Spontaneous Symmetry Breaking Mechanism in Biological Morphology

• Project/Area Number: 19680014
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Bioinformatics/Life informatics
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: SAKUMURA Yuichi Nara Institute of Science and Technology, 情報科学研究科, 特任准教授 (50324968)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2007: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: システム生物学 / 分子生物学 / 形態形成 / シグナル伝達 / 統計解析

Research Abstract

Developing neuron has several immature neurites with similar length and elongates one of neurites which becomes axon. In the development of vertebrates, the epithelized cell group called as somite is formed in uniformly distributed cell group. These symmetry breaking phenomena were studied with collaborators in experimental field by constructing mathematical model. In each study, novel mechanism was discovered and predictions from mathematical model were validated by experiments.

Research Products

• [Journal Article] 細胞形態変化の定量と現象論的モデル (2010)
  • Author(s): 塚田祐基, 作村諭一
  • Journal Title: 細胞工学(秀潤社) Pages: 339-343
• [Journal Article] Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse (2009)
  • Author(s): Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T, Bessho Y.
  • Journal Title: PSM. PToS One 4(5)
  • Peer Reviewed
• [Journal Article] an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM (2009)
  • Author(s): Hayashi S
  • Journal Title: PLoS One 4(5)
  • Peer Reviewed
• [Journal Article] Quantification of local morphodynamics and local GTPase activity by edge evolution tracking (2008)
  • Author(s): Tsukada Y, Aoki K, Nakamura T, Sakumura Y, Matsuda M, Ishii S.
  • Journal Title: PToS Comput. Biol. 4(11)
  • Peer Reviewed
• [Journal Article] Stochastic Control of Spontaneous Signal Generation for Gradient Sensing in Chemotaxis (2008)
  • Author(s): Honda N, Sakumura Y, Ishii S.
  • Journal Title: J. Theor. 255 Pages: 259-266
  • Peer Reviewed
• [Journal Article] Quantification of local morphodynamics and local GTPase activity by edge evolution tracking (2008)
  • Author(s): Tsukada Y.
  • Journal Title: PLoS Comput Biol. 4(11)
  • Peer Reviewed
• [Journal Article] Stochastic Control of Spontaneous Signal Generation for Gradient Sensing in Chemotaxis (2008)
  • Author(s): Honda N.
  • Journal Title: J. Theor Biol. 255 Pages: 259-266
  • Peer Reviewed
• [Journal Article] A Diffusion-based neurite length sensing mechanism involved in neuronal symmetry-breaking
  • Author(s): Toriyama M, *Sakumura Y, Shimada T, Ishii S, *Inagaki N
  • Journal Title: Molecular Systems Biology (in press)
  • NAID: 120005830837
  • Peer Reviewed
• [Presentation] 独立成分分析を用いた初期視覚野の二重反対色同心円型受容野の形成 (2010)
  • Author(s): 青木孝剛, 五十嵐康伸, 木村塁, 今基織, 作村諭一, 石井信
  • Place of Presentation: 玉川大学
• [Presentation] 独立成分分析を用いた初期視覚野の二重反対色同心円型受容野の形成 (2010)
  • Author(s): 青木孝剛
  • Organizer: ニューロコンピューティング研究会
  • Place of Presentation: 玉川大学
• [Presentation] A quantitative modeling of neural morphological polarization (2009)
  • Author(s): Sakumura Y
  • Organizer: Asia Simulation Conference(JSST2009)
  • Place of Presentation: 同志社大学
• [Presentation] 統計的手法を用いた神経軸索の形態予測 (2009)
  • Author(s): 内海将人, 作村諭一, 福西昭子, 山本亘彦, 石井信
  • Organizer: 電子情報通信学会技術研究報告
  • Place of Presentation: 玉川大学
• [Presentation] 脊椎動物の発達過程における分節時計の分子システム (2009)
  • Author(s): 伊坂弥花子, 山尾将隆, 作村諭一, 金雄, 松井貴輝, 別所康全, 石井信
  • Place of Presentation: 京都市
• [Presentation] A quantitative modeling of neural morphological polarization (2009)
  • Author(s): Sakumura Y
  • Organizer: Asia Simulation Conference
  • Place of Presentation: 立命館大学
• [Presentation] Activity Dependent Growth cone Guidance (2009)
  • Author(s): Hong K
  • Organizer: Collaborative Research in Computational Neuroscience
  • Place of Presentation: University of Pittsburgh
• [Presentation] A quantitative description of polarization in neural morphology (2008)
  • Author(s): Sakumura Y.
  • Organizer: バイオスーパーコンピューティング・シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-12-26
• [Presentation] A quantitative mathematical description of neural polarity (2008)
  • Author(s): Sakumura Y.
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] Rho/Rho-kinaseによるミオシンの動的リン酸化制御システム (2008)
  • Author(s): 河野(金兒)貴子
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] On the synchrony of morphological and molecular signaling events in cell migration (2008)
  • Author(s): Dauwels J.
  • Organizer: International Conference on Neural Informatit Processing (ICONIP 2008)
  • Place of Presentation: ニュージーランドーオークランド
  • Year and Date: 2008-11-26
• [Presentation] Quantitative Morphodynamic Analysis of FRET time-lapse imaging (2008)
  • Author(s): Tsukada Y.
  • Organizer: nternational Conference on Systems Biology (ICSB 2008)
  • Place of Presentation: スウェーテンヨーテボ
  • Year and Date: 2008-08-24
• [Presentation] A quantitative description of polarization in neural morphology (2008)
  • Author(s): Sakumura Y, Toriyama M, Inagaki N, Ishii S
  • Organizer: バイオスーパーコンピューティング・シンポジゥム(BSCS)
  • Place of Presentation: 東京丸の内
• [Presentation] A quantitative mathematical description of neural polarity (2008)
  • Author(s): Sakumura Y
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸市(シンポジウム)
• [Presentation] Rho/Rho-kinaseによるミオシンの動的リン酸化制御システム (2008)
  • Author(s): 河野(金兒)貴子, 本田直樹, 塚田祐基, 山尾将隆, 作村諭一, 石井信
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸市
• [Presentation] On the synchrony of morphological and molecular signaling events in cell migration (2008)
  • Author(s): Dauwels, J., Tsukada, Y., Sakumura, Y., Ishii, S., Aoki, K., Nakamura, T., Matsuda, M., Vialatte, F., Cichocki, A.
  • Organizer: International Conference on Neural Information Processing (ICONIP2008)
  • Place of Presentation: オークランドニュージーランド
• [Presentation] Quantitative Morphodynamic Analysis of FRET time-lapse imaging (2008)
  • Author(s): Tsukada, Y., Aoki, K., Sakumura, Y., Nakamura, T., Matsuda, M., Ishii, S.
  • Organizer: International Conference on Systems Biology (ICSB 2008)
  • Place of Presentation: ヨーテボリスウェーデン
• [Presentation] Shootinlと神経突起伸長Positive feedback loopによる神経極性形成機構 (2007)
  • Author(s): 鳥山道則
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-11
• [Presentation] Quantitative morphodynamic analysis of time-lapse imaging by edge evolution tracking. (2007)
  • Author(s): Tsukada, Y.
  • Organizer: International Conference on Neural Information Processing,
  • Place of Presentation: Kitakyushu, Japan.
  • Year and Date: 2007-11-13
• [Presentation] Spontaneous signal generation induced by reaction noise for gradient sensing in chemotaxis. (2007)
  • Author(s): Naoki, H.
  • Organizer: International Conference on Systems Biology,
  • Place of Presentation: California, USA
  • Year and Date: 2007-10-01
• [Presentation] Quantitative analysis of Shootinl and neurite elongation. (2007)
  • Author(s): Asano, T.
  • Organizer: The 30th Annual Meeting of the Japan Neuroscienee Society
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2007-09-10
• [Presentation] シグナル伝達の拡散と局所性を利用したシナプス可塑性 (2007)
  • Author(s): 作村諭一
  • Organizer: 2007年度シナプス研究会
  • Place of Presentation: 生理学研究所
• [Presentation] Quantitative Morphodynamic Analysis of Time-Lapse Imaging by Edge Evolution Tracking (2007)
  • Author(s): Tsukada, Y., Sakumura, Y., Ishii, S.
  • Organizer: International Conference on Neural Information Processing (ICONIP 2007)
  • Place of Presentation: 北九州
• [Presentation] Spontaneous signal generation induced by reaction noise for gradient sensing in chemotaxi s (2007)
  • Author(s): Naoki, H., Sakumura, Y., Ishii, S.
  • Organizer: International Conference of Systems Biology (ICSB 2007)
  • Place of Presentation: 米国カリフォルニア州
• [Remarks] 本研究課題と関係する国内外の研究者を招聘し、ワークショップ(システム神経生物学スプリングスクール)を開催した。
• [Remarks]
  • URL: http://nippon.naist.jp/SNSS2007
• [Remarks]
  • URL: http://nippon.naist.jp/SNSS2008
• [Remarks]
  • URL: http://nippon.naist.jp/SNSS2009
• [Remarks]
  • URL: http://nippon.naist.jp/SNSS2010
• [Remarks] システム神経生物学スプリングスクール2010
  • URL: http://nippon.naist.jp/SNSS2010/
• [Remarks] システム神経生物学スプリングスクール2009
  • URL: http://nippon.naist.jp/SNSS2009/
• [Remarks]
  • URL: http://nippon.naist.jp/SNSS2008/