Mechanisms of pain-induced emotion and its effects on learning and memory

• Project/Area Number: 19603004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pain science
• Research Institution: Kyushu University
• Principal Investigator: KATAFUCHI Toshihiko Kyushu University, 大学院・医学研究院, 准教授 (80177401)
• Co-Investigator(Kenkyū-buntansha): 吉村 恵 九州大学, 大学院・医学研究院, 教授 (10140641)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 感染ストレス / 辺縁系 / 下行性セロトニン系 / サイトカイン / セロトニントランスポーター / セロトニン1A 受容体 / 脊髄膠様質 / リアルタイムRT-PCR / 慢性疼痛 / 情動 / 学習 / 脊髄後角

Research Abstract

急性あるいは慢性的な疼痛をコントロールすることが困難な理由の一つに感染や疼痛というストレス刺激によって不安、恐怖、およびうつなどの情動が発現し、それらが学習記憶されることで感覚認知の鋭敏化や遷延化を引き起こしていることが考えられる。従って痛覚を受容する中枢神経系として、視床や大脳皮質感覚野以外に、視床下部や、扁桃体、海馬、および前帯状回などの辺縁系の重要性が示唆される。実際、poly I:Cによる感染ストレス時に、視床下部室傍核、視索前野および帯状回において、IFN-α、やセロトニントランスポーターの発現が増強し、痛覚伝達において重要な役割を果たしている脊髄後角膠様質ニューロンに対し、セロトニンが5-HT1A受容体を介して、K+イオンチャンネルの開放による抑制を起こすこと、および膠様質のGABA含有抑制性ニューロンに対し5-HT3受容体を介して活動を上昇させ抑制性シナプス後膜電流を増加させることなどが明らかになった。これらの作用は、侵害受容機構において、セロトニン下行性鎮痛系の作用機序をになうものと考えられた。

Research Products

• [Journal Article] Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro (2009)
  • Author(s): Abe, K., Kato, G., Katafuchi, T., Tamae, A., Furue, H. and Yoshimura, M.
  • Journal Title: Neuroscience 159 Pages: 316-324
  • Peer Reviewed
• [Journal Article] 免疫学的疲労モデルにおける疲労の分子神経メカニズム (2009)
  • Author(s): 片渕俊彦
  • Journal Title: 医学のあゆみ 第228巻第6号 Pages: 615-619
• [Journal Article] Cytokine-induced suppression of medial preoptic neurons: mechanisms and neuroimmunomodulatory effects (2009)
  • Author(s): Katafuchi, T., Duan, S., Take, S. and Yoshimura, M
  • Journal Title: Ann. N.Y. Acad. Sci 1153 Pages: 76-81
  • Peer Reviewed
• [Journal Article] Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro. (2009)
  • Author(s): Abe, K., et al.
  • Journal Title: Neuroscience 159 Pages: 316-324
  • Peer Reviewed
• [Journal Article] Cytokine-induced suppression of medial preoptic neurons : mechanisms and neuroimmunomodulatory effects. (2009)
  • Author(s): Katafuchi, T., et al.
  • Journal Title: Ann. N. Y. Acad. Sci. 1153 Pages: 76-81
  • Peer Reviewed
• [Journal Article] 慢性疲労症候群とサイトカイン. (2009)
  • Author(s): 片渕 俊彦
  • Journal Title: BRAIN MEDICAL 20 Pages: 153-158
• [Journal Article] 免疫学的疲労モデルにおける疲労の分子神経メカニズム. (2009)
  • Author(s): 片渕 俊彦
  • Journal Title: 医学のあゆみ 228 Pages: 615-619
• [Journal Article] 疲労モデルラットにおける脳内サイトカイン異常 (2008)
  • Author(s): 片渕俊彦
  • Journal Title: 治療 第90巻第3号 Pages: 562-567
• [Journal Article] 慢性疲労症候群とサイトカイン (2008)
  • Author(s): 片渕俊彦
  • Journal Title: BRAIN MEDICAL 第20巻第2号 Pages: 153-158
• [Journal Article] 疲労モデルラットにおける脳内サイトカイン異常. (2008)
  • Author(s): 片渕 俊彦
  • Journal Title: 治療 90 Pages: 562-567
• [Journal Article] 疲労モデルラットにおける脳内サイトカイン異常 (2008)
  • Author(s): 片渕 俊彦
  • Journal Title: 治療 90 Pages: 562-567
• [Journal Article] Role of substantia innominata in cerebral blood flow autoregulation (2007)
  • Author(s): Ota, K., Kitazono, T., Ooboshi, H., Kamouchi, M., Katafuchi, T., Aou, S., Yamashita, Y., Ibayashi, S. and Iida, M.
  • Journal Title: Brain Res. 1135 Pages: 146-153
  • Peer Reviewed
• [Journal Article] Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensory cortical neurons: in vivo patch-clamp analysis (2007)
  • Author(s): Doi, A., Mizuno, M., Katafuchi, T., Furue, H., Koga, K. and Yoshimura, M
  • Journal Title: Eur. J. Neurosci 26 Pages: 2565-2575
  • Peer Reviewed
• [Journal Article] 疲労および疲労感の中枢神経メカニズムとその防御 (2007)
  • Author(s): 片渕俊彦
  • Journal Title: PHARMSTAGE 第6巻11号 Pages: 29-34
• [Journal Article] Role of substantia innominata in cerebral blood flow autoregulation (2007)
  • Author(s): Ota, K., et. al.
  • Journal Title: Brain Research 1135 Pages: 146-153
  • Peer Reviewed
• [Journal Article] Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensory cortical neurons in vivo patch clamp analysis (2007)
  • Author(s): Doi, A, et. al.
  • Journal Title: European Journal of Neuroscience 26 Pages: 2565-2575
  • Peer Reviewed
• [Journal Article] 疲労および疲労感の中枢神経メカニズムとその防御 (2007)
  • Author(s): 片渕 俊彦
  • Journal Title: PHARMSTAGE 6 Pages: 29-34
• [Presentation] 脳-免疫系連関とストレス応答(12) (2009)
  • Author(s): 片渕俊彦
  • Organizer: シンポジウムセッション1「心身相関の基礎医学」アトピー性皮膚炎治療研究会 第14 回シンポジウム「アトピー背皮膚炎への心身医学的アプローチ」プログラム・抄録集
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-07
• [Presentation] 脳-免疫系連関とストレス応答. (2009)
  • Author(s): 片渕 俊彦
  • Organizer: アトピー性皮膚炎治療研究会
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-07
• [Presentation] Brain mechanisms of immunologically induced fatigue in the rat. (2008)
  • Author(s): Katafuchi, T.
  • Organizer: International Conference on Fatigue Science
  • Place of Presentation: 沖縄
  • Year and Date: 2008-09-04
• [Presentation] Cytokine-induced suppression of MPO neurons : its mechanisms and neuroimmunomodulatory effects. (2008)
  • Author(s): Katafuchi, T.
  • Organizer: International Society for Neuroimmunomodulation.
  • Place of Presentation: リオデジャネイロ(ブラジル)
  • Year and Date: 2008-04-25
• [Presentation] Cytokine-induced suppression of MPO neurons: its mechanisms and neuroimmunomodulatory effects(15) (2008)
  • Author(s): Katafuchi, T
  • Organizer: Round Table 3. Cytokines/chemokines regulating nervous/endocrine tissues. The 7th Meeting of the International Society for Neuroimmunomodulation. Program & Abstract book
  • Place of Presentation: Rio de Janeiro, BRAZIL
• [Presentation] Brain mechanisms of immunologically induced fatigue in the rat(48) (2008)
  • Author(s): Katafuchi, T., Take, S., Ifuku, M., Izumi, K., Noda, M. and Yoshimura M
  • Organizer: Symposium 4. Mechanisms of fatigue and fibromyalgia. International Conference on Fatigue Science 2008. Program & Abstract book
  • Place of Presentation: Okinawa
• [Presentation] Serotonin systgm in poly I:C-induced fatigue model in rats (2007)
  • Author(s): Katafuchi, T., et. al.
  • Organizer: International Symposium:Interaction of the nervous and immune systems in health and disease.
  • Place of Presentation: サンクトペテルブルグ
  • Year and Date: 2007-06-01
• [Presentation] Serotonin system in poly I:C-induced fatigue model in rats(32-33) (2007)
  • Author(s): Katafuchi, T., Take, S. and Yoshimura, M. Katafuchi, T., Take, S. and Yoshimura, M.
  • Organizer: International Symposium: Interaction of the nervous and immune systems in health and disease. Abstract book
  • Place of Presentation: St. Petersburg, RUSSIA(Chairman)
• [Book] Brain mechanisms of poly I:C-induced fatigue in rats(Eds. Watababe, Y., Evengard, B., Natelson, B.H., Jason, L.A. and Kuratsune, H.)(Springer-Verlag Tokyo, Tokyo,)(219-230) (2008)
  • Author(s): Katafuchi, T
  • Total Pages: 236
  • Publisher: In: Fatigue Science for Human Health
• [Book] Impairment of adaptive responses to heat exposure : aging and bacterial translocation. In: Adaptation Biology and Medicine : Health Potentials(Eds. Lukyanova, L., Takeda, N. and Singal, P.K.)(Vol.5)(339-345) (2008)
  • Author(s): Katafuchi, T
  • Total Pages: 360
  • Publisher: Narosa Publishers, New Delhi, India
• [Book] Involvement of brain cytokines in stress-induced immunosuppression. In: Cytokines and the Brain(Vol. 6)(Eds. Phelps, C. and Korneva, E.)(Elsevier Sci. Publ., Amsterdam)(391-401) (2008)
  • Author(s): Katafuchi, T
  • Total Pages: 608
  • Publisher: Neuroimmune Biology
• [Book] Fatigue Science for Human Health. (2008)
  • Author(s): Katafuchi, T.
  • Total Pages: 236
  • Publisher: Springer-Verlag
• [Book] Adaptation Biology and Medicine : Health Potentials. (2008)
  • Author(s): Katafuchi, T.
  • Total Pages: 360
  • Publisher: Narosa Publishers
• [Book] Neuroimmune Biology. (2008)
  • Author(s): Katafuchi, T.
  • Total Pages: 575
  • Publisher: Elsevier Sci. Publ.
• [Book] Fatigue Science for Human Health (2008)
  • Author(s): Katafuchi, T.
  • Total Pages: 236
  • Publisher: Springer-Verlag Tokyo
• [Book] Adaptation Biology and Medicine:Health Potentials (2008)
  • Author(s): Katafuchi, T.
  • Total Pages: 360
  • Publisher: Naroza Publishers
• [Book] Cytokines and the Brain(Neuroimmune Biology, vol.7) (2008)
  • Author(s): Katafuchi, T.
  • Total Pages: 608
  • Publisher: Elsevier Science Publishers
• [Book] 免疫系. 環境生理学(本間研一,彼末一之編)(101-112) (2007)
  • Author(s): 片渕俊彦
  • Total Pages: 446
  • Publisher: 北海道大学出版会
• [Book] 自律神経機能と免疫・内分泌との相関. 自律神経機能検査. 第4版(日本自律神経学会編)(東京)(77-78) (2007)
  • Author(s): 片渕俊彦
  • Total Pages: 433
  • Publisher: 文光堂
• [Book] 体温調節のしくみ. 人工環境デザインハンドブック. 第2 章 温熱環境(栃原裕編)(2.2 生理的評価)(東京)(25-28) (2007)
  • Author(s): 片渕俊彦, 吉村恵
  • Total Pages: 461
  • Publisher: 丸善株式会社
• [Book] In vivo patch-clamp technique. In: Patch-Clamp Analysis: advanced techniques, second edition(Ed. Walz, W.)(Totowa)(229-251) (2007)
  • Author(s): Furue, H., Katafuchi, T. and Yoshimura, M.
  • Total Pages: 475
  • Publisher: Humana Press Inc.
• [Book] 環境生理学 (2007)
  • Author(s): 片渕 俊彦
  • Total Pages: 446
  • Publisher: 北海道大学出版会
• [Book] 自律神経機能検査 (2007)
  • Author(s): 片渕 俊彦
  • Total Pages: 433
  • Publisher: 文光堂
• [Book] Patch-Clamp Analysis:advanced technique (2007)
  • Author(s): Furue, H, et. al.
  • Total Pages: 475
  • Publisher: Humana Press Inc.
• [Book] 人工環境デザインハンドブック (2007)
  • Author(s): 片渕 俊彦, 吉村 恵
  • Total Pages: 461
  • Publisher: 丸善株式会社
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/physiol/