Analysis of retinoid-responsive gene networks
| Project/Area Number |
19681021
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied genomics
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| Research Institution | Toho University |
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Principal Investigator |
YANAI Kazuyuki Toho University, 理学部, 准教授 (30360704)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2007: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 機能ゲノミクス / 発生・分化 / ゲノム / 発現制御 / 遺伝子 / レチノイン酸受容体 / ヒトゲノム / 転写 / 核内受容体 |
|---|
| Research Abstract |
Retinoids play an important role in development, differentiation, and homeostasis. To identify RXR homodimer-binding sites in the human genome, we performed a modified yeast one-hybrid system and identified 250 potential RXR-binding sites. In addition, TOHO rSNP database will be important for the elucidation of the physiological functions of RXRs.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q.2008
Author(s)
Takeuchi F, Ochiai Y, Serizawa M, Yanai K, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi Y, Yasuda K, Shirasawa S, Sasazuki T, Kato N.
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Journal Title
J Hum Genet. 53(4)
Pages: 314-24
Related Report
Peer Reviewed
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[Journal Article] High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project.2008
Author(s)
Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakayama T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H
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Journal Title
Hum Mol Genet. 17(4)
Pages: 617-27
Related Report
Peer Reviewed
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