Development of basic technologies for the practical production and particulate design of pharmaceutical organic nanoparticles by the rapid expansion of supercritical solutions (RESS) technique
| Project/Area Number |
19686046
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | Shinshu University |
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Principal Investigator |
UCHIDA Hirohisa Shinshu University, 工学部, 准教授 (70313294)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2007: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
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| Keywords | 超臨界二酸化炭素 / 医薬用有機物 / 超臨界溶体急速膨張法 / 晶析 / ナノ粒子 / 粒子設計 / 溶解度 / 気液固三相平衡 / 相関 |
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| Research Abstract |
The solubility of four pharmaceutical organic compounds in supercritical carbon dioxide and the solid-liquid-gas three-phase equilibria for eleven carbon dioxide + pharmaceutical organic compound systems, which are very important to understand and design the rapid expansion of supercritical solutions (RESS) technique, were measured. The nano-sized spherical particles (dav ≈ 200 nm) with the narrow particle size distribution of RS-(±)-ibuprofen, acetylsalicylic acid and theophylline were produced by the RESS technique. The properties of the nanoparticles produced by the RESS technique were found to be controlled by the supersaturation defined as the difference between the chemical potential of the solute at the section of preparing the supercritical solution saturated with the solute and that at the section of the collection of the produced particles.
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Report
(4 results)
Research Products
(67 results)
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[Presentation]2007
Author(s)
根橋直大, 小林徹郎, 佐藤少謙, 中西英貴, 内田博久, 杉本宣裕, 伊藤真義
Organizer
化学工学会第39回秋季大会
Place of Presentation
札幌
Year and Date
2007-09-14
Related Report
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