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Spontaneous Symmetry Breaking Mechanism in Biological Morphology

Research Project

Project/Area Number 19680014
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Bioinformatics/Life informatics
Research InstitutionNara Institute of Science and Technology

Principal Investigator

SAKUMURA Yuichi  Nara Institute of Science and Technology, 情報科学研究科, 特任准教授 (50324968)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywordsシステム生物学 / 分子生物学 / 形態形成 / シグナル伝達 / 統計解析
Research Abstract

Developing neuron has several immature neurites with similar length and elongates one of neurites which becomes axon. In the development of vertebrates, the epithelized cell group called as somite is formed in uniformly distributed cell group. These symmetry breaking phenomena were studied with collaborators in experimental field by constructing mathematical model. In each study, novel mechanism was discovered and predictions from mathematical model were validated by experiments.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (40 results)

All 2010 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (24 results) Remarks (8 results)

  • [Journal Article] 細胞形態変化の定量と現象論的モデル2010

    • Author(s)
      塚田祐基, 作村諭一
    • Journal Title

      細胞工学(秀潤社)

      Pages: 339-343

    • Related Report
      2009 Final Research Report
  • [Journal Article] Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse2009

    • Author(s)
      Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T, Bessho Y.
    • Journal Title

      PSM. PToS One 4(5)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM2009

    • Author(s)
      Hayashi S
    • Journal Title

      PLoS One 4(5)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of local morphodynamics and local GTPase activity by edge evolution tracking2008

    • Author(s)
      Tsukada Y, Aoki K, Nakamura T, Sakumura Y, Matsuda M, Ishii S.
    • Journal Title

      PToS Comput. Biol. 4(11)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stochastic Control of Spontaneous Signal Generation for Gradient Sensing in Chemotaxis2008

    • Author(s)
      Honda N, Sakumura Y, Ishii S.
    • Journal Title

      J. Theor. 255

      Pages: 259-266

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of local morphodynamics and local GTPase activity by edge evolution tracking2008

    • Author(s)
      Tsukada Y.
    • Journal Title

      PLoS Comput Biol. 4(11)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stochastic Control of Spontaneous Signal Generation for Gradient Sensing in Chemotaxis2008

    • Author(s)
      Honda N.
    • Journal Title

      J. Theor Biol. 255

      Pages: 259-266

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Diffusion-based neurite length sensing mechanism involved in neuronal symmetry-breaking

    • Author(s)
      Toriyama M, *Sakumura Y, Shimada T, Ishii S, *Inagaki N
    • Journal Title

      Molecular Systems Biology (in press)

    • NAID

      120005830837

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 独立成分分析を用いた初期視覚野の二重反対色同心円型受容野の形成2010

    • Author(s)
      青木孝剛, 五十嵐康伸, 木村塁, 今基織, 作村諭一, 石井信
    • Place of Presentation
      玉川大学
    • Related Report
      2009 Final Research Report
  • [Presentation] 独立成分分析を用いた初期視覚野の二重反対色同心円型受容野の形成2010

    • Author(s)
      青木孝剛
    • Organizer
      ニューロコンピューティング研究会
    • Place of Presentation
      玉川大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] A quantitative modeling of neural morphological polarization2009

    • Author(s)
      Sakumura Y
    • Organizer
      Asia Simulation Conference(JSST2009)
    • Place of Presentation
      同志社大学
    • Related Report
      2009 Final Research Report
  • [Presentation] 統計的手法を用いた神経軸索の形態予測2009

    • Author(s)
      内海将人, 作村諭一, 福西昭子, 山本亘彦, 石井信
    • Organizer
      電子情報通信学会技術研究報告
    • Place of Presentation
      玉川大学
    • Related Report
      2009 Final Research Report
  • [Presentation] 脊椎動物の発達過程における分節時計の分子システム2009

    • Author(s)
      伊坂弥花子, 山尾将隆, 作村諭一, 金雄, 松井貴輝, 別所康全, 石井信
    • Place of Presentation
      京都市
    • Related Report
      2009 Final Research Report
  • [Presentation] A quantitative modeling of neural morphological polarization2009

    • Author(s)
      Sakumura Y
    • Organizer
      Asia Simulation Conference
    • Place of Presentation
      立命館大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] Activity Dependent Growth cone Guidance2009

    • Author(s)
      Hong K
    • Organizer
      Collaborative Research in Computational Neuroscience
    • Place of Presentation
      University of Pittsburgh
    • Related Report
      2009 Annual Research Report
  • [Presentation] A quantitative description of polarization in neural morphology2008

    • Author(s)
      Sakumura Y.
    • Organizer
      バイオスーパーコンピューティング・シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-12-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] A quantitative mathematical description of neural polarity2008

    • Author(s)
      Sakumura Y.
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rho/Rho-kinaseによるミオシンの動的リン酸化制御システム2008

    • Author(s)
      河野(金兒)貴子
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] On the synchrony of morphological and molecular signaling events in cell migration2008

    • Author(s)
      Dauwels J.
    • Organizer
      International Conference on Neural Informatit Processing (ICONIP 2008)
    • Place of Presentation
      ニュージーランドーオークランド
    • Year and Date
      2008-11-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Quantitative Morphodynamic Analysis of FRET time-lapse imaging2008

    • Author(s)
      Tsukada Y.
    • Organizer
      nternational Conference on Systems Biology (ICSB 2008)
    • Place of Presentation
      スウェーテンヨーテボ
    • Year and Date
      2008-08-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] A quantitative description of polarization in neural morphology2008

    • Author(s)
      Sakumura Y, Toriyama M, Inagaki N, Ishii S
    • Organizer
      バイオスーパーコンピューティング・シンポジゥム(BSCS)
    • Place of Presentation
      東京丸の内
    • Related Report
      2009 Final Research Report
  • [Presentation] A quantitative mathematical description of neural polarity2008

    • Author(s)
      Sakumura Y
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸市(シンポジウム)
    • Related Report
      2009 Final Research Report
  • [Presentation] Rho/Rho-kinaseによるミオシンの動的リン酸化制御システム2008

    • Author(s)
      河野(金兒)貴子, 本田直樹, 塚田祐基, 山尾将隆, 作村諭一, 石井信
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Related Report
      2009 Final Research Report
  • [Presentation] On the synchrony of morphological and molecular signaling events in cell migration2008

    • Author(s)
      Dauwels, J., Tsukada, Y., Sakumura, Y., Ishii, S., Aoki, K., Nakamura, T., Matsuda, M., Vialatte, F., Cichocki, A.
    • Organizer
      International Conference on Neural Information Processing (ICONIP2008)
    • Place of Presentation
      オークランドニュージーランド
    • Related Report
      2009 Final Research Report
  • [Presentation] Quantitative Morphodynamic Analysis of FRET time-lapse imaging2008

    • Author(s)
      Tsukada, Y., Aoki, K., Sakumura, Y., Nakamura, T., Matsuda, M., Ishii, S.
    • Organizer
      International Conference on Systems Biology (ICSB 2008)
    • Place of Presentation
      ヨーテボリスウェーデン
    • Related Report
      2009 Final Research Report
  • [Presentation] Shootinlと神経突起伸長Positive feedback loopによる神経極性形成機構2007

    • Author(s)
      鳥山道則
    • Organizer
      第30回日本分子生物学会・第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Quantitative morphodynamic analysis of time-lapse imaging by edge evolution tracking.2007

    • Author(s)
      Tsukada, Y.
    • Organizer
      International Conference on Neural Information Processing,
    • Place of Presentation
      Kitakyushu, Japan.
    • Year and Date
      2007-11-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Spontaneous signal generation induced by reaction noise for gradient sensing in chemotaxis.2007

    • Author(s)
      Naoki, H.
    • Organizer
      International Conference on Systems Biology,
    • Place of Presentation
      California, USA
    • Year and Date
      2007-10-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Quantitative analysis of Shootinl and neurite elongation.2007

    • Author(s)
      Asano, T.
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscienee Society
    • Place of Presentation
      Yokohama, Japan.
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] シグナル伝達の拡散と局所性を利用したシナプス可塑性2007

    • Author(s)
      作村諭一
    • Organizer
      2007年度シナプス研究会
    • Place of Presentation
      生理学研究所
    • Related Report
      2009 Final Research Report
  • [Presentation] Quantitative Morphodynamic Analysis of Time-Lapse Imaging by Edge Evolution Tracking2007

    • Author(s)
      Tsukada, Y., Sakumura, Y., Ishii, S.
    • Organizer
      International Conference on Neural Information Processing (ICONIP 2007)
    • Place of Presentation
      北九州
    • Related Report
      2009 Final Research Report
  • [Presentation] Spontaneous signal generation induced by reaction noise for gradient sensing in chemotaxi s2007

    • Author(s)
      Naoki, H., Sakumura, Y., Ishii, S.
    • Organizer
      International Conference of Systems Biology (ICSB 2007)
    • Place of Presentation
      米国カリフォルニア州
    • Related Report
      2009 Final Research Report
  • [Remarks] 本研究課題と関係する国内外の研究者を招聘し、ワークショップ(システム神経生物学スプリングスクール)を開催した。

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://nippon.naist.jp/SNSS2007

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://nippon.naist.jp/SNSS2008

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://nippon.naist.jp/SNSS2009

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://nippon.naist.jp/SNSS2010

    • Related Report
      2009 Final Research Report
  • [Remarks] システム神経生物学スプリングスクール2010

    • URL

      http://nippon.naist.jp/SNSS2010/

    • Related Report
      2009 Annual Research Report
  • [Remarks] システム神経生物学スプリングスクール2009

    • URL

      http://nippon.naist.jp/SNSS2009/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://nippon.naist.jp/SNSS2008/

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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