| Budget Amount *help |
¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2007: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Research Abstract |
We observed structural polymorphism in the aggregates of huntingtin, a protein responsible for Huntington disease, both in vitro and in vivo. Among distinct conformations of huntingtin amyloids derived from a variety of brain regions, those in striatum showed the highest cytotoxicity. Therefore, amyloid conformation may be a critical determinant of regional specificity in Huntington disease. In addition, a genetic screening system that can detect cross-seeding between a certain protein and polyglutamine aggregates allows us to identify a novel yeast prion protein that lacks a Gln/Asn-rich domain.
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