Catalytic Asymmetric Hydrogenation of Polycyclic Aromatic Compounds
Project/Area Number |
19685008
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Single-year Grants |
Research Field |
Synthetic chemistry
|
Research Institution | Kyushu University |
Principal Investigator |
KUWANO Ryoichi Kyushu University, 大学院・理学研究院, 教授 (20273477)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2007: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
|
Keywords | 触媒的不斉合成 / 水素化 / 芳香族化合物 / ナフタレン / キノリン / 光学活性化合物 / ルテニウム / テトラリン / 5.6.7.8-テトラヒドロキノリン |
Research Abstract |
Hydrogenations of 2,6- or 2,7-disubstituted naphthalenes proceeded in high yields with high enantioselectivity in the presence of the ruthenium complex which was chelated with the optically active bisphosphine, PhTRAP. The catalytic asymmetric hydrogenation produced optically active tetralines with up to 92% ee. The chiral ruthenium catalyst is also effective for the hydrogenation of quinolines to give 5,6,7,8-tetrahydroquinolines selectively. The asymmetric hydrogenation proceeded with up to 84% ee.
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Report
(4 results)
Research Products
(39 results)