Development of a method for simultaneous measurement of artery-wall displacement and blood flow using ultrasonic echoes received by multi-channel array

• Project/Area Number: 19686026
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Measurement engineering
• Research Institution: Tohoku University
• Principal Investigator: HASEGAWA Hideyuki Tohoku University, 大学院医工学研究科, 准教授 (00344698)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 計測システム / 動脈壁変位 / 血流 / 多チャネル送受信 / 超音波 / 動脈硬化症

Research Abstract

心筋梗塞・脳梗塞などの重篤な循環器疾患は,動脈硬化症の進展にともない動脈壁に発生する病変の破裂により発生すると言われている.したがって,病変の破裂し易さに関係する動脈壁の弾性特性および破綻のトリガとなりうる血流の計測が重要である.本研究では,動脈壁の弾性特性と血流を同時に計測するために必要な高速(3500 Hz)超音波イメージング法を開発するとともに,それにより得られた超音波信号を解析することにより動脈壁のひずみ(弾性特性)および血流を描出する手法を開発した.

Research Products

• [Journal Article] Simultaneous imaging of artery-wall strain and blood flow by high frame rate acquisition of RF signals (2008)
  • Author(s): Hideyuki Hasegawa and Hiroshi Kanai
  • Journal Title: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control Vol. 55, No. 12 Pages: 2626-2639
  • NAID: 120002338360
  • Peer Reviewed
• [Journal Article] Reduction of influence of variation in center frequencies of RF echoes on estimation of artery-wall strain (2008)
  • Author(s): Hideyuki Hasegawa and Hiroshi Kanai
  • Journal Title: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control Vol. 55, No. 9 Pages: 1921-1934
  • NAID: 120002338359
  • Peer Reviewed
• [Journal Article] Ultrasonic measurement of strain distribution inside object cyclically compressed by dual acoustic radiation force (2008)
  • Author(s): Yoshitaka Odagiri, Hideyuki Hasegawa, and Hiroshi Kanai
  • Journal Title: Japanese Journal of Applied Physics Vol. 47, No. 5 Pages: 4193-4199
  • Peer Reviewed
• [Journal Article] Threshold setting for likelihood function for elasticity-based tissue classification of arterial wall by evaluating variance in measurement of radial strain (2008)
  • Author(s): Kentaro Tsuzuki, Hideyuki Hasegawa, Hiroshi Kanai, Masataka Ichiki, and Fumiaki Tezuka
  • Journal Title: Japanese Journal of Applied Physics Vol. 47, No. 5 Pages: 4180-4187
  • Peer Reviewed
• [Journal Article] Ultrasonic measurement of transient change in the stress-strain property of radial arterial wall caused by endothelial-dependent vasodilation (2008)
  • Author(s): Kazuki Ikeshita, Hideyuki Hasegawa, and Hiroshi Kanai
  • Journal Title: Japanese Journal of Applied Physics Vol. 47, No. 5 Pages: 4165-4169
  • Peer Reviewed
• [Journal Article] Automated segmentation of heart wall using coherence among ultrasonic RF echoes (2008)
  • Author(s): Takaomi Kinugawa, Hideyuki Hasegawa, and Hiroshi Kanai
  • Journal Title: Japanese Journal of Applied Physics Vol. 47, No. 5 Pages: 4165-4169
  • Peer Reviewed
• [Journal Article] Optimal region-of-interest settings for tissue characterization based on ultrasonic elasticity imaging (2008)
  • Author(s): Kentaro Tsuzuki, Hideyuki Hasegawa, Hiroshi Kanai, Masataka Ichiki, and Fumiaki Tezuka
  • Journal Title: Ultrasound in Medicine and Biology Vol. 34, No. 4 Pages: 573-585
  • Peer Reviewed
• [Journal Article] Optimal Region-of-Interest Settings for Tissue Characterization Based on Ultrasonic Elasticity Imaging (2008)
  • Author(s): Kentaro Tsuzuki
  • Journal Title: Ultrasound in Medicine and Biology 34 Pages: 573-585
  • Peer Reviewed
• [Journal Article] Reduction of Influence of Variation in Center Frequencies of RF Echoes on Estimation of Artery-Wall Strain (2008)
  • Author(s): Hideyuki Hasegawa
  • Journal Title: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 55 Pages: 1921-1934
  • NAID: 120002338359
  • Peer Reviewed
• [Journal Article] Simultaneous Imaging of Artery-Wall Strain and Blood Flow by High Frame Rate Acquisition of RF Signals (2008)
  • Author(s): Hideyuki Hasegawa
  • Journal Title: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 55 Pages: 2626-2639
  • NAID: 120002338360
  • Peer Reviewed
• [Journal Article] Measurement of angular dependence of ultrasonic scattering from wire phantom mimicking myocardial fiber (2007)
  • Author(s): Teppei Onodera, Hideyuki Hasegawa, and Hiroshi Kanai
  • Journal Title: Japanese Journal of Applied Physics Vol. 46, No. 7B Pages: 4897-4899
  • Peer Reviewed
• [Journal Article] Ultrasonic imaging of propagation of contraction and relaxation in the heart walls at high temporal resolution (2007)
  • Author(s): Hiroki Yoshiara, Hideyuki Hasegawa, Hiroshi Kanai, and Motonao Tanaka
  • Journal Title: Japanese Journal of Applied Physics Vol. 46, No. 7B Pages: 4889-4896
  • Peer Reviewed
• [Journal Article] Basic study on detection of outer boundary of arterial wall using its longitudinal motion (2007)
  • Author(s): Takanori Numata, Hideyuki Hasegawa, and Hiroshi Kanai
  • Journal Title: Japanese Journal of Applied Physics Vol. 46, No. 7B Pages: 4900-4907
  • Peer Reviewed
• [Journal Article] Measurement of angular dependence of ultrasonic echo for estimation of surface roughness (2007)
  • Author(s): Kazuki Kudo, Hideyuki Hasegawa, and Hiroshi Kanai
  • Journal Title: Japanese Journal of Applied Physics Vol. 46, No. 7B Pages: 4873-4880
  • Peer Reviewed
• [Journal Article] Ultrasonic measurement of change in elasticity due to endothelium dependent relaxation response by accurate detection of artery-wall boundary (2007)
  • Author(s): Takuya Kaneko, Hideyuki Hasegawa, and Hiroshi Kanai
  • Journal Title: Japanese Journal of Applied Physics Vol. 46, No. 7B Pages: 4881-4888
  • Peer Reviewed
• [Journal Article] Investigation of frequency characteristics in cutting of soft tissue using prototype ultrasonic knives (2007)
  • Author(s): Kosuke Ebina, Hideyuki Hasegawa, and Hiroshi Kanai
  • Journal Title: Japanese Journal of Applied Physics Vol. 46, No. 7B Pages: 4793-4800
  • Peer Reviewed
• [Journal Article] Accurate estimation of scattering strength distribution by simultaneous reception of ultrasonic echoes with multichannel transducer array (2007)
  • Author(s): Yusaku Abe, Hideyuki Hasegawa, and Hiroshi Kanai
  • Journal Title: Japanese Journal of Applied Physics Vol. 46, No. 7B Pages: 4813-4819
  • Peer Reviewed
• [Journal Article] Strain Imaging of Arterial Wall with Translational Motion Compensation and Error Correction (2007)
  • Author(s): Hideyuki Hasegawa
  • Journal Title: IEEE 2007 International Ultrasonics Symposium Proceedings Pages: 860-863
  • Peer Reviewed
• [Journal Article] 超音波RF信号の超高フレームレート収集による動脈壁のトラッキング (2007)
  • Author(s): 長谷川英之
  • Journal Title: 電子情報通信学会技術研究報告 107 Pages: 35-39
  • NAID: 110006452260
• [Presentation] 高周波超音波を用いた内皮依存性血管弛緩反応による橈骨動脈壁の粘弾性特性変化の計測 (2009)
  • Author(s): 池下和樹, 長谷川英之, 金井 浩
  • Organizer: 日本音響学会春季大会
  • Place of Presentation: 東京
• [Presentation] 血流速度ベクトルの計測を目指した超高速超音波イメージング (2008)
  • Author(s): 長谷川英之, 金井 浩
  • Organizer: 日本超音波医学会基礎技術研究会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-12
• [Presentation] Simultaneous Imaging of Artery-Wall Strain and Blood Flow Realized by High Frame Rate Acquisition of RF Echoes (2008)
  • Author(s): Hideyuki Hasegawa
  • Organizer: IEEE 2008 International Ultrasonics Symposium
  • Place of Presentation: 北京, 中国
  • Year and Date: 2008-11-02
• [Presentation] 超音波による動脈壁の変位計測に関する検討 (2008)
  • Author(s): 長谷川英之
  • Organizer: 電子情報通信学会応用音響研究会
  • Place of Presentation: 北京, 中国
  • Year and Date: 2008-08-04
• [Presentation] Viscoelasticity estimation of soft tissue for estimation of heat generation in application of ultrasonic surgical knife (2008)
  • Author(s): Naoki Suzuki, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: 29th Symposium on Ultrasonic Electronics
  • Place of Presentation: 仙台
• [Presentation] Measurement of scatterer-size dependent frequency characteristics of high frequency ultrasonic echoes for assessement of red blood cell aggregation (2008)
  • Author(s): Nobutaka Saitoh, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: 29th Symposimu on Ultrasonic Electronics
  • Place of Presentation: 仙台
• [Presentation] Optimization of window size and search region in 2D correlation function for assessment of regional myocardial contraction and relaxation (2008)
  • Author(s): Yasunori Honjo, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: 29th Symposium on Ultrasonic Electronics
  • Place of Presentation: 仙台
• [Presentation] Accuracy evaluation for high-frequency ultrasonic measurement of viscoelasticity of radial arterial wall by basic experiments (2008)
  • Author(s): Kazuki Ikeshita, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: 29th Symposium on Ultrasonic Electronics
  • Place of Presentation: 仙台
• [Presentation] Flow mediated change in viscoelasticity of radial artery noninvasively measured by 22-MHz ultrasound (2008)
  • Author(s): Kazuki Ikeshita, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: IEEE 2008 International Ultrasonics Symposium
  • Place of Presentation: 北京, 中国
• [Presentation] Accurate ultrasonic measurement of myocardial regional strain rate at high temporal and spatial resolutions (2008)
  • Author(s): Yasunori Honjo, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: IEEE 2008 International Ultrasonics Symposium
  • Place of Presentation: 北京, 中国
• [Presentation] Assessment of red blood cell aggregation using normalized power spectrum of high frequency ultrasound (2008)
  • Author(s): Nobutaka Saitoh, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: IEEE 2008 International Ultrasonics Symposium
  • Place of Presentation: 北京, 中国
• [Presentation] Simultaneous imaging of artery-wall strain and blood flow realized by high frame rate acquisition of RF echoes (2008)
  • Author(s): Hideyuki Hasegawa and Hiroshi Kanai
  • Organizer: IEEE 2008 International Ultrasonics Symposium
  • Place of Presentation: 北京, 中国
• [Presentation] 橈骨動脈壁のFlow-Mediated Dilationによる粘弾性特性の変化の高周波超音波による計測 (2008)
  • Author(s): 池下和樹, 長谷川英之, 金井 浩
  • Organizer: 日本超音波医学会第81回学術集会
  • Place of Presentation: 神戸
• [Presentation] 血管壁の弾性計測 (2008)
  • Author(s): 長谷川英之, 金井 浩
  • Organizer: 日本超音波医学会第81回学術集会
  • Place of Presentation: 神戸
• [Presentation] 内皮依存性弛緩反応による橈骨動脈壁粘弾性特性変化の超音波計測 (2008)
  • Author(s): 池下和樹, 長谷川英之, 金井 浩
  • Organizer: 日本音響学会春季大会
  • Place of Presentation: 千葉
• [Presentation] Accurate Tracking of Arterial Wall at High Frame Rate (2007)
  • Author(s): Hideyuki Hasegawa
  • Organizer: 28th Symposium on Ultrasonic Electronics
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2007-11-14
• [Presentation] Strain Imaging of Arterial Wall with Translational Motion Compensation and Error Correction (2007)
  • Author(s): Hideyuki Hasegawa
  • Organizer: IEEE 2007 International Ultrasonics Symposium
  • Place of Presentation: Hilton New York, USA
  • Year and Date: 2007-10-28
• [Presentation] 超音波RF信号の超高フレームレート収集による動脈壁のトラッキング (2007)
  • Author(s): 長谷川英之
  • Organizer: 電子情報通信学会 超音波研究会
  • Place of Presentation: 東北大学
  • Year and Date: 2007-09-27
• [Presentation] 超音波RF信号の高フレームレート計測による動脈壁ひずみ・血流の同時計測 (2007)
  • Author(s): 長谷川英之
  • Organizer: 日本音響学会秋季大会
  • Place of Presentation: 山梨大学
  • Year and Date: 2007-09-19
• [Presentation] Accurate tracking of arterial wall at high frame rate (2007)
  • Author(s): Hideyuki Hasegawa and Hiroshi Kanai
  • Organizer: 28th Symposium on Ultrasonic Electronics
  • Place of Presentation: 筑波
• [Presentation] Evaluation of coherence among ultrasonic RF echoes for automated identification of heart wall (2007)
  • Author(s): Takaomi Kinugawa, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: 28th Symposium on Ultrasonic Electronics
  • Place of Presentation: 筑波
• [Presentation] Ultrasonic measurement of transient change in viscoelasticity of radial artery wall caused by endothelial-dependent vasodilation (2007)
  • Author(s): Kazuki Ikeshita, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: 28th Symposium on Ultrasonic Electronics
  • Place of Presentation: 筑波
• [Presentation] Optimization of elasticity-based tissue characterization of arterial wall by evaluating variance in measurement of radial strain (2007)
  • Author(s): Kentaro Tsuzuki, Hideyuki Hasegawa, Hiroshi Kanai, Masataka Ichiki, and Fumiaki Tezuka
  • Organizer: 28th Symposium on Ultrasonic Electronics
  • Place of Presentation: 筑波
• [Presentation] Ultrasonic measurement of displacement distribution inside object cyclically compressed by dual acoustic radiation force (2007)
  • Author(s): Yoshitaka Odagiri, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: 28th Symposium on Ultrasonic Electronics
  • Place of Presentation: 筑波
• [Presentation] Measurement of angular dependence of ultrasonic scattering from nylon phantom which mimics bundle of myocardial fibers (2007)
  • Author(s): Teppei Onodera, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: 28th Symposium on Ultrasonic Electronics
  • Place of Presentation: 筑波
• [Presentation] Minute roughness measurement using phase tracking for arterial wall diagnosis noninvasively in vivo (2007)
  • Author(s): Magnus Cinthio, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: IEEE 2007 International Ultrasonics Symposium
  • Place of Presentation: ニューヨーク, アメリカ合衆国
• [Presentation] Identification of heart wall based on coherence of ultrasonic RF echoes evaluated in frequency domain (2007)
  • Author(s): Takaomi Kinugawa, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: IEEE 2007 International Ultrasonics Symposium
  • Place of Presentation: ニューヨーク, アメリカ合衆国
• [Presentation] Transient change in hysteresis property of the arterial wall due to flow-mediated dilation (2007)
  • Author(s): Kazuki Ikeshita, Hideyuki Hasegawa, and Hiroshi Kanai
  • Organizer: IEEE 2007 International Ultrasonics Symposium
  • Place of Presentation: ニューヨーク, アメリカ合衆国
• [Presentation] Angular dependence of ultrasonic echo from surface with minute roughness (2007)
  • Author(s): Hideyuki Hasegawa, Kazuki Kudo, and Hiroshi Kanai
  • Organizer: IEEE 2007 International Ultrasonics Symposium
  • Place of Presentation: ニューヨーク, アメリカ合衆国
• [Presentation] Strain imaging of arterial wall with translational motion compensation and error correction (2007)
  • Author(s): Hideyuki Hasegawa and Hiroshi Kanai
  • Organizer: IEEE 2007 International Ultrasonics Symposium
  • Place of Presentation: ニューヨーク, アメリカ合衆国
• [Presentation] 超音波RF信号の高フレームレート計測による動脈壁ひずみ・血流の同時計測 (2007)
  • Author(s): 長谷川英之, 金井 浩
  • Organizer: 日本音響学会秋季大会
  • Place of Presentation: 甲府
• [Presentation] 内皮依存性弛緩反応時における橈骨動脈壁応力-ひずみ特性変化の超音波計測 (2007)
  • Author(s): 池下和樹, 長谷川英之, 金井 浩
  • Organizer: 日本音響学会秋季大会
  • Place of Presentation: 甲府
• [Presentation] 対象物の位置変化の相殺によるひずみ計測精度向上 (2007)
  • Author(s): 長谷川英之, 金井 浩
  • Organizer: 日本超音波医学会第80回学術集会
  • Place of Presentation: 鹿児島
• [Presentation] 動脈壁の位置変化の相殺と超音波中心周波数の推定によるひずみ計測精度向上 (2007)
  • Author(s): 長谷川英之, 金井 浩
  • Organizer: 第46回日本生体医工学会大会
  • Place of Presentation: 仙台
• [Book] Acoustical Imaging (Strain imaging for arterial wall with translational motion compensation and center frequency estimation) (pp. 19-25) (Iwaki Akiyama Ed.) (2008)
  • Author(s): Hideyuki Hasegawa and Hiroshi Kanai
  • Publisher: Springer
• [Book] Acoustical Imaging (2008)
  • Author(s): Hideyuki Hasegawa
  • Publisher: Springer
• [Book] Biomedical Applications of Vibration and Acoustics in Imaging and Characterizations (Strain induced by dual acoustic radiation force and its ultrasonic measurement) (pp. 41-55) (Mostafa Fatemi and Ahmed Al-Jumaily Ed.)
  • Author(s): Hideyuki Hasegawa and Hiroshi Kanai
  • Publisher: ASME Press
• [Remarks] ホームページ等
  • URL: http://www.ecei.tohoku.ac.jp/~hkanai/