| Budget Amount *help |
¥115,180,000 (Direct Cost: ¥88,600,000、Indirect Cost: ¥26,580,000)
Fiscal Year 2011: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2010: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2009: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2008: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2007: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
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| Research Abstract |
We analyzed the mechanisms by which activity of innate immunity is regulated using two in vivo models, protozoan parasite infections and inflammatory diseases. In infectious models, we revealed a novel mechanism in which innate immunity induces Ca2+-dependent activation of adaptive immunity. In inflammatory disease models, we used inflammatory bowel disease models, and revealed that unique subsets of intestinal innate immune myeloid cells regulate intestinal homeostasis through induction of inflammatory and anti-inflammatory responses.
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