Spontaneous Symmetry Breaking Mechanism in Biological Morphology
Project/Area Number |
19680014
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Bioinformatics/Life informatics
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Research Institution | Nara Institute of Science and Technology |
Principal Investigator |
SAKUMURA Yuichi Nara Institute of Science and Technology, 情報科学研究科, 特任准教授 (50324968)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
Keywords | システム生物学 / 分子生物学 / 形態形成 / シグナル伝達 / 統計解析 |
Research Abstract |
Developing neuron has several immature neurites with similar length and elongates one of neurites which becomes axon. In the development of vertebrates, the epithelized cell group called as somite is formed in uniformly distributed cell group. These symmetry breaking phenomena were studied with collaborators in experimental field by constructing mathematical model. In each study, novel mechanism was discovered and predictions from mathematical model were validated by experiments.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse2009
Author(s)
Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T, Bessho Y.
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Journal Title
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Peer Reviewed
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[Presentation] On the synchrony of morphological and molecular signaling events in cell migration2008
Author(s)
Dauwels, J., Tsukada, Y., Sakumura, Y., Ishii, S., Aoki, K., Nakamura, T., Matsuda, M., Vialatte, F., Cichocki, A.
Organizer
International Conference on Neural Information Processing (ICONIP2008)
Place of Presentation
オークランドニュージーランド
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[Presentation] Quantitative Morphodynamic Analysis of FRET time-lapse imaging2008
Author(s)
Tsukada, Y., Aoki, K., Sakumura, Y., Nakamura, T., Matsuda, M., Ishii, S.
Organizer
International Conference on Systems Biology (ICSB 2008)
Place of Presentation
ヨーテボリスウェーデン
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