| Budget Amount *help |
¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2007: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Research Abstract |
We have developed new zincate reagents with high functional group tolerance. A novel zincate complex consisting of isopropyl ligands and magnesium salt as a counter cation ((iPr)_nZn)(MgCl)_<n-2>) was designed. Reactions of highly functionalized aromatic iodides with the zincate resulted in halogen-metal interconversion with excellent reactivity and high ligand selectivity. We have also developed a new organosilyl zincate complex. The reagents were found to be useful for novel silyl-metalation reactions. The mechanism of these chemical reactions was fully analyzed on the basis of spectroscopic techniques and theoretical calculations. The chemical reactions we developed would offer a new synthetic approach for preparing organic molecules for applications in various fields such as material sciences, biotechnology, and organic syntheses.
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