Does the periodontal therapy improve visceral fat and fatty liver? : Examination by abdominal CT

• Project/Area Number: 19592390
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: SONOKI Kazuo Kyushu Dental College, 歯学部, 助教 (50316155)
• Co-Investigator(Renkei-kenkyūsha): TAKATA Yutaka 九州歯科大学, 歯学部, 教授 (40163208) ; MURAOKA Kousuke 九州歯科大学, 歯学部, 助教 (80382422) ; KASAI Hironori 九州歯科大学, 歯学部, 助教 (60398469) ; KUBOTA Kouzou 九州歯科大学, 歯学部, 助教 (60161676) ; YOKOTA Makoto 九州歯科大学, 歯学部, 教授 (40107298) ; TANAKA Tatsurou 九州歯科大学, 歯学部, 講師 (50326469) ; MORIMOTO Ysuhiro 九州歯科大学, 歯学部, 教授 (00275447)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 歯周病 / 歯周病治療 / 腹部CT / 内臓脂肪 / 脂肪肝 / アディポサイトカイン / 酸化ストレス / 酸化ストレスマーカー

Research Abstract

To investigate the relationship between periodontal disease, visceral fat and fatty liver, we took abdominal CT scan and fasting blood, and measured visceral fat area and blood examination including liver function, adipocytokine produced by visceral fat, oxidative stress marker before and after periodontal therapy. We registered 27 patients from 2007, and analyzed 15 patients who finished periodontal therapy, CT scaning and blood examination. The visceral fat area (before therapy 93.5±48.4cm^2 (mean±SD), after therapy 94.4±55.1cm^2) and each blood examination did not change.

Research Products

• [Journal Article] Serum albumin levels as an independent predictor of 4-year mortality in a community-dwelling 80-year-old population. (2010)
  • Author(s): Takata Y, Ansai T, Soh I, Awano S, Sonoki K, Akifusa S, Kagiyama S, Hamasaki T, Torisu T, Yoshida A, Nakamichi I, Takehara T
  • Journal Title: Aging Clin Exp Res. 22(1) Pages: 31-35
  • Peer Reviewed
• [Journal Article] Quality of life and physical fitness in an 85-year-old population. (2010)
  • Author(s): Yutaka Takata, Toshihiro Ansai, Inho Soh, Shuji Awano, Yutaka Yoshitake, Yasuo Kimura, Kazuo Sonoki, Shuntaro Kagiyama, Akihiro Yoshida, Ikuo Nakamichi, Tomoko Hamasaki, Takehiro Torisu, Kuniaki Toyoshima, Tadamichi Takehara
  • Journal Title: Arch Gerontol Geriatr. 50(3) Pages: 272-276
  • Peer Reviewed
• [Journal Article] 学生の心理特性とシュミレーションテストによる歯周病実習試験成績の関係について (2009)
  • Author(s): 村岡宏祐、久保田浩三、笠井宏記、園木一男、中島啓介、高田豊、横田誠
  • Journal Title: 日本歯科医学教育学会雑誌 25(3) Pages: 171-175
  • Peer Reviewed
• [Journal Article] Does decreased diastolic blood pressure associate with increased mortality in 80-year-old Japanese? (2009)
  • Author(s): Kagiyama S, Takata Y, Ansai T, Matsumura K, Soh I, Awano S, Sonoki K, Yoshida A, Torisu T, Hamasaki T, Nakamichi I, Takehara T, Iida M.
  • Journal Title: Clin Exp Hypertens. 31(8) Pages: 639-647
  • Peer Reviewed
• [Journal Article] Relations of lysophosphatidylcholine in low-density lipoprotein with serum lipoprotein-associated phospholipase A2, paraoxonase and homocysteine thiolactonase activities in patients with type 2 diabetes mellitus. (2009)
  • Author(s): Sonoki K, Iwase M, Sasaki N, Ohdo S, Higuchi S, Matsuyama N, Iida M.
  • Journal Title: Diabetes Res Clin Pract. 86(2) Pages: 117-123
  • Peer Reviewed
• [Journal Article] Cognitive function and number of teeth in a community-dwelling elderly population without dementia. (2009)
  • Author(s): Takata Y, Ansai T, Soh I, Sonoki K, Awano S, Hamasaki T, Yoshida A, Ohsumi T, Toyoshima K, Nishihara T, Takehara T.
  • Journal Title: J Oral Rehabil. 36(11) Pages: 808-813
  • Peer Reviewed
• [Journal Article] Possible Association of Atrophic Gastritis and Arterial Stiffness in Healthy Middle-Aged Japanese. (2009)
  • Author(s): Torisu T, Takata Y, Ansai T, Matsumoto T, Sonoki K, Soh I, Awano S, Yoshida A, Hamasaki T, Kagiyama S, Nakamichi I, Ohsumi T, Toyoshima K, Nishihara T, Iida M, Takehara T.
  • Journal Title: J Atheroscler Thromb. 16(5) Pages: 691-697
  • NAID: 10026143884
  • Peer Reviewed
• [Journal Article] IgA Level Is Associated with Risk for Mortality in an Eighty-Year-Old Population. (2009)
  • Author(s): Torisu T, Takata Y, Ansai T, Soh I, Awano S, Sonoki K, Kagiyama S, Nakamichi I, Yoshida A, Hamasaki T, Matsumoto T, Iida M, Takehara T
  • Journal Title: Gerontology 55(2) Pages: 179-185
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor antagonists prevent glucose-induced increases in islet blood flow in rats. (2009)
  • Author(s): Iwase M, Uchizono Y, Nohara S, Sasaki N, Sonoki K, Iida M
  • Journal Title: Scand J Clin Lab Invest. 69(1) Pages: 145-150
  • Peer Reviewed
• [Journal Article] Relationship between chewing ability and high-level functional capacity in an 80-year-old population in Japan. (2008)
  • Author(s): Takata Y, Ansai T, Soh I, Akifusa S, Sonoki K, Fujisawa K, Yoshida A, Kagiyama S, Hamasaki T, Nakamichi I, Awano S, Torisu T, Takehara T
  • Journal Title: Gerodontology 25(3) Pages: 147-154
  • Peer Reviewed
• [Journal Article] Secretory PLA(2) inhibitor indoxam suppresses LDL modification and associated inflammatory responses in TNFalpha-stimulated human endothelial cells. (2008)
  • Author(s): Sonoki K, Iwase M, Sasaki N, Ohdo S, Higuchi S, Takata Y, Iida M
  • Journal Title: Br J Pharmacol 153(7) Pages: 1399-1408
  • Peer Reviewed
• [Journal Article] Association of chewing ability with cardiovascular disease mortality in the 80-year-old Japanese population. (2008)
  • Author(s): Ansai T, Takata Y, Soh I, Yoshida A, Hamasaki T, Awano S, Sonoki K, Akifusa S, Fukuhara M, Sogame A, Shimada N, Takehara T
  • Journal Title: Eur J Cardiovasc Prev Rehabil. 15(1) Pages: 104-106
  • Peer Reviewed
• [Journal Article] Lysophosphatidylcholine contents in plasma LDL in patients with type 2 diabetes mellitus: Relation with lipoprotein-associated phospholipase A2 and effects of simvastatin treatment (2008)
  • Author(s): Masanori Iwase, Kazuo Sonoki, Nobuhiro Sasaki, Shigehiro Ohdo, Shun Higuchi, Hiroaki Hattori, Mitsuo Iida
  • Journal Title: Atherosclerosis. 196(2) Pages: 931-936
  • Peer Reviewed
• [Journal Article] Association between blood pressure and mortality in 80-year-old subjects from a population-based prospective study in Japan (2008)
  • Author(s): Shuntaro Kagiyama, Masayo Fukuhara, Toshihiro Ansai, Kiyoshi Matsumura, Inho Soh, Yutaka Takata, Kazuo Sonoki, Shuji Awano, Tadamichi Takehara, Mitsuo Iida
  • Journal Title: Hypertension Research 31(2) Pages: 265-270
  • NAID: 10024359832
  • Peer Reviewed
• [Journal Article] Relationship between volatile sulfer compounds in mouth air and systemic disease. (2008)
  • Author(s): Shuji Awano, Toshihiro Ansai, Yutaka Takata, Inho Soh, Akihiro Yoshida, Tomoko Hamasaki, Shuntaro Kagiyama, Ikuo Nakamichi, Kazuo Sonoki, Tadamichi Takehara
  • Journal Title: Journal of Breath Research. 2 Pages: 1-4
  • Peer Reviewed
• [Journal Article] Oral health and mortality risk from pneumonia in the elderly. (2008)
  • Author(s): Awano S, Ansai T, Takata Y, Soh I, Akifusa S, Hamasaki T, Yoshida A, Sonoki K, Fujisawa K, Takehara T
  • Journal Title: J Dent Res. 87(4) Pages: 334-339
  • Peer Reviewed
• [Journal Article] Relationship between number of teeth and serum lipid peroxide in an 85-year-old population. (2008)
  • Author(s): Sonoki K, Takata Y, Ansai T, Fujisawa K, Fukuhara M, Wakisaka M, Awano S, Akifusa S, Yoshida A, Hamasaki T, Takehara T
  • Journal Title: Community Dental Health 25(4) Pages: 243-247
  • Peer Reviewed
• [Journal Article] Physical Fitness and Cognitive Function in an 85-Year-Old Community-Dwelling Population. (2008)
  • Author(s): Takata Y, Ansai T, Soh I, Kimura Y, Yoshitake Y, Sonoki K, Awano S, Kagiyama S, Yoshida A, Nakamichi I, Hamasaki T, Torisu T, Toyoshima K, Takehara T
  • Journal Title: Gerontology. 54(6) Pages: 354-360
  • Peer Reviewed
• [Journal Article] Association between salivary levels of chromogranin A and periodontitis in older Japanese (2008)
  • Author(s): Hironaka M, Ansai T, Soh I, Ishisaka A, Awano S, Yoshida A, Hamasaki T, Sonoki K, Takata Y, Takehara T
  • Journal Title: Biomed Res. 29(3) Pages: 125-130
  • NAID: 130004470705
  • Peer Reviewed
• [Journal Article] Association of cortisol and dehydroepiandrosterone sulphate levels in serum with periodontal status in older Japanese adults. (2008)
  • Author(s): Ishisaka A, Ansai T, Soh I, Inenaga K, Awano S, Yoshida A, Hamasaki T, Sonoki K, Takata Y, Nishihara T, Takehara T
  • Journal Title: J Clin Periodontol. 35(10) Pages: 853-61
  • Peer Reviewed
• [Journal Article] Atrophic gastritis, but not antibody to Helicobacter pylori, is associated with body mass index in a Japanese population (2008)
  • Author(s): Torisu T, Matsumoto T, Takata Y, Ansai T, Soh I, Awano S, Nakamichi I, Kagiyama S, Sonoki K, Yoshida A, Hamasaki T, Iida M, Takehara T
  • Journal Title: J Gastroenterol. 43(10) Pages: 762-766
  • NAID: 10024423396
  • Peer Reviewed
• [Journal Article] Chronic kidney disease increases cardiovascular mortality in 80-year-old subjects in Japan. (2008)
  • Author(s): Kagiyama S, Matsumura K, Ansai T, Soh I, Takata Y, Awano S, Sonoki K, Yoshida A, Takehara T, Iida M
  • Journal Title: Hypertens Res. 31(11) Pages: 2053-2058
  • NAID: 10024828165
  • Peer Reviewed
• [Journal Article] High-level functional capacity and 4-year mortality in an 80-year-old population. (2007)
  • Author(s): Takata Y, Ansai T, Akifusa S, Soh I, Sonoki K, Takehara T
  • Journal Title: Gerontology 53 Pages: 46-51
  • Peer Reviewed
• [Journal Article] Physical fitness and 4-year mortality in an 80-year-old population. (2007)
  • Author(s): Takata Y, Ansai T, Akifusa S, Soh I, Yoshitake Y, Kimura Y, Sonoki K, Fujisawa K, Awano S, Kagiyama S, Hamasaki T, Nakamichi I, Yoshida A, Takehara T.
  • Journal Title: J Gerontol A Biol Sci Med Sci. 62(8) Pages: 851-858
  • NAID: 110006453305
  • Peer Reviewed
• [Journal Article] Hyperglycemia promotes microinflammation as evaluated by C-reactive protein in the very elderly. (2007)
  • Author(s): Fukuhara M, Matsumura K, Wakisaka M, Takata Y, Sonoki K, Fujisawa K, Ansai T, Akifusa S, Fujii K, Iida M, Takehara T
  • Journal Title: Intern Med. 46(5) Pages: 207-212
  • NAID: 130000078552
  • Peer Reviewed
• [Journal Article] Association between body mass index and mortality in an 80-year-old population. (2007)
  • Author(s): Takata Y, Ansai T, Soh I, Akifusa S, Sonoki K, Fujisawa K, Awano S, Kagiyama S, Hamasaki T, Nakamichi I, Yoshida A, Takehara T
  • Journal Title: J Am Geriatr Soc. 55(6) Pages: 913-917
  • Peer Reviewed
• [Journal Article] Association of salivary levels of cortisol and dehydroepiandrosterone with periodontitis in older Japanese adults. (2007)
  • Author(s): Ishisaka A, Ansai T, Soh I, Inenaga K, Yoshida A, Shigeyama C, Awano S, Hamasaki T, Sonoki K, Takata Y, Takehara T
  • Journal Title: J Periodontol 78(9) Pages: 1767-1773
  • Peer Reviewed
• [Presentation] 2型糖尿病患者におけるテルミサルタンおよびピオグリタゾンのLDL中リゾリン脂質(LPC)に及ぼす効果 (2009)
  • Author(s): 園木一男、岩瀬正典、佐々木伸浩、飯田三雄、大戸茂弘、樋口駿、松山直人
  • Organizer: 第41回日本動脈硬化学会総会
  • Place of Presentation: 下関市
  • Year and Date: 2009-07-18
• [Presentation] 歯周病治療は内臓脂肪および脂肪肝を改善するか:腹部CTによる検討. (2009)
  • Author(s): 園木一男、高田豊、村岡宏祐、田中達朗、笠井宏記、久保田浩三、森本泰宏、横田誠
  • Organizer: 第69回九州歯科学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2009-05-31
• [Presentation] シンポジウム10:糖尿病患者の脂質異常症-量の異常から質の異常へ-糖尿病におけるldlリゾリン脂質と動脈硬化 (2009)
  • Author(s): 園木一男、岩瀬正典
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2009-05-23
• [Presentation] 歯周病をもつ80歳糖尿病患者は肺炎死のリスクが高い (2008)
  • Author(s): 園木一男、藤澤聖、岩瀬正典、高田豊、粟野秀慈、安細敏弘、竹原直道、飯田三雄
  • Organizer: 第46回日本糖尿病学会九州地方会
  • Place of Presentation: 久留米市
  • Year and Date: 2008-10-10
• [Presentation] OSCEにおける情動ストレスの検出と心理テストとの関係(第2報) (2008)
  • Author(s): 園木一男、村岡宏祐、笠井宏記、久保田浩三、芳賀健輔、鳥巣剛弘、中道郁夫、鍵山俊太郎、高田豊, 横田誠
  • Organizer: 第68回九州歯科学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2008-06-01
• [Presentation] 2型糖尿病患者におけるテルミサルタンおよびピオグリタゾンのLDL中リゾリン脂質(LPC)に及ぼす効果. (2008)
  • Author(s): 園木一男、岩瀬正典、佐々木伸浩、土井康文、藤井裕樹、菊池洋平、飯田三雄、松山直人
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 糖尿病合併症とhomocysteine thiolactonase、PAF-AHとの関係:リポバス投与による変化 (2007)
  • Author(s): 園木一男、岩瀬正典、佐々木伸浩、飯田三雄、松山直人
  • Organizer: 第50回日本糖尿病学会年次学術集会
  • Place of Presentation: 仙台市
  • Year and Date: 2007-05-26
• [Presentation] OSCEにおける情動ストレスの検出と心理テストとの関係 (2007)
  • Author(s): 園木一男, 村岡宏祐, 笠井宏記, 久保田浩三, 芳賀健輔, 中道郁夫, 鍵山俊太郎, 高田豊, 横田誠
  • Organizer: 第67回九州歯科学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2007-05-20
• [Presentation] 歯周病治療の血中アディポサイトカインへの影響 (2007)
  • Author(s): 園木一男, 村岡宏祐, 笠井宏記, 久保田浩三, 芳賀健輔, 中道郁夫, 鍵山俊太郎, 高田豊, 横田誠
  • Organizer: 第67回九州歯科学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2007-05-20
• [Presentation] 初老期高齢者における歯周病パラメーターとインスリン抵抗性(HOMA index)の関係 (2007)
  • Author(s): 園木一男, 高田豊, 安細敏弘, 邵仁浩, 粟野秀慈, 中道郁夫, 吉田明弘, 鍵山俊太郎, 濱嵜朋子, 竹原直道
  • Organizer: 第67回九州歯科学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2007-05-20
• [Presentation] 初老期高齢者の口臭と口腔内関連因子について (2007)
  • Author(s): 粟野秀慈, 安細敏弘, 邵仁浩, 濱嵜朋子, 吉田明弘, 園木一男, 高田豊, 竹原直道
  • Organizer: 第67回九州歯科学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2007-05-19
• [Presentation] 初老期高齢者における認知能と健全歯数の関係 (2007)
  • Author(s): 高田豊, 安細敏弘, 邵仁浩, 園木一男, 粟野秀慈, 中道郁夫, 吉田明弘, 鍵山俊太郎, 濱嵜朋子, 竹原直道
  • Organizer: 第67回九州歯科学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2007-05-19
• [Presentation] 80歳高齢住民における運動能力と死亡率の関係 (2007)
  • Author(s): 高田豊, 安細敏弘, 邵仁浩, 園木一男, 粟野秀慈, 中道郁夫, 吉田明弘, 鍵山俊太郎, 濱嵜朋子, 竹原直道
  • Organizer: 第67回九州歯科学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2007-05-19
• [Presentation] 80歳高齢住民の咀嚼機能と高次生活活動能力 (2007)
  • Author(s): 高田豊, 安細敏弘, 邵仁浩, 園木一男, 粟野秀慈, 中道郁夫, 吉田明弘, 鍵山俊太郎, 濱嵜朋子, 竹原直道
  • Organizer: 第67回九州歯科学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2007-05-19
• [Presentation] 初老期高齢者における咀嚼習慣と脂肪細胞由来ホルモンの関係 (2007)
  • Author(s): 安細敏弘, 高田豊, 園木一男, 粟野秀慈, 大住友子, 豊島邦昭, 西原達次, 竹原直道
  • Organizer: 第67回九州歯科学会総会
  • Place of Presentation: 北九州市
• [Presentation] 糖尿病におけるLDLリゾリン脂質含量と動脈硬化 (2007)
  • Author(s): 園木一男、岩瀬正典、松山直人
  • Organizer: 第39回日本動脈硬化学会総会
  • Place of Presentation: 大阪市
• [Presentation] 福岡県地域住民における歯周病とインスリン抵抗性の検討 (2007)
  • Author(s): 園木一男、岩瀬正典、高田豊、安細敏弘、竹原直道、飯田三雄
  • Organizer: 第45回日本糖尿病学会九州地方会
  • Place of Presentation: 宮崎市
• [Presentation] Secretory Phospholipase A2 Inhibitor Indoxam Suppresses LDL Modification and Associated Atherogenicity in vitro. American diabetes association (2007)
  • Author(s): Kazuo Sonoki, Masanori Iwase, Shigehiro Ohdo, Shun Higuchi, Yutaka Takata, Mitsuo Iida
  • Organizer: 67th scientific sessions
  • Place of Presentation: Chicago, IL
• [Book] 歯・咀嚼とQOL (2008)
  • Author(s): 高田豊, 安細敏弘, 園木一男, 邵仁浩, 竹原直道
  • Publisher: 日本臨床
• [Book] 歯周病と過酸化脂質. 総合臨床特集医科-歯科診療の連携 (2007)
  • Author(s): 園木一男, 高田豊, 横田誠