 永田俊彦
    • Organizer
      第51回日本歯周病学会秋季学術大会
    • Place of Presentation
      四目市
    • Year and Date
      2008-10-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 小柴胡湯がヒトロ腔上皮細胞の分化および抗菌ペプチド発現に及ぼす影響2008

    • Author(s)
      廣島佑香, 板東美香, 木戸淳一, 片岡正俊, 永田俊彦
    • Organizer
      第51回日本歯周病学会秋季学術大会
    • Place of Presentation
      四日市
    • Year and Date
      2008-10-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Interleukin-1αによるSI00A9遺伝子の転写調節2008

    • Author(s)
      板東美香, 他
    • Organizer
      第51回日本歯周病学会秋季学術大会
    • Place of Presentation
      三重県四日市市
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小柴胡湯がヒトロ腔上皮細胞の分化および抗菌ペプチド発現に及ぼす影響2008

    • Author(s)
      廣島佑香, 他
    • Organizer
      第51回日本歯周病学会秋季学術大会
    • Place of Presentation
      三重県四日市市
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sho-saiko-to increases calprotectin expression in human oral epithelial cells2008

    • Author(s)
      Hiroshima Y, Bando M, Kataoka M, Herzberg MC, Ross KF, Nagata T, Kido J
    • Organizer
      86^<th>General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 上皮細胞増殖因子(EGF)はヒトロ腔上皮細胞の抗菌ペプチド発現を調節する2008

    • Author(s)
      廣島佑香, 板東美香, 木戸淳一, 片岡正俊, 永田俊彦
    • Organizer
      第129回日本歯科保存学会秋季学術大会
    • Place of Presentation
      富山
    • Related Report
      2008 Final Research Report
  • [Presentation] IL-la and KGF regulate keratinocyte expression of antimicrobial peptides2008

    • Author(s)
      Bando M, Hiroshima Y, Kataoka M, Herzberg MC, Ross KF, Nagata T, Kido J
    • Organizer
      86^<th> General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2008 Final Research Report
  • [Presentation] 小柴胡湯はヒトロ腔上皮細胞のカルプロテクチン発現を増加する2008

    • Author(s)
      廣島佑香、板東美香、木戸淳一、片岡正俊、永田俊彦
    • Organizer
      第51回日本歯周病学会春季学術大会
    • Place of Presentation
      大宮
    • Related Report
      2008 Final Research Report
  • [Presentation] 小柴胡湯はヒトロ腔上皮細胞のカルプロテクチン発現を増加する2008

    • Author(s)
      廣島佑香, 他
    • Organizer
      第51回日本歯周病学会春季学術大会
    • Place of Presentation
      埼玉県大宮市
    • Related Report
      2008 Annual Research Report
  • [Presentation] IL-1α and KGF regulate keratinocyte expression of antim icrobial peptides.2008

    • Author(s)
      Bando M, et al.
    • Organizer
      86th General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sho-saiko-to increases calprotectin expression in humanoral epithelial cells.2008

    • Author(s)
      Hiroshima Y, et al.
    • Organizer
      86th General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2008 Annual Research Report
  • [Presentation] 上皮細胞増殖因子(EGF)はヒトロ腔上皮細胞の抗菌ペプチド発現を調節する2008

    • Author(s)
      廣島佑香, 他
    • Organizer
      第129回日本歯科保存学会秋季学術大会
    • Place of Presentation
      富山県富山市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sho-saiko-to increases calprotectin expression in human oral epithelial cells2007

    • Author(s)
      Y Hiroshilna, et. al.
    • Organizer
      The 2nd Intemational Symposium"The Future Direction of Oral Sciences in the 21st Century"
    • Place of Presentation
      Tokushima,Japan
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] IL-1α and KGF diffbrentially regulate antimicrobial peptide expression in keratinocytes2007

    • Author(s)
      M Bando, et. al.
    • Organizer
      21th International Associatlon fbr Dental Research and 19th South East Asia Association for Dental Education
    • Place of Presentation
      Bali,Indonesia
    • Year and Date
      2007-09-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト上皮細胞の抗菌ペプチド発現に及ぼすIL-1αの影響2007

    • Author(s)
      廣島佑香、板東美香、木戸淳一、片岡正俊、永田俊彦
    • Organizer
      第50回日本歯周病学学会秋季学術大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] IL-1αandKGF differentialiy regulate antimiorobial peptide expression in keratinocytes IL-1αandKGF differentialiy regulate antimiorobial peptide expression in keratinocytes2007

    • Author(s)
      Bando M, Hiroshima Y, KataokaM, Nagata T,Kido J
    • Organizer
      21th hlternational Assocfation for Dental Research and 19th South East Asia Association for Dental Eduoation, Bali
    • Place of Presentation
      Indonesia, Sept
    • Related Report
      2008 Final Research Report
  • [Presentation] IL-la regulates the expression of antimicrobial peptides in human keratinocytes2007

    • Author(s)
      Hiroshima Y, Bando M, Kataoka M, Nagata T, Kido J
    • Organizer
      21th International Association for Dental Research and 19th South East Asia Association for Dental Education, Bali
    • Place of Presentation
      Indonesia, Sept
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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