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Application of Kampo medicine to periodontal disease treatment and clarification of its mechanisms

Research Project

Project/Area Number 19592419
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

WANG Pao-li  Matsumoto Dental University, 歯学部, 教授 (20213613)

Co-Investigator(Kenkyū-buntansha) IMAMURA Yasuhiro  松本歯科大学, 歯学部, 講師 (00339136)
ARA Toshiaki  松本歯科大学, 歯学部, 助教 (90387423)
HUJIGAKI Yoshihisa  松本歯科大学, 歯学部, 助教 (80367523)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords歯周病 / LPS / PGE_2 / COX-2 / 小柴胡湯 / 抗炎症作用 / 漢方薬
Research Abstract

歯周病は、歯周病関連細菌の菌体成分(LPSなど)刺激によりヒト歯肉線維芽細胞(HGFs)などが炎症性サイトカイン、プロスタグランジン(PG)E2などを産生することで生じる慢性炎症疾患である。一般的に歯周病治療は歯石・プラークの除去を行うが、炎症症状が著しい場合には抗炎症薬を投与することがある。しかし、一般的な抗炎症薬は胃腸障害などの副作用がある。抗炎症作用を示す漢方薬、小柴胡湯にはこれら副作用がない。小柴胡湯によるHGFsの炎症性物質産生抑制効果を検討し、明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (7 results)

All 2008 2007 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] Preventive effects of a Kampo medicine, Shosaikoto, on inflammatory responses in LPS-treated human gingival fibroblasts.2008

    • Author(s)
      Ara, T., Maeda, Y., Fujinami, Y., Imamura, Y., Hattori, T., and Wang, P.-L.
    • Journal Title

      Biol. Pharm. Bull. 31

      Pages: 1141-1144

    • NAID

      110006684330

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effects of a Kampo medicine, Shosaikoto, on inflammatory responses in LPS-treated human gingival fibroblasts2008

    • Author(s)
      Ara, T.
    • Journal Title

      Biol. Pharm. Bull. 31

      Pages: 1141-1144

    • NAID

      110006684330

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effects of a Kampo medicine, Shosaikoto, on inflammatory responses in LPS-treated human gingival fibroblasts2008

    • Author(s)
      Ara T.
    • Journal Title

      Biol. Pharm. bull. (掲載確定)(in press)

    • NAID

      110006684330

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article]

    • Pages
      0-0
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト歯肉線維芽細胞を用いた歯周病モデルにおける小柴胡湯の抗炎症作用の解明2008

    • Author(s)
      荒敏昭
    • Organizer
      第51回秋季日本歯周病学会学術大会
    • Place of Presentation
      愛知県四日市市
    • Year and Date
      2008-10-19
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト歯肉線維芽細胞を用いた歯周病モデルにおける小柴胡湯の抗炎症作用の解明2008

    • Author(s)
      荒 敏昭
    • Organizer
      第51回秋季日本歯周病学会学術大会
    • Place of Presentation
      愛知県四日市市四日市市文化会館
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] in vitro歯周病モデルにおける小柴胡湯の抗炎症作用の検討2007

    • Author(s)
      荒 敏昭
    • Organizer
      第27回日本歯科薬物療法学会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-22
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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