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Analysis of retinoid-responsive gene networks

Research Project

Project/Area Number 19681021
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Applied genomics
Research InstitutionToho University

Principal Investigator

YANAI Kazuyuki  Toho University, 理学部, 准教授 (30360704)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2007: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords機能ゲノミクス / 発生・分化 / ゲノム / 発現制御 / 遺伝子 / レチノイン酸受容体 / ヒトゲノム / 転写 / 核内受容体
Research Abstract

Retinoids play an important role in development, differentiation, and homeostasis. To identify RXR homodimer-binding sites in the human genome, we performed a modified yeast one-hybrid system and identified 250 potential RXR-binding sites. In addition, TOHO rSNP database will be important for the elucidation of the physiological functions of RXRs.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 2008 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (10 results) Remarks (2 results)

  • [Journal Article] Identification and characterization of glucocorticoid receptor-binding sites in the human genome.2010

    • Author(s)
      Taniguchi-Yanai K, Koike Y, Hasegawa T, Furuta Y, Serizawa M, Ohshima N, Kato N, Yanai K.
    • Journal Title

      J Recept Signal Transduct Res. 30(2)

      Pages: 88-105

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of glucocorticoid receptor-binding sites in the human genome.2010

    • Author(s)
      Taniguchi-Yanai K, Koike Y, Hasegawa T, Furuta Y, Serizawa M, Ohshima N, Kato K, Yanai K.
    • Journal Title

      J Recept Signal Transduct Res. 30

      Pages: 88-105

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population.2009

    • Author(s)
      Tsuchihashi-Makaya M, Serizawa M, Yanai K, Katsuya T, Takeuchi T, Fujioka A, Yamori Y, Ogihara T, Kato N
    • Journal Title

      Hypertens Res. 32(3)

      Pages: 207-13

    • NAID

      10024830066

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population.2009

    • Author(s)
      Tsuchihashi-Makaya M, Serizawa M, Yanai K, Katsuya T, Takeuchi T, Fujioka A, Yamori Y, Ogihara T, Kato N
    • Journal Title

      Hypertens Res. 32

      Pages: 209-217

    • NAID

      10024830066

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q.2008

    • Author(s)
      Takeuchi F, Ochiai Y, Serizawa M, Yanai K, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi Y, Yasuda K, Shirasawa S, Sasazuki T, Kato N.
    • Journal Title

      J Hum Genet. 53(4)

      Pages: 314-24

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation.2008

    • Author(s)
      Tanimoto K, Sugiura A, Kanafusa S, Saito T, Masui N, Yanai K, Fukamizu A.
    • Journal Title

      J Clin Invest. 118(3)

      Pages: 1006-16

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project.2008

    • Author(s)
      Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakayama T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H
    • Journal Title

      Hum Mol Genet. 17(4)

      Pages: 617-27

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] DNA-タンパク相互作用検出を目指した新しい架橋剤の合成と性質」2010

    • Author(s)
      山内翔偉・山岸英明・豊島拓也・柳内圭子・長谷川貴士・柳内和幸・渡邊総一郎
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      近畿大学、本部キャンパス
    • Year and Date
      2010-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] エストロゲン応答性の違いを生むヒトゲノム上のSNPの同定2009

    • Author(s)
      柳内圭子、高橋磨理子、古田裕一、長谷川貴士、大島範子、柳内和幸
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒトゲノムからのレチノイドX受容体結合配列の系統的な同定とその解析2009

    • Author(s)
      古田裕一、柳内圭子、池嶋真奈、渡邊未知也、今井友理香、中山美佳、伊藤真弓、高橋磨理子、大島範子、柳内和幸
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒトゲノムからのHepatocyte Nuclear Factor 4結合配列の系統的な同定2009

    • Author(s)
      長谷川貴士、柳内圭子、渡邉未知也、今井友理香、中山美佳、伊藤真弓、大島範子、柳内和幸
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] エストロゲン応答性の違いを生むヒトゲノム上のSNPの同定」2009

    • Author(s)
      柳内圭子、高橋磨理子、古田裕一、長谷川貴士、大島範子、柳内和幸
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川、パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒトゲノムからのレチノイドX受容体結合配列の系統的な同定とその解析2009

    • Author(s)
      古田裕一、柳内圭子、池嶋真奈、渡邊未知也、今井友理香、中山美佳、伊藤真弓、高橋磨理子、大島範子、柳内和幸
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川、パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒトゲノムからのHepatocyte Nuclear Factor 4結合配列の系統的な同定2009

    • Author(s)
      長谷川貴士、柳内圭子、渡邉未知也、今井友理香、中山美佳、伊藤真弓、大島範子、柳内和幸
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      神奈川、パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] DNA-タンパク相互作用検出のための新しいクロスリンカーの合成2009

    • Author(s)
      豊島拓也、青木淳一、平本隆祐、谷口圭子、柳内和幸、渡邊総一郎
    • Organizer
      日本化学会第89春季年会
    • Place of Presentation
      千葉、日本大学理工学部船橋キャンパス
    • Year and Date
      2009-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] DNA-タンパク相互作用検出のための新しいクロスリンカーの合成2008

    • Author(s)
      豊島拓也, 谷口圭子, 柳内和幸, 渡邊総一郎
    • Organizer
      第2回東邦大学複合物性研究センターシンポジウム
    • Place of Presentation
      千葉、東邦大学
    • Year and Date
      2008-10-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 改良型Yeast One-Hybrid法を用いたヒトゲノムからのエストロゲン受容体結合配列の系統的な同定と解析」2008

    • Author(s)
      柳内圭子, 高橋磨理子, 古田裕一, 長谷川貴志, 大島範子, 柳内和幸
    • Organizer
      日本人類遺伝学会第53回大会
    • Place of Presentation
      神奈川、パシフィコ横浜
    • Year and Date
      2008-09-29
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.drkazu.com/TOHOrSNPdb.htm

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.drkazu.com/TOHOrSNPdb.htm

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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