| Project/Area Number |
19592420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
NAGANO Yutaka Osaka Dental University, 歯学部, 講師 (80228048)
|
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| Co-Investigator(Kenkyū-buntansha) |
DOMAE Naochika 大阪歯科大学, 歯学部, 教授 (60115889)
KAMBARA Masaki 大阪歯科大学, 歯学部, 教授 (90103085)
MIYAKE Taturou 大阪歯科大学, 歯学部, 准教授 (40200141)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 社会歯学 / 内科 / 歯学 / メタボリックシンドローム / 歯周炎 / 歯周病 / メタボリック シンドローム / シグナル伝達 / 社会医学 |
|---|
| Research Abstract |
In this project, we investigated the relevance of periodontal condition and markers for common systemic diseases. The results revealed that, in middle-aged subjects, the abnormalities of systemic data were seen more frequently in subjects with periodontal problems. We also looked at the mechanisms of bone resorption under chronic inflammatory condition, and demonstrated that osetoprotegerin, a molecule that regulate bone resorption, was clearly induced when monocytes differentiate into macrophages. The results are considered to be useful for early detection of periodontitis and prevention of alveolar bone loss.
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