| Budget Amount *help |
¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Research Abstract |
Small-molecule microarray and affinity matrix technologies have been developed. Firstly, by introducing a cleavable site in a photoactivatable linker, which is used to immobilize small molecules on an affinity matrix, validation of the immobilized small molecule on the affinity matrix became possible for the first time. The newly developed cleavable photoactivatable platform also permits the efficient detection of proteins covalently bound to the immobilized small molecule. Secondly, small-molecule microarray platforms that detect substrate specificity of cytochrome P450 have been developed.
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