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Study on the infection control and prevention based on oriental philosophy

Research Project

Project/Area Number 19592432
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Fundamental nursing
Research InstitutionUniversity of Toyama

Principal Investigator

OCHIAI Hiroshi  University of Toyama, 医学薬学研究部(医学), 教授 (30018692)

Co-Investigator(Kenkyū-buntansha) YOSHII Miho  富山大学, 医学薬学研究部(医学), 講師 (30334733)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords感染看護 / 和漢薬 / インフルエンザウイルス / 芳香暴露 / シナモン / マイタケ / インフルエンザ / 植物精油 / 病室環境衛生
Research Abstract

東洋の知に基づく和漢薬を対象にすることは、感染予防の面からも西洋医学にはない新たな可能性が期待できる。その和漢薬の一つ桂皮アルデヒド(シナモン)(200~20μM)はインフルエンザウイルス感染後3-4時間の1時間添加した時最大のウイルス増殖抑制作用を示した。またその芳香吸入は感染マウスの生残率を有意に改善した。そこで再度芳香暴露の影響を検討したところ、37℃、1時間芳香暴露で生残ウイルスはおよそ1/10に減少することを見いだした。このことからシナモン芳香暴露はインフルエンザウイルス感染予防に有用かつ新しい方法であることが示唆された。同時にマイタケ抽出液は、マクロファージを刺激し抗インフルエンザウイルス蛋白質(TNF-α)を産生させることを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (49 results)

All 2009 2008 2007 Other

All Journal Article (28 results) (of which Peer Reviewed: 13 results) Presentation (21 results)

  • [Journal Article] 植物精油の直接接触および芳香暴露の抗インフルエンザウイルス作用に関する研究2009

    • Author(s)
      中平比沙子、小尾信子、宮原龍郎、落合宏
    • Journal Title

      アロマテラピー学雑誌 9

      Pages: 38-46

    • Related Report
      2008 Final Research Report
  • [Journal Article] The depressive effects of 5,8,11-eicosatrienoic acid (20 : 3n-9) on osteoblasts2009

    • Author(s)
      Hamazaki T., Suzuki N., Ochiai H., et.al.
    • Journal Title

      Lipids 44

      Pages: 97-102

    • Related Report
      2008 Final Research Report
  • [Journal Article] Inhibitory effect of TNF-αprouced by macrophages timuated with Grifol frondosa extract(ME) on the growth of influenza A/Aichi/2/68 virus in MDCK cells. Am2008

    • Author(s)
      Obi N., Hayashi K., Ochiai H., et al.
    • Journal Title

      J. Chinese Med 36

      Pages: 1171-1183

    • Related Report
      2008 Final Research Report
  • [Journal Article] Approach to a new dihydrofuran-fused cyclic system by a remarkable switching of endolexo selectivity of a [4+2] cycloaddition reaction. Eur2008

    • Author(s)
      Matsuy Y., Imamura ., Miyahara T., Ociai H., and Nemoto H.
    • Journal Title

      J. Org. Chem

      Pages: 1426-1430

    • Related Report
      2008 Final Research Report
  • [Journal Article] 看護学生の臨地実習における感染防止対策に関する意識と実際2008

    • Author(s)
      吉井美穂, 八塚美樹、塚原節子、落合宏
    • Journal Title

      富山大学看護学会誌 8(1)

      Pages: 63-67

    • NAID

      120005304882

    • Related Report
      2008 Final Research Report
  • [Journal Article] 看護師の試験的使用を通したゲル状擦式手指消毒剤の評価2008

    • Author(s)
      境美代子、吉井美穂、小尾信子、落合宏
    • Journal Title

      富山大学看護学会誌 8(1)

      Pages: 33-40

    • NAID

      120005304879

    • Related Report
      2008 Final Research Report
  • [Journal Article] ホタテ貝殻焼成粉末の殺菌および殺インフルエンザウイルス作用について2008

    • Author(s)
      村田亜悠美、小尾信子、中平比沙子、宮原龍郎、落合宏
    • Journal Title

      富山大学看護学会誌 7(2)

      Pages: 39-49

    • NAID

      110007125877

    • Related Report
      2008 Final Research Report
  • [Journal Article] 終末期がん患者の男性家族員が捉えたギアチュンジ2008

    • Author(s)
      長光代、落合宏、上野栄一
    • Journal Title

      富山大学看護学会誌 7(2)

      Pages: 15-28

    • Related Report
      2008 Final Research Report
  • [Journal Article] ポリクオタニウム-51含有エタノールの手指消毒効果とマウス皮膚保護作用2008

    • Author(s)
      安東則子、小尾信子、宮崎剛、落合宏
    • Journal Title

      日本環境感染学会誌 23

      Pages: 35-39

    • NAID

      10024358740

    • Related Report
      2008 Final Research Report
  • [Journal Article] Approach to a new dihydrofuran-fused cyclic system by a remarkable switching of endolexo selectivity of A [4+2] cycloaddition reaction2008

    • Author(s)
      Matsuya Yuji
    • Journal Title

      European Journal of Organic Chemistry

      Pages: 1426-1430

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of TNF-α produced by macrophages stimulated with Grifola frondosa extract(ME) on the growth of influenza A/Aichi/2/68 virus in MDCK cells2008

    • Author(s)
      Obi Nobuko
    • Journal Title

      American Journal of Chinese Medicine 36

      Pages: 1171-1183

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ポリクオタニウム-51含有エタノールの手指消毒効果とマウス皮膚保護作用2008

    • Author(s)
      安東則子
    • Journal Title

      日本環境感染学会誌 23

      Pages: 35-39

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 終末期がん患者の男性家族員が捉えたギアチエンジ2008

    • Author(s)
      長 光代
    • Journal Title

      富山大学看護学会誌 7

      Pages: 15-28

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ホタテ貝殻焼成粉末の殺菌および殺インフルエンザウイルス作用について2008

    • Author(s)
      村田亜悠美
    • Journal Title

      富山大学看護学会誌 7

      Pages: 39-49

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 看護師の試験的使用を通したゲル状擦式手指消毒剤の評価2008

    • Author(s)
      境 美代子
    • Journal Title

      富山大学看護学会誌 8

      Pages: 33-40

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 看護学生の臨地実習における感染防止対策に関する意識と実際2008

    • Author(s)
      吉井美穂
    • Journal Title

      富山大学看護学会誌 8

      Pages: 63-67

    • NAID

      40016415620

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 看護の場のダブルバインド2007

    • Author(s)
      山根節子、落合宏
    • Journal Title

      看護展望 32

      Pages: 89-94

    • Related Report
      2008 Final Research Report
  • [Journal Article] Chotosan enhances macrophage colony-stimulating factor mRNA expression in the ischemic rat brain and C6Bu-1 glioma cells2007

    • Author(s)
      Obi R., Tohda M., Ochiai H., et al.
    • Journal Title

      Biol. Pharm. Bull 30(12)

      Pages: 2250-2256

    • NAID

      110006546420

    • Related Report
      2008 Final Research Report
  • [Journal Article] Study on the infection-preventive characteristics of Japanese green tea2007

    • Author(s)
      Matsubara H., Yoshii M., Miyahara T., Obi N., and Ochiai H.
    • Journal Title

      J. Nursing Soc. of Univ. 7

      Pages: 23-31

    • NAID

      110007125872

    • Related Report
      2008 Final Research Report
  • [Journal Article] Synthesis and biological evaluation of dihydrofuran-fused perhydrophenanthrenes as a new anti-influenza agent having novel structural characteristic2007

    • Author(s)
      Matsuya Y., Sasaki K., Ochiai H., and Nemoto H.
    • Journal Title

      Bioorg. Med. Chem 15

      Pages: 424-432

    • Related Report
      2008 Final Research Report
  • [Journal Article] Inhibitory effect of cinnam-aldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo2007

    • Author(s)
      Hayashi K., Imanishi N., Ochiai H.
    • Journal Title

      Antiviral Res 74

      Pages: 1-8

    • Related Report
      2008 Final Research Report
  • [Journal Article] Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo2007

    • Author(s)
      Hayashi Katsumi
    • Journal Title

      Antiviral Research 74

      Pages: 1-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological evaluation of dihydrofhran-fhsed perhydrophennthrenes as a new anti-influenza agent having novel structural characteristic2007

    • Author(s)
      Matsuya Yuji
    • Journal Title

      Bioorganic and Medical Chemistry 15

      Pages: 424-432

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on the infection-preventive characteristics of Japanese green tea2007

    • Author(s)
      Matsubara Hisako
    • Journal Title

      Journal of Nursing Society of University of Toyama 7

      Pages: 23-31

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ohotosan enhances macrophage colony-stimulating factor mRNAexpression in the ischemic rat brain and C6Bu-1 glioma cells2007

    • Author(s)
      Obi Ryusuke
    • Journal Title

      Biological and Pharmaceutical Bulletin 30

      Pages: 2250-2256

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lamp法によるセラチア菌の迅速診断に関する研究2007

    • Author(s)
      河野 彩
    • Journal Title

      富山大学看護学会誌 7

      Pages: 13-22

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 看護の場のダブルバインド2007

    • Author(s)
      山根 節子
    • Journal Title

      看護展望 32

      Pages: 89-94

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lamp法によるセラチア菌の迅速診断に関する研究

    • Author(s)
      河野 彩、小尾信子、吉井美穂、宮原龍郎、落合宏
    • Related Report
      2008 Final Research Report
  • [Presentation] 茶抽出液が細胞に及ぼす影響2008

    • Author(s)
      吉井美穂、小尾信子、宮原龍郎、落合宏
    • Organizer
      第9回富山大学看護学会学術集会
    • Place of Presentation
      富山
    • Year and Date
      2008-12-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 茶抽出液が細胞に及ぼす影響2008

    • Author(s)
      吉井美穂
    • Organizer
      第9回富山大学看護学会学術集会
    • Place of Presentation
      富山県富山市
    • Year and Date
      2008-12-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Inhibitory effect of an essential oil derived from Melaleuca alternifolia on the influenza virus infection in in vitro2008

    • Author(s)
      Obi N., Nakahira H., Nishitani M., Miyahara T., and Ochiai H.
    • Organizer
      The 7^<th> East Asian Conference on Infection Control and Prevention
    • Place of Presentation
      Soul, Korea
    • Year and Date
      2008-11-13
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] The effect of n-9 eicosatrienoic acid (mead acid) on osteoblasts2008

    • Author(s)
      Hamazaki T., Suzuki N., Widyowati R., Miyahara T., Kadota S., Ochiai H. and Hamazaki K.
    • Organizer
      Intrnational Society for the Study of Fatty Acids and Lipids
    • Place of Presentation
      Kansas City, USA
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] The effect of n-9 eicosatrienoic acid (mead acid) on osteoblast2008

    • Author(s)
      Hamazaki Tomohito
    • Organizer
      International Society for the Study of Fatty Acids and Lipids
    • Place of Presentation
      Kansas city, USA
    • Year and Date
      2008-05-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Attitude of the nursing school students to learn Kamp(Japanese herbal) medicine2008

    • Author(s)
      Obi N., Nakahira H., Miyahara T., and Ochiai H.
    • Organizer
      2008International Conference on Traditional Nursing
    • Place of Presentation
      Toyama
    • Year and Date
      2008-05-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Inhibitory effect of several essential oils on the growth of influenza virus2008

    • Author(s)
      Nakahira H., Obi N., Miyahara T. and Ochiai H.
    • Organizer
      2008International Conference on Traditional Nursing
    • Place of Presentation
      Toyama
    • Year and Date
      2008-05-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Evaluation of inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza virus in vitro and in vivo2008

    • Author(s)
      Hayashi K., Obi N., Kashiwayama Y., Terasawa K., Shimasa Y. and Ochiai H.
    • Organizer
      2008International Conference on Traditional Nursing
    • Place of Presentation
      Toyama
    • Year and Date
      2008-05-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Attitude of the nursing school students to learn Kampo (Japanese herbal) medicine2008

    • Author(s)
      Obi Nobuko
    • Organizer
      2008 International Conference on Traditional Nursing
    • Place of Presentation
      富山県富山市
    • Year and Date
      2008-05-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Inhibitory effect of several kinds of essential oil on the growth of influenza virus2008

    • Author(s)
      Nakahira Hisako
    • Organizer
      2008 International Conference on Traditional Nursing
    • Place of Presentation
      富山県富山市
    • Year and Date
      2008-05-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Evaluation of inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza virus in vitro and in vivo2008

    • Author(s)
      Hayashi Katsumi
    • Organizer
      2008 International Conference on Traditional Nursing
    • Place of Presentation
      富山県富山市
    • Year and Date
      2008-05-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 医療安全教育分野のシュミレーション教育に関する日米比較2007

    • Author(s)
      片田祐子, 八塚美樹, 落合宏
    • Organizer
      第8回富山医科薬科大学看護学会学術集会
    • Place of Presentation
      富山
    • Year and Date
      2007-11-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 第8回富山大学看護学会学術集会2007

    • Author(s)
      片田 裕子
    • Organizer
      医療安全教育分野のシュミレーション教育に関する日米比較
    • Place of Presentation
      富山市
    • Year and Date
      2007-11-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] 乾姜エキスの抗インフルエンザウイルス作用について2007

    • Author(s)
      小尾信子, 中平比沙子, 嶋田豊, 落合宏
    • Organizer
      富山大学21世紀COEプログラムシンポジウム
    • Place of Presentation
      富山
    • Year and Date
      2007-11-16
    • Related Report
      2008 Final Research Report
  • [Presentation] 桂皮アルデヒドの抗インフルエンザウイルス作用について2007

    • Author(s)
      林克美, 小尾信子, 嶋田豊, 寺澤捷年, 落合宏
    • Organizer
      21世紀COEプログラムシンポジウム
    • Place of Presentation
      富山
    • Year and Date
      2007-11-16
    • Related Report
      2008 Final Research Report
  • [Presentation] 乾姜エキスの抗インフルエンザウイルス作用について2007

    • Author(s)
      小尾 信子
    • Organizer
      富山大学21世紀COEプログラムシンポジウム
    • Place of Presentation
      富山市
    • Year and Date
      2007-11-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 桂皮アルデヒドの抗インフルエンザウイルス作用について2007

    • Author(s)
      林 克美
    • Organizer
      富山大学21世紀COEプログラムシンウム
    • Place of Presentation
      富山市
    • Year and Date
      2007-11-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 乾姜エキスのA型インフルエンザウイルス増殖抑制に関する研究2007

    • Author(s)
      小尾 信子
    • Organizer
      第44回日本細菌学会中部支部総会
    • Place of Presentation
      愛知県蒲郡市
    • Year and Date
      2007-10-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 茶抽出液によるEHEC0157の増殖抑制効果とその形態学的変化2007

    • Author(s)
      吉井 美穂
    • Organizer
      第44回日本細菌学会中部支部総会
    • Place of Presentation
      愛知県蒲郡市
    • Year and Date
      2007-10-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 乾姜エキスのA型インフルエンザウイルス増殖抑制に関する研究2007

    • Author(s)
      小尾信子, 中平比沙子, 吉井美穂, 宮原龍郎, 落合宏
    • Organizer
      第44回日本細菌学会中部支部総会
    • Place of Presentation
      愛知
    • Year and Date
      2007-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 茶抽出液によるEHEC0157の増殖抑制効果とその形態学的変化2007

    • Author(s)
      吉井美穂, 中平比抄子, 小尾信子, 落合宏, 太田美智雄
    • Organizer
      第44回日本細菌学会中部支部総会
    • Place of Presentation
      愛知
    • Year and Date
      2007-10-11
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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