| Budget Amount *help |
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Research Abstract |
In this project, we carried out structural and biochemical studies on bacterial intramembrane proteases so as to elucidate the molecular mechanism of the regulated intramembrane proteolysis (RIP). We succeeded in purifying one of the intramembrane proteases with high purity and stability. In addition, we have found that the extracellular region of proteases is involved in the interaction with the substrate in the course of RIP.
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