Development of novel photo-cleavable linker for the target identification of bio-active compound using affinity resins
| Project/Area Number |
19599025
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Hyogo University of Health Sciences |
|---|
Principal Investigator |
AKITO Tanaka Hyogo University of Health Sciences, 薬学部, 教授 (30454789)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,630,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,200,000 (Direct Cost: ¥2,200,000)
|
|---|
| Keywords | アフィニティ樹脂 / ターゲット探索 / 生理活性物質 / 光反応 |
|---|
| Research Abstract |
I have developed a photo-cleavable linker for identifications of the target proteins of attractive bio-active compounds. We here demonstrated that known target proteins such as FKBP12, CAII, and so on, were selectively eluted from affinity resins using our method, only by irradiation under protein-friendly mild conditions. This development is important for the identification.
|
Report
(4 results)
Research Products
(10 results)
