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脳信号解読技術を用いた言語機能再建の試み

Research Project

Project/Area Number 19650153
Research Category

Grant-in-Aid for Exploratory Research

Allocation TypeSingle-year Grants
Research Field Rehabilitation science/Welfare engineering
Research InstitutionOsaka University

Principal Investigator

平田 雅之  Osaka University, 医学系研究科, 助教 (30372626)

Co-Investigator(Kenkyū-buntansha) 佐藤 雅昭  株式会社国際電気通信基礎技術研究所, 脳情報研究所, 室長 (90395129)
依藤 史郎  大阪大学, 医学系研究科, 教授 (80191675)
加藤 天美  近畿大学, 医学部, 教授 (00233776)
神谷 之康  株式会社国際電気通信基礎技術研究所, 脳情報研究所, 主任研究員 (50418513)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2008: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywords機能再建 / 機能局在 / 言語 / 脳律動 / 脳信号復号化 / ブレイン・コンピュータ・インターフェース
Research Abstract

(1)MEG、皮質脳波(ECoG)を用いた脳律動計測
ECoGとMEGとで同一課題施行し、解析ソフトBESAを用いて時間周波数解析、coherence解析を行った。詳細な脳内処理過程が明らかになるとともに、言語領野に共通の律動帯域と特有の律動帯域があることが明らかなり、現在論文投稿準備中である。
(2)脳磁図(MEG)での言語優位半球の評価、言語機能局在の評価
単語黙読課題を用いた場合、アミタールテストとの比較で85%一致、電気刺激によるマッピング法との位置の差は6.3±7.1mmであり、非侵襲的検査法として優れた方法であると証明された。アミタールテスト、脳表電気刺激の結果と比較し、成果を論文に投稿した。
(3)脳信号解読
まず、言語機能解読の基礎となる運動機能についてもsupport vector machineを用いて運動内容解読を試みた。運動内容推定については3種の運動内容弁別が80-90%の正答率でリアルタイムに弁別できることが明らかとなり、英文誌Neuroimageに発表した。
言語に関しても時の皮質脳波を計測し、support vector machineを用いた脳信号複号化により発語内容推定を行った。カテゴリー別語想起課題にたいするカテゴリー識別は有意差のある結果が得られなかった。ピ、ポ、ギ、ゴなど単純な発語課題の識別率は運動内容解読には及ばないものの、本方法で言語内容解読がリアルタイムに可能なことが明らかになった。今後さらに性能向上のために計測・解析方法に工夫が必要であると考えられた。

Report

(2 results)
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (49 results)

All 2009 2008 2007

All Journal Article (23 results) (of which Peer Reviewed: 14 results) Presentation (22 results) Book (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Neural decoding using gyral and intrasulcal electrocorticograms.2009

    • Author(s)
      Yanagisawa, T
    • Journal Title

      Neuroimage (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ナビゲーション誘導下反復的経頭蓋磁気刺激による誘発視覚の定量的解析2009

    • Author(s)
      平田雅之
    • Journal Title

      臨床脳波 51

      Pages: 12-18

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Cortical oscillatory power changes during auditory oddball task revealed by spatially filtered magnetoencephalography.2009

    • Author(s)
      Ishii R
    • Journal Title

      Clin Neurophysiol. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cortical oscillatory power changes during auditory oddball task revealed by spatially filtered magnetoencephalography.2009

    • Author(s)
      Kato A
    • Journal Title

      Clin Neurophysiol. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 頭蓋内電極を用いたブレインマシンインターフェースの現状2008

    • Author(s)
      平田雅之
    • Journal Title

      計測と制御 47

      Pages: 537-540

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 皮質脳波を用いた脳・コンピュータ連結2008

    • Author(s)
      柳澤琢史
    • Journal Title

      機能的脳神経外科 47

      Pages: 130-133

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ブレイン・マシン・インターフェースの臨床応用 : 皮質脳波を用いた運動機能再建2008

    • Author(s)
      平田雅之
    • Journal Title

      脳2 1 11

      Pages: 187-192

    • Related Report
      2008 Annual Research Report
  • [Journal Article] ヒト脳の可塑性と再生・再建2008

    • Author(s)
      吉峰俊樹
    • Journal Title

      脳21 11

      Pages: 130-142

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Electrical Stimulation of primary motor cortex within the central sulcus for intractable neuropathic pain.2008

    • Author(s)
      Hosomi, K
    • Journal Title

      Clin Neurophysiol 119

      Pages: 993-1001

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ipsilateral motor-related hyperactivity in patients wi th cerebral occlusive vascular disease2008

    • Author(s)
      Oshino, S
    • Journal Title

      Stroke 39

      Pages: 2769-2775

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion Tensor Fiber Tracking in Patients with Centra1 Post-stroke Pain : Correlation with Efficacy of Repetitive Transcranial Magnetic Stimulation.2008

    • Author(s)
      Goto T
    • Journal Title

      Pain 140

      Pages: 509-518

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SAM/BESAを併用した暗算時の脳内局所律動変化の解析-そろばん熟練者と非熟練者の比較-2008

    • Author(s)
      魚川江津子
    • Journal Title

      臨床脳波 50

      Pages: 291-296

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 幻肢痛に対する大脳皮質刺激療法のメカニズム解析2008

    • Author(s)
      柳澤琢史
    • Journal Title

      Pain Research 23

      Pages: 27-34

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined harpoonlike jagged microneedles imitating mosquito's proboscis and its insertion experiment with vibration.2008

    • Author(s)
      Izumi H
    • Journal Title

      IEEJ Trans 3

      Pages: 425-431

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Motor control and epilepsy-Functional restoration after surgical treatment for intractable epilepsy-2008

    • Author(s)
      Kato, A
    • Journal Title

      Proceedings of JEPICC2007 (In press)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ブレイン・マシン・インターフェースの臨床応用:皮質脳波を用いた運動機能再建2008

    • Author(s)
      平田, 雅之
    • Journal Title

      脳21 (In press)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 頭蓋内電極を用いたブレインマシンインターフェースの現状2008

    • Author(s)
      平田 雅之
    • Journal Title

      計測と制御 (In press)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Effects of the emotional connotations in words on the frontal areas-aspatially filtered MEG study2007

    • Author(s)
      Hirata, M
    • Journal Title

      NeuroImage 35

      Pages: 420-429

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnetoencephalographic analysis of cortical oscillatory activity in patients with brain tumors: Synthetic aperture magnetometry (SAM) functional imaging of delta band activity2007

    • Author(s)
      Oshino, S
    • Journal Title

      NeuroImage 34

      Pages: 957-64

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Late response evoked by cerebellar stimuli: effect of optokinetic stimulation2007

    • Author(s)
      Sakihara, K
    • Journal Title

      NeuroReport 18

      Pages: 891-894

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 皮質脳波を用いたbrain mappingとneural decoding2007

    • Author(s)
      平田, 雅之
    • Journal Title

      信学技報 52

      Pages: 105-108

    • NAID

      110006452966

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 局所脳律動変化にもとづいた脳機能マッピングと脳機能再建への応用2007

    • Author(s)
      平田, 雅之
    • Journal Title

      機能的脳神経外科 46

      Pages: 129-134

    • NAID

      10024369282

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 幻肢痛に対する大脳皮質刺激療法のメカニズム解析2007

    • Author(s)
      柳澤, 琢史
    • Journal Title

      Pain Research 23

      Pages: 27-34

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Neural processing of mental calculation : comparison between abacus experts and nonexperts2008

    • Author(s)
      Hirata M
    • Organizer
      the Society for Neuroscience's 38th annual meeting
    • Place of Presentation
      Washington
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳磁図、皮質電位、ファイバートラッキング、経頭蓋磁気刺激を用いた術前術中視覚機能評価2008

    • Author(s)
      平田雅之
    • Organizer
      第38回日本臨床神経生理学会・学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] ブレインマシンインターフェースを用いた運動機能再建2008

    • Author(s)
      平田雅之
    • Organizer
      平成20年度情報処理学会関西支部支部大会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] てんかん外科のための皮質電気刺激と皮質脳波律動変化を併用した脳機能マツピング2008

    • Author(s)
      平田雅之
    • Organizer
      第42回日本てんかん学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 皮質脳波を用いたBrain machine interfaceによるリアルタイムロボット制御 : 現状と今後の展望2008

    • Author(s)
      平田雅之
    • Organizer
      日本脳神経外科学会第67回学術総会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳表脳波計測に基づく運動制御の実時間復号化2008

    • Author(s)
      平田雅之
    • Organizer
      第23回生体・生理工学シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Real time decoding of motor control using electrocorticograms2008

    • Author(s)
      Hirata. M
    • Organizer
      Satelite symposiurn of bionmag2008
    • Place of Presentation
      Sapporo
    • Year and Date
      2008-08-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳磁図、皮質電位、ファイバートラッキング、経頭蓋磁気刺激を用いた術前術中視覚機能評価2008

    • Author(s)
      平田雅之
    • Organizer
      第8回日本脳神経外科術中画像研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-07-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural processing of mental calculation : comparison between abacus experts and nonexperts2008

    • Author(s)
      平田雅之
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 臨床神経生理学分野における医工連携の重要性2008

    • Author(s)
      平田雅之
    • Organizer
      第23回日本生体磁気学会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 言語領野皮質機能マッピングの現状と将来 : 侵襲的電気刺激から非侵襲機能画像と経頭蓋磁気刺激の併用へ2008

    • Author(s)
      平田雅之
    • Organizer
      第10回日本ヒト脳機能マッピング学会
    • Place of Presentation
      山形
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳表脳波を用いたブレイン・コンピュータ・インターフェース2008

    • Author(s)
      平田雅之
    • Organizer
      第52回システム制御情報学会研究発表講演会
    • Place of Presentation
      京都
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低侵襲型BMI : 皮質脳波を用いたBMIによる 脳機能再建2008

    • Author(s)
      平田雅之
    • Organizer
      多次元共同脳科学推進センターキックオフシンポジウム「日本における脳科学研究および教育の現状と将来に関する検討会」
    • Place of Presentation
      岡崎
    • Year and Date
      2008-04-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 開口合成脳磁図を用いた言語優位半球、言語機能局在の術前評価2007

    • Author(s)
      平田, 雅之
    • Organizer
      第41回日本てんかん学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 単語黙読時における脳内局所脳律動変化の解析2007

    • Author(s)
      梅川, 夕佳
    • Organizer
      第37回日本臨床神経生理学会学術大会
    • Place of Presentation
      宇都宮
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 皮質脳波を用いたbrain mappingとneural decoding2007

    • Author(s)
      平田, 雅之
    • Organizer
      ニューロコンピューティング研究会
    • Place of Presentation
      仙台
    • Year and Date
      2007-10-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 開口合成脳磁図を用いた言語優位半球、言語機能局在の術前評価:侵襲的検査法との比較検証2007

    • Author(s)
      平田, 雅之
    • Organizer
      第66回日本脳神経外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hierarchical network of the human sensorimotor cortex: coherence analysis using gyral and intrasulcal electrocorticograms2007

    • Author(s)
      Hirata, M
    • Organizer
      The post-Conference Workshops of the 22nd Annual Conference on Neural Information Processing Systems
    • Place of Presentation
      Whistler
    • Year and Date
      2007-09-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Noninvasive evaluation of language dominance and localization using synthetic aperture magnetometry: comparison with the Wada test and stimulation mapping2007

    • Author(s)
      Hirata, M
    • Organizer
      The First Conference of the International Society for the Advancement of Clinical Magnetoencephalography
    • Place of Presentation
      Matsushima
    • Year and Date
      2007-08-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Functional brain mapping and restoration using event-related oscillatory changes2007

    • Author(s)
      Hirata, M
    • Organizer
      6th Congress of the Asian Society for Stereotactic, Functional and Computer Assisted Neurosurgery
    • Place of Presentation
      Mt. Fuji
    • Year and Date
      2007-05-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Noninvasive evaluation of language dominance and localization using synthetic aperture magnetometry: comparison with the Wada test and stimulation mapping2007

    • Author(s)
      Hirata, M
    • Organizer
      27th International Epilepsy Congress
    • Place of Presentation
      Singapore
    • Related Report
      2007 Annual Research Report
  • [Presentation] Functional brain mappihg using electrocorticographic oscillatory changes2007

    • Author(s)
      Hirata, M
    • Organizer
      2nd Congress of the International Society of Reconstructive Neurosurgery and 5th Scientific Meeting of the Neurorehabilitation and Reconstructive Neurosurgery Committee of the World Federation of Neurosurgical Societies
    • Place of Presentation
      Taipei
    • Related Report
      2007 Annual Research Report
  • [Book] Motor control and epilepsy-Functional restoration aftersurgical treatment for intractable epilepsy. In Event-related Potentials in Patients with Epilepsy : from Current stateto Future Prospects2008

    • Author(s)
      Kato A
    • Publisher
      John Libbery Eurotext, Paris
    • Related Report
      2008 Annual Research Report
  • [Book] MEG neuroimaging of delisions in episodic interictal psychosis of epilepsy2007

    • Author(s)
      Kato, A
    • Publisher
      Elsevier
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 頭蓋内電極構造体およびその製造方法2009

    • Inventor(s)
      平田雅之, 他6名
    • Industrial Property Rights Holder
      大阪大学
    • Filing Date
      2009-02-22
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 頭蓋内電極構造体およびその製造方法2007

    • Inventor(s)
      平田 雅之, 他4名
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      2007-216461
    • Filing Date
      2007-08-22
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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