Development of Asymmetric Supramolecular Catalysts with Antibodies and Transition Metal Complexes
| Project/Area Number |
19685010
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Polymer chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAGUCHI Hiroyasu Osaka University, 大学院・理学研究科, 講師 (00314352)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | モノクローナル抗体 / 遷移金属錯体 / 超分子 / 立体選択性 / 不斉触媒 / エネルギー変換 / 触媒 / 抗原抗体反応 / 光学活性 / 不斉認識 / 不斉反応 |
|---|
| Research Abstract |
Some monoclonal antibodies which can bind organic metal complexes with high specificity and high affinity were prepared in order to construct a specific reaction field utilizing their antigen-binding sites. Unique functions were developed by the incorporation of metal complexes into the binding site of monoclonal antibodies. Monoclonal antibodies for stereoisomers of transition metal complexes or enantiomers of organic compounds were also prepared successfully.
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Report
(4 results)
Research Products
(112 results)
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[Journal Article] Self-Assembly of One- and Two- Dimensional Hemoprotein Systems by Polymerization through Heme-Heme Pocket Interactions2009
Author(s)
Kitagishi, H., Kakikura, Y., Yamaguchi, H., Oohora, K., Harada, A., Hayashi, T.
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Journal Title
Angew. Chem. Int. Ed. 48
Pages: 1271-1274
Related Report
Peer Reviewed
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[Journal Article] Supramolecular Hemoprotein Linear Assembly by Successive Interprotein Heme-Heme Pocket Interactions2007
Author(s)
Kitagishi, H., Oohora, K., Yamaguchi, H., Sato, H., Matsuo, T., Harada, A., Hayashi, T.
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Journal Title
J. Am. Chem. Soc. 129
Pages: 10326-10327
Related Report
Peer Reviewed
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