Environmental impact of toxic substances on wildlife and species differences

• Project/Area Number: 19671001
• Research Category: Grant-in-Aid for Young Scientists (S)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Hokkaido University
• Principal Investigator: ISHIZUKA Mayumi 北海道大学, 大学院・獣医学研究科, 教授 (50332474)
• Project Period (FY): 2007 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥112,580,000 (Direct Cost: ¥86,600,000、Indirect Cost: ¥25,980,000); Fiscal Year 2011: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2010: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000); Fiscal Year 2009: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000); Fiscal Year 2008: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000); Fiscal Year 2007: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
• Keywords: トキシコロジー / 環境化学物質 / 野生動物 / アフリカ / シトクロムP450

Research Abstract

The effects of environmental pollution on wildlife and domestic animals were investigated in Japan and African countries. In addition, the species differences in the roles of molecular factors which contribute to the chemical sensitivity in animals were clarified.

Research Products

• [Journal Article] Cytochrome P450 (CYP) in fish (2012)
  • Author(s): Uno T, Ishizuka M, Itakura T
  • Journal Title: Environ Toxicol Pharmacol. Volume: (印刷中) Issue: 1 Pages: 1-13
  • DOI: 10.1016/j.etap.2012.02.004
  • Peer Reviewed
• [Journal Article] Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer) (2012)
  • Author(s): Suzuki S, Konnai S, Okagawa T, Githaka N W, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K
  • Journal Title: Int J Immunogenet Volume: 39 Issue: 2 Pages: 170-182
  • DOI: 10.1111/j.1744-313x.2011.01062.x
  • Peer Reviewed
• [Journal Article] Sudan III dye strongly induces CYP1A1 mRNA expression in HepG2 cells (2012)
  • Author(s): 大野円実
  • Journal Title: Journal of Biochemical and Molecular Toxicology Volume: 26 Issue: 1 Pages: 16-22
  • DOI: 10.1002/jbt.20408
  • Peer Reviewed
• [Journal Article] Molecular Evidence Predicts Aryl Hydrocarbon Receptor Ligand Insensitivity in the Peregrine Falcon (Falco peregrines) (2012)
  • Author(s): Fujisawa, N., Ikenaka, Y., Kim, E.Y., Lee, J.S., Iwata, H., Ishizuka, M.
  • Journal Title: Eur.J.Wildlife.Res. Volume: 58 Issue: 1 Pages: 167-175
  • DOI: 10.1007/s10344-011-0559-1
  • NAID: 120005183149
  • Peer Reviewed
• [Journal Article] All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells (2012)
  • Author(s): 大野円実
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 417 Issue: 1 Pages: 484-489
  • DOI: 10.1016/j.bbrc.2011.11.146
  • Peer Reviewed
• [Journal Article] Downregulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microti (2012)
  • Author(s): Shimamoto, Y., Sasaki, M., Ikadai, H., Ishizuka, M., Yokoyama, N., Igarashi, I., Hoshi, F., Kitamura, H.
  • Journal Title: Journal of Veterinary Medical Science Volume: 74 Issue: 2 Pages: 241-245
  • DOI: 10.1292/jvms.11-0036
  • NAID: 130001190494
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed
• [Journal Article] Metal and metalloid contamination in roadside soil and wild rats around a Pb-Zn mine in Kabwe, Zambia (2011)
  • Author(s): Nakayama SMM, Ikenaka Y, Hamada K, Muzandu K, Choongo K, Teraoka H, Mizuno N, Ishizuka M.
  • Journal Title: Environ Pollut Volume: 159(1) Issue: 1 Pages: 175-81
  • DOI: 10.1016/j.envpol.2010.09.007
  • NAID: 120002564662
• [Journal Article] Astaxanthin can alter CYP1A-dependent activities via two different mechanisms : Induction of protein expression and inhibition of NADPH P450 reductase dependent electron transfer (2011)
  • Author(s): Ohno, M., Darwish, W.S., Ikenaka, Y., Miki, W., Ishizuka, M
  • Journal Title: Food Chem.Toxicol Volume: 49 Issue: 6 Pages: 1285-1291
  • DOI: 10.1016/j.fct.2011.03.009
  • Peer Reviewed
• [Journal Article] Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens (2011)
  • Author(s): Sasaki, N., Matsumoto, T., Ikenaka, Y., Kazusaka, A., Ishizuka, M., Fujita, S.
  • Journal Title: Pestic.Biochem.Physiol Volume: 100 Issue: 2 Pages: 135-139
  • DOI: 10.1016/j.pestbp.2011.02.013
  • Peer Reviewed
• [Journal Article] Phase-II conjugation ability for PAH metabolism in amphibians : Characteristics and inter-species differences (2011)
  • Author(s): Ueda, H., Ikenaka, Y., Nakayama, S.M., Tanaka-Ueno, T., Ishizuka, M.
  • Journal Title: Aquat.Toxicol. Volume: 105 Issue: 3-4 Pages: 337-343
  • DOI: 10.1016/j.aquatox.2011.07.004
  • NAID: 120003762598
  • Peer Reviewed
• [Journal Article] Astaxanthin rich crude extract of Haematococcus pluvialis induces cytochrome P450 1A1 mRNA by activating aryl hydrocarbon receptor in rat hepatoma H4IIE cells (2011)
  • Author(s): Ohno, M., Darwish, W.S., Ikenaka, Y., Miki, W., Fujita, S., Ishizuka, M.
  • Journal Title: Food Chem. Volume: 130 Pages: 356-361
  • Peer Reviewed
• [Journal Article] Uptake of lead, cadmium, and other metals in the liver and kidneys of cattle near a lead-zinc mine in Kabwe, Zambia (2011)
  • Author(s): Yabe, J., Nakayama, S.M., Ikenaka, Y., Muzandu, K., Ishizuka, M., Umemura, T.
  • Journal Title: Environ.Toxicol.Chem. Volume: 30 Issue: 8 Pages: 1892-1897
  • DOI: 10.1002/etc.580
  • Peer Reviewed
• [Journal Article] Comparative metabolism of warfarin in rats and chickens (2011)
  • Author(s): Aksorn Saengtienchai
  • Journal Title: Poultry Science Volume: 90 Issue: 12 Pages: 2775-2781
  • DOI: 10.3382/ps.2010-01257
  • Peer Reviewed
• [Journal Article] Astaxanthin can alter CYP1A-dependent activities via two different mechanisms : Induction of protein expression and inhibition of NADPH P450 reductase dependent electron transfer (2011)
  • Author(s): Ohno M., et al.
  • Journal Title: Food Chem Toxicol. Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens. (2011)
  • Author(s): Sasaki N., et al.
  • Journal Title: Pesticide Biochemistry and Physiology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Heavy metal contamination of soil and sediment in Zambia. (2011)
  • Author(s): Ikenaka Y., et al.
  • Journal Title: African Journal of Environmental Science and Technology Volume: 4 Pages: 729-739
  • Peer Reviewed
• [Journal Article] Metal and metalloid contamination in roadside soil and wild rats around a Pb-Zn mine in Kabwe, Zambia (2011)
  • Author(s): Nakayama SMM., Et al.
  • Journal Title: Environ Pollut. Volume: 159 Pages: 175-181
  • Peer Reviewed
• [Journal Article] The CYP1D subfamily of genes in mammals and other vertebrates (2010)
  • Author(s): Kawai YK, Ikenaka Y, Fujita S, Ishizuka M.
  • Journal Title: Mammalian Genome Volume: 21(5-6) Issue: 5-6 Pages: 320-9
  • DOI: 10.1007/s00335-010-9263-9
  • NAID: 120003059573
• [Journal Article] Comparison of warfarin sensitivity between rat and bird species (2010)
  • Author(s): Watanabe KP, Saengtienchai A, Tanaka KD, Ikenaka Y, Ishizuka M.
  • Journal Title: Comp Biochem Physiol C Toxicol Pharmacol Volume: 152(1) Issue: 1 Pages: 114-9
  • DOI: 10.1016/j.cbpc.2010.03.006
  • NAID: 120002208932
• [Journal Article] Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue (2010)
  • Author(s): Takiguchi M, Darwish WS, Ikenaka Y, Ohno M, Ishizuka M.
  • Journal Title: Toxicol Sci Volume: 116(1) Issue: 1 Pages: 79-91
  • DOI: 10.1093/toxsci/kfq087
  • NAID: 120002834690
• [Journal Article] Carotenoids as regulators for inter-species difference in Cytochrome P450 1A expression and activity in ungulates and rats. (2010)
  • Author(s): Darwish WS., et al.
  • Journal Title: Food Chem Toxicol. Volume: 48 Pages: 3201-3208
  • Peer Reviewed
• [Journal Article] Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells. (2010)
  • Author(s): Chang HS., Et al.
  • Journal Title: Nutr Res. Volume: 30 Pages: 435-440
  • Peer Reviewed
• [Journal Article] Mutagenic activation and detoxification of benzo[a]pyrene in vitro by hepatic cytochrome P450 1A1 and phase II enzymes in three meat-producing animals. (2010)
  • Author(s): Darwish WS., et al.
  • Journal Title: Food Chem Toxicol. Volume: 48 Pages: 2526-2531
  • Peer Reviewed
• [Journal Article] High expression of the mRNA of cytochrome P450 and phase II enzymes in the lung and kidney tissues of cattle. (2010)
  • Author(s): Darwish WS., et al.
  • Journal Title: Animal Volume: 4 Pages: 2023-2029
  • Peer Reviewed
• [Journal Article] Current levels of heavy metal pollution in Africa. (2010)
  • Author(s): Yabe J., et al.
  • Journal Title: J Vet Med Sci. Volume: 72 Pages: 1257-1263
  • Peer Reviewed
• [Journal Article] The CYP1D subfamily of genes in mammals and other vertebrates. (2010)
  • Author(s): Kawai YK., Et al.
  • Journal Title: Mammalian Genome Volume: 21 Pages: 320-329
  • Peer Reviewed
• [Journal Article] Identification and phylogenetic analysis of novel cytochrome P450 1A genes from ungulate species. (2010)
  • Author(s): Darwish WS., et al.
  • Journal Title: J Vet Med Sci. Volume: 72 Pages: 1237-1241
  • Peer Reviewed
• [Journal Article] Comparison of warfarin sensitivity between rat and bird species. (2010)
  • Author(s): Watanabe KP., Et al.
  • Journal Title: Comp Biochem Physiol C Toxicol Pharmacol. Volume: 152 Pages: 114-119
  • Peer Reviewed
• [Journal Article] Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue. (2010)
  • Author(s): Takiguchi M, et al.
  • Journal Title: Toxicol Sci. Volume: 116 Pages: 79-91
  • Peer Reviewed
• [Journal Article] Heavy metal accumulation in lake sediments, fish (Oreochromis niloticus and Serranochromis thumbergi) and crayfish (Cherax quadricarinatus) in Lake Itezhi-tezhi and Lake Kariba, Zambia. (2010)
  • Author(s): Nakayama MMS., Et al.
  • Journal Title: Arch Environ Contam Toxicol. Volume: 59 Pages: 291-300
  • Peer Reviewed
• [Journal Article] Cytochrome P450 1A dependent activities in deer, cattle, and horses. (2010)
  • Author(s): Darwish WS
  • Journal Title: J Vet Med Sci. Volume: 72 Pages: 561-566
  • Peer Reviewed
• [Journal Article] Expression and Sequence of CYP1A in Camel. J Vet Med Sci. (2010)
  • Author(s): Darwish WS, Morshdy AE, Ikenaka Y, Ibrahim ZS, Fujita S, Ishizuka M.
  • Journal Title: J Vet Med Sci. 72(in press) Pages: 221-224
  • Peer Reviewed
• [Journal Article] Diazepam metabolism in kidney of male and female rats of varying strain. (2010)
  • Author(s): Kim HS, Sakai N, Saito K, Fujita S, Ishizuka M.
  • Journal Title: J Vet Med Sci. 72 Pages: 7-11
  • Peer Reviewed
• [Journal Article] Warfarin-resistant of rats in Japan (2009)
  • Author(s): Tanaka K., Harunari T., Tanikawa T., Ikenaka Y., Ishizuka M.
  • Journal Title: Jpn.J.Environ.Toxicol. 12 Pages: 61-70
  • NAID: 130004542781
  • Peer Reviewed
• [Journal Article] Impact of rat P450 genetic polymorphism on diazepam metabolism. (2009)
  • Author(s): Sakai N., Ishizuka M.
  • Journal Title: Expert Opinion On Drug Metabolism and Toxicology 5 Pages: 109-118
  • Peer Reviewed
• [Journal Article] rotective effect of Pleurotus cornucopiae mushroom on carbon tetrachloride-induced hepatotoxicity. (2009)
  • Author(s): El Bohi KM, Hashimoto Y, Muzandu K, Ikenaka Y, Ibrahim ZS, Kazusaka A, Fujita S, Ishizuka M.
  • Journal Title: Jpn J Vet Res. 57 Pages: 109-118
  • Peer Reviewed
• [Journal Article] Molecular cloning of novel cytochrome P450 1A genes from nine Japanese amphibian species. (2009)
  • Author(s): Nakayama SMM, Tanaka-Ueno T, Sakamoto QK, Fujita S, Ishizuka M.
  • Journal Title: J Vet Med Sci. 71 Pages: 1407-1411
  • NAID: 130000134310
  • Peer Reviewed
• [Journal Article] The importance of heterogeneous nuclear ribonucleoprotein K on Cytochrome P450 2D2 gene regulation : its binding is reduced in Dark Agouti rats. (2009)
  • Author(s): Sakai N, Sakamoto KQ, Fujita S, Ishizuka M
  • Journal Title: Drug Metab Dispos. 37 Pages: 1703-1710
  • Peer Reviewed
• [Journal Article] Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolev ulinate. (2009)
  • Author(s): Nakano K, Ishizuka M, Sakamoto QK, Fujita S
  • Journal Title: Biometals 22 Pages: 345-351
  • Peer Reviewed
• [Journal Article] Morphological features and blood parameters of Weddell seal (Leptony chotes weddellii) mothers and pups during the breeding season (2009)
  • Author(s): Sakamoto KQ, Sato K, Naito Y, Habara Y, Ishizuka M, Fujita S.
  • Journal Title: J Vet Med Sci 71 Pages: 341-344
  • Peer Reviewed
• [Journal Article] Genetic basis of inter- and intrastrain differences in diazepam p-hydroxylation in rats (2009)
  • Author(s): Sakai N, Saito K, Sakamoto KQ, Ishizuka M, Fujita S.
  • Journal Title: Drug Metab Dispos 37 Pages: 268-271
  • Peer Reviewed
• [Journal Article] Pesticide resistance in wild mammals--mechanisms of anticoagulant res istance in wild rodents (2008)
  • Author(s): Ishizuka M, Tanikawa T, Tanaka KD, Heewon M, Okajima F, Sakamoto KQ, Fujita S.
  • Journal Title: J Toxicol Sci 33 Pages: 283-291
  • Peer Reviewed
• [Journal Article] Downregulation of male-specific cytochrome P450 by profenofos (2008)
  • Author(s): Moustafa GG, Ibrahim ZS, Ahmed MM, Ghoneim MH, Sakamoto KQ, Ishizuka M, Fujita S.
  • Journal Title: Jpn J Vet Res 56 Pages: 109-118
  • NAID: 120000947265
  • Peer Reviewed
• [Journal Article] Analysis of acrylamide in a complex matrix of polyacrylamide solutions treated by heat and ultraviolet light (2008)
  • Author(s): Ishizuka M, Fujioka K, Shibamoto T.
  • Journal Title: J Agric Food Chem 56 Pages: 6093-6096
  • Peer Reviewed
• [Journal Article] The induction of cytochrome P450 1A1 by sudan dyes (2008)
  • Author(s): Refat NA, Ibrahim ZS, Moustafa GG, Sakamoto KQ, Ishizuka M, Fujita S.
  • Journal Title: J Biochem Mol Toxicol 22 Pages: 77-84
  • Peer Reviewed
• [Journal Article] Adverse birth outcomes associated with maternal smoking and polymorphisms in the N-Nitrosamine-metabolizing enzymegenes NQO1 and CYP2E1 (2008)
  • Author(s): Sasaki S, Sata F, Katoh S, Saijo Y, Nakajima S, Washino N, Konishi K, Ban S, Ishizuka M, Kishi R.
  • Journal Title: Am J Epidemiol. 15 Pages: 719-26
  • Peer Reviewed
• [Journal Article] Antibiotic Furazolidone Induces CYP1A But Not CYP2E1 Subfamily in Rat Liver (2008)
  • Author(s): Sasaki N, Sakai N, Ikenaka Y, Kamiya T, Heewon M, Sakamoto KQ, Ishizuka M, Fujita S
  • Journal Title: J Vet Med Sci 70 Pages: 223-226
  • NAID: 130000447004
  • Peer Reviewed
• [Journal Article] Elevated warfarin metabolism in warfarin-resistant roof rats (Rattus rattus) in Tokyo (2007)
  • Author(s): Ishizuka M, Okajima F, Tanikawa T, Min H, Tanaka KD, Sakamoto KQ, Fujita S.
  • Journal Title: Drug Metab Dispos 35 Pages: 62-66
  • Peer Reviewed
• [Journal Article] Di-(2-ethylhexyl)phthalate suppresses tamoxifen-induced a poptosis in GH3 pituitary cells (2007)
  • Author(s): Kim HS, Ishizuka M, Kazusaka A, Fujita S.
  • Journal Title: Arch. Toxicol. 81 Pages: 27-33
  • Peer Reviewed
• [Journal Article] Using Microarray Analysis to Evaluate Genetic Polymorphisms Involved in the Metabolism of Environmental Chemicals (2007)
  • Author(s): Ban S, Kondo T, Ishizuka M, Sasaki S, Konishi K, Washino N, Fujita S, Kishi R.
  • Journal Title: Fukuoka Acta Medica 89 Pages: 208-214
  • NAID: 120000987163
  • Peer Reviewed
• [Journal Article] Plasma pharmacokinetics and CYP3A12-dependent metabolism of c-kit inhibitor imatinib in dogs (2007)
  • Author(s): Ishizuka M, Nagai S, Sakamoto KQ, Fujita S
  • Journal Title: Xenobiotica 37 Pages: 503-513
  • Peer Reviewed
• [Journal Article] Testicular toxicity of profenofos in matured male rats (2007)
  • Author(s): Moustafa GG, Ibrahim ZS, Hashimoto Y, Alkelch AM, Sakamoto KQ, Ishizuka M, Fujita S
  • Journal Title: Arch Toxicol 81 Pages: 875-881
  • NAID: 120000951584
  • Peer Reviewed
• [Journal Article] Metal and metalloid levels and bio-accumulation characteristics in soil, sediment, land plants and hippopotami (Hippopotamus amphibius L) from the South Luangwa National Park, Zambia
  • Author(s): Nakayama SM, Ikenaka Y, Muzandu K, Choongo K, M'kandawire E, Yasuda J, Ishizuka M
  • Journal Title: Ecotoxicol.Environ.Safe. Volume: (印刷中)
  • NAID: 120005946615
  • Peer Reviewed
• [Journal Article] The CYP1D subfamily of genes in mammals and other vertebrates
  • Author(s): Kawai YK, Ikenaka Y, Fujita S, Ishizuka M
  • Journal Title: Mammalian Genome (in press)
  • NAID: 120003059573
• [Journal Article] Comparison of warfarin sensitivity between rat and bird species
  • Author(s): Watanabe KP, Saengtienchai A, Tanaka KD, Ikenaka Y, Ishizuka M
  • Journal Title: Comp Biochem Physiol C Toxicol Pharmacol (in press)
  • NAID: 120002208932
  • Peer Reviewed
• [Journal Article] Heavy metal accumulation in lake sediments, fish (Oreochromis niloticus and Serranochromis thumbergi) and crayfish (Cherax quadricarinatus) in Lake Itezhi-tezhi and Lake Kariba, Zambia
  • Author(s): Nakayama MMS, Ikenaka Y, Muzandu K, Choongo K, Oroszlany B, Teraoka H, Mizuno N, Ishizuka M
  • Journal Title: Arch Environ Contam Toxicol (in press)
  • NAID: 120002248697
  • Peer Reviewed
• [Journal Article] Comparison of warfarin sensitivity between rat and bird species.
  • Author(s): Watanabe KP, Saengtienchai A, Tanaka KD, Ikenaka Y, Ishizuka M.
  • Journal Title: Comp Biochem Physiol C Toxicol Pharmacol. (印刷中)
  • NAID: 120002208932
  • Peer Reviewed
• [Journal Article] Heavy metal accumulation in lake sediments, fish(Oreochromis niloticus and Serranochromis thumbergi) and crayfish(Cherax quadricarinatus) in Lake Itezhi-tezhi and Lake Kariba, Zambia.
  • Author(s): Nakayama MMS, Ikenaka Y, Muzandu K, Choongo K, Oroszlany B, Tera oka H, Mizuno N, Ishizuka M.
  • Journal Title: Arch Environ Contam Toxicol (印刷中)
  • NAID: 120002248697
  • Peer Reviewed
• [Journal Article] Cytochrome P450 1A dependent activities in deer, cattle, and horses.
  • Author(s): Darwish WS, Ikenaka Y, Eldaly EA, Ohno M, Sakamoto KQ, Fujita S, Ishizuka M.
  • Journal Title: J Vet Med Sci. (印刷中)
  • NAID: 130000149970
  • Peer Reviewed
• [Journal Article] Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue.
  • Author(s): Takiguchi M, Darwish WS, Ikenaka Y, Ohno M, Ishizuka M.
  • Journal Title: Toxicol.Sci. (印刷中)
  • NAID: 120002834690
  • Peer Reviewed
• [Presentation] 鳥類における第I相および第II相反応の特徴と種差 (2012)
  • Author(s): 河田みなみ, 池中良徳, 渡邉研右, アクソルン・サエンティエンチャイ, 大野円実, 石塚真由美
  • Organizer: 第153回日本獣医学会
  • Place of Presentation: 大宮ソニックシティー(大宮市)
  • Year and Date: 2012-03-28
• [Presentation] Species diversity in phase II reaction in polycyclic aromatic hydrocarbons (PAHs) (2011)
  • Author(s): Aksorn Saengtienchai, Yohinori Ikenaka, Michito Shimozuru, Mariko Sajika, Toshio Tsubota, Amnart Poapolathep, Mayumi Ishizuka
  • Organizer: The 14^<th> Seoul National University-Hokkaido University Joint Symposium 21^<st> Century Advances in Veterinary Medical Sciences
  • Place of Presentation: College of Veterinary Medicine, Seoul National University, Seoul, Korea
  • Year and Date: 2011-11-18
• [Presentation] 有害生物の薬剤抵抗性-スーパーラットの汚染環境適応戦略- (2011)
  • Author(s): 石塚真由美
  • Organizer: ペストロジー学会
  • Place of Presentation: 京葉銀行文化プラザ(千葉市)(招待講演)
  • Year and Date: 2011-11-17
• [Presentation] GIS based source estimation of Cu pollution in Lake Itezhi-tezhi and Cu accumulation profile in Oreochromis sp.from the field and laboratory studies (2011)
  • Author(s): Shouta M.M.Nakayama, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, John Yabe, Taro Muroya, Shigeho Ijiri, Takashi Umemura, Maymni Ishizuka
  • Organizer: SETAC North America 32^<nd> Annual Meeting
  • Place of Presentation: Hynes Convention Center (Boston, USA)
  • Year and Date: 2011-11-15
• [Presentation] 汚染環境下の野生動物の適応と毒性 (2011)
  • Author(s): 石塚真由美、池中良徳
  • Organizer: フォーラム2011・衛生薬学環境トキシコロジーシンポジウム
  • Place of Presentation: 金沢エクセルホテル東急(金沢)(招待講演)
  • Year and Date: 2011-10-28
• [Presentation] アカハライモリとアフリカツメガエルにおける異物代謝酵素の比較 (2011)
  • Author(s): 上田春樹、中山翔太、川合佑典、田中-上野寛子、池中良徳・石塚真由美
  • Organizer: 日本爬虫両棲類学会第50回大会
  • Place of Presentation: 京都大学北部構内 理学部(京都)
  • Year and Date: 2011-10-08
• [Presentation] ラットの消化管における異物代謝酵素の比較 (2011)
  • Author(s): 糸谷悠美、池中良徳、大野円実、中山翔太、ワギソベイ、石塚真由美
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学(堺市)
  • Year and Date: 2011-09-21
• [Presentation] ラットにおける薬物代謝酵素シトクロムP450の系統差について (2011)
  • Author(s): 西山義広、池中良徳、大野円実、渡邉研右、川合佑典、中山翔太、田中和之、石塚真由美
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学(堺市)
  • Year and Date: 2011-09-21
• [Presentation] レチノイン酸はAH受容体介在の遺伝子転写調節機構を阻害する (2011)
  • Author(s): 大野円実、池中良徳、石塚真由美
  • Organizer: 第25回カロテノイド研究談話会
  • Place of Presentation: 茨城県つくば市つくば国際会議場
  • Year and Date: 2011-09-13
• [Presentation] Effects of current malaria control in lake environment ; The levels of Organochlorine pesticide and toxic metals in fish species from Lake Awassa, Ethiopia (2011)
  • Author(s): Yoshinori IKENAKA, Yared Beyene, Kensuke WATANABE, Aksorn Saengtienchai, Shouta NAKAYAMA, Mayumi ISHIZUKA
  • Organizer: 3rd International Toxicology Symposium in Africa
  • Place of Presentation: University of Zambia (Lusaka, Zambia)
  • Year and Date: 2011-09-08
• [Presentation] GIS-based source estimation of Cu pollution in Lake Itezhi-tezhi and metal accumulation profiles in Oreochromis sp.and other fish species from both and laboratory studies (2011)
  • Author(s): Shouta M.M.Nakayama, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, John Yabe, Taro Muroya, Shigeho Ijiri, Takashi Umemura, Mayumi Ishizuka
  • Organizer: 3rd International Toxicology Symposium in Africa
  • Place of Presentation: University of Zambia (Lusaka, Zambia)
  • Year and Date: 2011-09-08
• [Presentation] Metal concentration and stable isotope ratio analysis (d13C and d15N) in water, sediment and fish from Lake Itezhi-tezhi, Zambia (2011)
  • Author(s): Shouta M.M.Nakayama, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, John Yabe, Taro Muroya, Takashi Umemura, Mayumi Ishizuka
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本県立大学(熊本)
  • Year and Date: 2011-07-17
• [Presentation] Metal and metalloid levels and bio-accumulation characteristics in soil, sediment, land plants and hippopotami (Hippopotamus amphibius L) from the South Luangwa National Park, Zambia (2011)
  • Author(s): Shouta M.M.Nakayama, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, Ethel M'kandawire, Jun Yasuda, Mayumi Ishizuka
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本県立大学(熊本)
  • Year and Date: 2011-07-17
• [Presentation] Effects of current malaria control in lake environment ; The levels of Organochlorine pesticide and toxic metals in fish species from Lake Awassa, ETHIOPIA (2011)
  • Author(s): YARED Beyene, Yoshinori IKENAKA, Kensuke WATANABE, Aksorn SAENGT IENCHAI, Shouta NAKAYAMA, Mayumi ISHIZUKA
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本県立大学(熊本)
  • Year and Date: 2011-07-17
• [Presentation] ガーナの金鉱山周辺(オブアシ自治区)における金属汚染と野生ラットにおける毒性影響評価 (2011)
  • Author(s): 大谷豪, 池中良徳, 中山翔太, Osei Akoto, Joseph APAU, Elvis BAIDOO, 石塚真由美
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本県立大学(熊本)
  • Year and Date: 2011-07-17
• [Presentation] Species diversity in phase II reaction of pyrene metabolism (2011)
  • Author(s): SAENGTIENCHAI, Yoshinori IKENAKA, Mayumi ISHIZUKA
  • Organizer: 第38回日本トキシコロジー学会
  • Place of Presentation: Attractive Convention Complex, Pacifico Yokohama (Japan)
  • Year and Date: 2011-07-12
• [Presentation] 多環芳香族炭化水素類(PAHs)に対する魚類の異物代謝機構の解明:魚類で観察された第II相抱合反応の特徴と種差 (2011)
  • Author(s): 小栗真美, 池中良徳, Aksorn Saengtienchai, 上田春樹, 石塚真由美
  • Organizer: 第38回日本トキシコロジー学会
  • Place of Presentation: Attractive Convention Complex, Pacifico Yokohama (Japan)
  • Year and Date: 2011-07-12
• [Presentation] All-trans retinoic acid negatively regulates AHR-mediated CYP1A1 transcription in human hepatoma, HepG2. (2011)
  • Author(s): Marumi Ohno, Yoshinori Ikenaka, and Mayumi Ishizuka
  • Organizer: 17th International Symposium on Cytochrome P450.
  • Place of Presentation: The University of Manchester, Manchester (UK)
  • Year and Date: 2011-06-27
• [Presentation] All-trans retinoic acid negatively regulates AHR-mediated CYP1A1 transcription in human hepatoma, HepG2 (2011)
  • Author(s): Marumi Ohno, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 17th International Symposium on Cytochrome P450
  • Place of Presentation: The University of Manchester, Manchester (UK)
  • Year and Date: 2011-06-27
• [Presentation] Metal concentration and stable isotope ratio analysis (d13C and d15N) in water, sediment and fish from Lake Itezhi-tezhi, Zambia (2011)
  • Author(s): Shouta M.M.Nakayama, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, Jun Yasuda, Mayumi Ishizuka
  • Organizer: 3rd CSTS and 5th SETAC-Africa Joint Toxicology Conference
  • Place of Presentation: University of Buea (Buea, Cameroon)
  • Year and Date: 2011-06-03
• [Presentation] Concentration and bioaccumulation of 10 metals in soil, river sediment, plant and hippopotamus (Hippopotamus amphibius L) in the South Luangwa National Park, Zambia (2011)
  • Author(s): Shouta M.M.Nakayama, Yoshinori Ikenaka, Kaampwe Muzandu, Kennedy Choongo, Jun Yasuda, Mayumi Ishizuka
  • Organizer: 3rd CSTS and 5th SETAC-Africa Joint Toxicology Conference
  • Place of Presentation: University of Buea (Buea, Cameroon)
  • Year and Date: 2011-06-02
• [Presentation] 野生げっ歯類におけるワルファリン抵抗性機構と遺伝的背景 (2011)
  • Author(s): 田中和之, 他
  • Organizer: 日本獣医師会獣医学術年会年次大会
  • Place of Presentation: 長良川国際会議場(岐阜市)
  • Year and Date: 2011-02-11
• [Presentation] All-trans retinoic acid negatively regulates AHR-mediated CYP1A1 transcription in human hepatoma, HepG2 (2011)
  • Author(s): Marumi Ohno, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 7th Dusseldorf Symposium on Immunotoxicology Biology of the Arylhydrocarbon Receptor-AHR 2011
  • Place of Presentation: The University of Dusseldorf, Dusseldorf, Germany
• [Presentation] The environmental pollution in African countries : Effects of heavy metals observed in wild/domestic animals inhabit in mining areas in Zambia. (2010)
  • Author(s): Ishizuka M.
  • Organizer: Workshop : Environmental pollution and Food safety
  • Place of Presentation: Zagazig University, Zagazig, Egypt 招待講演
  • Year and Date: 2010-12-13
• [Presentation] Comparative metabolism of warfarin in rat and chicken. (2010)
  • Author(s): Saengtienchai A., et al.
  • Organizer: The 3^<rd> Thailand-Japan International Academic Conference
  • Place of Presentation: 名古屋大学(名古屋市)
  • Year and Date: 2010-11-19
• [Presentation] 野生動物の化学物質感受性と生体防御機構 (2010)
  • Author(s): 石塚真由美
  • Organizer: 第43回安全工学研究発表会
  • Place of Presentation: 女性と仕事の未来館(東京都) 招待講演
  • Year and Date: 2010-11-12
• [Presentation] The Environmental Pollution in Zambia : Current status of POPs and heavy metals pollution in wildlife and domestic animals in Zambia. (2010)
  • Author(s): Ikenaka Y., et al.
  • Organizer: SETAC North America 31^<st> Annual Meeting
  • Place of Presentation: Oregon Convention Center (Port land), USA
  • Year and Date: 2010-11-10
• [Presentation] The Environmental Pollution in Zambia : Effects of heavy metals observed in wild rats inhabit in mining area in Zambia. (2010)
  • Author(s): Hamada K., et al.
  • Organizer: SETAC North America 31^<st> Annual Meeting
  • Place of Presentation: Oregon Convention Center (Port land), USA
  • Year and Date: 2010-11-10
• [Presentation] The CYP1D subfamily of genes in tetrapods (2010)
  • Author(s): Kawai K., et al.
  • Organizer: 10^<th> International Symposium on Cytochrome P450 Biodiversity and Biotechnology
  • Place of Presentation: Woods Hole (Massachusetts), USA
  • Year and Date: 2010-10-04
• [Presentation] The environmental pollution in African countries : Effects of heavy metals observed in wild/domestic animals inhabit in mining areas in Zambia. (2010)
  • Author(s): Ishizuka M.
  • Organizer: The 10th Meeting of Asian Association of Veterina ry Schools
  • Place of Presentation: 北海道大学(札幌市) 招待講演
  • Year and Date: 2010-09-21
• [Presentation] ザンビア共和国の鉱床活動による微量元素汚染の野生ラットへの影響 (2010)
  • Author(s): 濱田恭平, 他
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(帯広市)
  • Year and Date: 2010-09-16
• [Presentation] ザンビア共和国をモデルとした微量元素汚染:ウシにおける微量元素濃度とメタロチオネインおよびサイトカインmRNA発現量 (2010)
  • Author(s): 室谷太郎, 他
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(帯広市)
  • Year and Date: 2010-09-16
• [Presentation] 野生ネズミの微量金属汚染-日本におけるバイオモニターリングとその生体影響 (2010)
  • Author(s): オロスラーニュ・バラージュ, 他
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(帯広市)
  • Year and Date: 2010-09-16
• [Presentation] アスタキサンチンによるCYP1A1転写調節機構についての研究 (2010)
  • Author(s): 大野円実, 他
  • Organizer: 第24回カロテノイド研究談話会
  • Place of Presentation: 徳島大学付属病院(徳島市)
  • Year and Date: 2010-09-14
• [Presentation] The Environmental Pollution in Zambia : Effects of heavy metals observed in wild rats inhabit in mining areas in Zambia. (2010)
  • Author(s): Ikenaka Y., et al.
  • Organizer: 2^<nd> International Field Toxicology Symposium in Africa
  • Place of Presentation: University of Zambia, Lusaka, Zambia 招待講演
  • Year and Date: 2010-09-09
• [Presentation] Concentration and bioaccumulation of 10 metals in soil, sediment, plant and hippopotamus (Hippopotamus amphibius L) in the South Luangwa National Park. (2010)
  • Author(s): Nakayama SMM., et al.
  • Organizer: 2^<nd> International Field Toxicology Symposium in Africa
  • Place of Presentation: University of Zambia, Lusaka, Zambia
  • Year and Date: 2010-09-09
• [Presentation] 野生げっ歯類におけるワルファリン抵抗性機構と遺伝的背景について (2010)
  • Author(s): 田中和之, 他
  • Organizer: 第61回北海道獣医師大会 平成22年度 獣医学術北海道地区学会 日本獣医公衆衛生
  • Place of Presentation: 花びしホテル(函館市)
  • Year and Date: 2010-09-09
• [Presentation] Can food ingredients be homeostasis disruptor?~CYP1A1 activity can be affected by astaxanthin, one of xanthophylls~ (2010)
  • Author(s): Ohno M., et al.
  • Organizer: 2^<nd> International Field Toxicology Symposium in Africa
  • Place of Presentation: University of Zambia, Lusaka, Zambia
  • Year and Date: 2010-09-09
• [Presentation] Genomic analysis of mammalian P450 1 family enzymes and UGT1A6. (2010)
  • Author(s): Kawai K., et al.
  • Organizer: 2^<nd> International Field Toxicology Symposium in Africa
  • Place of Presentation: University of Zambia, Lusaka, Zambia
  • Year and Date: 2010-09-09
• [Presentation] 芳香族炭化水素受容体(AhR)の分子生物学的解析による鳥類のダイオキシン類感受性評価 (2010)
  • Author(s): 藤澤希望, 他
  • Organizer: 第61回北海道獣医師大会 平成22年度 獣医学術北海道地区学会日本獣医公衆衛生
  • Place of Presentation: 花びしホテル(函館市)
  • Year and Date: 2010-09-09
• [Presentation] Heavy Metal Pollution in Zambia : The Effects of Heavymetal Pollution in Domestic Cattles. (2010)
  • Author(s): Muroya T., et al.
  • Organizer: 2^<nd> International Field Toxicology Symposium in Africa
  • Place of Presentation: University of Zambia, Lusaka, Zambia
  • Year and Date: 2010-09-09
• [Presentation] ザンビアのカブウェ鉱床における重金属汚染～土壌および野生ラットを用いた汚染モニタリング～ (2010)
  • Author(s): 中山翔太, 他
  • Organizer: 第19回環境化学討論会
  • Place of Presentation: 中部大学(名古屋市)
  • Year and Date: 2010-06-22
• [Presentation] ザンビア共和国をモデルとした重金属類汚染～家畜における重金属類濃度とバイオマーカーmRNA発現量～ (2010)
  • Author(s): 室谷太郎, 他
  • Organizer: 第19回環境化学討論会
  • Place of Presentation: 中部大学(名古屋市)
  • Year and Date: 2010-06-22
• [Presentation] 野生ネズミを用いた生体影響評価:重金属汚染のモニタリングとバイオマーカーの解析 (2010)
  • Author(s): オロスラーニュ・バラージュ, 他
  • Organizer: 第19回環境化学討論会
  • Place of Presentation: 中部大学(名古屋市)
  • Year and Date: 2010-06-22
• [Presentation] 鳥類におけるワルファリン感受性の比較 (2010)
  • Author(s): 渡邉研右, 他
  • Organizer: 第37回日本トキシコロジー学会学術年会
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
  • Year and Date: 2010-06-18
• [Presentation] 芳香族炭化水素受容体(AhR)の分子生物学的解析による鳥類のダイオキシン類感受性評価 (2010)
  • Author(s): 藤澤希望, 他
  • Organizer: 第37回 日本トキシコロジー学会学術年会
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
  • Year and Date: 2010-06-17
• [Presentation] Elucidation of metabolic pathway of PAHs in amphibians : The unique phase II reaction and its species specificity observed in amphibians. (2010)
  • Author(s): 上田春樹, 他
  • Organizer: 第37回 日本トキシコロジー学会学術年会
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
  • Year and Date: 2010-06-16
• [Presentation] ザンビア共和国における水圏・陸圏の野生動物への重金属汚染の影響 (2010)
  • Author(s): 濱田恭平, 他
  • Organizer: 国際開発学会 第11回春季大会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2010-06-05
• [Presentation] Toxicological aspects of heavy metals in a broad area of Zambia (2009)
  • Author(s): Shouta M.M.NAKAYAMA, Yoshinori IKENAKA, Kaampwe MUZANDU, Kennedy CHOONGO, Balazs OROSZLANY, Hiroki TERAOKA, Naoharu MIZUNO, Mayumi ISHIZUKA.
  • Organizer: The 4th SETAC Africa meeting
  • Place of Presentation: Spoke Resort & Conference Centre in Munyonyo, Kampala, Uganda
  • Year and Date: 2009-11-02
• [Presentation] 舌に発現する薬物代謝酵素群と変異原物質の代謝機構. (2009)
  • Author(s): 滝口真美, Wageh Sobhy, 池中良徳, 藤田正一, 石塚真由美
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: とりぎん文化会館(鳥取県民文化会館)、鳥取市、鳥取県
  • Year and Date: 2009-09-27
• [Presentation] 鳥類ビタミンKエポキシド還元酵素のワルファリン感受性. (2009)
  • Author(s): 渡邉研右、田中和之、池中良徳、藤田正一、石塚真由美
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: とりぎん文化会館(鳥取県民文化会館)(鳥取市、鳥取県)
  • Year and Date: 2009-09-27
• [Presentation] Mutagenic activation and detoxification of Benzo[a] pyrene by liver of meat producing animals (2009)
  • Author(s): ワギソブヒ、石塚真由美、坂本健太郎、藤田正一
  • Organizer: 日本獣医学会
  • Place of Presentation: 宮崎県ワールドコンベンションセンター・サミット(シーガイア)
  • Year and Date: 2009-09-24
• [Presentation] 野生生物の持つ汚染環境への適応戦 (2009)
  • Author(s): 石塚真由美, フィールドトキシコロジー
  • Organizer: 資源・素材関係学協会合同秋季大会 (大会記念講演)
  • Place of Presentation: 札幌市
  • Year and Date: 2009-09-09
• [Presentation] 野生生物の持つ汚染環境への適応戦 (2009)
  • Author(s): 石塚真由美
  • Organizer: 資源・素材関係学協会合同秋季大会
  • Place of Presentation: 北海道大学(札幌市、北海道)
  • Year and Date: 2009-09-09
• [Presentation] ワルファリン抵抗性ドブネズミ及びクマネズミにおける新規抵抗性機構の解明 (2009)
  • Author(s): 田中和之、春成常仁、谷川力、川上泰、坂本健太郎、藤田正一、石塚真由美
  • Organizer: 第36回日本トキシコロジー学会
  • Place of Presentation: アイーナ(岩手県民情報交流センター)(盛岡市、岩手県)
  • Year and Date: 2009-07-08
• [Presentation] A possible cause for the inter-species difference in CYP1A expression and activity in ungulates and rat (2009)
  • Author(s): Wageh Sobhy Abdelrahem, Yoshinori Ikenaka, Kentaro Q Sakamoto, Shoichi Fuiita, Mavumi Ishizuka
  • Organizer: 16^<th> International Conference on Cytochrome P450
  • Place of Presentation: 万国津梁館(名護市、沖縄県)
  • Year and Date: 2009-06-22
• [Presentation] Effects of astaxanthin on CYP1A expression and dependent metabolism (2009)
  • Author(s): Marumi Ohno, Wataru Miki, Kentaro Q Sakamoto, Shoichi Fujita, Mayumi Ishizuka
  • Organizer: 16^<th> International Conference on Cytochrome P450
  • Place of Presentation: 万国津梁館(名護市、沖縄県)
  • Year and Date: 2009-06-22
• [Presentation] cDNA cloning and characterization of cytochrome P450 1As form mammalian species. (2009)
  • Author(s): Yusuke Kawai, Hideaki Yamamoto, Kentaro Q Sakamoto, Mami Takiguchi, Shoichi Fujita, Mayumi Ishizuka
  • Organizer: 16^<th> International Conference on Cytochrome P450
  • Place of Presentation: 万国津梁館(名護市、沖縄県)
  • Year and Date: 2009-06-22
• [Presentation] Arylhydrocarbon receptor(AhR)の分子生物学的解析によるハヤブサの環境汚染物質の感受性評価. (2009)
  • Author(s): 藤澤希望, 山本秀明, 川合佑典, 坂本健太郎, 藤田正一, 石塚真由美
  • Organizer: 第147回日本獣医学会学術集会
  • Place of Presentation: 栃木県総合文化センター、栃木県自治会館(宇都宮市、栃木県)
  • Year and Date: 2009-04-04
• [Presentation] 舌に発現するシトクロムP450 (2009)
  • Author(s): 滝口真美, 安東志麻, Wageh Sobhy, 大野円実, 坂本健太郎, 藤田正一, 石塚真由美
  • Organizer: 第147回日本獣医学会学術集会
  • Place of Presentation: 栃木県総合文化センター、栃木県自治会館(宇都宮市、栃木県)
  • Year and Date: 2009-04-04
• [Presentation] Sources and distributions of heavy metals in Zambia : Environmental monitoring between lake Kariba and lake Itezhi-tezhi (2009)
  • Author(s): Ikenaka Y, Nakayama SMM, Muzandu K, Choongo K, Teraoka H, Mizuno N, Ishizuka. M
  • Organizer: SETAC North America 30th Annual Meeting
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] Sources and distributions of heavy metals in Zambia : Environmental monitoring between lake Kariba and lake Itezhi-tezhi. (2009)
  • Author(s): Yoshinori IKENAKA, Shouta M.M.NAKAYAMA, Kaampwe MUZANDU, Kennedy CHOONGO, Hiroki TERAOKA, Naoharu MIZUNO, Mayumi ISHTZUKA.
  • Organizer: SETAC North America 30th Annual Meeting
  • Place of Presentation: Hilton Riverside, New Orleans, Louisiana
• [Presentation] 環境化学物質が野生動物に引き起こす毒性と適応 (2008)
  • Author(s): 石塚真由美
  • Organizer: 農学会(受賞講演)
  • Place of Presentation: 東京都文京区(東京大学)
  • Year and Date: 2008-11-26
• [Presentation] ワルファリン耐性クマネズミにおける耐性機構の解明 (2008)
  • Author(s): 安東志麻、谷川力、田中和之、坂本健太郎、石塚真由美、藤田正一
  • Organizer: 日本獣医学会
  • Place of Presentation: 宮崎県・ワールドコンベンションセンター・サミット(シーガイア)
  • Year and Date: 2008-09-24
• [Presentation] 2つの異なる遺伝子変異がもたらすラットCYP2D依存の薬物代謝活性の系統差及び個体差 (2008)
  • Author(s): 酒井紀彰、斎藤愛、坂本健太郎、石塚真由美、藤田正一
  • Organizer: 日本トキシコロジー学会
  • Place of Presentation: 東京都・国立オリンピック記念青少年総合センター
  • Year and Date: 2008-06-26
• [Presentation] Role of phase II metabolizing enzymes in decreasing the mutagenic activity of Ungulates microsomes (2008)
  • Author(s): ワギソブヒ、石塚真由美、坂本健太郎、藤田正一
  • Organizer: 日本トキシコロジー学会
  • Place of Presentation: 東京都・国立オリンピック記念青少年総合センター
  • Year and Date: 2008-06-26
• [Presentation] ラットにおけるCYP2D2, 2D3依存の薬物代謝酵素活性の系統差及び個体差〜2つの異なる遺伝子変異の影響〜 (2008)
  • Author(s): 酒井紀彰, 斉藤愛, 坂本健太郎, 石塚真由美, 藤田正一
  • Organizer: 第145回日本獣医学会学術集会
  • Place of Presentation: 神奈川県相模原市(麻布大学)
• [Presentation] カカオマス製品の粗抽出液の抗変異原作用 (2008)
  • Author(s): 大野円実, 坂本健太郎, 石塚真由美, 藤田正一
  • Organizer: 第145回日本獣医学会学術集会
  • Place of Presentation: 神奈川県相模原市(麻布大学)
• [Presentation] ワルファリン耐性ドブネズミにおける耐性機構の解明 (2008)
  • Author(s): 田中和之, 谷川力, 石塚真由美, 坂本健太郎, 藤田正一
  • Organizer: 第145回日本獣医学会学術集会
  • Place of Presentation: 神奈川県相模原市(麻布大学)
• [Presentation] 野生生物の持つ汚染環境への適応戦資源 (2007)
  • Author(s): 石塚真由美
  • Organizer: 素材関係学協会合同秋季大会
  • Place of Presentation: 北海道大学(札幌市、北海道)(招待講演)
  • Year and Date: 2007-09-09
• [Presentation] Environmental impact of toxic substances on wildlife (2007)
  • Author(s): 石塚真由美
  • Organizer: Current Trends in Toxicology
  • Place of Presentation: Korea(Kangwon University)
• [Presentation] 両生類、特に有尾類アカハライモリを中心としたCYP 1 A のcharacterization (2007)
  • Author(s): 中山翔太, 石塚真由美, 田中_上野寛子, 坂本健太郎, 藤田正一
  • Organizer: 第144回日本獣医学会学術集会
  • Place of Presentation: 北海道江別市(酪農学園大学)
• [Presentation] Characterization of cytochrome P450 1 A in Ungulates (2007)
  • Author(s): Wageh Sobhy, 石塚真由美, Ibrahim Zein Shaban, 坂本健太郎, 藤田正一
  • Organizer: 第144回日本獣医学会学術集会
  • Place of Presentation: 北海道江別市(酪農学園大学)
• [Presentation] Environmental impact of persistent toxic substances on wildlife (2007)
  • Author(s): Fujita S, Sakamoto K, Ishizuka M
  • Organizer: 13th INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT
  • Place of Presentation: Toyama city(Toyama Prefectural Hall)
• [Presentation] ワルファリン耐性ドブネズミ及びクマネズミにおける新規耐性機構の解明 (2007)
  • Author(s): 田中和之, 谷川力, 石塚真由美, 坂本健太郎, 藤田正一
  • Organizer: 第34回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京都江戸川区(タワーホール船堀)
• [Presentation] 野生動物のCYP1Aサブフアミリーの種差とキヤラクタライゼーシヨン (2007)
  • Author(s): 川合佑典, 石塚真由美, 山本秀明, 坂本健太郎, 藤田正一
  • Organizer: 第34回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京都江戸川区(タワーホール船堀)
• [Presentation] 野生生物のシトクロムP450と汚染環境への適応機構に関する研究 (2007)
  • Author(s): 石塚真由美
  • Organizer: 第34回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京都江戸川区(タワーホール船堀)
• [Presentation] Mechanism of low expression of CYP2D2 mRNA in Dark Agoutirats (2007)
  • Author(s): Sakai N., Q Sakamoto K., Ishizuka M., Fujita S.
  • Organizer: International Congress of Toxicology
  • Place of Presentation: Montreal, Canada(the Palais des congres de Montreal)
• [Book] 環境修復の科学と技術 (2007)
  • Author(s): 北海道大学大学院環境科学院編
  • Total Pages: 256
  • Publisher: 北海道大学出版会
• [Remarks] 【受賞】:科学技術分野の文部科学大臣表彰・若手科学者賞(2009年)野生動物のシトクロムP450と汚染環境適応能力解明の研究