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Specific inflammatory condition in the nucleus tractus solitarii and human essential hypertension

Research Project

Project/Area Number 19599022
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionWakayama Medical University

Principal Investigator

WAKI Hidefumi  Wakayama Medical University, 医学部, 講師 (50274957)

Co-Investigator(Kenkyū-buntansha) MAEDA Masanobu  和歌山県立医科大学, 医学部, 教授 (80181593)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywords循環調節 / 高血圧 / 炎症反応 / 神経科学 / 循環調節中枢 / サイトカイン / 遺伝子
Research Abstract

我が国では60才以上の高齢者の約半数が本態性高血圧症であると言われているが、その発症機序は未だ不明である。本研究では血圧調節中枢の異常が高血圧発症の一因であるという仮説のもと、高血圧の動物モデル(ラット)を用いてこの仮説を検証した。その結果、血圧調節中枢の一部における炎症反応異常が高血圧発症の一因となっている可能性が示唆された。これらの結果は今後の高血圧症治療の発展に寄与するものと思われる

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (18 results)

All 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (13 results)

  • [Journal Article] Complex cardiovascular actions of α-adrenergic receptors expressed in the nucleus tractus solitarii of rats2009

    • Author(s)
      Bhuiyan MER、Waki H、Takagishi M、 Gouraud SS、Cui H、Yamazaki T、Kohsaka A and Maeda M
    • Journal Title

      Exp Physiol. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiles of major cytokines in the nucleus tractussolitarii of the spontaneouslyhypertensive rat2008

    • Author(s)
      Waki H、Gouraud SS、Maeda M、Paton JF
    • Journal Title

      Auton Neurosci 142

      Pages: 40-44

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Specific inflammatory condition innucleus tractus solitarii of the SHR : Novel insight for neurogenichypertension?2008

    • Author(s)
      Waki H、Gouraud SS、Maeda M、Paton JF
    • Journal Title

      Auton Neurosci 142

      Pages: 25-31

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Specific inflammatory condition in nucleus tractus solitarii of the SHR : novel insight for neurogenic hypertension?2008

    • Author(s)
      Hidefumi Waki
    • Journal Title

      Autonomic Neuroscience : Basic & Clinical 142

      Pages: 25-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiles of major cytokines in the nucleus tractus solitarii of the spontaneously hypertensive rat2008

    • Author(s)
      Hidefumi Waki
    • Journal Title

      Autonomic Neurosc ience : Basic & Clinical 142

      Pages: 40-44

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 延髄孤束核における遺伝子発現異常と高血圧発症との関係2008

    • Author(s)
      和気秀文
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      別府ビーコンプラザ
    • Year and Date
      2008-09-19
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 延髄孤束核におけるロイコトリエンB4過剰生成と高血圧発症との関係2008

    • Author(s)
      和気秀文
    • Organizer
      第101回近畿生理学談話会
    • Place of Presentation
      国立循環器病センター
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 延髄孤束核へのIL-6微量注入は圧受容器反射機能を抑制する2008

    • Author(s)
      高岸美和
    • Organizer
      第101回近畿生理学談話会
    • Place of Presentation
      国立循環器病センター
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Complex cardiovascular actions ofadrenergic receptors expressed inthe nucleus tractus solitarii2008

    • Author(s)
      Mohammad ER Bhuiyan
    • Organizer
      第101回近畿生理学談話会
    • Place of Presentation
      国立循環器病センター
    • Year and Date
      2008-09-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Gene expression profiles of cytokines, chemokines, neurotorophines and apoptosis factors in the nucleus tractus solitarii ofspontaneously hypertensive rat2008

    • Author(s)
      Sabine S Gouraud
    • Organizer
      第101回近畿生理学談話会
    • Place of Presentation
      国立循環器病センター
    • Year and Date
      2008-09-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Complex cardiovascular actions of α adrenergic receptors expressed in the nucleus tractus solitarii2008

    • Author(s)
      Mohammad ER Bhuiyan
    • Organizer
      第101回近畿生理学談話会
    • Place of Presentation
      国立循環器病センター
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gene expression profiles of cytokines, chemokines, neurotorophines and apoptosis factors in the nucleus tractus solitarii of spontaneously hypertensive rat2008

    • Author(s)
      Sabine S Gouraud
    • Organizer
      第101回近畿生理学談話会
    • Place of Presentation
      国立循環器病センター
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 循環調節中枢における炎症反応と本態性高血圧発症との関連2008

    • Author(s)
      和気秀文
    • Organizer
      第9回Neurocardiology Workshop
    • Place of Presentation
      東京ステーションコンファレンス
    • Year and Date
      2008-07-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 循環調節中枢における炎症反応と本態性高血圧発症との関連2008

    • Author(s)
      和気 秀文
    • Organizer
      第9回Neurocardiology Workshop
    • Place of Presentation
      東京ステーションコンフアレンス
    • Year and Date
      2008-07-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] IL-6 in the NTS attenuates baroreflex in rats2008

    • Author(s)
      和気秀文
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 延髄孤束核における炎症反応異常と高血圧発症との関係2008

    • Author(s)
      和気秀文
    • Organizer
      第7回九州脳と高血圧研究会
    • Place of Presentation
      ホテル日航福岡
    • Year and Date
      2008-07-05
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Up-regulation of Leukotriene B4 in the NTS of SHR maybe pro-hypertensive2008

    • Author(s)
      和気秀文
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2008-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Up-regulation of Leukotriene B4 in the NTS of SHR may bepro-hypertensive2008

    • Author(s)
      和気 秀文
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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