Rejuvenation with oral aging analysis

• Project/Area Number: 19592414
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: MATSUZAKA Kenichi Tokyo Dental College, 歯学部, 准教授 (70266568)
• Co-Investigator(Kenkyū-buntansha): YOSHINARI Masao 東京歯科大学, 歯学部, 教授 (10085839) ; ISHIHARA Kazuyuki 東京歯科大学, 歯学部, 教授 (00212910) ; INOUE Takashi 東京歯科大学, 歯学部, 教授 (20125008)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 老年歯科学 / 老化 / 再生医学 / アンチエイジング / 口腔 / 細菌 / 口腔加齢

Research Abstract

Although morphological and functional changes with age cannot be kept away, environment factors play an important role for controlling the excessive changes. This study revealed that excessive changes with age could be regulated using the controlling of environment factors.

Research Products

• [Journal Article] Effects of epidermal growth factor and/or nerve growth factor on Malassez's epithelial rest cells in vitro : mRNA expression of osteopontin (2010)
  • Author(s): Yamawaki K., Matsuzaka K., Kokubu E., Inoue T.
  • Journal Title: BMP-2 and VEGF,J Periodont Res 45 Pages: 421-427
  • Peer Reviewed
• [Journal Article] Responces of immature dental pulp under hypoxic conditions in vitro (2010)
  • Author(s): Senzui S., Matsuzaka K., Fukuhara F., Shintani S., Inoue T.
  • Journal Title: Oral Med Pathol 14 Pages: 107-111
  • Peer Reviewed
• [Journal Article] Age-related differences in the expression of heat shock protein 27 by rat periodontal ligament cells in culture (2010)
  • Author(s): Matsuzaka K., Kokubu E., Ito F., Ishida S., Endoh T., Katakura A., Yoshinari M., Inoue T.
  • Journal Title: Oral Med Pathol 14 Pages: 131-134
  • NAID: 130004509536
  • Peer Reviewed
• [Journal Article] Effect of mechanical loading on cultured osteogenic cells derived from different stages of bone wound healing in rats : experimental models for immediate or early loading implant models (2010)
  • Author(s): Sato D., Matsuzaka K., Kokubu E., Inoue T.
  • Journal Title: Oral Med Pathol 14 Pages: 143-151
  • Peer Reviewed
• [Journal Article] Effects of an atelocollagen sponge during the wound healing of tooth extraction sockets at an early stage (2010)
  • Author(s): Iwata S, Matsuzaka K, Inou,e T
  • Journal Title: Oral Medicine and Pathology Volume: 15 Pages: 15-20
  • NAID: 130004509541
  • Peer Reviewed
• [Journal Article] The expression of RANKL, OPG and TNF-alpha and/or tissues around alveolar bone during early-stage rat tooth germ development (2010)
  • Author(s): Fukuhara F, Matsuzaka K, Senzui S, Shintani S, Inoue T
  • Journal Title: Oral Medicine and Pathology Volume: 15 Pages: 39-43
  • Peer Reviewed
• [Journal Article] The effect of different surface roughnesses on the differentiation of MT3T3-E1 mouse osteoblasts in vitro (2010)
  • Author(s): Takemoto K, Matsuzaka K, Shimono M, Yoshinari M, Inoue T
  • Journal Title: Oral Medicine and Pathology Volume: 15 Pages: 45-51
  • Peer Reviewed
• [Journal Article] Age-related differences in the expression of heat shock protein 27 by rat periodontal ligament cells in culture (2010)
  • Author(s): Matsuzaka K, Kokubu E, Ito F, Ishida S, Endoh T, Katakura A, Yoshinari M, Inoue T
  • Journal Title: Oral Med Pathol 14(in press)
  • NAID: 130004509536
  • Peer Reviewed
• [Journal Article] Effect of mechanical loading on cultured osteogenic cells derived from different stages of bone wound healing in rats : experimental models for immediate or early loading implant models (2010)
  • Author(s): Sato D, Matsuzaka K, Kokubu E, Inoue T
  • Journal Title: Oral Med Pathol 14(in press)
  • Peer Reviewed
• [Journal Article] Responces of immature dental pulp under hypoxic conditions in vitro (2010)
  • Author(s): Senzui S, Matsuzaka K, Fukuhara F, Shintani S, Inoue T
  • Journal Title: Oral Med Pathol 14 Pages: 107-111
  • Peer Reviewed
• [Journal Article] Effects of epidermal growth factor and/or nerve growth factor on Malassez's epithelial rest cells in vitro : mRNA expression of osteopontin, BMP-2 and VEGF (2010)
  • Author(s): Yamawaki K, Matsuzaka K, Kokubu E, Inoue T
  • Journal Title: J Periodont Res, on line publication
  • Peer Reviewed
• [Journal Article] Effects of nicotine on Malassez' epithelial rest cells in early primary culture : cell proliferation and mRNA expression of heat shock protein 70 and vascular endothelial growth factor. (2009)
  • Author(s): Nakagawa E., Matsuzaka K., Naruse S., Naito K., Inoue T.
  • Journal Title: Oral Med Pathol 13 Pages: 41-45
  • NAID: 130004509517
  • Peer Reviewed
• [Journal Article] Mechanical force promotes proliferation and early differentiation of bone marrow derived osteoblast-like cells in vitro. (2009)
  • Author(s): Naito K., Matsuzaka K, Ishigami K., Inoue T.
  • Journal Title: Oral Med Pathol 13 Pages: 151-157
  • NAID: 130004509526
  • Peer Reviewed
• [Journal Article] Molecular and morphological analyses of the osteogenic activity of rat cultured periosteum cells in vivo and in vivo (2009)
  • Author(s): Soumiya H., Matsuzaka K., Shibahara T., Inoue T.
  • Journal Title: Oral Med Pathol 14 Pages: 19-28
  • Peer Reviewed
• [Journal Article] Molecular and morphological analyses of the osteogenic activity of rat cultured periosteum cells in vivo and in vivo (2009)
  • Author(s): Soumiya H, Matsuzaka K, Shibahara T, Inoue T
  • Journal Title: Oral Med Pathol 14 Pages: 19-28
  • Peer Reviewed
• [Journal Article] Mechanical force promotes proliferation and early differentiation of bone marrow derived osteoblast-like cells in vitro (2009)
  • Author(s): Naito K, Matsuzaka K, Ishigami K, Inoue T
  • Journal Title: Oral Med Pathol 13 Pages: 151-157
  • NAID: 130004509526
  • Peer Reviewed
• [Journal Article] Effects of nicotine on Malassez' epithelial rest cells in early primary culture : cell proliferation and mRNA expression of heat shock protein 70 and vascular endothelial growth factor (2009)
  • Author(s): Nakagawa E, Matsuzaka K, Naruse S, Naito K, Inoue T
  • Journal Title: Oral Med Pathol 13 Pages: 41-45
  • NAID: 130004509517
  • Peer Reviewed
• [Journal Article] Effects of nicotine on Malassez' epithelial rest cells in early primary culture : cell proliferation and mRNA expression of heat shock protein 70 and vascular endothelial growth factor (2009)
  • Author(s): Nakagawa E, Matsuzaka K, et al.
  • Journal Title: Oral Medicine and Pathology 13 Pages: 41-45
  • NAID: 130004509517
  • Peer Reviewed
• [Journal Article] Mechanical force promotes proliferation and early differentiation of bone marrow derived osteoblast-like cells in vitro (2009)
  • Author(s): Naito K, Matsuzaka K, et al.
  • Journal Title: Oral Medicine and Pathology 13 Pages: 151-157
  • NAID: 130004509526
  • Peer Reviewed
• [Journal Article] Molecular and morphological analyses of the osteogenic activity of rat cultured periosteum cells in vivo and in vivo (2009)
  • Author(s): Soumiya H, Matsuzaka K, et al.
  • Journal Title: Oral Medicine and Pathology 14 Pages: 19-28
  • Peer Reviewed
• [Journal Article] Changes in the homeostatic mechanism of dental pulp with age : Expression of CBFA-1, dentin sialoprotein (2008)
  • Author(s): Matsuzaka K., Muramatsu T., Katakukra A., Ishihara K., Hashimoto S., Yoshinari M., Endo T., Tazaki M., Shintani M., Sato Y., Inoue T.
  • Journal Title: VEGF and HSP-27 mRNAs,J Endodontics 34(7) Pages: 818-821
  • Peer Reviewed
• [Journal Article] Changes in the homeostatic mechanism of dental pulp with age : Expression of CBFA-1, dentin sialoprotein, VEGF and HSP-27 mRNAs (2008)
  • Author(s): Matsuzaka K, Muramatsu T, Katakukra A, Ishihara K, Hashimoto S, Yoshinari M, Endo T, Tazaki M, Shintani M, Sato Y, Inoue T
  • Journal Title: J Endodontics 34 Pages: 818-821
  • Peer Reviewed
• [Journal Article] Changes in the homeostatic mechanism of dental pulp with age : Expression of CBFA-1, dentin sialoprotein, VEGF and HSP-27mRNAs (2008)
  • Author(s): Matsuzaka, et al.
  • Journal Title: J Endodontics 34 Pages: 818-821
  • Peer Reviewed
• [Journal Article] Effect on the amount of bone-implant contact when splinting immediate-loaded dental implants (2007)
  • Author(s): Matsuzaka K., Nakajima T., Soejima Y., Kido, H., Matsuura M., Inoue T.
  • Journal Title: Implant Dentistry 16,(3) Pages: 309-316
  • Peer Reviewed
• [Journal Article] Characteristics of newly formed bone during guided bone regeneration Analysis of Cbfa-1 (2007)
  • Author(s): Tanaka S., Matsuzaka K., Sato D., Inoue T.
  • Journal Title: osteocalcin, and VEGF expression, JOral Implantology 33(6) Pages: 321-326
  • Peer Reviewed
• [Journal Article] Effect on the amount of bone-implant contact when splinting immediate-loaded dental implants. (2007)
  • Author(s): Matsuzaka K, et. al.
  • Journal Title: Implant Dentistry 16 Pages: 309-316
  • Peer Reviewed
• [Journal Article] Characteristics of newly formed bone during guided bone regeneration:Analysis of CBFA-1,osteocalcin,and VEGF expression (2007)
  • Author(s): Tanaka S, Matsuzaka k, et. al.
  • Journal Title: Journal of Oral Implantology 33 Pages: 321-326
  • Peer Reviewed
• [Remarks] ホームページ等