薬物依存に関係する新しいタンパクの生理機能の解明

• Project/Area Number: 19659017
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Meijo University
• Principal Investigator: 鍋島 俊隆 Meijo University, 薬学部, 教授 (70076751)
• Co-Investigator(Kenkyū-buntansha): 新田 淳美 名古屋大学, 医学部付属病院, 准教授 (20275093)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,000,000 (Direct Cost: ¥3,000,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,300,000); Fiscal Year 2008: ¥600,000 (Direct Cost: ¥600,000); Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: shati / piccolo / 薬物依存 / メタンフェタミン / ドパミン再取り込み / ドパミントランスポーター / cDNAサブトラクション法 / 側坐核 / cDNAサブストラクション法 / 遺伝子 / 神経科学 / 生体分子

Research Abstract

本年度は、依存性薬物メタンフェタミン(METH)の投与によりマウス脳の側坐核において発現が有意に増加する因子として同定された新規機能分子'shati'および'piccolo'について、神経系における機能及び薬物依存に対する関与を、神経化学的、行動実験的手法をそれぞれ用い検証した。
shatiに関して免疫組織染色法による解析を行ったところ、グリア細胞ではなく神経細胞に局在していることが判明し、さらに各種受容体拮抗薬を用いた薬理学的解析により、METHによるshatiの発現増加はドパミンD1及びD2受容体を介して生じることが明らかとなった。また、前年度までに報告しているshatiのドパミン再取り込み促進効果はTNF-αの放出を介し発現していることが培養細胞を用いた実験により明らかとなり、shatiのMETH依存形成に対する抑制機能の根底にある分子機序が明らかとなった。
piccoloに対するアンチセンスオリゴヌクレオチドを作成し、脳室内投与することでpiccolo遺伝子のノックダウンを行ったところ、モリス水迷路試験において空間認知記憶の障害が認められた。また、海馬のCA1領域を用いた電気生理学的な解析においてはLTPの低下が認められた。さらに、マイクロダイアリシス法により,piccoloノックダウンマウスでは高カリウム刺激後のグルタミン酸の放出量の低下が認められた。以上の結果は、piccoloがグルタミン酸の放出制御により海馬依存的な学習・記憶に関与していることを示す結果であり、METHが惹起する空間作業記憶障害に関与している可能性が示唆された。
今後はさらに、遺伝子組み換え動物を用い、行動学的、神経化学的な解析を通して、shatiやpiccoloの依存形成メカニズムへの関与を解明し、薬物依存形成機構の解明と治療薬の開発に繋げたい。

Research Products

• [Journal Article] Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase (2010)
  • Author(s): Alkam T, et.al.
  • Journal Title: Behav.Brain Res. (in press)
  • Peer Reviewed
• [Journal Article] The Role of Cyclophilin D in Learning and Memory (2010)
  • Author(s): Mouri A, et.al.
  • Journal Title: Hippocampus 20 Pages: 293-304
  • Peer Reviewed
• [Journal Article] Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine : involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems (2010)
  • Author(s): Noda Y, et.al.
  • Journal Title: Int.J.Neuropsychipharmacol. (in press)
  • Peer Reviewed
• [Journal Article] Prenatal exposure to phencyclidine produces abnormal behaviour and NMDA receptor expression in postpubertal mice (2010)
  • Author(s): Lu L, et.al.
  • Journal Title: Int.J.Neuropsychopharmacol (in press)
  • Peer Reviewed
• [Journal Article] Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood (2010)
  • Author(s): Ibi D, et.al.
  • Journal Title: Behav.Brain Res. 206 Pages: 32-37
  • Peer Reviewed
• [Journal Article] Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin in duced by repeated methamphetamine treatment (2010)
  • Author(s): Lu P, et.al.
  • Journal Title: Behav Brain Res 207 Pages: 387-393
  • Peer Reviewed
• [Journal Article] Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region (2010)
  • Author(s): Ibi D, et.al.
  • Journal Title: Neurochem Int. 56 Pages: 77-83
  • Peer Reviewed
• [Journal Article] Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia : Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches. (2010)
  • Author(s): Ikeda M, et.al.
  • Journal Title: Biol.Psychiatry 67 Pages: 263-269
  • Peer Reviewed
• [Journal Article] Nociceptin and its metabolite attenuate U0126-induced memory impairment through anociceptin opioid peptide(NOP)receptor-independent mechanism (2010)
  • Author(s): Miwa M, et.al.
  • Journal Title: Neurobiol.Learn.Mem. 93 Pages: 396-405
  • Peer Reviewed
• [Journal Article] Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits (2010)
  • Author(s): Niwa M, et.al.
  • Journal Title: Neuron 65 Pages: 480-489
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 野田幸裕, 毛利彰宏, 鍋島俊隆
  • Journal Title: 実践行動薬理学(第I編基礎編:行動薬理研究における実験技術10.統合失調症動物モデルとその評価法)(金芳堂) Pages: 79-93
• [Journal Article] (2010)
  • Author(s): 永井拓, 鍋島俊隆, 山田清文
  • Journal Title: 実践行動薬理学(第II編応用編:行動薬理研究の現在、第4章報酬機構関連、3.依存性薬物による精神障害の分子機序)(金芳堂) Pages: 272-281
• [Journal Article] Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice (2009)
  • Author(s): Kurata K, et.al.
  • Journal Title: Am.J.Physiol.Renal.Physiol. 297
  • Peer Reviewed
• [Journal Article] Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice.: Silibinin and memory deficits (2009)
  • Author(s): Lu P, et.al.
  • Journal Title: Br.J.Pharmacol. 157 Pages: 1270-1277
  • Peer Reviewed
• [Journal Article] Identification of Usp46, encoding a ubiquitin specific peptides, as a quantitative trait gene regulating mouse immobile behavior in the tail suspension test and the forced swimming test (2009)
  • Author(s): Tomida S, et.al.
  • Journal Title: Nat.Genet. 43 Pages: 648-653
  • Peer Reviewed
• [Journal Article] Fustin flavonoid attenuates β-amyloid(1-42)-induced learning impairment (2009)
  • Author(s): Jin CH, et.al.
  • Journal Title: J.Neurosci.Res. 87 Pages: 3658-3670
  • Peer Reviewed
• [Journal Article] Role of microsomal epoxide hydrolase in methamphetamine-induced drug dependence in mice. (2009)
  • Author(s): Shin EJ, et.al.
  • Journal Title: J.Neurosci.Res. 87 Pages: 3679-3686
  • Peer Reviewed
• [Journal Article] Matrix metalloprotease-9 inhibition improves amyloid β-mediated cognitive impairment and neurotoxicity in mice (2009)
  • Author(s): Mizoguchi H, et.al.
  • Journal Title: J.Pharmacol.Exp.Ther. 331 Pages: 14-22
  • Peer Reviewed
• [Journal Article] Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating : involvement of pallidotegmental neurons (2009)
  • Author(s): Mizoguchi H, et.al.
  • Journal Title: Psychopharmacology 207 Pages: 235-243
  • Peer Reviewed
• [Journal Article] Mouse model of relapse to the abuse of drugs : Procedural considerations and characterizations. (2009)
  • Author(s): Yijin Yan, et al.
  • Journal Title: Behavioral Brain Research 196 Pages: 1-10
  • Peer Reviewed
• [Journal Article] メタンフェタミン依存症関連分子の生理機能の解明と創薬へのアプローチ. (2009)
  • Author(s): 丹羽美苗, 他
  • Journal Title: 分子精神医学 9 Pages: 2-11
  • Peer Reviewed
• [Journal Article] A novel molecule‘shati'increases dopamine uptake via the induction of tumor necrosis factor-α in pheochromocytoma-12 cells. (2008)
  • Author(s): Minae Niwa, et al.
  • Journal Title: The Journal of Neurochemistry 107 Pages: 1697-1708
  • Peer Reviewed
• [Journal Article] Genes and molecules that can potentiate or attenuate models of psychostimulant dependence : relevance of data from animal models to human addiction. (2008)
  • Author(s): Minae Niwa, et al.
  • Journal Title: Annual the New York Academy of Sciences 1141 Pages: 76-95
  • Peer Reviewed
• [Journal Article] Identification of piccolo as a regulator of behavioral plasticity and dopamine transporter internalization. (2008)
  • Author(s): Xiaobo Cen, et al.
  • Journal Title: Molecular Psychiatry 13(Cover Art掲載) Pages: 451-463
  • Peer Reviewed
• [Journal Article] Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens. (2008)
  • Author(s): Ayumi Fukakusa, et al.
  • Journal Title: The Journal of Neurochemistry 105 Pages: 436-444
  • Peer Reviewed
• [Journal Article] Neuropsychotoxicity of abused drugs : involvement of matrix metalloproteinase-2 and -9 and tissue inhibitor of matrix metalloproteinase-2 in methamphetamine-induced behavioral sensitization and reward in rodents. (2008)
  • Author(s): Hiroyuki Mizoguchi, et al.
  • Journal Title: Journal of Pharmacological Sciences 106 Pages: 9-14
  • Peer Reviewed
• [Journal Article] Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity. (2008)
  • Author(s): Ayumi Fukakusa, et al.
  • Journal Title: Journal of Pharmacological Sciences 106 Pages: 321-324
  • Peer Reviewed
• [Journal Article] Neuropsychotoxicity of abused drugs : potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects. (2008)
  • Author(s): Eun-Joo Shin, et al.
  • Journal Title: Journal of Pharmacological Sciences 106 Pages: 22-27
  • Peer Reviewed
• [Journal Article] Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startlereflex in mice : reversal by GABAB receptor agonist baclofen. (2008)
  • Author(s): Sawako Arai, et al.
  • Journal Title: Neuropsychopharmacology 33 Pages: 3164-3175
  • Peer Reviewed
• [Journal Article] Basic and translational research on proteinase-activated receptors : regulation of nicotine reward by the tissue plasminogen activator (tPA) - plasmin system via proteinase-activated receptor 1. (2008)
  • Author(s): Taku Nagai, et al.
  • Journal Title: Journal of Pharmacological Sciences 108 Pages: 408-414
  • Peer Reviewed
• [Journal Article] GDNFおよびTNF-a誘導剤が薬物依存症治療薬になり得る. (2008)
  • Author(s): 丹羽美苗, 他
  • Journal Title: 分子精神医学 8 Pages: 84-87
  • Peer Reviewed
• [Journal Article] 組織ブラスミノーゲン活性化因子による依存性薬物の報酬効果の制御. (2008)
  • Author(s): 永井拓, 他
  • Journal Title: 日本神経精神薬理学雑誌 28 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Transient drug-primed but persistent cue-induced reinstatement of extinguished methamphetamine-seeking behavior in mice. (2007)
  • Author(s): Yan, Y., Yamada, K., Nitta, A. and Nabeshima, T.
  • Journal Title: Behav. Brain Res. 177 Pages: 261-268
  • Peer Reviewed
• [Journal Article] Involvement of glial cell-line derived neurotrophic factor inhibitory effects of a hydorophobic dipeptide Leu-Ile on morphine-induced sensitization and rewarding effects. (2007)
  • Author(s): Niwa, M., Nitta, A., Shen, L., Noda, Y. and Nabeshima, T.
  • Journal Title: Behav. Brain Res., 179 Pages: 167-171
  • Peer Reviewed
• [Journal Article] An inducer for glial cell line-derived neurotrophic factor and tumor necrosis factor-α protects against methamphetamine-induced rewarding effects and sensitization. (2007)
  • Author(s): Niwa, M., Nitta, A., Yamada, Y., Nakajima, A., Saito, K., Seishima, M., Shen, L., Noda, Y., Furukawa, S. and Nabeshima, T
  • Journal Title: Biol. Psychiatry 61 Pages: 890-901
  • Peer Reviewed
• [Journal Article] Tumor Necrosis Factor-alpha and Its Inducer Inhibit Morphine-Induced Rewarding Effects and Sensitization. (2007)
  • Author(s): Niwa, M., A. Nitta, Yamada Y, Nakajima A, Saito K, Seishima M, Noda Y, Nabeshima T.
  • Journal Title: Biol. Psychiatry 62 Pages: 658-668
  • Peer Reviewed
• [Journal Article] Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant mice. (2007)
  • Author(s): Yan, Y., Yamada, K., Niwa, M., Nagai, T., Nitta, A. and Nabeshima, T
  • Journal Title: FASEB J. 21 Pages: 1994-2004
  • Peer Reviewed
• [Journal Article] A novel molecule 'shati' is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preference. (2007)
  • Author(s): Niwa, M., Nitta, A., Mizoguchi, H., Ito, Y., Noda, Y., Nagai, T. and Nabeshima, T.
  • Journal Title: J. Neurosci., 27 Pages: 7604-7615
  • Peer Reviewed
• [Journal Article] Reinforcing effects of morphine are reduced in tissue plasminogen activator(tPA)-knockout mice. (2007)
  • Author(s): Yan, Y., Yamada, K., Mizoguchi, H., Noda, Y., Nagai, T., Nitta, A. and Nabeshima, T.
  • Journal Title: Neuroscience 146 Pages: 50-59
  • Peer Reviewed
• [Journal Article] Repeated methamphetamine treatment impairs spatial working memory in rats:reversal by clozapine but not haloperidol. (2007)
  • Author(s): Nagai, T., Takuma, K., Dohniwa, M., Ibi, D., Mizoguchi, H., Kamei, H., Nabeshima, T. and Yamada, K.
  • Journal Title: Psychopharmacology(Berl.) 194 Pages: 21-32
  • Peer Reviewed
• [Presentation] 新規蛋白質 Shati をノックアウトしたマウスの行動解析 (2010)
  • Author(s): 日比(古川)陽子, 新田淳美, 鍋島俊隆, 山田清文
  • Organizer: 第83回日本薬理学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-17
• [Presentation] マウスのメタンフェタミン探索行動に対するガランタミンの効果 (2010)
  • Author(s): 古関竹直, 毛利彰宏, 間宮隆吉, 鍋島俊隆
  • Organizer: 第83回日本薬理学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-17
• [Presentation] A Novel Molecule "Shati" which inhibits the development of Methamphe tamine-induced dependence (2009)
  • Author(s): 鍋島俊隆
  • Organizer: Mini-Symposium on Methamphetamine Addiction
  • Place of Presentation: 台湾
  • Year and Date: 2009-12-14
• [Presentation] ピッコロによるドパミントランスポーター内在化抑制とマウス行動変化 (2009)
  • Author(s): 新田淳美, 山田清文, 鍋島俊隆
  • Organizer: 第32回日本神経科学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] 覚せい剤誘発感覚情報処理機能障害に対するニコチンの有効性 (2009)
  • Author(s): 溝口博之, 衣斐大祐, 亀井浩之, 鍋島俊隆, H-C Kim, 田熊一敞, 山田清文
  • Organizer: 第32回日本神経科学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Shati-over-expressed mice shows similar symptoms to the autism (2009)
  • Author(s): Wenting Liu, 新田淳美, 日比(古川)陽子, 鍋島俊隆, 山田清文
  • Organizer: The 6th Nagoya-Nanjing-Shenyang Symposium on Pharmaceutical and Life Science
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-14
• [Presentation] Effect of galantamine on methamphetamine-seeking behavior in mice induced by drug-associated environmental stimuli (2009)
  • Author(s): 古関竹直, 毛利彰宏, 間宮隆吉, 鍋島俊隆
  • Organizer: The 6th Nagoya-Nanjing-Shenyang Symposium on Pharmaceutical and Life Science
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-14
• [Presentation] 覚せい剤により誘発される精神障害に対するガランタミンの効果 (2009)
  • Author(s): 毛利彰宏, 野田幸裕, Dayong Wang, 安藤雄, 脇由香里, 古関竹直, 間宮隆吉, 鍋島俊隆
  • Organizer: 第44回日本アルコール・薬物医学会総会・第21回日本アルコール精神医学会・第12回ニコチン・薬物依存研究フォーラム平成21年度合同学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-09-08
• [Presentation] ニコチンの報酬効果における組織プラスミノーゲン活性化因子の関与 (2009)
  • Author(s): 永井拓, 鍋島俊隆, 山田清文
  • Organizer: 第44回日本アルコール・薬物医学会総会・第21回日本アルコール精神医学会・第12回ニコチン・薬物依存研究フォーラム平成21年度合同学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-09-08
• [Presentation] Roles of a novel molecule 'shati' in the development of methamphetamine-induced dependence (2009)
  • Author(s): Toshitaka Nabeshima, Minae Niwa, Xiaobo Cen, Hiroyuki Mizoguchi, Yasutomo Itoh, Kiyoyuki Kitaichi, Taku Nagai, Norio Ozaki, Yukihiro Noda, Atsumi Nitta
  • Organizer: The Second Annual International Drug Abuse Research Society/International Society for Neruochemistry Satellite Meeting
  • Place of Presentation: 韓国
  • Year and Date: 2009-08-18
• [Presentation] 脳神経発達過程におけるピッコロC_2Aドメインの過剰発現が成長後の社会性行動などに及ぼす影響. (2009)
  • Author(s): 新田淳美, 日比陽子, 劉文亭山田清文, 鍋島俊隆
  • Organizer: 第2回学術フロンティア推進事業研究報告会、第13回神経科学領域における分子モニタリングシンポジウム合同学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-01-09
• [Presentation] Methamphetamine dependence-related molecule ‘shati'increases dopamineuptake via the induction of tumor necrosis factor-α in PC-12 cells. (2008)
  • Author(s): Minae Niwa, Atsumi Nitta, XB Cen, Norio Ozaki, Toshitaka Nabeshima
  • Organizer: International Symposium on Brain Development and Neuropsychiatric Disorders
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2008-09-24
• [Presentation] Role of tPA-plasmin system in neuropsychological abnormalitiesinduced by morphine. (2008)
  • Author(s): Taku Nagai, Toshitaka Nabeshima, Kiyofumi Yamada
  • Organizer: 第51回日本神経化学学会年会日本生物学的精神医学会合同シンポジウム
  • Place of Presentation: Toyama, Japan
  • Year and Date: 2008-09-13
• [Presentation] The functional roles of"shati"in the dependence on methamphetamine (METH) (2008)
  • Author(s): 丹羽美苗, 新田淳美, 溝口博之, 伊藤康之, 野田幸裕, 永井拓, 尾崎紀夫, 鍋島俊隆
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] 薬物依存における精神障害の科学. (2008)
  • Author(s): 鍋島俊隆
  • Organizer: 第27回城南地区薬剤師セミナー『青少年の薬物乱用防止における薬剤師の役割』
  • Place of Presentation: 東京
  • Year and Date: 2008-07-05
• [Presentation] メタンフェタミン依存関連分子‘shati'の生理機能の解明. (2008)
  • Author(s): 丹羽美苗, 新田淳美, 溝口博之, 伊藤康友, 野田幸裕, 永井拓, 尾崎紀夫, 鍋島俊隆
  • Organizer: 第13回日本行動薬理研究会
  • Place of Presentation: 千葉
  • Year and Date: 2008-06-06
• [Presentation] 薬物依存・乱用について. (2008)
  • Author(s): 鍋島俊隆
  • Organizer: コンサータ適正使用についての講習会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-05-31
• [Presentation] 遺伝子変異マウスを用いた薬物依存モデルの行動解析 : Behavioral analysis of animal model for drug dependence / addiction in mutant mice. (2008)
  • Author(s): 山田清文, Yan Yijin, 永井拓, 溝口博之, 新田淳美, 鍋島俊隆
  • Organizer: 日本実験動物科学技術2008大会(第55回日本実験動物学会総会、第42回日本実験動物技術者協会総会)
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-15
• [Presentation] The functional roles of methamphetamine dependence-related molecule‘shati'. (2008)
  • Author(s): Minae Niwa, Atsumi Nitta, Hiroyuki Mizoguchi, XB Cen, Yoshitomo Itoh, Norio ozaki, Toshitaka Nabeshima
  • Organizer: The 19^<th> Korea-Japan Joint Seminar on Pharmacology
  • Place of Presentation: Busan, Korea
• [Presentation] A novel molecule “shati" inhibits methamphetamine-inducedhyperlocomotion, sensitization, and conditioned place preference via tumornecrosis factor-α. (2008)
  • Author(s): Minae Niwa, Atsumi Nitta, Hiroyuki Mizoguchi, Yoshitomo Itoh, Yukihiro Noda, Taku Nagai Norio Ozaki, Toshitaka Nabeshima
  • Organizer: 38^<th> Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington, U.S.A.
• [Presentation] Role of microsomal epoxide hydrolase in methamphetamine-induced drug dependence in mice. (2008)
  • Author(s): Shin E-J, Bing G, Chae JS, Kim HJ, Park DH, Yamada K, Nabeshima T, Kim H-C
  • Organizer: 38^<th> Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington, U.S.A.
• [Presentation] ダリア細胞株由来神経栄養因子および腫瘍壊死因子産生誘導を誘導するジペプチドLeu-Heの薬物依存治療薬としての可能性. (2008)
  • Author(s): 新田淳美, 丹羽美苗, 山田裕一郎, 山田清文, 鍋島俊隆
  • Organizer: 生体機能と創薬シンポジウム2008
  • Place of Presentation: 東京
• [Presentation] A novel molecule‘shati'ameliorates the methamphetamine-induceddecrease in dopamine uptake via tumor necrosis factor- in PC12 cells (2008)
  • Author(s): 丹羽美苗, 新田淳美, XB CEN 尾崎紀夫, 鍋島俊隆
  • Organizer: 第51回日本神経化学大会
  • Place of Presentation: 富山
• [Presentation] Identification of piccolo as a regulator of behavioral plasticity and dopamine transportor internalization. (2008)
  • Author(s): 新田淳美, XB Cen, 衣斐大祐, 丹羽美苗, 山田清文, 鍋島俊隆
  • Organizer: 第51回日本神経化学大会
  • Place of Presentation: 富山
• [Presentation] メタンフェタミン依存マウスにおける薬物探索行動 : GDNFの役割. (2008)
  • Author(s): 山田清文, 鍋島俊隆
  • Organizer: 第51回日本神経化学大会
  • Place of Presentation: 富山
• [Presentation] 覚せい剤精神病から単離・同定したpiccolo分子の生理機能について研究. (2008)
  • Author(s): 新田淳美, Cen XB, 衣斐大祐日比陽子, 丹羽美苗, 伊藤友康, 山田清文, 鍋島俊隆
  • Organizer: 第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会 合同年会
  • Place of Presentation: 東京
• [Presentation] メタンフェタミン連続投与マウスに認められる認知障害に対するガランタミンの作用 : ドパミンextracellular signal-regulatedkinase 1/2系の関与 (2008)
  • Author(s): 安藤雄, 野田幸裕, Wang Dayong, 山田真之亮, 吉見陽, 脇由香里, 玉地亜衣, 毛利彰宏, 鍋島俊隆
  • Organizer: 第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
• [Presentation] 新規機能分子"shati"はメタンフェタミン依存形成に関与する (2008)
  • Author(s): 丹羽 美苗、新田 淳美、溝口 博之、伊藤 康友、野田 幸裕、永井 拓、鍋島 俊隆
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] Involvement of a novel molecular "shati" in methamphetamine-induced hyperlocomotion, sensitization and conditioned place preference (2007)
  • Author(s): Nabeshima T.(Invited lecture)Niwa M. Nitta A. Mizoguchi H. Ito Y. Noda Y. Nagai T.'
  • Organizer: A Memorial Event for the 60th Anniversary of Founding of Kangwon National University
  • Place of Presentation: Chunchon, Korea
  • Year and Date: 2007-10-25
• [Presentation] The role of tissue plasminogen active in methamphetamine-induced reward, behavioral sensitization and cognitive deficit in mice. (2007)
  • Author(s): Yamada K. Mizoguchi H., Takuma K., Nabeshima T., and H-C, Kim.
  • Organizer: A Memorial Event for the 60th Anniversary of Founding of Kangwon National University
  • Place of Presentation: Chunchon, Korea
  • Year and Date: 2007-10-25
• [Presentation] Enduring vulnerability to reinstatement of Methamphetamine-seeking behavior in GDNF mutant mice. (2007)
  • Author(s): Nabeshima T. and Yan Y.
  • Organizer: 7th IBRO
  • Place of Presentation: Melborne,
  • Year and Date: 2007-06-16
• [Presentation] Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant mice. (2007)
  • Author(s): Yan, Y., Yamada, K., Niwa, M., Nagai, T., Nitta A. and Nabeshima T
  • Organizer: 第111回日本薬理学会近畿部会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-15
• [Presentation] Tumor necrosis factor-α and its inducer inhibit drug-induced dependence. (2007)
  • Author(s): Nabeshima, T., Niwa, M., Yamada, K., Saito, K., Seishima, M., Noda, Y. and Nitta, A.
  • Organizer: 69th Annual Meeting of College on Problems of Drug Dependence
  • Place of Presentation: Quebec City, Canada
• [Presentation] The blocking mechanisms of Leu-I le against methamphetamine and morphine dependence in mice. (2007)
  • Author(s): Nitta, A., Cen, X., Niwa, M., Ohya, Y., Yamada, Y., Nakajima, A., Saito, K., Seishima, M., Shen, L., Suzuki, M., Saito, K., Noda, Y., Furukawa, S. and Nabeshima, T.
  • Organizer: 69th Annual Meeting of College on Problems of DrugDependence
  • Place of Presentation: Quebec City, Canada
• [Presentation] Tissue plasminogen activator-plasmin-protease activated receptor 1 system regulates rewarding effect of nicotine (2007)
  • Author(s): Nagai, T., Ito, M., Nakamichi, M., Kamei, H., Fukakusa, A., Nabeshima, T., Takuma, K. and Yamada, K.
  • Organizer: 69th Annual Meeting of College on Problems of Drug Dependence
  • Place of Presentation: Quebec City, Canada
• [Book] 医薬品の安全性(長尾拓 編)第9章臓器毒性V 神経毒性 (2008)
  • Author(s): 鍋島俊隆
  • Publisher: 南山堂
• [Book] XI. 心身・精神疾患 214. 薬物依存症(Drug Dependence), 総合臨床2008(Vol. 57)増刊 新版処方計画法 (2008)
  • Author(s): 辻美江
  • Publisher: 永井書店
• [Remarks]
  • URL: http://www-yaku.meijo-u.ac.jp/Research/Laboratory/chem_pharm/index.html
• [Remarks]
  • URL: http://www-yaku.meijo-u.ac.jp/frontier_meijo/index.html
• [Remarks]
  • URL: http://www-yaku.meijo-u.ac.jp/Research/Laboratory/chem_pharm/index.html
• [Remarks]
  • URL: http://www-yaku.meijo-u.ac.jp/frontier_meijo/index.html
• [Patent(Industrial Property Rights)] 新規ステロイド誘導体及びその製造方法、並びにその新規ステロイド誘導体を含有する医薬 (2010)
  • Inventor(s): 小鹿一, 鍋島俊隆, 間宮隆吉
  • Industrial Property Rights Holder: 名古屋大学、名城大学
  • Filing Date: 2010-02-22
• [Patent(Industrial Property Rights)] 脳内酸化抑制剤およびその使用 (2008)
  • Inventor(s): 新田淳美, 鍋島俊隆
  • Industrial Property Rights Holder: 国立大学法人名古屋大学, 協和発酵バイオ株式会社
  • Filing Date: 2008-05-02
  • Overseas