P2X receptor-mediated modulation of nociceptive transmission in neuropathic pain model rats

• Project/Area Number: 19603007
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pain science
• Research Institution: Saga University
• Principal Investigator: 中塚 映政 Saga University, 医学部, 准教授 (30380752)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 疼痛 / 神経科学 / 生理学 / 脳・神経 / シグナル伝達 / 疼痛学

Research Abstract

ATPP2X受容体は末梢における痛覚受容に関与するだけでなく、脊髄後角においても侵害感覚情報を増強することが明らかとなり、大変注目されている。今回、神経因性痺痛モデルラット脊髄スライス標本を用いたパッチクランプ記録を行い、脊髄後角深層細胞のシナプス後細胞におけるATP受容体の役割を検討した。代謝安定型のATP受容体広作動域作動薬であるATP-γSを潜流投与すると、約40%の脊髄後角深層細胞において内向き電流と興奮性シナプス後電流の発生頻度の増強効果が観察された。一方、α, β-methylene ATPの潜流投与を行うと内向き電流は観察されず、興奮性シナプス後電流の発生頻度の増強効果のみが観察された。ATP-γSにより生じた内向き電流は、各種P2Y受容体作動薬の潜流投与によって再現されなかった。また、細胞膜G蛋白質阻害薬存在下において、ATP-γS潜流投与による内向き電流は抑制されなかった。さらに、ATP-γS潜流投与によって生じた内向き電流ならびに興奮性シナプス後電流の発生頻度の増強効果は、P2X受容体括抗薬であるPPADS(10μM)の存在下において完全に阻害されたが、TNP-ATP(20μM)の存在下において影響されなかった。以上の結果から、ATP P2X受容体は脊髄後角深層細胞のシナプス前のみならず、シナプス後細胞においても発現しており、シナプス前とシナプス後細胞に発現しているP2X受容体は異なるサブタイプであることが明らかとなった。このように様々なサブタイプのP2X受容体が広く脊髄後角に分布しており、P2X受容体は末梢からの感覚情報を多彩に修飾していることが示唆された。

Research Products

• [Journal Article] TRPA1 activation by lidocaine in nerve terminals results in glutamate release increase. (2009)
  • Author(s): Piao Lian-Hua
  • Journal Title: Biochem Biophys Res Commun 379 Pages: 980-984
  • Peer Reviewed
• [Journal Article] Activation of GIRK Channels in substantia gelatinosa neurones of the adult rat spinal cord : apossible invoIvement of somatostatin (2008)
  • Author(s): Nakatsuka T, Fujita T, Inoue K, Kumamoto E
  • Journal Title: Journal of Physiology 586 Pages: 2511-2522
  • Peer Reviewed
• [Journal Article] Phospholipase A2 Activation enhances inhibitory synaptic transmission in rat substantia gelatinosa neurons (2008)
  • Author(s): Liu T, Fujita T, NakatsukaT, Kumamoto E
  • Journal Title: Journal of NeurOphysiology 99 Pages: 1274-1284
  • Peer Reviewed
• [Journal Article] Inhibitory effects of opioids on compound action potentials in fog sciatic nerves and their chemical structures (2008)
  • Author(s): Mizuta K, Fujita T, Nakatsuka T, Kumamoto E
  • Journal Title: Life Sciences 83 Pages: 198-207
  • Peer Reviewed
• [Journal Article] Adenosine suppress neuronal death induced by experimental ischemia in spinal motoneurons (2008)
  • Author(s): Miyazaki N, Nakatsuka T, Takeda D, Nohda K, Sakanaka J, Yoshida M
  • Journal Title: Pfltlgers Archiv, European Journal of Physiology 457 Pages: 441-451
  • NAID: 40016473965
  • Peer Reviewed
• [Journal Article] Adenosine suppress neuronal death induced by experimentalischemia in spinal motoneurons (2008)
  • Author(s): Miyazaki N, Nakatsuka T, Takeda D, Nishi H, Nohda K, Sakanaka J, Yoshida M
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 30 Pages: 18-24
  • Peer Reviewed
• [Journal Article] Excitation of spinal motoneurons by activation of ATP receptors (2008)
  • Author(s): Aoyama T, Nakatsuka T, Koga S, Fujita T, Kumamoto E
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 30 Pages: 25-31
  • NAID: 40016473966
  • Peer Reviewed
• [Journal Article] Effects of galanin on excitatory synaptic transmission in adult rat substantia gelatinosa neurons (2008)
  • Author(s): Yue H-Y, Fujita T, Liu T, Piao L-H, Jiang C-Y, Mizuta K, Tomohiro D, Nakatsuka T, Kumamoto E
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 30 Pages: 32-41
  • Peer Reviewed
• [Journal Article] Cellular mechanism of dopaminergic modulation in spinal motoneurons (2008)
  • Author(s): Sakanaka J, Nakatsuka T, Miyazaki N, Nohda K, Takeda D, Yoshida M
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 30 Pages: 42-48
  • NAID: 40016473968
  • Peer Reviewed
• [Journal Article] 痛覚ニューロン活動 : 分子レベルから臨床像へ (2008)
  • Author(s): 中塚映政, 藤田亜美, 川崎康彦, 熊本栄一
  • Journal Title: 理学療法 25 Pages: 831-839
  • Peer Reviewed
• [Journal Article] Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord : a possible involvement of somatostatin. (2008)
  • Author(s): Nakatsuka Terumasa
  • Journal Title: Journal of Physiology 586 Pages: 2511-2522
  • Peer Reviewed
• [Journal Article] Phospholipase A_2 Activation enhances inhibitory synaptic tran smission in rat substantia gelatinosa neurons. (2008)
  • Author(s): Liu Tao
  • Journal Title: Journal of Neurophysiology 99 Pages: 1274-1284
  • Peer Reviewed
• [Journal Article] Inhibitory effects of opioids on compound action potentials in fog sciatic nerves and their chemical structures. (2008)
  • Author(s): Mizuta Kotaro
  • Journal Title: Life Sciences 83 Pages: 198-207
  • Peer Reviewed
• [Journal Article] Adenosine modulates excitatory synaptic transmission and suppresses neuronal death induced by ischaemia in rat spinal motoneurons. (2008)
  • Author(s): Miyazaki Nobuyuki
  • Journal Title: Pflugers Archiv 457 Pages: 441-451
  • Peer Reviewed
• [Journal Article] Adenosine suppress neuronal death induced by experimental is chemia in spinal motoneurons (2008)
  • Author(s): Miyazaki Nobuyuki
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 30 Pages: 18-24
  • Peer Reviewed
• [Journal Article] Excitation of spinal motoneurons by activation of ATP receptors. (2008)
  • Author(s): Aoyama Takahiro
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 30 Pages: 25-31
  • Peer Reviewed
• [Journal Article] Effects of galanin on excitatory synaptic transmission in adult rat substantia gelatinosa neurons. (2008)
  • Author(s): Yue Hai-Yuan
  • Journal Title: The Journal of Functional Diagnosis of the spinal Cord 30 Pages: 32-41
  • Peer Reviewed
• [Journal Article] Cellular mechanism of dopaminergic modulation in spinal motoneurons. (2008)
  • Author(s): Sakanaka Junya
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 30 Pages: 42-48
  • Peer Reviewed
• [Journal Article] 痛覚ニューロン活動 : 分子レベルから臨床像へ (2008)
  • Author(s): 中塚 映政
  • Journal Title: 理学療法 25 Pages: 931-938
• [Journal Article] Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord: a possible involvement of somatostatin (2008)
  • Author(s): Nakatsuka Terumasa
  • Journal Title: Journal of Physiology (On line)
  • Peer Reviewed
• [Journal Article] Phospholipase A_2 activation enhances inhibitory synaptic transmission in rat substantia gelatinosa neurons (2008)
  • Author(s): Liu Tao
  • Journal Title: Journal of Neurophysiology 99 Pages: 1279-1289
  • Peer Reviewed
• [Journal Article] Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord (2007)
  • Author(s): Kosugi M, Nakatsuka T, Fujita T, Kuroda Y, Kumamoto E
  • Journal Title: Journal of Neuroscience 27 Pages: 4443-4451
  • Peer Reviewed
• [Journal Article] Hypothermia suppresses excitatory synaptic transmission and neuronal death induced by experimental ischemia in spinal ventral horn neurons (2007)
  • Author(s): Nishi H, Nakatsuka T, Takeda D, Miyazaki N, Sakanaka J, Yamada H, Yoshida M
  • Journal Title: Spine 32 Pages: 741-747
  • Peer Reviewed
• [Journal Article] Selective vulnerability to ischemia in the rat spinal cord-A comparison between ventral and dorsal horn neurons (2007)
  • Author(s): Nohda K, Nakatsuka T, Takeda D, Miyazaki N, Nishi H, Sonobe H, Yoshida M
  • Journal Title: Spine 32 Pages: 1060-1066
  • Peer Reviewed
• [Journal Article] The activation of nicotinic acetylcholine receptors enhances the inhibitory synaptic transmission in the deep dorsal horn neurons of the adult rat spinal cord (2007)
  • Author(s): Takeda D, Nakatsuka T, Gu JG, Yoshida M
  • Journal Title: Molecular Pain 3(27) Pages: 1-9
  • Peer Reviewed
• [Journal Article] Proteinase-activated receptor-1 activation presynaptically enhances spontaneous exci tatory synaptic transmission in adult rat substantia gelatinosa neurons (2007)
  • Author(s): Fujita T, Liu T, Mizuta K, Nakatsuka T, Kumamoto E
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 29 Pages: 8-14
  • Peer Reviewed
• [Journal Article] The effect of TRPA1 activation on excitatory synaptic transmission in the spinal dorsal horn (2007)
  • Author(s): Kosugi M, Nakatsuka T, Fujita T, Aoyama T, Kumamoto E
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 29 Pages: 15-20
  • NAID: 40016271743
  • Peer Reviewed
• [Journal Article] Cellular mechanism on spinal ventral horn neurons by the activation of adenosine A_<2A> receptor (2007)
  • Author(s): Miyazaki N, Nakatsuka T, Sonobe H, Takeda D, Nishi H, Nohda K, Sakanaka J, Iwasaki H, Yoshida M
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 29 Pages: 21-27
  • Peer Reviewed
• [Journal Article] 痛みの基礎研究-生理学的立場から- (2007)
  • Author(s): 中塚映政, 藤田亜美, 熊本栄一
  • Journal Title: 臨床整形外科 42 Pages: 539-544
  • Peer Reviewed
• [Journal Article] 難治性痺痛を理解するための最新基礎知識<基礎編> (2007)
  • Author(s): 中塚映政, 藤田亜美, 熊本栄一
  • Journal Title: 医学のあゆみ 223 Pages: 791-793
  • Peer Reviewed
• [Journal Article] 痛みの統御機構 : 最近の話題 (2007)
  • Author(s): 中塚映政
  • Journal Title: ペインクリニック 28 Pages: 522-529
  • Peer Reviewed
• [Journal Article] 痛みの概念, 急性痛と慢性痛 (2007)
  • Author(s): 中塚映政
  • Journal Title: Monthly Book Medical Rehabilitation 79 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord (2007)
  • Author(s): Kosugi Masafumi
  • Journal Title: Journal of Neuroscience 27 Pages: 4443-4451
  • Peer Reviewed
• [Journal Article] Hypothermia suppresses excitatory synapitc transmission and neuronal death induced by experimental ischemia in spinal ventral horn neurons (2007)
  • Author(s): Nishi Hideto
  • Journal Title: Spine 32
  • Peer Reviewed
• [Journal Article] The activation of nicotinic acetylcholine receptors enhances the inhibitory synaptic transmission in the deep dorsal horn neurons of the adult rat spinal cord (2007)
  • Author(s): Takeda Daisuke
  • Journal Title: Molecular Pain 3(27) Pages: 1-9
  • Peer Reviewed
• [Journal Article] Selective vulnerability to ischemia in the rat spinal cord - A comparison between ventral and dorsal horn neurons (2007)
  • Author(s): Nohda Kazuhiro
  • Journal Title: Spine 32 Pages: 1060-1066
  • Peer Reviewed
• [Journal Article] (2007)
  • Author(s): Liu Tao
  • Journal Title: Pain Research 22 Pages: 11-18
  • Peer Reviewed
• [Journal Article] Proteinase-activated receptor-1 activation presynaptically enhances spontaneous excitatory synaptic transmission in adult rat substantia gelatinosa neurons (2007)
  • Author(s): Fujita Tsugumi
  • Journal Title: Journal of Functional Diagnosis of the Spinal Cord 29 Pages: 8-11
  • Peer Reviewed
• [Journal Article] The effect of TRPA1 activation on excitatory synaptic transmission in the spinal dorsal horn (2007)
  • Author(s): Kosugi Masafumi
  • Journal Title: Journal of Functional Diagnosis of the Spinal Cord 29 Pages: 15-20
  • Peer Reviewed
• [Journal Article] A cellular mechanism on spinal ventral horn neurons by the activation of adenosine A_<2A> receptor (2007)
  • Author(s): Miyazaki Nobuyuki
  • Journal Title: Journal of Functional Diagnosis of the Spinal Cord 29 Pages: 21-26
  • Peer Reviewed
• [Presentation] パッチクランプ法を用いた脊髄電気刺激による鎮痛機構の解明 (2009)
  • Author(s): 中塚 映政
  • Organizer: 生理学研究所研究会「筋・骨格系と内臓の痛み研究会」
  • Place of Presentation: 岡崎
  • Year and Date: 2009-01-22
• [Presentation] レシニフェラトキシンはラット脊髄後角ニューロンのグルタミン酸作動性の自発性興奮性シナプス伝達を促進する (2008)
  • Author(s): 蒋 昌宇
  • Organizer: 第46回日本生物物理学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-12-03
• [Presentation] オピオイドによる蛙坐骨神経の複合活動電位抑制とその化学構造との関連 (2008)
  • Author(s): 水田恒太郎
  • Organizer: 第46回日本生物物理学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-12-03
• [Presentation] Cellular mechanism of spinal cord stimulation-evoked analgesia : a possible involvement of somatostatin. (2008)
  • Author(s): Nakatsuka Terumasa
  • Organizer: 38th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-15
• [Presentation] L-Glutamate release from nerve terminals in the adult rat spinal dorsal horn neuron is more effectively increased by PAR-1 than PAR-2 and PAR-4 agonists. (2008)
  • Author(s): Fujita Tsugumi
  • Organizer: 38th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-15
• [Presentation] Cellular mechanisms for the phospholipase A2-mediated enhancement of inhibitory synaptic transmission in adult rat substantia gelatinosa neurons. (2008)
  • Author(s): Liu Tao
  • Organizer: 38th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-15
• [Presentation] Pre- and postsynaptic modulation by galanin of glutamatergic excitatory synaptic transmission in adult rat substantia gelatinosa neurons. (2008)
  • Author(s): Yue Hai-Yuan
  • Organizer: 38th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-15
• [Presentation] Resiniferatoxin enhances excitatory synaptic transmission in adult rat spinal dorsal horn neurons. (2008)
  • Author(s): Jiang Chang-Yu
  • Organizer: 38th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-15
• [Presentation] Relationship of the chemical structures of opioids to their inhibitory actions on compound action potentials in frog sciatic nerves. (2008)
  • Author(s): Mizuta Kotaro
  • Organizer: 38th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-15
• [Presentation] Capsaicin and its analogs inhibit compound action potentials in frog sciatic nerves. (2008)
  • Author(s): Tomohiro Daisuke
  • Organizer: 38th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-15
• [Presentation] Inhibition by dexmedetomidine of compound action potentials in frog sciatic nerves without α2 adrenoceptor activation. (2008)
  • Author(s): Kosugi Toshifumi
  • Organizer: 38th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-15
• [Presentation] ラツト脊髄後角膠様質ニューロンの膜興奮性に及ぼすガラニンの二相性作用 (2008)
  • Author(s): 岳海源
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-03
• [Presentation] カェル坐骨神経の複合活動電位に及ぼすカプサイシンとその関連物質の抑制効果 (2008)
  • Author(s): 友廣大輔
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-03
• [Presentation] ラット脊髄後角膠様質ニューロンの自発性興奮性シナプス伝達に対するレシニフェラトキシンの作用 (2008)
  • Author(s): 蒋昌宇
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-03
• [Presentation] Facilitation by phospholipase A_2 activation of inhibitory synaptic transmission in rat substantia gelatinosa neurons. (2008)
  • Author(s): Kumamoto Eiichi
  • Organizer: 12th World Congress on Pain
  • Place of Presentation: Glasgow
  • Year and Date: 2008-08-17
• [Presentation] TRPAl mediated facilitation of excitatory synaptic transmission in the spinal dorsal horn (2008)
  • Author(s): Nakatsuka Terumasa
  • Organizer: 12th World Congress on Pain
  • Place of Presentation: Glasgow
  • Year and Date: 2008-08-17
• [Presentation] PAR-1 activating peptides and proteinases enhance the spontaneous release of L-glutamate from nerve terminals in adult spinal dorsal horn neurons. (2008)
  • Author(s): Fujita Tsugumi
  • Organizer: 12th World Congress on Pain
  • Place of Presentation: Glasgow
  • Year and Date: 2008-08-17
• [Presentation] 脊髄電気刺激による鎮痛機構 (2008)
  • Author(s): 中塚 映政
  • Organizer: 第30回日本疼痛学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-07-19
• [Presentation] ラット脊髄膠様質の抑制性シナプス伝達のホスホリパーゼA2活性化による促進の機序 (2008)
  • Author(s): 柳 涛
  • Organizer: 第30回日本疼痛学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-07-19
• [Presentation] 脊髄後角ニューロンの興奮性シナプス伝達に対するガラニンのシナプス前性および後性作用 (2008)
  • Author(s): 岳 海源
  • Organizer: 第30回日本疼痛学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-07-19
• [Presentation] カエル坐骨神経の複合活動電位に及ぼすデクスメデトミジンの作用 (2008)
  • Author(s): 小杉 寿文
  • Organizer: 第30回日本疼痛学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-07-19
• [Presentation] TRPA1 channel-mediated enhancement of excitatory synaptic tran smission in the spinal dorsal horn. (2008)
  • Author(s): Nakatsuka Terumasa
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] L-Glutamate release from nerve terminals is enhanced by PAR-1 activation in the adult rat spinal dorsal horn. (2008)
  • Author(s): Fujita Tsugumi
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] Mechanisms for phospholipase A_2-mediated enhancement of inhibitory transmission in rat substantia gelatinosa neurons. (2008)
  • Author(s): Liu Tao
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] Galanin pre- and postsynaptically modulates excitatory synaptic transmission in rat substantia gelatinosa neurons (2008)
  • Author(s): Yue Hai-Yuan
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] Inhibition by tramadol of excitatory synaptic transmission in rat spinal dorsal horn neurons through mu-opioid receptor activation but not monoamine uptake inhibition. (2008)
  • Author(s): Piao Lian-Hua
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] Relationship between the chemical structures of opioids and their inhibitory actions on compound action potentials in frog sciatic nerves. (2008)
  • Author(s): Mizuta Kotaro
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] Inhibitory actions of capsaicin and its analogs on compound action potentials in frog sciatic nerves. (2008)
  • Author(s): Tomohiro Daisuke
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] Effect of resiniferatoxin on excitatory synaptic transmission in adult rat substantia gelatinosa neurons. (2008)
  • Author(s): Jiang Chang-Yu
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] Dexmedetomidine inhibits compound action potentials in frog sciatic nerves without alpha2 adrenoceptor activation. (2008)
  • Author(s): Kosugi Toshifumi
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] Enhancement of inhibitory synaptic transmission in the spinal deep dorsal horn through activation of nicotinic acetylcholine receptors. (2008)
  • Author(s): Takeda Daisuke
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] 脊髄後角におけるGIRKチャネルの活性化-内因性ソマトスタチンの関与の可能性について (2008)
  • Author(s): 中塚 映政
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] 脊髄後角におけるホスホリパーゼA2活性化による抑制性シナプス伝達促進の作用機序 (2008)
  • Author(s): 柳 涛
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] プリン受容体活性化による脊髄運動ニューロンの興奮性シナプス伝達の増強 (2008)
  • Author(s): 青山 貴博
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] ラット脊髄膠様質ニューロンの興奮性シナプス伝達に及ぼすガラニンの効果 (2008)
  • Author(s): 岳 海源
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] カプサイシンとその類似物質は蛙坐骨神経の複合活動電位を抑制する (2008)
  • Author(s): 友廣 大輔
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] デクスメデトミジンは蛙坐骨神経の複合活動電位を抑制する (2008)
  • Author(s): 小杉 寿文
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] 慢性痛のターゲットは? -末梢から中枢まで-脊髄内疼痛伝達機構の可塑的変化 (2008)
  • Author(s): 中塚 映政
  • Organizer: 第12回日本神経麻酔・集中治療研究会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-11
• [Presentation] P2XならびにP2Y受容体の活性化によるラット脊髄運動ニューロンの直接的な興奮 (2008)
  • Author(s): 青山 貴博
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-07
• [Presentation] ガラニンはラット脊髄膠様質ニューロンの興奮性シナプス伝達を修飾する (2008)
  • Author(s): 岳 海源
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-07
• [Presentation] PAR-1活性化ペプチドとプロテアーゼは成熟ラット脊髄後角ニューロンにおけるグルタミン酸作動性興奮性シナプス伝達を促進する (2008)
  • Author(s): 藤田 亜美
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-07
• [Presentation] トラマドールはモノアミン取り込み阻害なしにμ型オピオイド受容体活性化によりグルタミン酸作動性の興奮性シナプス伝達を抑制する (2008)
  • Author(s): 朴 蓮花
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-07
• [Presentation] メリチンによるラット脊髄後角ニューロンのGABA作動性抑制性シナプス伝達の促進はアセチルコリンとノルエピネフリンの作用による (2008)
  • Author(s): 友廣 大輔
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-07
• [Presentation] 成熟ラット脊髄膠様質の興奮性シナプス伝達に及ぼすガラニンの作用 (2008)
  • Author(s): 岳 海源
  • Organizer: 第30回脊髄機能診断研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-02
• [Presentation] ATP受容体の活性化による脊髄運動ニューロンの興奮 (2008)
  • Author(s): 青山 貴博
  • Organizer: 第30回脊髄機能診断研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-02
• [Presentation] 脊髄運動ニューロンにおける虚血負荷に対するアデノシンの神経保護作用 (2008)
  • Author(s): 宮崎 展行
  • Organizer: 第30回脊髄機能診断研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-02
• [Presentation] ドーパミンによる脊髄運動ニューロンの制御機構 (2008)
  • Author(s): 阪中 淳也
  • Organizer: 第30回脊髄機能診断研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-02
• [Presentation] Cellular mechanism of spinal cord stimulation-evoked analgesia : a possible involvement of somatostatin (2008)
  • Author(s): Nakatsuka T, Fujita T, Aoyama T, Taniguchi W, Kawasaki Y, Kumamoto E
  • Organizer: 38th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC
• [Presentation] Presynaptic TRPA1 mediated facilitation of excitatory synaptic transmission in the spinal dorsal horn (2008)
  • Author(s): Nakatsuka T, Kosugi M, Fujita T, Kumamoto E
  • Organizer: 12th World Congress on Pain
  • Place of Presentation: Glasgow
• [Presentation] 脊髄電気刺激による鎮痛機構 (2008)
  • Author(s): 中塚映政、藤田亜美、青山貴博、熊本栄一
  • Organizer: 第30回日本痺痛学会
  • Place of Presentation: 福岡
• [Presentation] TRPA1 channel-mediated enhancement of excitatory synaptic transmission in the spinal dorsal horn (2008)
  • Author(s): Nakatsuka T, Kosugi M, Fujita T, Aoyama T, Kumamoto E
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
• [Presentation] Enhancement of inhibitory synaptic transmission in the spinal deep dorsal horn through activation of nicotinic acetylcholine receptors (2008)
  • Author(s): Takeda D, Nakatsuka T, Gu JG, Yoshida M
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka
• [Presentation] 脊髄後角におけるGIRKチャネルの活性化一内因性ソマトスタチンの関与の可能性について (2008)
  • Author(s): 中塚映政、藤田亜美、青山貴博、谷口亘、熊本栄一
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 脊髄におけるシナプス前TRPA1チャネルの機能的意義について (2008)
  • Author(s): 中塚映政、小杉雅史、藤田亜美、熊本栄一
  • Organizer: 生理学研究所研究会「TRPチャネルの機能的多様性とその統一的理解」
  • Place of Presentation: 岡崎
• [Presentation] シンポジウム-慢性痛のターゲットは--末梢から中枢まで-脊髄内痺痛伝達機構の可塑的変化 (2008)
  • Author(s): 中塚映政
  • Organizer: 第12回日本神経麻酔・集中治療研究会
  • Place of Presentation: 新潟
• [Presentation] 成熟ラット脊髄膠様質ニューロンにおける内因性のソマトスタチンによるGIRKチャネルの活性化 (2008)
  • Author(s): 中塚映政、藤田亜美、青山貴博、谷口亘、熊本栄一
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] ホスホリパーゼA_2活性化を介したラット脊髄膠様質ニューロンのGABAとグリシンによる抑制性シナプス伝達の促進 (2007)
  • Author(s): 熊本 栄一
  • Organizer: 生理学研究所研究会「筋・骨格系と内臓の痛み研究会」
  • Place of Presentation: 岡崎
  • Year and Date: 2007-12-01
• [Presentation] TRPA1の活性化による興奮性シナプス伝達の増強 (2007)
  • Author(s): 中塚 映政
  • Organizer: 生理学研究所研究会「シナプス伝達ダイナミクス解明の新戦略-シナプス伝達の細胞分子調節機構-」
  • Place of Presentation: 岡崎
  • Year and Date: 2007-11-22
• [Presentation] Direct activation of postsynaptic NMDA receptors by TRPA1-induced glutamate release onto substantia gelatinosa neurons of the adult rat spinal cord (2007)
  • Author(s): Nakatsuka Terumasa
  • Organizer: Neuroscience 2007
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-03
• [Presentation] Phospholipase A_2 activation enhances inhibitory synaptic transmission in rat spinal dorsal horn neurons (2007)
  • Author(s): Liu Tao
  • Organizer: Neuroscience 2007
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-03
• [Presentation] Tramadol presynaptically inhibits glutamatergic excitatory synaptic transmission in rat spinal dorsal horn neurons by activating μ-opioid receptors (2007)
  • Author(s): Koga Akiko
  • Organizer: Neuroscience 2007
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-03
• [Presentation] Opioids reduce the peak amplitude of compound action potential in frog sciatic nerves (2007)
  • Author(s): Mizuta Kotaro
  • Organizer: Neuroscience 2007
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-03
• [Presentation] Extracellular ATP facilitates excitatory synaptic transmission in rat spinal motoneurons. (2007)
  • Author(s): Aoyama Takahiro
  • Organizer: Neuroscience 2007
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-03
• [Presentation] Enhancement by PAR-1 activation of the spontaneous release of L-glutamate from nerve terminals in the adult rat spinal dorsal horn (2007)
  • Author(s): Fujita Tsugumi
  • Organizer: Neuroscience 2007
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-03
• [Presentation] Adenosine suppresses neuronal death induced by experimental ischemia in spinal motoneurons. (2007)
  • Author(s): Miyazaki Nobuyuki
  • Organizer: Neuroscience 2007
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-03
• [Presentation] 実験的虚血負荷による脊髄運動ニューロンの細胞死に対するアデノシンの作用 (2007)
  • Author(s): 宮崎 展行
  • Organizer: 第22回日本整形外科学会基礎学術集会
  • Place of Presentation: 浜松
  • Year and Date: 2007-10-25
• [Presentation] 脊髄運動ニューロンにおけるドーパミンの作用 (2007)
  • Author(s): 阪中 淳也
  • Organizer: 第22回日本整形外科学会基礎学術集会
  • Place of Presentation: 浜松
  • Year and Date: 2007-10-25
• [Presentation] ラット脊髄後角のGABAとグリシンによる抑制性シナプス伝達のメリチンによる促進 (2007)
  • Author(s): 柳 涛
  • Organizer: 第58回西日本生理学会
  • Place of Presentation: 福岡
  • Year and Date: 2007-10-19
• [Presentation] 脊髄運動ニューロンにおけるATP受容体の機能的役割について (2007)
  • Author(s): 青山 貴博
  • Organizer: 第58回西日本生理学会
  • Place of Presentation: 福岡
  • Year and Date: 2007-10-19
• [Presentation] オピオイドによるカエル坐骨神経の複合活動電位抑制と構造活性連関 (2007)
  • Author(s): 水田 恒太郎
  • Organizer: 第58回西日本生理学会
  • Place of Presentation: 福岡
  • Year and Date: 2007-10-19
• [Presentation] トラマドールとその代謝物mono-O-demethyl-tramadol(M1)のカエル坐骨神経複合活動電位に対する作用 (2007)
  • Author(s): 香月 亮
  • Organizer: 第58回西日本生理学会
  • Place of Presentation: 福岡
  • Year and Date: 2007-10-19
• [Presentation] シナプス前TRPA1の活性化によって成熟ラット脊髄膠様質にグルタミン酸の放出が増強する (2007)
  • Author(s): 小杉 雅史
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] オピオイドによるカエル坐骨神経の活動電位抑制 (2007)
  • Author(s): 水田 恒太郎
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] トラマドールはオピオイド受容体活性化やモノアミン取り込み阻害と無関係に神経伝導ブロックを起こす (2007)
  • Author(s): 香月 亮
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] ホスホリパーゼA_2活性化によるラット膠様質ニューロンのグリシンとGABA作動性抑制性シナプス伝達の促進 (2007)
  • Author(s): 柳 涛
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] Proteinase-activated receptor-1活性化による成熟ラット脊髄膠様質のグルタミン酸作動性興奮性シナプス伝達促進 (2007)
  • Author(s): 藤田 亜美
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 脊髄後角におけるTRPA1受容体による興奮性シナプス伝達の増強 (2007)
  • Author(s): 小杉 雅史
  • Organizer: 第29回日本疼痛学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-07-07
• [Presentation] 蛙坐骨神経の複合活動電位に及ぼすオピオイドの抑制効果 (2007)
  • Author(s): 水田 恒太郎
  • Organizer: 第29回日本疼痛学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-07-07
• [Presentation] 成熟ラット脊髄膠様質のproteinase-activated receptor-1活性化によるグルタミン酸放出促進 (2007)
  • Author(s): 藤田 亜美
  • Organizer: 第29回日本疼痛学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-07-07
• [Presentation] 痛みのターゲットは末梢か中枢か?慢性痛はどこを治療したらいいか?(東京)2007.6.30-7.1. (2007)
  • Author(s): 中塚 映政
  • Organizer: 第5回整形外科痛みを語る会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-30
• [Presentation] TRPA1の活性化による興奮性シナプス伝達の増強 (2007)
  • Author(s): 中塚映政、小杉雅史、藤田亜美、熊本栄一
  • Organizer: 生理学研究所研究会(シナプス伝達の細胞分子調節機構)
  • Place of Presentation: 岡崎
• [Presentation] Direct activation of postsynaptic NMDA receptors by TRPAl-induced glutamate release onto substantia gelatinosa neurons of the adult rat spinal cord (2007)
  • Author(s): Nakatsuka T, Kosugi M, Fujita T, Aoyama T, Mizuta K, Tomohiro D, Kumamoto E
  • Organizer: 37th Annual Meeting of Society for Neuroscience(Program No. 821.17. 2007 Abstract Viewer and Itinerary Planner. Washington, DC : Society for Neuroscience 2007)
  • Place of Presentation: San Diego
• [Presentation] Enhancement by PAR-1 activation of the spontaneous release of L-glutamate from nerve terminals in the adult rat spinal dorsal horn (2007)
  • Author(s): Fujita T, Nakatsuka T, Liu T, Kumamoto E
  • Organizer: 37th Annual Meeting of Society for Neuroscience(Program No. 821.16. 2007 Abstract Viewer and Itinerary Planner. Washington, DC : Society for Neuroscience, 2007)
  • Place of Presentation: San Diego
• [Presentation] Phospholipase A2 activation enhances inhibitory synaptic transmission in rat spinal dorsal horn neurons (2007)
  • Author(s): Liu T, Fujita T, Yue H-Y, Piao L-H, Nakatsuka T, Kumamoto E
  • Organizer: 37th Annual Meeting of Society for Neuroscience(Program No. 821.19. 2007 Abstract Viewer and Itinerary Planner. Washington, DC : Society for Neuroscience, 2007)
  • Place of Presentation: San Diego
• [Presentation] Extracellular ATP facilitates excitatory synaptic transmission in rat spinal motoneurons (2007)
  • Author(s): Aoyama T, Nakatsuka T, Koga S, Fujita T, Mizuta K, Takeda D, Kumamoto E
  • Organizer: 37th Annual Meeting of Society for Neuroscience(Program No. 408.10. 2007 Abstract Viewer and Itinerary Planner. Washington, DC : Society for Neuroscience, 2007)
  • Place of Presentation: San Diego
• [Presentation] Opioids reduce the peak amplitude of compound action potential in frog sciatic nerves (2007)
  • Author(s): Mizuta K, Fujita T, Liu T, PiaoL-H, Yue H-Y, Nakatsuka T, Masuko S, Kumamoto E
  • Organizer: 37th Annual Meeting of Society for Neuroscience(Program No. 509.15. 2007 Abstract Viewer and Itinerary Planner. Washington, DC : Society for Neuroscience, 2007)
  • Place of Presentation: San Diego
• [Presentation] Tramadol presynaptically inhibits glutamatergic excitatory synaptic transmission in rat spinal dorsal horn neurons by activating mu-opioid receptors (2007)
  • Author(s): Koga A, Fujita T, Liu T, Mizuta K, Nakatsuka T, Hasuo H, Kumamoto E
  • Organizer: 37th Annual Meeting of Society for Neuroscience(Program No. 821.18. 2007 Abstract Viewer and Itinerary Planner. Washington, DC : Society for Neuroscience, 2007)
  • Place of Presentation: San Diego
• [Presentation] Adenosine suppresses neuronal death induced by experimental ischemia in spinal motoneurons (2007)
  • Author(s): Miyazaki N, Takeda D, Nohda K, Sakanaka J, Yoshida M, Nakatsuka T
  • Organizer: 37th Annual Meeting of Society for Neuroscience(Program No. 726.9. 2007 Abstract Viewer and Itinerary Planner. Washington, DC : Society for Neuroscience, 2007)
  • Place of Presentation: San Diego
• [Presentation] Enhancement by PAR-1 activation of glutamatergic excitatory transmission in adult rat substantia gelatinosa neurons (2007)
  • Author(s): Fujita T, Liu T, Nakatsuka T, Kumamoto E
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society, The 50th Annual Meeting of the Japanese Society for Neurochemistry, The 17th Annual Meeting of the Japanese Neural Network Society(Neurosci. Res. 58(Suppl.) : S73)
  • Place of Presentation: Yokohama
• [Presentation] Enhancement by phospholipase A2 activation of glycinergic and GABAergic inhibitory transmission in rat substantia gelatinosa neurons (2007)
  • Author(s): Liu T, Fujita T, Yue H-Y, Mizuta K, Piao L-H, Nakatsuka T, Kumamoto E
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society, The 50th Annual Meeting of the Japanese Society for Neurochemistry, The 17th Annual Meeting of the Japanese Neural Network Society(Neurosci. Res. 58(Suppl.) : S72)
  • Place of Presentation: Yokohama
• [Presentation] Presynaptic TRPA1 activation enhances glutamate release onto substantia gelatinosa neurons of the adult rat spinal cord (2007)
  • Author(s): Kosugi M, Nakatsuka T, Fujita T, Aoyama T, Kumamoto E
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society, The 50th Annual Meeting of the Japanese Society for Neurochemistry, The 17th Annual Meeting of the Japanese Neural Network Society(Neurosci. Res. 58(Suppl.) : S73)
  • Place of Presentation: Yokohama
• [Presentation] 脊髄運動ニューロンにおけるプリン受容体を介するシナプス前性および後性作用 (2007)
  • Author(s): 青山 貴博
  • Organizer: 生理学研究所研究会「生体システム間境界領域におけるATP・アデノシン情報伝達の役割」
  • Place of Presentation: 岡崎
• [Book] エッセンシャル神経科学 (2008)
  • Author(s): 中塚映政, 熊本栄一
  • Publisher: 脊髄, 丸善株式会社
• [Book] エッセンシャル神経科学 (2008)
  • Author(s): 中塚 映政
  • Total Pages: 574
  • Publisher: 丸善株式会社
• [Book] Research Signpost, Cellular and Molecular Mechanisms for the Modulation of Nociceptive Transmission in the Peripheral and Central Nervous Systems (2007)
  • Author(s): Nakatsuka T, Fujita T, Kumamoto E
  • Publisher: P2X receptors and pain sensations
• [Book] Research Signpost, Cellular and Molecular Mechanisms for the Modulation of Nociceptive Transmission in the Peripheral and Central Nervous Systems (2007)
  • Author(s): Fujita T, Nakatsuka T, Kumamoto E
  • Publisher: Opioid receptor activation in spinal dorsal horn
• [Book] Research Signpost, Cellular and Molecular Mechanisms for the Modulation of Nociceptive Transmission in the Peripheral and Central Nervous Systems (2007)
  • Author(s): Kumamoto E, Liu T, Fujita T, Yue H-Y, Nakatsuka T
  • Publisher: Role of phospholipase A2 in modulating synaptic transmission in the spinal dorsal horn
• [Book] よくわかる病態生理一神経疾患 (2007)
  • Author(s): 中塚映政
  • Publisher: 大脳皮質の機能局在, 日本医事新報
• [Book] 痛みとイオンチャネル(運動器の痛み診療ハンドブック) (2007)
  • Author(s): 中塚映政
  • Total Pages: 18
  • Publisher: 南江堂
• [Book] 大脳皮質の機能局在 (2007)
  • Author(s): 中塚 映政
  • Total Pages: 4
  • Publisher: 日本医事新報
• [Book] 運動器の痛み診療ハンドブック (2007)
  • Author(s): 中塚 映政
  • Total Pages: 1
  • Publisher: 南江堂
• [Book] Cellular and Molecular Mechanisms for the Modulation of Nociceptive Trans mission in the Peripheral and Central Nervous Systems (2007)
  • Author(s): Nakatsuka Terumasa
  • Total Pages: 18
  • Publisher: Research Signpost
• [Book] Cellular and Molecular Mechanisms for the Modulation of Nociceptive Trans mission in the Peripheral and Central Nervous Systems (2007)
  • Author(s): Fujita Tsugumi
  • Total Pages: 24
  • Publisher: Research Signpost
• [Book] Cellular and Molecular Mechanisms for the Modulation of Nociceptive Trans mission in the Peripheral and Central Nervous Systems (2007)
  • Author(s): Kumamoto Eiichi
  • Total Pages: 18
  • Publisher: Research Signpost
• [Remarks]
  • URL: http://www.neurophysiology.med.saga-u.ac.jp/