A study on acceleration of bone resorption by immunized cells

• Project/Area Number: 19592389
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Nagasaki University
• Principal Investigator: HARA Yoshitaka Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (60159100)
• Co-Investigator(Kenkyū-buntansha): 吉村 篤利 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (70253680) ; 金子 高士 長崎大学, 大学院・医歯薬学総合研究科, 助教 (10284697)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 骨吸収 / 免疫系細胞 / 感作 / リポ多糖 / リポ多糖(LPS) / T cell / LPS誘導型骨吸収 / RANKL / interferon-γ / interleukin-4

Research Abstract

細菌と免疫系が歯周炎の発症に重要な関わりをもつことは、既に知られている。しかし実際の関与の様式は明らかでなかった。本研究では免疫系細胞のうちT細胞に焦点を合わせ、細菌由来のリポ多糖(LPS)誘導型骨吸収におけるその関与を検討した。その結果、T細胞は単独(B細胞不在下)でもLPS誘導型骨吸収に促進的に働くこと、さらに感作された個体のT細胞は骨吸収局所において、その促進作用を発揮していることを明らかにした。

Research Products

• [Journal Article] Locally administered T cells from mice immunized with lipopolysaccharide (LPS) accelerate LPS-induced bone resorption (2009)
  • Author(s): Ozaki Y, Ukai T, Yamaguchi M, Yokoyama M, Ayon Haro ER, Kaneko T, Yoshinaga M, Nakamura H, Shiraishi C, Hara Y
  • Journal Title: Bone, (in press)
  • Peer Reviewed
• [Journal Article] Locally administered T cells from mice immunized with lipopoly saccharide (LPS)accelerate LPS-induced bone resorption. (2009)
  • Author(s): Ozaki Y, et al
  • Journal Title: Bone (掲載確定In press)
  • Peer Reviewed
• [Journal Article] T cells areable to promote lipopolysaccharide-induced bone resorption in mice in the absence of B cells (2008)
  • Author(s): Yamaguchi M, Ukai T, Kaneko T, Yoshinaga M, Yokoyama M, Ozaki Y, Hara Y
  • Journal Title: J Periodontal Res 43 (5) Pages: 549-555
  • Peer Reviewed
• [Journal Article] T cells are able to promote LPS-induced bone resorption under the absence of B cells in mice.
  • Author(s): M. Yamaguchi, et. al.
  • Journal Title: Journal of Periodontal Research (印刷中)
  • Peer Reviewed
• [Presentation] Locally administated T cells fromLPS-induced bone resorption (2008)
  • Author(s): Hara Y
  • Organizer: The 10th IEIIS meeting
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 2008-07-31
• [Presentation] Locally administrated T cells from LPS-immunized mice accelerate LPS-induced bone resorption (2008)
  • Author(s): Hara Y, Ozaki Y, Yokoyama M, Shiraishi C, Yoshinaga Y, Ukai T
  • Organizer: The 10th International Endotoxin and Innate Immunity Society meeting
  • Place of Presentation: Edinburgh, UK
• [Presentation] T cells are closely related to LPS-induced bone resorption. The 11th^<th> International Biennial Congress of International Academy of Periodontology (2007)
  • Author(s): Hara Y, Yamaguchi M, Ukai T, Onoyama M, Yokoyama M, Ozaki Y, Kaneko T
  • Organizer: Bern, Switzerland
• [Presentation] T cells are closely related to LPS-induced bone resorption. (2007)
  • Author(s): Y Hara, et. al.
  • Organizer: International Academy of Periodontology
  • Place of Presentation: Bern, Switzerland