Detection of epithelial growth factor for middle ear cholesteatoma using an experimental model

• Project/Area Number: 19599017
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Ehime University
• Principal Investigator: HINOHIRA Yasuyuki Ehime University, 医学部・附属病院, 講師 (00238320)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Shoichiro 愛媛大学, 医学部・附属病院, 医員 (70403821)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,700,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
• Keywords: 耳科学 / 中耳真珠腫 / 実験的真珠腫 / 病理組織学的検討 / マイクロアレイ解析 / 組織増殖能 / 実験モデル / 遺伝子解析

Research Abstract

中耳真珠腫は強い増殖性と周囲組織の破壊をもたらす疾患であるが、これまで成因が明らかにされておらず、真珠腫に特異的な発現を示す増殖因子も確定されていなかった。本研究では再現性のある動物実験モデルを、ゲノム解析が終了した動物であるラットにおいて作成することに成功した。
この真珠腫モデルを用いて真珠腫増殖に関連する遺伝子を同定する手がかりが得られた。

Research Products

• [Journal Article] Total mastoid obliteration in staged intact canal wall tympanoplasty far cholesteatoma facilitates tympanic aeration. (2009)
  • Author(s): Yanagihara N, Komori M, Hinohira Y.
  • Journal Title: Otology Neurotology (In press)
  • Peer Reviewed
• [Journal Article] Improvements to staged canal wall up tympanoplasty for middle ear cholesteatoma (2007)
  • Author(s): Hinohira Y, Yanagihara N, Gyo K.
  • Journal Title: Otolaryngol Head Neck Surg 137 Pages: 913-917
  • Peer Reviewed
• [Journal Article] 真珠腫性中耳炎・術後再発例の手術における後壁処理 (2007)
  • Author(s): 谷口昌史, 比野平恭之
  • Journal Title: MB ENT 76 Pages: 55-61
• [Journal Article] Improvements to staged canal wall up tympancplasty for middle ear cholesteatoma. (2007)
  • Author(s): Hinohira Y, et. al.
  • Journal Title: Otolaryngol Head Nech Surg 137 Pages: 913-917
  • Peer Reviewed
• [Journal Article] 真珠腫性中耳炎 術後再発例の手術にける後壁処理 (2007)
  • Author(s): 谷口昌史, 比野平恭之
  • Journal Title: MB ENT 76 Pages: 55-61
• [Journal Article] Total mastoid obliteration in staged intact canal wall tympanoplasty for cholesteatoma facilitates tympanic aeration
  • Author(s): Yanagihara N, Komori M, Hinohira Y.
  • Journal Title: Otology Neurotology (in press)
  • Peer Reviewed
• [Presentation] 真珠腫に対する後壁保存段階的鼓室形成術から見た術後性ポケットの成因について (2008)
  • Author(s): 比野平恭之, 柳原尚明, 谷口昌史, 他
  • Organizer: 第17回日本耳科学会総会
  • Place of Presentation: 福岡(口演発表)
  • Year and Date: 2008-10-18
• [Presentation] A new role of staged tympanoplasty for cholesteatoma (2008)
  • Author(s): Hinohira Y, Yanagihara N, Hato N.
  • Organizer: 2008 AAO-HNSF Annual Meeting & OTO EXPO
  • Place of Presentation: Chicago(口演発表)
  • Year and Date: 2008-09-24
• [Presentation] A new role of staged tympanoplasty far cholesteatnma. (2008)
  • Author(s): Hinohira Y, Yanagihara N, Hato N
  • Organizer: 2008 AAO-INSF Annual Meeting & OTO EXPO
  • Place of Presentation: Chicago, USA
  • Year and Date: 2008-09-24
• [Presentation] Staged tympanoplasty for the treatment of cholesteatoma using intact canal wall technique : A reliable measure to prevent postoperative retraction pocket (2008)
  • Author(s): Hinohira Y, Yanagihara Y.
  • Organizer: 8th international conference on cholesteatoma and ear surgery(Instruction course)
  • Place of Presentation: Antalya, Turkey(教育講演)
  • Year and Date: 2008-06-20
• [Presentation] Staged tympanoplasty for the treatment of cholesteatoma using intact canal wall technique : A reliable measure to prevent postoperative retraction pocket. (2008)
  • Author(s): Hinohira Y, Yanagihara Y.
  • Organizer: 8th international conference on cholesteatoma
  • Place of Presentation: Antalya, TRNC
  • Year and Date: 2008-06-20
• [Presentation] Postoperative managements of cholesteatoma and less invasive revision surgery for the recurrence (2008)
  • Author(s): Hinohira Y.
  • Organizer: 8th international conference on cholesteatoma and ear surgery(Work Shop : Tracking the residual and/or recurrent disease)
  • Place of Presentation: Antalya, Turkey(ワーク・ショップ)
  • Year and Date: 2008-06-19
• [Presentation] Postoperative managements of cholesteatoma and less invasive revision surgery for the recurrence. (2008)
  • Author(s): Hinohira Y.
  • Organizer: 8th international conference on cholesteatoma
  • Place of Presentation: Antalya, TRNC
  • Year and Date: 2008-06-19
• [Presentation] Does the use of reconstruction techniques regarding the scutum defect and the mastoid cavity influence the staging? (2008)
  • Author(s): Hinohira Y.
  • Organizer: 8th international conference on cholesteatoma and ear surgery(Symposium : Staging of tympanoplasty in cholesteatoma)
  • Place of Presentation: Antalya, Turkey(シンポジウム)
  • Year and Date: 2008-06-18
• [Presentation] Does the use of reconstruction techniques regarding the scutum defect and the mastoidcavity influence the staging? (2008)
  • Author(s): Hinohira Y.
  • Organizer: 8th international conference on cholesteatoma
  • Place of Presentation: Antalya, TRNC
  • Year and Date: 2008-06-18
• [Presentation] 真珠腫に対する後壁保存段階的鼓室形成術から見た術後性ぽケットの成因について (2007)
  • Author(s): 比野平恭之、他
  • Organizer: 日本耳科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2007-10-18