| Budget Amount *help |
¥115,180,000 (Direct Cost: ¥88,600,000、Indirect Cost: ¥26,580,000)
Fiscal Year 2011: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2010: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2009: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2008: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2007: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
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| Research Abstract |
γ-Secretase is an intramembrane protease that is responsible for the generation of amyloid-βpeptide linked to the pathogenesis of Alzheimer disease. Thus, modulation ofγ-secretase activity is a plausible therapeutics for Alzheimer disease. We have unveiled the novel molecular mechanisms of theγ-secretase cleavage, and established the novelγ-secretase inhibitors by rational design based on the mechanism. These developments offer a promise for development of a disease-modifying drug for Alzheimer disease.
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