• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of new analgesics and therapy for intractable pain

Research Project

Project/Area Number 19603011
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pain science
Research InstitutionTohoku Pharmaceutical University

Principal Investigator

SAKURADA Shinobu  Tohoku Pharmaceutical University, 薬学部, 教授 (30075816)

Co-Investigator(Kenkyū-buntansha) MIZOGUCHI Hirokazu  東北薬科大学, 薬学部, 准教授 (30360069)
WATANABE Chizuko  東北薬科大学, 薬学部, 助教 (90296020)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords難治性疼痛 / 鎮痛薬 / オピオイド / 内因性ペプチド / ジーンセラピー
Research Abstract

We investigated the mechanism for the reduced effectiveness of morphine in neuropathic pain stage in this project. With the mechanism investigated, we tried to develop the gene therapy for neuropathic pain. In addition, we also developed the new analgesic amidino-TAPA, which is extremely effective against neuropathic pain.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (77 results)

All 2009 2008 2007 Other

All Journal Article (20 results) (of which Peer Reviewed: 17 results) Presentation (50 results) Book (7 results)

  • [Journal Article] New therapy for neuropathic pain2009

    • Author(s)
      H. Mizoguchi, C. Watanabe, A. Yonezawa, S. Sakurada
    • Journal Title

      Int. Rev. Neurobiol 85

      Pages: 249-260

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intraplantar injection of bergamot essential oil into the mouse hindpaw: effects on capsaicin-induced nociceptive behaviors2009

    • Author(s)
      T. Sakurada, H. Kuwahata, S. Katsuyama, T. Komatsu, L.A. Morrone, M.T. Corasaniti, G. Bagetta, S. Sakurada
    • Journal Title

      Int. Rev. Neurobiol 85

      Pages: 237-248

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] (-)-Linalool attenuates allodynia in neuropathic pain induced by spinal nerve ligation in c57/bl6 mice2009

    • Author(s)
      L. Berliocchi, R. Russo, A. Levato, V. Fratto, G. Bagetta, S. Sakurada, T. Sakurada, N.B. Mercuri, M.T. Corasaniti
    • Journal Title

      Int. Rev. Neurobiol 85

      Pages: 221-235

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nociceptive behavior induced by the endogenous opioid peptides dynorphins in uninjured mice: evidence with intrathecal N-ethylmaleimide inhibiting dynorphin degradation2009

    • Author(s)
      K. Tan-No, H. Takahashi, O. Nakagawasai, F. Niijima, S. Sakurada, G. Bakalkin, L. Terenius, T. Tadano
    • Journal Title

      Int. Rev. Neurobiol 85

      Pages: 191-205

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nociceptive behavior induced by the endogenous opioid peptides dynorphins inuninduce with intrathecal n-ethylmaleimide inhibitiong dynorphin degradation2009

    • Author(s)
      Koichi Tan-No
    • Journal Title

      Int.Rev.Neurobiol. 85

      Pages: 191-205

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (-)-Linalool attenuates allodynia in neuropathic pain induced by spinal nerve ligation in C57/BL6 mice2009

    • Author(s)
      Laura Berliocchi
    • Journal Title

      Int.Rev.Neurobiol. 85

      Pages: 221-235

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraplantar injection of bergamot essential oil into the mouse hindpaw : effects on capsaicin-induced nociceptive behaviors2009

    • Author(s)
      Tsukasa Sakurada
    • Journal Title

      Int.Rev.Neurobiol. 85

      Pages: 237-248

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New therapy for neuropathic pain2009

    • Author(s)
      Hirokazu Mizoguchi
    • Journal Title

      Int.Rev.Neurobiol. 85

      Pages: 249-260

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      溝口広一
    • Journal Title

      生体の科学60((財)金原一郎記念医学医療振興財団/医学書院)

      Pages: 448-449

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      溝口広一
    • Journal Title

      安全性薬理試験マニュアル(エル・アイ・シー)

      Pages: 258-264

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      Giacinto Bagetta
    • Journal Title

      In Memory of Vittorio Erspamer(EXORMA)

      Pages: 101-113

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Possible involvement of dynorphin A release viaμ1-opioid receptor on supraspinal antinociception of endomorphin-22008

    • Author(s)
      S. Sakurada, T. Sawai, H. Mizoguchi, H. Watanabe, C. Watanabe, A. Yonezawa, M. Morimoto, T. Sato, T. Komatsu, T. Sakurada
    • Journal Title

      Peptides 29

      Pages: 1554-1560

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of dynorphin A release via μ_1-opioid receptor on supraspinal antinociception of endomorphin-22008

    • Author(s)
      Shinobu Sakurada
    • Journal Title

      Peptides 29

      Pages: 1554-1560

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms responsible for the enhanced antinociceptive effects ofμ-opioid receptor agonists in the rostral ventromedial medulla of male rats with persistent inflammatory pain2007

    • Author(s)
      K.T. Sykes, S.R. White, R.W. Hurley, H Mizoguchi, L.F. Tseng, D.L. Hammond
    • Journal Title

      J. Pharmacol. Exp. Ther. 322

      Pages: 813-821

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Tyr-W-MIF-1 analog containing D-Pro2 discriminates among antinociception in mice mediated by different classes ofμ-opioid receptors2007

    • Author(s)
      D. Nakayama, C. Watanabe, H. Watanabe, H. Mizoguchi, T. Sakurada, S. Sakurada
    • Journal Title

      Eur. J. Pharmacol 563

      Pages: 109-116

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of endogenous opioid peptides in the antinociception induced by the novel dermorphin tetrapeptide analog amidino-TAPA2007

    • Author(s)
      H. Mizoguchi, C. Watanabe, H. Watanabe, K. Moriyama, B. Sato, K. Ohwada, A. Yonezawa, T. Sakurada, S. Sakurada
    • Journal Title

      Eur. J. Pharmacol 560

      Pages: 150-159

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of endogenous opioid peptides in the antinociception induced by the novel dermorphin tetrapeptide analog amidino-TAPA2007

    • Author(s)
      Hirokazu Mizoguchi
    • Journal Title

      Eur. J. Pharmacol. 560

      Pages: 150-159

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Tyr-W-MIF-1 analog containing D-Pro^2 discriminates among antinociception mice mediated by different classes of μ-opioid receptors2007

    • Author(s)
      Daisuke Nakayama
    • Journal Title

      Eur. J. Pharrnacol. 563

      Pages: 109-116

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms responsible for the enhanced antinociceptive effects of μ-opioid receptor agonists in the rostral ventromedial medulla of male rats with persistent inflammatory pain2007

    • Author(s)
      Kenneth T. Sykes
    • Journal Title

      J. Pharmacol. Exp. Ther. 322

      Pages: 813-821

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New therapy for neuropathic pain

    • Author(s)
      Hirokazu Mizoguchi
    • Journal Title

      Int. Rev. Neurobiol. (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dermorphin, a powerful analgesic peptide from amphibian skin2009

    • Author(s)
      Shinobu Sakurada
    • Organizer
      Workshop In Memory of Vittorio Erspamer
    • Place of Presentation
      Italy
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 炎症性疼痛形成時におけるMOR-1スプライスバリアントの発現変化とmorphine鎮痛効力との相関性2009

    • Author(s)
      武田 久美子
    • Organizer
      第18回神経行動薬理若手研究者の集い
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 多発性硬化症疼痛におけるモルヒネの鎮痛効力の変化2009

    • Author(s)
      原内珠江、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] エンドモルフィン-2の抗侵害作用における上位中枢μ1オピオイド受容体を介したダイノルフィンA遊離の関与2009

    • Author(s)
      澤井敏樹、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] ペプチド性新規難治性疼痛治療薬amidino-TAPAの鎮痛特性2009

    • Author(s)
      溝口広一、櫻田忍
    • Organizer
      第36回薬物活性シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 神経損傷モデルにおけるヒスタミン誘発疼痛関連行動に及ぼすトランスグルタミナーゼの影響2009

    • Author(s)
      円子顕子、小林悠佳、米澤章彦、溝口広一、渡辺千寿子、櫻田忍
    • Organizer
      第13回日本ヒスタミン学会
    • Place of Presentation
      仙台
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Dermorphin, a powerful analgesic peptide from amphibian skin2009

    • Author(s)
      G. Bagetta, S. Sakurada
    • Organizer
      Workshop in Memory of Vittorio Erspamer
    • Place of Presentation
      Italy
    • Related Report
      2009 Final Research Report
  • [Presentation] 難治性疼痛下におけるmorphine鎮痛効力の変化ならびにそのメカニズムの解明2009

    • Author(s)
      溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第4回東北薬科大学ハイテク・リサーチ・シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Bergamot essential oil(BEO)ならびにBEO含有成分linaloolの抗侵害作用における末梢性オピオイド受容体の関与について2009

    • Author(s)
      櫻田司、勝山壮、小松生明、桑波田日香里、Bagetta Giacinto、櫻田忍
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] 炎症性疼痛形成時におけるMOR-1スプライスバリアントの発現変化とmorphine鎮痛効力との相関性2009

    • Author(s)
      武田久美子、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第18回神経行動薬理若手研究者のつどい
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Gene-based therapeutic aspects of synthesized opioid peptides against neuropathic pain2009

    • Author(s)
      H. Mizoguchi, C. Watanabe, A. Yonezawa, S. Sakurada
    • Organizer
      XI WORKSHOP ON APOPTOSIS IN BIOLOGY AND MEDICINE
    • Place of Presentation
      Sendai
    • Related Report
      2009 Final Research Report
  • [Presentation] 新規鎮痛薬amidino-TAPAの神経障害性疼痛に対する有効性について2008

    • Author(s)
      溝口 広一
    • Organizer
      第2回日本緩和医療薬学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] [dimethyl-Tyr^1]導入endomorphin-1誘導体の薬理特性2008

    • Author(s)
      志村 幸子
    • Organizer
      第59回日本薬理学会北部会
    • Place of Presentation
      仙台
    • Year and Date
      2008-09-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gene-based therapeutic aspect of synthesized opioid peptides against neuropathic pain2008

    • Author(s)
      Hirokazu Mizoguchi
    • Organizer
      XI WORKSHOP ON APOPTOSIS IN BIOLOGY AND MEDICINE
    • Place of Presentation
      仙台
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Antinociceptive profile of novel peptidic analgesics amidino-TAPA2008

    • Author(s)
      Hirokazu Mizoguchi
    • Organizer
      First meeting of the Japan Branch of the International Neuropeptide Society
    • Place of Presentation
      仙台
    • Year and Date
      2008-08-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 難治性疼痛におけるμオピオイド受容体スプライスバリアントの機能的関与2008

    • Author(s)
      武田久美子、溝口広一、夏井早苗、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第61回日本薬理学会西南部会
    • Place of Presentation
      米子
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 新規鎮痛薬amidino-TAPAの神経障害性疼痛に対する有効性について2008

    • Author(s)
      溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第2回日本緩和医療薬学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] [dimethyl-Tyr1]導入endomorphin-1誘導体の薬理特性2008

    • Author(s)
      志村幸子、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第59回日本薬理学会北部会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] Effect of intrathecal substance P(1-7) on substance P-induced nociceptive response: involvement of spinal mu-opioid receptor2008

    • Author(s)
      S. Katsuyama, K. Sanai, T. Komatsu, S. Sakurada, T. Sakurada
    • Organizer
      XI WORKSHOP ON APOPTOSIS IN BIOLOGY AND MEDICINE
    • Place of Presentation
      Sendai
    • Related Report
      2009 Final Research Report
  • [Presentation] Intrathecal N-ethylmaleimide, a cysteine protease inhibitor, produces nociceptive behavior through inhibition of dynorphin degradation2008

    • Author(s)
      K. Tan-No, H. Takahashi, O. Nakagawasai, F. Niijima, S. Sakurada, G. Bakalkin, L. Terenius, T. Tadano
    • Organizer
      XI WORKSHOP ON APOPTOSIS IN BIOLOGY AND MEDICINE
    • Place of Presentation
      Sendai
    • Related Report
      2009 Final Research Report
  • [Presentation] Antinociceptive property of novel peptidic analgesics, a N-terminal tetrapeptide derivative of dermorphin containing 2', 6'-dimethylphenylalanine (Dmp)2008

    • Author(s)
      T. Higashiya, H. Mizoguchi, C. Watanabe, A. Yonezawa, Y. Sasaki, A. Ambo, S. Sakurada
    • Organizer
      XI WORKSHOP ON APOPTOSIS IN BIOLOGY AND MEDICINE
    • Place of Presentation
      Sendai
    • Related Report
      2009 Final Research Report
  • [Presentation] Endomorphin analogues discriminate the antinociception mediated by different classes ofμ-opioid receptors in mice2008

    • Author(s)
      T. Hayashi, T. Suzuki, S. Sakurada
    • Organizer
      XI WORKSHOP ON APOPTOSIS IN BIOLOGY AND MEDICINE
    • Place of Presentation
      Sendai
    • Related Report
      2009 Final Research Report
  • [Presentation] Intraplantar injection of bergamot essential oil into the mouse hindpaw:Effects on capsaicin-induced nociceptive behaviors2008

    • Author(s)
      T. Sakurada, S. Sakurada, L.A. Morrone, G. Bagetta
    • Organizer
      XI WORKSHOP ON APOPTOSIS IN BIOLOGY AND MEDICINE
    • Place of Presentation
      Sendai
    • Related Report
      2009 Final Research Report
  • [Presentation] Antinociceptive profile of novel peptidic analgesics amidino-TAPA2008

    • Author(s)
      H. Mizoguchi, C. Watanabe, A. Yonezawa, S. Sakurada
    • Organizer
      First meeting of the Japan Branch of the International Neuropeptide Society
    • Place of Presentation
      Sendai
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経障害性疼痛治療薬の開発戦略2008

    • Author(s)
      溝口広一
    • Organizer
      平成20年度日本薬学会東北支部総会・学術講演会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 神経障害性疼痛モデルにおけるhistamine誘発性疼痛関連行動の発現機構2008

    • Author(s)
      加藤慧、小林悠佳、米澤章彦、渡辺千寿子、溝口広一、櫻田忍
    • Organizer
      第3回東北薬科大学ハイテク・リサーチ・シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] 依存性の無い難治性疼痛治療薬の開発2008

    • Author(s)
      溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第3回東北薬科大学ハイテク・リサーチ・シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Linalool含有各種エッセンシャルオイルの鎮痛作用2008

    • Author(s)
      秋吉真喜子、桑波田日香里、小松生明、櫻田忍、Giacinto Bagetta、櫻田司
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経障害性疼痛モデルマウスの痛覚過敏発現におけるヒスタミンの役割2007

    • Author(s)
      小林悠佳、米澤章彦、渡辺千寿子、溝口広一、櫻田忍
    • Organizer
      第11回ヒスタミン学会
    • Place of Presentation
      富山
    • Related Report
      2009 Final Research Report
  • [Presentation] エッセンシャルオイル含有Linaloolによるモルヒネ抗侵害刺激増強作用について2007

    • Author(s)
      秋吉真喜子、桑波田日香里、小松生明、櫻田忍、Giacinto Bagetta、櫻田司
    • Organizer
      第24回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Related Report
      2009 Final Research Report
  • [Presentation] Methadoneの上位中枢における抗侵害作用の発現機序について2007

    • Author(s)
      吉岡麻也、溝口広一、漆山莉絵、米澤章彦、渡辺千寿子、櫻田忍
    • Organizer
      第1回日本緩和医療薬学会年会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 麻薬性鎮痛薬であるMorphine, FentanylおよびOxycodoneの抗侵害作用の解析について2007

    • Author(s)
      谷内理枝子、米澤章彦、溝口広一、渡辺千寿子、櫻田忍
    • Organizer
      第1回日本緩和医療薬学会年会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] ペプチド性鎮痛薬amidino-TAPAの特性2007

    • Author(s)
      溝口広一、櫻田忍
    • Organizer
      第1回日本緩和医療薬学会年会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] カプサイシン誘発侵害刺激に対するエッセンシャルオイル含有リナロールの抑制効果2007

    • Author(s)
      桑波田日香里、小松生明、渡辺千寿子、Giacinto Bagetta、櫻田司、櫻田忍
    • Organizer
      第46回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] Endomorphinの抗侵害作用における脊髄μ1およびμ2受容体の多様的関与2007

    • Author(s)
      高木宏和、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第46回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] オピオイド性鎮痛薬Morphine, FentanylおよびOxycodoneの抗侵害作用の特性について2007

    • Author(s)
      谷内理枝子、米澤章彦、溝口広一、渡辺千寿子、櫻田忍
    • Organizer
      第46回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経障害性疼痛の発現に関わるμオピオイド受容体スプライスバリアントの変化2007

    • Author(s)
      夏井早苗、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第46回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Amidino-TAPAの脳室内投与における抗侵害作用の特性2007

    • Author(s)
      吉岡麻也、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第46回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 新規dermorphin N末端テトラペプチド誘導体であるamidino-TAPAの上位中枢における抗侵害作用と動機付け効果2007

    • Author(s)
      吉岡麻也、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第28回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経因性疼痛に対するamidino-TAPAの抗アロディニア作用とその発現における脊髄μ受容体スプライスバリアントの関与2007

    • Author(s)
      溝口広一、武田哲志、夏井早苗、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第116回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Amidino-TAPAのμオピオイド受容体スプライスバリアントに対する選択性とその生理作用への関与について2007

    • Author(s)
      夏井早苗、溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第2回東北薬科大学ハイテク・リサーチ・シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 神経損傷モデルにおけるヒスタミンの疼痛伝達機構2007

    • Author(s)
      小林悠佳、米澤章彦、渡辺千寿子、溝口広一、櫻田忍
    • Organizer
      第2回東北薬科大学ハイテク・リサーチ・シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] 依存性の無い難治性疼痛治療薬の開発2007

    • Author(s)
      溝口広一、渡辺千寿子、米澤章彦、櫻田忍
    • Organizer
      第2回東北薬科大学ハイテク・リサーチ・シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] 依存性の無い難治性疼痛薬の開発2007

    • Author(s)
      溝口 広一
    • Organizer
      第2回東北薬科大学ハイテク・リサーチ・シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神経因性終痛に対するamidino-TAPAの抗アロディニア作用とその発現における登髄μ受容体スプライスバリアントの関与2007

    • Author(s)
      溝口 広一
    • Organizer
      第116回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規dermorphinN末端テトラペプチド誘導体であるamidino-TAPAの上位中枢における抗侵害作用と動機付け効果2007

    • Author(s)
      吉岡 麻也
    • Organizer
      第28回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] オピオイド性鎮痛薬 Morphine,FentanylおよびOxycodoneの抗侵害作用の特性について2007

    • Author(s)
      谷内 理枝子
    • Organizer
      第46回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Presentation] Endomorohinの抗侵害作用における脊髄μ_1およびμ_2受容体の多様的関与2007

    • Author(s)
      高木 宏和
    • Organizer
      第46回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Presentation] ペプチド性鎮痛薬amidhlo-TAPAの特性2007

    • Author(s)
      溝口 広一
    • Organizer
      第1回日本緩和医療薬学会年会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 麻薬性鎮痛薬であるMorphine,FentanylおよひOxycodoneの抗侵害作用の解析について2007

    • Author(s)
      谷内 理枝子
    • Organizer
      第1回日本緩和医療薬学会年会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Book] Memory of Vittorio Erspamer2009

    • Author(s)
      G. Bagetta, S. Sakurada
    • Publisher
      EXORMA
    • Related Report
      2009 Final Research Report
  • [Book] 安全性薬理試験マニュアル2009

    • Author(s)
      溝口広一、櫻田忍
    • Publisher
      エル・アイ・シー
    • Related Report
      2009 Final Research Report
  • [Book] 生体の科学602009

    • Author(s)
      溝口広一、櫻田忍
    • Publisher
      金原一郎記念医学医療振興財団/医学書院
    • Related Report
      2009 Final Research Report
  • [Book] 生理活性ペプチドハンドブック

    • Author(s)
      櫻田忍、溝口広一
    • Publisher
      メディカル・ドゥ(印刷中)
    • Related Report
      2009 Final Research Report
  • [Book] 生理活性ペプチドハンドブック

    • Author(s)
      櫻田忍
    • Publisher
      メディカル・ドゥ(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Book] 生理活性ペプチドハンドブック

    • Author(s)
      櫻田 忍
    • Publisher
      メディカル・ドウ(印刷中)
    • Related Report
      2008 Annual Research Report
  • [Book] 安全性薬理試験マニュアル

    • Author(s)
      溝口 広一
    • Publisher
      エル・アイ・シー(印刷中)
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi