|Budget Amount *help
¥114,010,000 (Direct Cost: ¥87,700,000、Indirect Cost: ¥26,310,000)
Fiscal Year 2011: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2009: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2008: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2007: ¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
In order to investigate the neural mechanisms of top-down behavioral control based on category and rule, we recorded single-unit activity in the monkey prefrontal cortex during task performance. Many of the recorded neurons were found to code category, rule, or predicted outcome. We also performed reversible functional inhibition of the prefrontal cortex by low-frequency repetitive trans-cranial stimulation (rTMS). By inhibiting the prefrontal cortex, immediate adaptation of behavior based on category and rule was impaired, whereas the basic ability for association learning remained unimpaired. These results suggest that the prefrontal cortex plays an important role in the top-down control of behavior based on category and rule. Based on the properties of the recorded neurons, we proposed a neuron circuit model of the prefrontal cortex for top-down behavioral control.