| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2007: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Research Abstract |
In this project, intracellular trafficking of nano-carrier was controlled from the point of view of intracellular dynamics (i.e. vesicular transport and/or microtubule-dependent transport), dispersity and homogeneity to improve the transfection activity. These technologies will be valuable as used in DNA vaccine and liver-targeting gene carriers. Furthermore, novel peptide was discovered, which confer the activity to pass through the cell monolayer via transcytosis pathway. This device will be useful to overcome the vesicular barriers which limits the delivery to tissue parenchyma.
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