| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2007: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
|
|---|
| Research Abstract |
The solubility of four pharmaceutical organic compounds in supercritical carbon dioxide and the solid-liquid-gas three-phase equilibria for eleven carbon dioxide + pharmaceutical organic compound systems, which are very important to understand and design the rapid expansion of supercritical solutions (RESS) technique, were measured. The nano-sized spherical particles (dav ≈ 200 nm) with the narrow particle size distribution of RS-(±)-ibuprofen, acetylsalicylic acid and theophylline were produced by the RESS technique. The properties of the nanoparticles produced by the RESS technique were found to be controlled by the supersaturation defined as the difference between the chemical potential of the solute at the section of preparing the supercritical solution saturated with the solute and that at the section of the collection of the produced particles.
|
