Development of Asymmetric Supramolecular Catalysts with Antibodies and Transition Metal Complexes

• Project/Area Number: 19685010
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Polymer chemistry
• Research Institution: Osaka University
• Principal Investigator: YAMAGUCHI Hiroyasu Osaka University, 大学院・理学研究科, 講師 (00314352)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2007: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: モノクローナル抗体 / 遷移金属錯体 / 超分子 / 立体選択性 / 不斉触媒 / エネルギー変換 / 触媒 / 抗原抗体反応 / 光学活性 / 不斉認識 / 不斉反応

Research Abstract

Some monoclonal antibodies which can bind organic metal complexes with high specificity and high affinity were prepared in order to construct a specific reaction field utilizing their antigen-binding sites. Unique functions were developed by the incorporation of metal complexes into the binding site of monoclonal antibodies. Monoclonal antibodies for stereoisomers of transition metal complexes or enantiomers of organic compounds were also prepared successfully.

Research Products

• [Journal Article] Photoinduced Hydrogen Evolution System with an Antibody-Porphyrin Complex as a Photosensitizer (2009)
  • Author(s): Yamaguchi, H., Onji, T., Ohara, H., Ikeda, N., Harada, A.
  • Journal Title: Bull. Chem. Soc. Jpn. 82 Pages: 1341-1346
  • NAID: 10027169857
  • Peer Reviewed
• [Journal Article] Polymeric Rotaxanes (2009)
  • Author(s): Harada, A., Hashidzume, A., Yamaguchi, H., Takashima, Y.
  • Journal Title: Chem. Rev. 109 Pages: 5974-6023
  • Peer Reviewed
• [Journal Article] 自己組織化による超分子・分子マシンの構築 (2009)
  • Author(s): 原田明, 山口浩靖
  • Journal Title: 高分子 58 Pages: 457-460
  • NAID: 10025093480
• [Journal Article] Asymmetric Hydrogenation with Antibody-Achiral Rhodium Complex (2009)
  • Author(s): Yamaguchi, H., Hirano, T., Kiminami, H., Harada, A.
  • Journal Title: J. Biol. Inorg. Chem. 14
• [Journal Article] Self-Assembly of One- and Two- Dimensional Hemoprotein Systems by Polymerization through Heme-Heme Pocket Interactions (2009)
  • Author(s): Kitagishi, H., Kakikura, Y., Yamaguchi, H., Oohora, K., Harada, A., Hayashi, T.
  • Journal Title: Angew. Chem. Int. Ed. 48 Pages: 1271-1274
  • Peer Reviewed
• [Journal Article] Photoinduced Hydrogen Evolution System with an Antibody-Porphyrin Complex as a Photosensitizer (BCSJ Award Article) (2009)
  • Author(s): Yamaguchi, H.
  • Journal Title: Bull.Chem.Soc.Jpn. 82 Pages: 1341-1346
  • Peer Reviewed
• [Journal Article] Asymmetric Hydrogenation with Antibody-Achiral Rhodium Complex (2009)
  • Author(s): Yamaguchi, H.
  • Journal Title: J.Biol.Inorg.Chem. 14
• [Journal Article] Polymeric Rotaxanes (2009)
  • Author(s): Harada, A.
  • Journal Title: Chem.Rev. 109 Pages: 5974-6023
  • Peer Reviewed
• [Journal Article] Cyclodextrin-Based Supramolecular Polymers (2009)
  • Author(s): Harada, A.
  • Journal Title: Chem.Soc.Rev 38 Pages: 875-882
  • Peer Reviewed
• [Journal Article] Face Selective Translation of a Cyclodextrin Ring along an Axle (2009)
  • Author(s): Oshikiri, T.
  • Journal Title: Chem.Commun. Pages: 5515-5517
  • Peer Reviewed
• [Journal Article] 自己組織化による超分子・分子マシンの構築 (2009)
  • Author(s): 原田明
  • Journal Title: 高分子 58 Pages: 457-460
• [Journal Article] Self-Assembly of One-and Two-Dimensional Hemoprotein Systems by Polymerization through Heme-Heme Pocket Interactions (2009)
  • Author(s): Kitagishi, H.
  • Journal Title: Angew. Chem. Int. Ed. 48 Pages: 1271-1274
  • Peer Reviewed
• [Journal Article] Cyclodextrin-Based Supramolecular Polymers (2009)
  • Author(s): Harada, A.
  • Journal Title: Chem. Soc. Rev. 38(In press)
  • Peer Reviewed
• [Journal Article] Switching of Polymerization Activity of Cinnamoyl-alpha-Cyclodextrin (2009)
  • Author(s): Osaki, M.
  • Journal Title: Org. Biomol. Chem. 7(In press)
  • Peer Reviewed
• [Journal Article] Nanospheres with Polymerization Ability Coated by Polyrotaxane (2009)
  • Author(s): Osaki, M.
  • Journal Title: J. Org. Chem. 74(In press)
  • Peer Reviewed
• [Journal Article] Functionalized Antibodies as Biosensing Materials and Catalysts (2008)
  • Author(s): Yamaguchi, H., Harada, A.
  • Journal Title: Chem. Lett. 37 Pages: 1184-1189
  • NAID: 10024397389
  • Peer Reviewed
• [Journal Article] Functionalized Antibodies as Biosensing Materials and Catalysts (2008)
  • Author(s): Yamaguchi, H.
  • Journal Title: Chem. Lett. 37 Pages: 1184-1189
  • NAID: 10024397389
  • Peer Reviewed
• [Journal Article] Ring-Opening Polymerization of Cyclic Esters by Cyclodextrins (2008)
  • Author(s): Harada, A.
  • Journal Title: Acc. Chem. Res. 41 Pages: 1143-1152
  • Peer Reviewed
• [Journal Article] Construction of Chemical-Responsive Supramolecular Hydrogels from Guest-Modified Cyclodextrins (2008)
  • Author(s): Deng, W.
  • Journal Title: Chem. Asian J. 3 Pages: 687-695
  • Peer Reviewed
• [Journal Article] Construction of Chemical-Responsive Supramolecular Hydrogels from guest-Modified Cyclodixtrins (2008)
  • Author(s): Deng, W.
  • Journal Title: Chem. ASian J. in press
  • Peer Reviewed
• [Journal Article] Supramolecular Hemoprotein Linear Assembly by Successive Interprotein Heme-Heme Pocket Interactions (2007)
  • Author(s): Kitagishi, H., Oohora, K., Yamaguchi, H., Sato, H., Matsuo, T., Harada, A., Hayashi, T.
  • Journal Title: J. Am. Chem. Soc. 129 Pages: 10326-10327
  • Peer Reviewed
• [Journal Article] A Chemical-Responsive Supramolecular Hydrogel from Modified Cyclodixtrins (2007)
  • Author(s): Deng, W.
  • Journal Title: Angew. Chem, Int Ed. 46 Pages: 5144-5147
  • Peer Reviewed
• [Journal Article] Supranclecular Hemprotein Linear Assembly by Successive Interprotein Heme-Heme Pocket Interactions (2007)
  • Author(s): Kitagishi, H.
  • Journal Title: J. Am. Chem. Soc. 129 Pages: 10326-10327
  • Peer Reviewed
• [Journal Article] Face SElective [2] and [3] Rotaxanes: Kinetic Control of Threading direction of cyclodextrins (2007)
  • Author(s): Oshikiri, T.
  • Journal Title: Chem. Eur. J. 13 Pages: 7091-7098
  • Peer Reviewed
• [Presentation] ポルフィリン-抗体錯体を用いたエネルギー変換・触媒システム (2010)
  • Author(s): 山口浩靖, 原田明
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪)
  • Year and Date: 2010-03-29
• [Presentation] ポルフィリン-抗体錯体を用いたエネルギー変換・触媒システム (2010)
  • Author(s): 山口浩靖
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪府)
  • Year and Date: 2010-03-29
• [Presentation] モノクローナル抗体による遷移金属錯体の配位子の立体特異的認識 (2010)
  • Author(s): 祇園珠木, 山口浩靖, 原田明
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪)
  • Year and Date: 2010-03-28
• [Presentation] モノクロナール抗体を用いたピレン誘導体の光物性制御 (2010)
  • Author(s): 夛田まや子, 山口浩靖, 原田明
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪)
  • Year and Date: 2010-03-28
• [Presentation] モノクローナル抗体を用いたビナフチル誘導体の新規光学分割法の構築 (2010)
  • Author(s): 尾高友紀, 山口浩靖, 原田明
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪)
  • Year and Date: 2010-03-28
• [Presentation] モノクローナル抗体による遷移金属錯体の配位子の立体特異的認識 (2010)
  • Author(s): 祇園珠木
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪府)
  • Year and Date: 2010-03-28
• [Presentation] モノクロナール抗体を用いたピレン誘導体の光物性制御 (2010)
  • Author(s): 夛田まや子
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪府)
  • Year and Date: 2010-03-28
• [Presentation] モノクローナル抗体を用いたビナフチル誘導体の新規光学分割法の構築 (2010)
  • Author(s): 尾高友紀
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪府)
  • Year and Date: 2010-03-28
• [Presentation] Monoclonal Antibodies with Specific Binding Affinity for Binaphthyl Enantiomers (2010)
  • Author(s): Odaka, T., Yamaguchi, H., Harada, A.
  • Organizer: 239th ACS National Meeting
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2010-03-24
• [Presentation] Monoclonal Antibodies with Specific Binding Affinity for Binaphthyl Enantiomers (2010)
  • Author(s): Odaka, T.
  • Organizer: 239th ACS National Meeting
  • Place of Presentation: San Francisco (California, USA)
  • Year and Date: 2010-03-24
• [Presentation] Monoclonal Antibodies with Specific Binding Affinity for Binaphthyl Enantiomers (2009)
  • Author(s): Odaka, T., Yamaguchi, H., Harada, A.
  • Organizer: Osaka University Macromolecular Symposium '09
  • Place of Presentation: 大阪大学(大阪)
  • Year and Date: 2009-12-13
• [Presentation] Preparation of Monoclonal Antibodies for Ruthenium (II) Tris-Bipyridine Complex and Their Enantioselective Binding Properties (2009)
  • Author(s): Gionn, T., Yamaguchi, H., Harada, A.
  • Organizer: Osaka University Macromolecular Symposium '09
  • Place of Presentation: 大阪大学(大阪)
  • Year and Date: 2009-12-13
• [Presentation] Construction of Specific Reaction Control Systems Using Antigen Binding Sites of Antibodies (2009)
  • Author(s): Yamaguchi, H., Harada, A.
  • Organizer: Osaka University Macromolecular Symposium '09
  • Place of Presentation: 大阪大学(大阪)
  • Year and Date: 2009-12-13
• [Presentation] Monoclonal Antibodies with Specific Binding Affinity for Binaphthyl Enantiomers (2009)
  • Author(s): Odaka, T.
  • Organizer: Osaka University Macromolecular Symposium '09
  • Place of Presentation: 大阪大学(大阪府)
  • Year and Date: 2009-12-13
• [Presentation] Preparation of Monoclonal Antibodies for Ruthenium (II) Tris-Bipyridine Complex and Their Enantioselective Binding Properties (2009)
  • Author(s): Gionn, T.
  • Organizer: Osaka University Macromolecular Symposium'09
  • Place of Presentation: 大阪大学(大阪府)
  • Year and Date: 2009-12-13
• [Presentation] A Photoinduced Electron Transfer Based on Supramolecular Complex Formation of Porphyrin-PEG Derivatives with Aceptor-Modified Cyclodextrins (2009)
  • Author(s): Takeda, Y.
  • Organizer: Osaka University Macromolecular Symposium '09
  • Place of Presentation: 大阪大学(大阪府)
  • Year and Date: 2009-12-13
• [Presentation] Construction of Specific Reaction Control Systems Using Antigen Binding Sites of Antibodies (2009)
  • Author(s): Yamaguchi, H.
  • Organizer: Osaka University Macromolecular Symposium '09
  • Place of Presentation: 大阪大学(大阪府)
  • Year and Date: 2009-12-13
• [Presentation] モノクローナル抗体を用いた機能性超分子錯体の合成 (2009)
  • Author(s): 山口浩靖, 原田明
  • Organizer: 京都高分子研究所KIPS若手高分子シンポジウム
  • Place of Presentation: 京都大学(京都)
  • Year and Date: 2009-12-11
• [Presentation] モノクローナル抗体を用いた機能性超分子錯体の合成 (2009)
  • Author(s): 山口浩靖
  • Organizer: 京都高分子研究所KIPS若手高分子シンポジウム(招待講演)
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2009-12-11
• [Presentation] Construction of Chemical-Responsive Supramolecular Gels Using Guest-Modified Cyclodextrins (2009)
  • Author(s): Yamaguchi, H.
  • Organizer: GelSympo 2009 "Polymer Gels : Science and Technology as Advanced Soft Materials"
  • Place of Presentation: 関西大学(大阪府)
  • Year and Date: 2009-12-03
• [Presentation] Functionalized Catalysts with Monoclonal Antibodies (2009)
  • Author(s): Yamaguchi, H., Harada, A.
  • Organizer: IUPAC 5th International Symposium on Novel Materials and Synthesis (NMS-V)
  • Place of Presentation: Shanghai (China)
  • Year and Date: 2009-10-20
• [Presentation] Functionalized Catalysts with Monoclonal Antibodies (2009)
  • Author(s): Yamaguchi, H.
  • Organizer: IUPAC 5th International Symposium on Novel Materials and Synthesis (NMS-V)(招待講演)
  • Place of Presentation: Fudan University(Shanghai, China)
  • Year and Date: 2009-10-20
• [Presentation] フェナントレン誘導体に対するモノクロナール抗体の結合特性及び光化学的挙動 (2009)
  • Author(s): 夛田まや子, 山口浩靖, 原田明
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学工学部(熊本)
  • Year and Date: 2009-09-17
• [Presentation] 抗体-カーボンナノチューブ複合材料を用いた検出シグナルの増幅 (2009)
  • Author(s): 大井航
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学工学部(熊本県)
  • Year and Date: 2009-09-17
• [Presentation] ビナフチル光学異性体に特異的に結合するモノクローナル抗体の作製 (2009)
  • Author(s): 尾高友紀
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学工学部(熊本県)
  • Year and Date: 2009-09-17
• [Presentation] フェナントレン誘導体に対するモノクロナール抗体の結合特性及び光化学的挙動 (2009)
  • Author(s): 夛田まや子
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学工学部(熊本県)
  • Year and Date: 2009-09-17
• [Presentation] 機能性抗体超分子の合成 (2009)
  • Author(s): 山口浩靖, 原田明
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学工学部(熊本)
  • Year and Date: 2009-09-16
• [Presentation] ルテニウムトリスビピリジン錯体とモノクローナル抗体の錯体の光化学的特性 (2009)
  • Author(s): 祇園珠木, 山口浩靖, 原田明
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学工学部(熊本)
  • Year and Date: 2009-09-16
• [Presentation] ビナフチル光学異性体に特異的に結合するモノクローナル抗体の作製 (2009)
  • Author(s): 尾高友紀, 山口浩靖, 原田明
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学工学部(熊本)
  • Year and Date: 2009-09-16
• [Presentation] 機能性抗体超分子の合成 (2009)
  • Author(s): 山口浩靖
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学工学部(熊本県)
  • Year and Date: 2009-09-16
• [Presentation] ルテニウムトリスビピリジン錯体とモノクローナル抗体の錯体の光化学的特性 (2009)
  • Author(s): 祇園珠木
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学工学部(熊本県)
  • Year and Date: 2009-09-16
• [Presentation] アクセプター修飾シクロデキストリンとポルフィリン-PEG誘導体との超分子錯体形成に基づく光誘起電子移動 (2009)
  • Author(s): 竹田由実
  • Organizer: 第58回高分子討論会
  • Place of Presentation: 熊本大学工学部(熊本県)
  • Year and Date: 2009-09-16
• [Presentation] シクロデキストリンからなる超分子錯体のダイナミクス制御と機能化 (2009)
  • Author(s): 山口浩靖
  • Organizer: 第26回シクロデキストリンシンポジウム(招待講演)
  • Place of Presentation: 栃木県総合文化センター(栃木県)
  • Year and Date: 2009-09-09
• [Presentation] 電子アクセプター修飾シクロデキストリンを用いた光誘起電子移動システムの構築 (2009)
  • Author(s): 竹田由実
  • Organizer: 第26回シクロデキストリンシンポジウム
  • Place of Presentation: 栃木県総合文化センター(栃木県)
  • Year and Date: 2009-09-09
• [Presentation] 抗体-ポルフィリン錯体を光増感剤とする光誘起水素発生システム (2009)
  • Author(s): 山口浩靖, 陰地威史, 大原英剛, 池田憲昭, 原田明
  • Organizer: 第19回バイオ・高分子シンポジウム
  • Place of Presentation: 東京大学(東京)
  • Year and Date: 2009-07-30
• [Presentation] 抗体-ポルフィリン錯体を光増感剤とする光誘起水素発生システム (2009)
  • Author(s): 山口浩靖
  • Organizer: 第19回バイオ・高分子シンポジウム
  • Place of Presentation: 東京大学先端研(東京都)
  • Year and Date: 2009-07-30
• [Presentation] Asymmetric Hydrogenation with Antibody-Achiral Rhodium Complex (2009)
  • Author(s): Yamaguchi, H., Hirano, T., Kiminami, H., Harada, A.
  • Organizer: 14th International Conference on Biological Inorganic Chemistry
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-07-27
• [Presentation] ビナフチル基のキラリティを認識するモノクローナル抗体の作製 (2009)
  • Author(s): 尾高友紀
  • Organizer: 第55回高分子研究発表会(神戸)
  • Place of Presentation: 兵庫県民会館(兵庫県)
  • Year and Date: 2009-07-17
• [Presentation] Asymmetric Hydrogenation with Antibody-Achiral Rhodium Complex (2009)
  • Author(s): Yamaguchi, H.
  • Organizer: 14th International Conference on Biological Inorganic Chemistry
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2009-07-17
• [Presentation] 光学活性ビナフチル誘導体に対するモノクローナル抗体の作製 (2009)
  • Author(s): 尾高友紀, 山口浩靖, 原田明
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学(千葉)
  • Year and Date: 2009-03-29
• [Presentation] 抗体-カーボンナノチューブ複合材料の構築 (2009)
  • Author(s): 大井航
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学(千葉)
  • Year and Date: 2009-03-27
• [Presentation] Hydrogen Evolution System Using Artificial Porphyrin-Antibody Complexes (2009)
  • Author(s): Yamaguchi, H., Onji, T., Ohara, H., Ikeda, N., Harada, A.
  • Organizer: The 237th ACS National Meeting
  • Place of Presentation: Salt Lake City (USA)
  • Year and Date: 2009-03-24
• [Presentation] Hydrogen Evolution System Using Artificial Porphyrin-Antibody Complexes (2009)
  • Author(s): Yamaguchi, H.
  • Organizer: The 237th ACS National Meeting
  • Place of Presentation: Salt Lake City(USA)
  • Year and Date: 2009-03-24
• [Presentation] 抗体-遷移金属錯体を用いた不斉水素化触媒 (2008)
  • Author(s): 山口浩靖, 平野瞳子, 木南英明, 原田明
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪市立大学(大阪)
  • Year and Date: 2008-09-26
• [Presentation] 抗体-ポルフィリン錯体を光増感剤とする光誘起水素発生システム (2008)
  • Author(s): 山口浩靖, 陰地威史, 大原英剛, 池田憲昭, 原田明
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪市立大学(大阪)
  • Year and Date: 2008-09-26
• [Presentation] 牛血清アルブミン存在下でのスチルベン誘導体の光異性化反応 (2008)
  • Author(s): 夛田まや子
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪市立大学(大阪)
  • Year and Date: 2008-09-24
• [Presentation] A Hydrogen Evolution System Using Artificial Porphyrin-Antibody Complexes (2008)
  • Author(s): Yamaguchi, H., Onji, T., Ikeda, N., Harada, A.
  • Organizer: LXII Yamada Conference 2008
  • Place of Presentation: 淡路島(兵庫)
  • Year and Date: 2008-09-03
• [Presentation] Asymmetric Hydrogenation with Antibody-Achiral Rhodium Complex (2008)
  • Author(s): Yamaguchi, H., Hirano, T., Kiminami, H., Harada, A.
  • Organizer: LXII Yamada Conference 2008
  • Place of Presentation: 淡路島(兵庫)
  • Year and Date: 2008-09-03
• [Presentation] Construction of Chemical-Responsive Supramolecular Gels Using Guest-Modified Cyclodextrins (2008)
  • Author(s): Yamaguthi, H.
  • Organizer: LXII Yamada Conference 2008
  • Place of Presentation: 淡路島(兵庫)
  • Year and Date: 2008-09-03
• [Presentation] A Signal Amplifitation Method in a Biosensing System with Antibodies (2008)
  • Author(s): Yugawa, K.
  • Organizer: LXII Yamada Conference 2008
  • Place of Presentation: 淡路島(兵庫)
  • Year and Date: 2008-09-03
• [Presentation] Preparation of Monoclonal Antibodies against Ruthenium Tris-Bipyridine Comnlexes toward Enantioselective Molecular Recognition (2008)
  • Author(s): Gionn, T.
  • Organizer: LXII Yamada Conference 2008
  • Place of Presentation: 淡路島(兵庫)
  • Year and Date: 2008-09-03
• [Presentation] Photoinduced Electron Transfer by the Supramolecular Complex Formation of Porphyrin with Cyclodextrin Bearing Viologen (2008)
  • Author(s): Takeda, Y.
  • Organizer: LXII Yamada Conference 2008
  • Place of Presentation: 淡路島(兵庫)
  • Year and Date: 2008-09-03
• [Presentation] Photoisomerization Behavior of Stilbene Derivatives in the Presence of Bovine Serum Albumin (2008)
  • Author(s): Tada, M.
  • Organizer: LXII Yamada Conference 2008
  • Place of Presentation: 淡路島(兵庫)
  • Year and Date: 2008-09-03
• [Presentation] ルテニウム(II)トリスビピリジン錯体に対するモノクローナル抗体の作製 (2008)
  • Author(s): 祇園珠木, 夛田まや子, 山口浩靖, 原田明
  • Organizer: 第54回高分子研究発表会
  • Place of Presentation: 神戸(兵庫)
  • Year and Date: 2008-07-18
• [Presentation] ルテニウム(II)トリスビピリジン錯体に対するモノクローナル抗体の作製 (2008)
  • Author(s): 祇園珠木
  • Organizer: 第54回高分子研究発表会[神戸]
  • Place of Presentation: 神戸(兵庫)
  • Year and Date: 2008-07-18
• [Presentation] Construction of Biosensing Materials and Catalysts Using Monoclonal Antibodies (2008)
  • Author(s): Yamaguchi, H., Harada, A.
  • Organizer: The 3rd International Symposium on Polymer Chemistry (PC'2008)
  • Place of Presentation: Hefei (China)
  • Year and Date: 2008-06-17
• [Presentation] Construction of Biosensing Materials and Catalysts Using Monoclonal Antibodies (2008)
  • Author(s): Yamaguchi, H.
  • Organizer: The 3rd International Symposium on Polymer Chemistry(PC'2008)
  • Place of Presentation: Hefei(China)
  • Year and Date: 2008-06-17
• [Presentation] フルオレセイン-抗体錯体における特異的な光物理的特性 (2008)
  • Author(s): 山口浩靖
  • Organizer: 第57回高分子学会年次大会
  • Place of Presentation: 横浜(神奈川)
  • Year and Date: 2008-05-30
• [Presentation] 高分子添加による水溶性イリジウム錯体の発光増大 (2008)
  • Author(s): 小西 孝治
  • Organizer: 日本化学会春季年会
  • Place of Presentation: 立教大学
  • Year and Date: 2008-03-29
• [Presentation] ポルフィリン-高分子複合体形成によるポルフィリンからビオロゲンへの電子移動の制御 (2008)
  • Author(s): 陰地威史, 山口浩靖, 池田憲昭, 原田明
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学(東京)
  • Year and Date: 2008-03-28
• [Presentation] Construction of Chemical-Responsive Supramolecular Gels Using Guest-Modified Cyclodextrins (2008)
  • Author(s): Deng Wei
  • Organizer: 日本化学会春季年会
  • Place of Presentation: 立教大学
  • Year and Date: 2008-03-28
• [Presentation] 牛血清アルブミン存在下でのスチルベン誘導体の光異性化挙動 (2008)
  • Author(s): 山口 浩靖
  • Organizer: 日本化学会春季年会
  • Place of Presentation: 立教大学
  • Year and Date: 2008-03-28
• [Presentation] 抗体結合部位に取り込まれたフルオレセインの特異な光物理的挙動 (2008)
  • Author(s): 竹中 宏人
  • Organizer: 日本化学会春季年会
  • Place of Presentation: 立教大学
  • Year and Date: 2008-03-28
• [Presentation] ポルフィリンー高分子複合体形成仁よるポルフィリンからピオロゲンへの電子移動の制御 (2008)
  • Author(s): 陰山 威史
  • Organizer: 日本化学会春季年会
  • Place of Presentation: 立教大学
  • Year and Date: 2008-03-28
• [Presentation] 特異的結合特性を肴ずる抗ナルオシ.ヒイン抗体の特性 (2007)
  • Author(s): 竹中 宏人
  • Organizer: 第56回高分子討論会
  • Place of Presentation: 名古屋工業大学
  • Year and Date: 2007-09-20
• [Presentation] 抗体超分子を用いたセンシングシステム (2007)
  • Author(s): 山口浩靖, 原田明
  • Organizer: 第56回高分子討論会
  • Place of Presentation: 名古屋工業大学(愛知)
  • Year and Date: 2007-09-19
• [Presentation] 抗体超分子を用いたセンシングシステム (2007)
  • Author(s): 山口 浩靖
  • Organizer: 第56回高分子討論会
  • Place of Presentation: 名古屋工業大学
  • Year and Date: 2007-09-19
• [Presentation] Chemical-rcsponsivc Supramolecular Hydrogel Fromation Based on Self-Assembly of Modifide Cyclodextrin (2007)
  • Author(s): Wei Deng
  • Organizer: 第25回シクロデキストリンシンポジウム
  • Place of Presentation: 鳥取県立県民文化会館
  • Year and Date: 2007-09-11
• [Presentation] Asymmetric Hydrogenation with Antibody-Achiral Rhodium Complex (2007)
  • Author(s): Harada, A., Hirano, T., Kiminami, H., Yamaguchi, H.
  • Organizer: 12th IUPAC International Symposium on MacroMolecular Complexes
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2007-08-29
• [Presentation] Construction of a Hydrogen Evolution System by Using Artificial Porphyrin-Antibody Complexes (2007)
  • Author(s): Yamaguchi, H., Onji, T., Ikeda, N., Harada, A.
  • Organizer: 12th IUPAC International Symposium on MacroMolecular Complexes
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2007-08-27
• [Presentation] Consturction of a Hydrogen Evolution System by Using Artificial Porphyrin-Antibody Complexes (2007)
  • Author(s): Yamaguchi, H.
  • Organizer: 12th IUPAC INternational Symposiurn on MacroMolecular Complexes
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2007-08-27
• [Presentation] Construction of Functionalized Catalysts Using Monoclonal Antibodies with Nonchiral Rhodium Complexes (2007)
  • Author(s): Yamaguchi, H., Hirano, T., Kiminami, H., Harada, A.
  • Organizer: 234th ACS National Meeting
  • Place of Presentation: Boston, MA (USA)
  • Year and Date: 2007-08-21
• [Presentation] Construction of Functionalized Catalysts Using MOnoclonal Antbodics with Nonchiral Rhodiam Complexes (2007)
  • Author(s): Yamaguchi, H.
  • Organizer: 234th ACS National Meeting
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 2007-08-21
• [Presentation] 遷移金属錯体を抗原結合部位に導入したモノクローナル抗体による触媒機能制御 (2007)
  • Author(s): 山口浩靖, 平野瞳子, 木南英明, 原田明
  • Organizer: 第17回バイオ・高分子シンポジウム
  • Place of Presentation: 上智大学(東京)
  • Year and Date: 2007-07-30
• [Presentation] 遷移金属錯体を抗原結合部位に導入したモノクローナル抗体による触媒機能制御 (2007)
  • Author(s): 山口 浩靖
  • Organizer: 第17回バイオ・高分子シンポジウム
  • Place of Presentation: 上智大学
  • Year and Date: 2007-07-30
• [Presentation] ポルフィリン-抗体錯体を光増感剤とする水素発生システム (2007)
  • Author(s): 陰地威史, 山口浩靖, 池田憲昭, 原田明
  • Organizer: 第56回高分子学会年次大会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 2007-05-30
• [Presentation] ポルフィリンー抗体錯体を光増感剤とする水素発生システム (2007)
  • Author(s): 山口 浩靖
  • Organizer: 第56回高分子学会年次大会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2007-05-30
• [Presentation] モノクローナル抗体を用いた特異的TNT検出 (2007)
  • Author(s): 山口 浩靖
  • Organizer: 第56回高分子学会年次大会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2007-05-30
• [Presentation] 抗体結合部位に取り込まれた桂皮酸誘導体め光異性化反応 (2007)
  • Author(s): 山口 浩靖
  • Organizer: 第56回高分子学会年次大会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2007-05-30
• [Presentation] Supramolecular Hydrogel Formation BAsed on Self-assembilies of Modified Cyclodextrin (2007)
  • Author(s): Deng. W.
  • Organizer: 4th Asian Cyclodextrin conference
  • Place of Presentation: 同志社大学
  • Year and Date: 2007-05-18
• [Book] Sensor Deveropment Using Existing Scaffolds, Chemosensors: Principles, Strategies, and Applications (2010)
  • Author(s): Yamaguchi, H., Ogoshi, T., Harada, A.
  • Publisher: Wiley-VCH(in press)
• [Book] Sensor Development Using Existing Scaffolds in "Chemosensors : Principles, Strategies, and Applications" (2010)
  • Author(s): Yamaguchi, H.
  • Publisher: Wiley-VCH(in press)
• [Book] 抗体エンジニアリング, 超分子サイエンス&テクノロジー-基礎からイノベーションまで- (2009)
  • Author(s): 山口浩靖, 原田明
  • Publisher: NTS
• [Book] 抗体エンジニアリングin"超分子 サイエンス&テクノロジー -基礎からイノベーションまで-" (2009)
  • Author(s): 山口浩靖
  • Total Pages: 1340
  • Publisher: NTS
• [Book] 超分子サイエンス基礎から材料への展開 (2009)
  • Author(s): 原田明・山口浩靖
  • Publisher: NTS(In press)
• [Remarks]
  • URL: http://www.chem.sci.osaka-u.ac.jp/lab/harada/index.html
• [Patent(Industrial Property Rights)] 爆発物に対する抗体およびその製作方法 (2009)
  • Inventor(s): 原田明, 山口浩靖, 松本達, 上條憲一
  • Industrial Property Rights Holder: 日本電子株式会社,国立大学法人大阪大学
  • Industrial Property Number: 2009-119827
  • Filing Date: 2009-05-18
• [Patent(Industrial Property Rights)] 抗マラリア薬の抗体、ならびにモノクローナル抗体、およびその製作方法 (2009)
  • Inventor(s): 原田明, 山口浩靖, 松本達, 上條憲一
  • Industrial Property Rights Holder: 日本電子株式会社,国立大学法人大阪大学
  • Industrial Property Number: 2009-119829
  • Filing Date: 2009-05-18