Rational Design of Unnatural Substrates for Expanded Ribosomal Synthesis of Sequence-Regulated Compounds
Project/Area Number |
19685016
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Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Single-year Grants |
Research Field |
Chemistry related to living body
|
Research Institution | Kyoto University |
Principal Investigator |
SANDO Shinsuke Kyoto University, 稲盛フロンティア研究センター, 教授 (20346084)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2007: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
|
Keywords | 蛋白質 / リボソーム / 配列制御型合成 / 配列制御合成 / 核酸 / たんぱく質 / アミノ酸 |
Research Abstract |
The cellular translation system is a sophisticated molecular system that can polymerize substrates (amino acids) in a highly sequence-programmed manner to produce biomolecules (proteins). In this research, we challenged expansion of substrates that can be used for ribosomal-synthesis of a variety of artificial compounds, especially by chemical approach, and developed a new method for efficient use of such unnatural substrates.
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Report
(4 results)
Research Products
(10 results)