| Project/Area Number |
19603017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
KAWAKAMI Yoriko Tokyo Women's Medical University, 医学部, 教授 (40075601)
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| Co-Investigator(Kenkyū-buntansha) |
林 基弘 東京女子医科大学, 医学部, 講師 (20256499)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 難治性疼痛 / ガンマナイフ / 下垂体 / 三叉神経痛 / マクロファージ / エンドルフィン / グリア細胞 / エンケファリン |
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| Research Abstract |
Gamma knife surgery (GKS), which is a minimally invasive therapy for brain diseases, is currently used for intractable pain disorders such as trigeminal neuralgia, central pain and cancer pain. However, the mechanism underlying the anti-nociceptive effects of GKS is still unknown. The experiments were performed in two ways. (1) We examined the anti-nociceptive mechanism of GKS in the neuropathic pain model of rats (2) How dose Gamma Knife (GK) irradiation to the pituitary gland affect central pain? [Results] (1) We found that GK irradiation reduced mechanical allodynia in neuropathic pain rats. Immunoblotting and histochemical analysis showed that Iba-1 positive macrophage was significantly increased at the GK treated injured nerve. Moreover, myelin debris was removed more efficiently by GK irradiation. These results suggest that Iba-1 positive macrophage in irradiation areas is related to the anti-nociceptive effect of GKS. (2) We established the technical methods of GK irradiation to the rat pituitary gland. We also examined that acute and chronic pain induced Fos activities in the anterior lobe of the pituitary gland, but not in the posterior lobe.
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