• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a novel strategy for the prevention and treatment of gastric cancer through epigenetic regulation of microRNAs

Research Project

Project/Area Number 19599024
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionKeio University

Principal Investigator

SAITO Yoshimasa  Keio University, 医学部, 助教 (90360114)

Co-Investigator(Kenkyū-buntansha) SUZUKI Hidekazu  慶應義塾大学, 医学部, 講師 (70255454)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsmicroRNA / DNAメチル化 / ヒストン修飾 / エピジェネティック治療 / 胃がん / エピジェネティクス / H.pylori
Research Abstract

DNAやヒストン(DNAが巻き付いている蛋白質)がメチル化やアセチル化などの修飾を受けると遺伝子の発現が変化することが知られており、これをエピジェネティクスと呼んでいます。本研究ではDNAメチル化阻害薬やヒストン脱アセチル化酵素阻害薬を用いたエピジェネティック治療が胃がん細胞においてmicroRNAという小さなRNA であるmiR-512-5pを誘導し、その標的であるがん遺伝子Mcl-1を不活性化することで細胞死を引き起こすことが示されました。microRNAを介したエピジェネティック治療が胃がんの新たな予防・治療戦略となることが期待されます。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (8 results)

All 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells2009

    • Author(s)
      Saito Y, Suzuki H, Tsugawa H, Nakagawa I, Matsuzaki J, Kanai Y, Hibi T
    • Journal Title

      Oncogene (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells2009

    • Author(s)
      Saito Y, Friedman JM, Chihara Y, Egger G, Chuang JC, Liang G
    • Journal Title

      Biochem Biophys Res Commun 379(3)

      Pages: 726-731

    • Related Report
      2008 Final Research Report
  • [Journal Article] The role of microRNAs in gastrointestinal cancers2009

    • Author(s)
      Saito Y, Suzuki H, Hibi T
    • Journal Title

      J Gastroenterol 19

      Pages: 18-22

    • NAID

      10025176863

    • Related Report
      2008 Final Research Report
  • [Journal Article] Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced miRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells2009

    • Author(s)
      Yoshimasa Saito, 他
    • Journal Title

      Oncogene (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of microRNAs in gastrointestinal cancers.2009

    • Author(s)
      Yoshimasa Saito, 他
    • Journal Title

      Journal of Gastroenterology 44 Suppl19

      Pages: 18-22

    • NAID

      10025176863

    • Related Report
      2008 Annual Research Report
  • [Presentation] マイクロRNAを標的とした胃がんに対するエピジェネティック治療2008

    • Author(s)
      斎藤義正、鈴木秀和、日比紀文
    • Organizer
      第16回浜名湖シンポジウム
    • Place of Presentation
      静岡県浜名湖
    • Year and Date
      2008-12-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Activation of Alu-associated microRNAs by epigenetic therapy of human gastric cancer cells (Oral presentation)2008

    • Author(s)
      Saito Y, Suzuki H, Hibi T
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      米国San Diego
    • Year and Date
      2008-05-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Activation of Alu-associated microRNAs by epigenetic therapy of human gastric cancer cells2008

    • Author(s)
      Yosh imasa Saito, 他
    • Organizer
      アメリカ消化器病学会(DDW 2008)
    • Place of Presentation
      米国カリフォルニア州サンディェゴ
    • Year and Date
      2008-05-19
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi