Innovative nano-therapy based on nanocarriers equipped with the ability to circumvent biological barriers
Project/Area Number |
19680026
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | The University of Tokyo |
Principal Investigator |
NISHIYAMA Nobuhirp The University of Tokyo, 大学院・医学系研究科, 准教授 (10372385)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2007: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
|
Keywords | ドラッグデリバリー / 高分子ミセル / がん治療 / 生体内バリア / 光エネルギー / ナノキャリア / がん化学療法 / 遺伝子治療 |
Research Abstract |
To realize the targeting therapy against intractable tumors such as pancreatic tumors and molecular cancer therapy using nucleic acids, we developed novel nanocarriers based on polymeric micelles, which can avoid biological barriers at the tissue and organelle levels and function responding to environmental changes or physical stimuli, by engineering functional polymeric materials. The usefulness of such nanocarriers has been demonstrated by in vitro and in vivo experiments.
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Report
(4 results)
Research Products
(96 results)
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[Journal Article] Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanine.2009
Author(s)
N. Nishiyama, Y. Nakagishi, Y. Morimoto, P. -S. Lai, K. Miyazaki, K. Urano, S. Horie, M. Kumagai, S. Fukushima, Y. Cheng, W. -D. Jang, M. Kikuchi, K. Kataoka
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Journal Title
J. Control. Release 133(3)
Pages: 245-251
Related Report
Peer Reviewed
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[Journal Article] Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue.2008
Author(s)
K. Miyata, M. Oba, M.R. Kano, S. Fukushima, Y. Vachutinsky, M. Han, H. Koyama, K. Miyazono, N. Nishiyama, K. Kataoka
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Journal Title
Pharm. Res. 25(12)
Pages: 2924-2936
Related Report
Peer Reviewed
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[Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-signaling.2007
Author(s)
M.R. Kano, Y. Bae, C. Iwata, Y. Morishita, M. Yashiro, M. Oka, T. Fujii, A. Komuro, K. Kiyono, M. Kaminishi, K. Hirakawa, Y. Ouchi, N. Nishiyama, K. Kataoka, K. Miyazono
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Journal Title
Proc. Natl. Acad. Sci. U.S.A. 104(9)
Pages: 3460-3465
Related Report
Peer Reviewed
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[Book] 血管医学2007
Author(s)
西山伸宏、片岡一則
Publisher
ドラッグデリバリーシステム(DDS)と血管
Related Report
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[Book] ゲノム医学2007
Author(s)
西山伸宏、片岡一則
Publisher
分子標的治療薬とDDSの融合とのその可能性
Related Report
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[Book] 呼吸と循環2007
Author(s)
西山伸宏、鄭雄一、片岡一則
Publisher
循環器疾患の治療のためのナノDDS
Related Report
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