Budget Amount *help |
¥6,138,150 (Direct Cost: ¥5,838,150、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥870,469 (Direct Cost: ¥870,469)
Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2008: ¥1,467,681 (Direct Cost: ¥1,467,681)
Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
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Research Abstract |
The TSC-Rheb signaling pathway plays critical roles in the regulation of cell growthunder various conditions. In Schizosaccharomyces pombe, the amount of amino acid transporters at the cell surface is tightly regulated in response to environmental condition. However, how cellular localization of amino acid transporters is regulated under certain conditions remains obscure. Here we demonstrate that ubiquitin ligasePub1 and arrestin-like protein Any1 coordinate regulation of aminoacid transporters and TSC-Rheb signaling pathway controls this regulation.
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