Research of γδ T cells in Sjogren, s syndrome model mouse

• Project/Area Number: 19599009
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kanazawa University
• Principal Investigator: UEDA Ikuko Kanazawa University, 医学系, 助教 (80452100)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,790,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
• Keywords: 皮膚生理学 / シェーグレン症候群 / γδT 細胞 / Id3- / - / γδT細胞

Research Abstract

Id3-/-マウスにおいてγδT細胞の増殖の異常が出現する機序と、シェーグレン症候群様症状発症との関連の検証を行った。γδT細胞の増加は胸腺におけるT 細胞発生の段階のうちβ鎖再編成の進んだ段階でおこっていた。γδT細胞の多くがVγ1陽性でレパトアの異常があり、刺激によるIFN-γ産生は亢進していた。さらにId3-/-γδT細胞を野生型マウスに移入したところ、唾液腺への細胞浸潤を認め、シェーグレン症候群発症への関与が示唆された。

Research Products

• [Journal Article] Id3 restricts the developmental potential of gd lineage during thymopoiesis (2009)
  • Author(s): Ikuko Ueda-Hayakawa, Josh Malios, and Yuan Zhuang
  • Journal Title: J Immunol 182 Pages: 5306-5316
• [Journal Article] Id3 restricts the developmental potential in gd lineage during thymopoiesis (2009)
  • Author(s): Ikuko Ueda-Hayakawa, Josh Mahlios, Yuan Zhuang
  • Journal Title: Journal of Immunology 182(掲載確定)
  • Peer Reviewed
• [Journal Article] The clinical relevance of serum antinuclear antibodies in Japanese patients with systemic sclerosis (2008)
  • Author(s): Yasuhito Hamaguchi, Minoru Hasegawa, Manabu Fujimoto, Ikuko Hayakawa(他9名)
  • Journal Title: Br J Dermatol 158 Pages: 487-95
• [Journal Article] Antigen specificity of antihistone antibodies in connective tissue disease patients with anti-U1RNP antibodies (2007)
  • Author(s): Takamasa Wayaku, Minoru Hasegawa, Kenzo Kaji, Ikuko Hayakawa(他11名)
  • Journal Title: 28 Pages: 113-119
• [Journal Article] B-lymphocyte depletion ameliorates Sjogren syndrome in Id3 knockout mice (2007)
  • Author(s): Ikuko Hayakawa, Thomas F. Tedder, Yuan Zhuang
  • Journal Title: 122 Pages: 73-9
• [Journal Article] Reduced red blood cell velocity in nailfold capillaries as a sensitive and specific indicator of microcirculation injury in systemic sclerosis
  • Author(s): Mugii Naoki, Minoru Hasegawa, Yasuhito Hamaguchi, Ikuko Ueda-Hayakawa(他10 名)
  • Journal Title: Rheumatology in press
• [Presentation] Id3 is required to suppress γδ lineage development post TCRβ gene rearrangement (2007)
  • Author(s): Ikuko Hayakawa and Yuan Zhuang
  • Organizer: 第37 回日本免疫学会総会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Id3 is required to suppress Yδ lineage development post TCRβ gene rearrangement (2007)
  • Author(s): 早川郁子
  • Organizer: 第37回日本免疫学会総会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21