Structural studies on the cellular machineries involved in protein disulfide bond generation

• Project/Area Number: 19687005
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Structural biochemistry
• Research Institution: Kyushu University
• Principal Investigator: INABA Kenji Kyushu University, 生体防御医学研究所, 准教授 (10423039)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000); Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000); Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
• Keywords: ジスルフィド結合 / レドックス / 細胞品質管理 / DsbB / Ero1 / PDI / X線結晶構造解析 / 小胞体 / Erol / DsbA / ユビキノン / 膜蛋白質 / 大腸菌 / ジスルフイド結合 / 膜タンパク質

Research Abstract

The formation and cleavage of disulfide bonds play a critical role in the folding into native protein structure and the elimination of misfolded proteins. Receiving the support by a Grant-in-Aid for Young Scientists (A) from MEXT, I have accomplished structural and biochemical analyses of DsbB, an E. coli membrane protein, and Ero1α, a human flavoenzyme, both of which are responsible for protein disulfide bond generation in cells. I also succeeded in the crystal structure analysis of ERdj5, a protein disulfide reductase that accelerates degradation of misfolded proteins and thereby clarified its mechanism of operation to drive the ER-associated degradation.

Research Products

• [Journal Article] Molecular basis of cyclic and specific disulfide interchange between human Ero1α and PDI (2011)
  • Author(s): Masui, S., Vavassori, S., Fagioli, C., Sitia, R., Inaba, K.
  • Journal Title: J.Biol.Chem. 286 Pages: 16261-16271
  • Peer Reviewed
• [Journal Article] Structural basis of an ERAD pathway mediated by the ER-resident disulfide reductase ERdj5 (2011)
  • Author(s): Hagiwara, M., Maegawa, K., Suzuki, M., Ushioda, R., Araki, K., Matsimoto, Y., Hoseki, J., Nagata, K., Inaba, K.
  • Journal Title: Mol.Cell 41 Pages: 432-444
  • Peer Reviewed
• [Journal Article] Homo-dimerization of Nemo-like kinase is essential for activation and nuclear localization (2011)
  • Author(s): Ishitani, S., Inaba, K., Matsumoto, K., Ishitani, T.
  • Journal Title: Mol.Biol.Cell 22 Pages: 266-277
  • NAID: 120004979399
  • Peer Reviewed
• [Journal Article] 小胞体品質管理を支えるジスルフィド結合形成・開裂因子の構造基盤 (2011)
  • Author(s): 稲葉謙次
  • Journal Title: 生体機能関連化学ニュースレター Vol.25 Pages: 3-6
• [Journal Article] Molecular bases of cyclic and specific disulfide interchange between Ero1α and PDI (2011)
  • Author(s): Masui, S., et al.
  • Journal Title: Journal of Biological Chemistry Volume: (in press)
  • Peer Reviewed
• [Journal Article] Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5 (2011)
  • Author(s): Hagiwara, M., et al.
  • Journal Title: Molecular Cell Volume: 41 Pages: 432-444
  • Peer Reviewed
• [Journal Article] Homo-dimerization of Nemo-like kinase is essential for activation and nuclear localization (2011)
  • Author(s): Ishitani, S., et al.
  • Journal Title: Molecular Biology of the Cell Volume: 22 Pages: 266-277
  • Peer Reviewed
• [Journal Article] 小胞体品質管理を支えるジスルフィド結合形成・開裂因子の構造基盤 (2011)
  • Author(s): 稲葉謙次
  • Journal Title: 生体機能関連化学ニュースレター Volume: 25 Pages: 3-6
• [Journal Article] Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI (2010)
  • Author(s): Inaba, K., Masui, S., Iida, H., Vavassori, S., Sitia, R., Suzuki, M.
  • Journal Title: EMBO J. 29 Pages: 3330-3343
  • NAID: 120002816360
  • Peer Reviewed
• [Journal Article] Structural basis of protein disulfide bond generation in the cell (2010)
  • Author(s): Inaba, K.
  • Journal Title: Genes to Cells 15 Pages: 935-943
  • Peer Reviewed
• [Journal Article] Redox-dependent intramolecular domain rearrangement of protein disulfide isomerase coupled with exposure of its substrate-binding hydrophobic surface. (2010)
  • Author(s): Serve, O., Kamiya, Y., Maeno, A., Nakano, M., Murakami, C., Sasakawa, H., Yamaguchi, Y., Harada, T., Kurimoto, E., Yagi-Utsumi, M., Iguchi, T., Inaba, K., Kikuchi, J., Asami, O., Kajino, T., Oka, T., Nakasako, M., Kato, K.
  • Journal Title: J.Mol.Biol. 396 Pages: 361-374
  • Peer Reviewed
• [Journal Article] Crystal structures of human Ero1a reveal the mechanisms of regulated and targeted oxidation of PDI (2010)
  • Author(s): Inaba, K., et al.
  • Journal Title: EMBO Journal Volume: 29 Pages: 3330-3343
  • Peer Reviewed
• [Journal Article] Structural basis of protein disulfide bond generation in the cell (2010)
  • Author(s): Inaba K.
  • Journal Title: Genes to Cells Volume: 15 Pages: 935-943
  • Peer Reviewed
• [Journal Article] Redox-dependent domain rearrangement of protein disulfide isomerase coupled with exposure of its substrate-binding hydrophobic surface (2010)
  • Author(s): Serve, et al.
  • Journal Title: Journal of Molecular Biology 396 Pages: 361-374
  • Peer Reviewed
• [Journal Article] Dynamic nature of disulfide bond formation catalysts revealed by crystal structures of DsbB (2009)
  • Author(s): Inaba, K., Murakami, S., Nakagawa, A., Iida, H., Kinjo, M., Ito, K., Suzuki, M.
  • Journal Title: EMBO J 28 Pages: 779-791
  • Peer Reviewed
• [Journal Article] Disulfide bond formation system in Eschericia coli (2009)
  • Author(s): Inaba, K.
  • Journal Title: J.Biochem. 146 Pages: 591-597
  • Peer Reviewed
• [Journal Article] DsbBの結晶構造が解かれるまでー臥薪嘗胆、初志貫徹 (2009)
  • Author(s): 稲葉謙次
  • Journal Title: 実験医学(羊土社) Vol.26 Pages: 945-948
• [Journal Article] 大腸菌におけるDsbB-DsbA タンパク質ジスルフィド結合形成システムの構造と機能発現メカニズム (2009)
  • Author(s): 稲葉謙次
  • Journal Title: 日本結晶学会誌 第51巻 Pages: 100-103
  • NAID: 10024820472
• [Journal Article] Dynamic nature of disulfide bond formation catalysts revealed by crystal structures of DsbB (2009)
  • Author(s): Inaba, K. *, Murakami, S., Nakagawa, A., Iida, H., Kinjo, M., Ito, K., Suzuki, M.
  • Journal Title: EMBO J 28 Pages: 779-791
  • Peer Reviewed
• [Journal Article] Disulfide bond formation system in Eschericia coli (2009)
  • Author(s): Inaba, K. *
  • Journal Title: J. Biochem. 146 Pages: 591-597
  • Peer Reviewed
• [Journal Article] Disulfide bond formation system in Eschericia coli (2009)
  • Author(s): Inaba, K.
  • Journal Title: Journal of Biochemistry 146 Pages: 591-597
  • Peer Reviewed
• [Journal Article] Dynamic nature of disulfide bond formation catalysts revealed by cry stal structures of DsbB (2009)
  • Author(s): Inaba, K., et.al.
  • Journal Title: EMBO Journal 28 Pages: 779-791
  • Peer Reviewed
• [Journal Article] 大腸菌におけるDsbB-DsbAタンパク質ジスルフィド結合形成システムの構造と機能発現メカニズム (2009)
  • Author(s): 稲葉謙次
  • Journal Title: 日本結晶学会誌 51 Pages: 100-103
  • NAID: 10024820472
  • Peer Reviewed
• [Journal Article] DsbBの結晶構造が解かれるまで-臥薪嘗胆、初志貫徹 (2009)
  • Author(s): 稲葉謙次
  • Journal Title: 実験医学(羊土社) 26 Pages: 945-948
• [Journal Article] A pair of circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of E.coli (2008)
  • Author(s): Inaba, K., Suzuki, M., Maegawa, K., Akiyama, S., Ito, K., Akiyama, Y.
  • Journal Title: J.Biol.Chem. 283 Pages: 35042-35052
  • Peer Reviewed
• [Journal Article] The disulfide bond formation (Dsb) system (2008)
  • Author(s): Ito, K., Inaba, K.
  • Journal Title: Curr.Opin.Struct.Biol. 18 Pages: 450-458
  • Peer Reviewed
• [Journal Article] Protein disulfide bond generation in Escherichia coli DsbB-DsbA (2008)
  • Author(s): Inaba, K.
  • Journal Title: J.Synchr.Rad. 15 Pages: 199-201
  • Peer Reviewed
• [Journal Article] Structure and mechanisms of the DsbB-DsbA disulfide bond generation machine (2008)
  • Author(s): Inaba, K., Ito, K.
  • Journal Title: Biochem.Biophys.Acta.Molecular Cell Research 1783 Pages: 520-529
  • Peer Reviewed
• [Journal Article] A pair of circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of E. coli (2008)
  • Author(s): Inaba, K., Suzuki, M., Maegawa, K., Akiyama, S., Ito, K., Akiyama, Y.
  • Journal Title: J. Biol. Chem. 283 Pages: 35042-35052
  • Peer Reviewed
• [Journal Article] The disulfide bond formation (Dsb) system (2008)
  • Author(s): Ito, K., Inaba, K.
  • Journal Title: Curr. Opin. Struct. Biol. 18 Pages: 450-458
  • Peer Reviewed
• [Journal Article] Protein disulfide bond generation in Escherichia coli DsbB-DsbA (2008)
  • Author(s): Inaba, K. *
  • Journal Title: J. Synchr. Rad. 15 Pages: 199-201
  • Peer Reviewed
• [Journal Article] Structure and mechanisms of the DsbB-DsbA disulfide bond generation machine (2008)
  • Author(s): Inaba, K., Ito, K.
  • Journal Title: Biochem. Biophys. Acta. Molecular Cell Research 1783 Pages: 520-529
  • Peer Reviewed
• [Journal Article] The disulfide bond formation(Dsb)system (2008)
  • Author(s): Ito, K. and Inaba, K
  • Journal Title: Current Opinion in Structural Biology 18 Pages: 450-458
  • Peer Reviewed
• [Journal Article] Structure and mechanisms of the DsbB-DsbA disulfide bond generatio n machine (2008)
  • Author(s): Inaba, K. and Ito, K
  • Journal Title: Biochem. Biophys. Acta. Molecular Cell Research 1783 Pages: 520-529
  • Peer Reviewed
• [Journal Article] Protein disulfide bond generation in Escherichia coli DsbB-DsbA (2008)
  • Author(s): Inaba, K.
  • Journal Title: Journal of Synchrotron Radiation 15 Pages: 199-201
  • Peer Reviewed
• [Journal Article] A pair of circularly permutated PDZ domains control RseP, the S2P familv intramembrane nrotease of E. coli (2008)
  • Author(s): Inaba, K., et.al.
  • Journal Title: Journal of Biological Chemistry 283 Pages: 35042-35052
  • Peer Reviewed
• [Journal Article] Structure and mechanisms of the DsbB-DsbA disulfide bond generation machine. (2008)
  • Author(s): Inaba, K・Ito, K
  • Journal Title: Biochem. Biophys. Acta. Mol. Cell Res. 1783 Pages: 520-529
  • Peer Reviewed
• [Journal Article] Protein disulfide bond generation in Escherichia coli DsbB-DabA. (2008)
  • Author(s): Inaba, K
  • Journal Title: Journal of Synchrotron Radiation (in press)
  • Peer Reviewed
• [Journal Article] The disuifide bond formation(Dsb) system (2008)
  • Author(s): Ito, K・Inaba, K
  • Journal Title: Current Opinion in Structural Biology (in press)
  • Peer Reviewed
• [Journal Article] 構造が明らかにしたジスルフィド結合の形成機構 (2008)
  • Author(s): 稲葉 謙次, 伊藤 維昭
  • Journal Title: 蛋白質核酸酵素 52 Pages: 853-861
  • NAID: 40015530561
• [Journal Article] ジスルフィド結合の形成メカニズム (2008)
  • Author(s): 伊藤 維昭, 稲葉 謙次
  • Journal Title: Medical Bio 4 Pages: 58-65
  • NAID: 40015350673
• [Journal Article] タンパク質ジスルフィド結合の形成に関わる酵素群購造が明らかにしたそのメカニズム (2008)
  • Author(s): 稲葉 謙次
  • Journal Title: 酵素工学ニュース 57 Pages: 17-23
• [Journal Article] 構造が明らかにしたジスルフィド結合の形成機構 (2007)
  • Author(s): 稲葉謙次、伊藤維昭
  • Journal Title: 蛋白質核酸酵素、共立出版 Vol.52 Pages: 853-861
  • NAID: 40015530561
• [Journal Article] タンパク質ジスルフィド結合の形成に関わる酵素群-構造が明らかにしたそのメカニズム (2007)
  • Author(s): 稲葉謙次
  • Journal Title: 酵素工学ニュース、日本酵素工学会 Vol.57 Pages: 17-23
• [Journal Article] ジスルフィド結合の形成メカニズム (2007)
  • Author(s): 伊藤維昭、稲葉謙次
  • Journal Title: Medical Bio、オーム社 Vol.4 Pages: 58-65
  • NAID: 40015350673
• [Journal Article] 細胞内に張り巡らされた蛋白質ジスルフィドネットワーク (2007)
  • Author(s): 稲葉謙次、伊藤維昭
  • Journal Title: 蛋白質の一生 集中マスター、羊土社 Pages: 77-85
• [Journal Article] 構造が明らかにしたジスルフィド結合の形成機構 (2007)
  • Author(s): 稲葉謙次, 伊藤維昭
  • Journal Title: 蛋白質核酸酵素(共立出版) Vol.52 Pages: 853-861
  • NAID: 40015530561
• [Journal Article] 小胞体に内在するジスルフィド還元酵素ERdj5により促進される小胞体関連分解経路の構造的な基盤
  • Author(s): 萩原誠智、永田和宏、稲葉謙次
  • Journal Title: 新着論文ニュースレター
  • URL: http://first.lifesciencedb.jp/archives/2403#more-2403)
• [Presentation] 蛋白質ジスルフィド結合の形成および開裂に関わる細胞レドックスシステムの構造的基盤 (2011)
  • Author(s): 稲葉謙次
  • Organizer: 大阪大学蛋白質研究所セミナー
  • Place of Presentation: 大阪
• [Presentation] ヒト細胞中における蛋白質ジスルフィド結合形成システムEro1-PDIの分子基盤 (2011)
  • Author(s): 増井翔史, 他5名
  • Organizer: 大阪大学蛋白質研究所セミナー
  • Place of Presentation: 大阪
• [Presentation] Crystal structures of Ero1 and ERdj5 reveal the mechanisms of ER quality control in mammalian cells (2011)
  • Author(s): Inaba, K.
  • Organizer: The 7th G-COE international symposium on Stem Cells and Regenerative Medicine
  • Place of Presentation: シンガポール
• [Presentation] 細胞における蛋白質ジスルフィド結合形成の構造基盤 (2010)
  • Author(s): 稲葉謙次
  • Organizer: 日本生化学会北海道支部講演会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-15
• [Presentation] 細胞における蛋白質ジスルフィド結合形成の分子基盤 (2010)
  • Author(s): 稲葉謙次
  • Organizer: 東京工業大学資源化学研究所講演会
  • Place of Presentation: 横浜
  • Year and Date: 2010-01-22
• [Presentation] Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5 (2010)
  • Author(s): Inaba, K.
  • Organizer: The 10th conference of the Asian Crystallographic Association
  • Place of Presentation: Busan, Korea(invited)
• [Presentation] Structural basis of regulated protein disulfide bond formation in human cells (2010)
  • Author(s): Inaba, K.
  • Organizer: The 3rd international symposium on protein community
  • Place of Presentation: Nara, Japan(invited)
• [Presentation] Structures of mammalian Ero1a and ERdj5 (2010)
  • Author(s): Inaba, K.
  • Organizer: Gordon Reserch Conference on thiol-based redox regulation & signaling
  • Place of Presentation: Lucca, Italy(invited)
• [Presentation] Convergent evolution of the protein disulfide bond formation systems in the biological kingdoms (2010)
  • Author(s): 稲葉謙次
  • Organizer: BMB2010
  • Place of Presentation: 神戸(招待講演)
• [Presentation] Convergent evolution of the protein disulfide bond formation systems in the biological kingdoms (2010)
  • Author(s): 稲葉謙次
  • Organizer: BMB2010
  • Place of Presentation: 神戸
• [Presentation] ヒト細胞におけるタンパク質ジスルフィド結合形成システムEro1-PDIの分子基盤 (2010)
  • Author(s): 増井翔史, 他5名
  • Organizer: BMB2010
  • Place of Presentation: 神戸
• [Presentation] 細胞内の蛋白質ジスルフィド結合形成装置の構造的基盤 (2010)
  • Author(s): 稲葉謙次
  • Organizer: 日本結晶学会年会
  • Place of Presentation: 大阪
• [Presentation] Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5 (2010)
  • Author(s): Inaba, K.
  • Organizer: The 10th conference of the Asian Crystallographic Association
  • Place of Presentation: Busan, Korea
• [Presentation] Structural basis of regulated protein disulfide bond formation in human cells (2010)
  • Author(s): Inaba, K.
  • Organizer: The 3^<rd> international symposium on protein community
  • Place of Presentation: 奈良
• [Presentation] 小胞体品質管理にかかわるジスルフィド結合形成・開裂因子の分子基盤 (2010)
  • Author(s): 稲葉謙次
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌
• [Presentation] 小胞体内在性ジスルフィド結合還元酵素ERdj5を介した小胞体関連分解経路の構造的基盤 (2010)
  • Author(s): 前川憲一, 他8名
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌
• [Presentation] Crystal structures of mammalian human Ero1α and ERdj5, the enzymes involved in ER quality control (2010)
  • Author(s): Inaba, K.
  • Organizer: Gordon Research Conference on thiol-based redox regulation & signaling
  • Place of Presentation: Lucca, Italy
• [Presentation] Structures of mammalian Ero1a and ERdj5 (2010)
  • Author(s): Inaba, K.
  • Organizer: Gordon Reserch Conference on thiol-based redox regulation & signaling
  • Place of Presentation: Lucca, Italy
• [Presentation] Structural and mechanistic basis of protein disulfide bond generation in the cell (2010)
  • Author(s): Inaba, K.
  • Organizer: Fifty Years of Biophysics Research at Nagoya University
  • Place of Presentation: 名古屋
• [Presentation] 細胞品質管理に関わるタンパク質ジスルフィド結合形成・開裂因子の構造的基盤の確立 (2009)
  • Author(s): 稲葉謙次
  • Organizer: 第32回日本分子生物学会年会 第7回日本分子生物学会三菱化学奨励賞受賞記念講演会
  • Place of Presentation: 横浜(招待講演)
  • Year and Date: 2009-12-11
• [Presentation] 細胞品質管理に関わるタンパク質ジスルフィド結合形成・開裂因子の構造的基盤の確立 (2009)
  • Author(s): 稲葉謙次
  • Organizer: 第32回日本分子生物学会年会第7回日本分子生物学会三菱化学奨励賞受賞記念講演会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] Molecular basis for protein disulfide formation in the cell (2009)
  • Author(s): Inaba. K
  • Organizer: The 3^<rd> G-COE international symposium on Stem Cells and Regenerative Medicine
  • Place of Presentation: Singapore
  • Year and Date: 2009-02-16
• [Presentation] Structural basis of an ERAD pathway mediated by an ER-resident protein disulfide reductase, ERdj5 (2009)
  • Author(s): 稲葉謙次, 他5名
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 細胞品質管理に関わるタンパク質ジスルフィド結合形成・開裂因子の構造基盤の確立 (2009)
  • Author(s): 稲葉謙次
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] 細胞が蛋白質ジスルフィド結合を創りだす巧妙な仕組み (2009)
  • Author(s): 稲葉謙次
  • Organizer: 第17回農芸化学Frontiersシンポジウム
  • Place of Presentation: 福岡
• [Presentation] Structural and functional analyses of an ER-resident protein disulfide reductase, ERdj5 (2008)
  • Author(s): Maegawa, et.al.
  • Organizer: The 2nd Global COE International Symposium
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2008-11-09
• [Presentation] 細胞における蛋白質ジスルフィド結合形成の分子基盤 (2008)
  • Author(s): 稲葉謙次
  • Organizer: 東京大学化学生命工学第一回談話会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-02
• [Presentation] Structure and mechanism of the DsbB-DsbA protein disulfide generation system in E.coli (2008)
  • Author(s): Inaba, K.
  • Organizer: XXI Congress and General Assembly of the International union of Crystallography
  • Place of Presentation: Osaka, Japan(invited)
• [Presentation] Structural basis for protein disulfide generation in the cell (2008)
  • Author(s): Inaba, K.
  • Organizer: Gordon conference on thiol-based redox regulation & signaling
  • Place of Presentation: Lucca, Italy(invited)
• [Presentation] Structure and mechanism of the DsbB-DsbA protein disulfide generation system in E. coli (2008)
  • Author(s): Inaba, K.
  • Organizer: XXI Congress and General Assembly of the International union of Crystallography
  • Place of Presentation: Osaka, Japan
• [Presentation] Structural basis for protein disulfide generation in the cell (2008)
  • Author(s): Inaba, K.
  • Organizer: Gordon conference on thiol-based redox regulation & signaling
  • Place of Presentation: Lucca, Italy
• [Presentation] Structural basis for protein disulfide generation in the cell (2008)
  • Author(s): Inaba, K
  • Organizer: Gordon conference on thiol-based redox regulati on & signaling
  • Place of Presentation: Lucca, Italy
• [Presentation] Structure and mechanism of the DsbB-DsbA protein disulfide generati on system in E. coli (2008)
  • Author(s): Inaba. K
  • Organizer: XXI Congress and General Assembly of the Int ernational Union of Crystallography
  • Place of Presentation: Osaka, Japan
• [Presentation] Molecular basis for protein disulfide bond formation in E. coli (2008)
  • Author(s): Inaba. K
  • Organizer: BMB2008
  • Place of Presentation: Kobe, Japan
• [Presentation] 小胞体に内在するジスルフィド結合還元酵素ERdj5の構造・機能解析 (2008)
  • Author(s): 前川憲一, 他
  • Organizer: The 2nd Global COE International Symposium
  • Place of Presentation: 福岡
• [Presentation] Dsbシステム、チオレドキシンフォールド、ジスルフィド結合 (2008)
  • Author(s): 稲葉謙次
  • Organizer: 蛋白質の一生キーワード (共立出版)
  • Place of Presentation: 940, 969, 10431
• [Presentation] Struchtural and chemincal basis for disulfide bond formation in the cell(invited lecture) (2008)
  • Author(s): Inaba, K.
  • Organizer: G-COE International Symposium on Frontier of Organelle Dynamics and Portein Function
  • Place of Presentation: Nagoya, Japan
• [Presentation] Structural basis of the DsbA-DsbB-UQ oxidative system in E.coli. (2007)
  • Author(s): Inaba, K.
  • Organizer: Boden Conference on disulfide bonds and their role in protein folding and function
  • Place of Presentation: Queensland, Australia(invited)
• [Presentation] Structural basis of the DsbA-DsbB-UQ oxidative system in E. coli. (2007)
  • Author(s): Inaba, K.
  • Organizer: Boden Conference on disulfide bonds and their role in protein folding and function
  • Place of Presentation: Queensland, Australia
• [Presentation] Crystal structure of the DsbB-DsbA complex reveals a mechanism of protein disulfide bond generation in E. coli.(invited lecture) (2007)
  • Author(s): Inaba, K.
  • Organizer: 2nd International Symposium on Diffraciton strctrual Biology 2007
  • Place of Presentation: Tokyo, Japan
• [Presentation] Structural basis of the DsbA-DsbB-UQ oxidative system in E. coli.(invited lecture) (2007)
  • Author(s): Inaba, K.
  • Organizer: Boden Conference on disulfide bonds and their role in protein folding and function
  • Place of Presentation: Queensland, Australia
• [Presentation] 細胞におけるタンパク質ジスルフィド結合形成の仕組みを考える(招待講演) (2007)
  • Author(s): 稲葉 謙次
  • Organizer: 第45回日本生物物理学会年会
  • Place of Presentation: 横浜
• [Presentation] 第40回同本発生生物学会、第59回日本細胞生物学会合同大会 (2007)
  • Author(s): 稲葉 謙次
  • Organizer: Structrual balil for protein disulfide bond formation in the cell(招待講演)
  • Place of Presentation: 福岡
• [Presentation] 蛋白質ジスルフィド結合形成に関わる細胞システムの構造と機能(兼オーガナイザー) (2007)
  • Author(s): 稲葉 謙次
  • Organizer: 第7回日本蛋白質科学会年会
  • Place of Presentation: 仙台
• [Book] ジスルフィド結合、チオレドキシンフォールド、Dsb蛋白質 キーワード:蛋白質の一生 Vol.53 (2008)
  • Author(s): 稲葉謙次
  • Publisher: 共立出版
• [Book] ジスルフィド結合、チオレドキシンフォールド、Dsb蛋白質 (2008)
  • Author(s): 稲葉謙次
  • Total Pages: 9409691043
  • Publisher: 共立出版
• [Book] 細胞内に張り巡らされた蛋白質ジスルフィドネットワーク 蛋白質の一生 集中マスター (2007)
  • Author(s): 稲葉謙次、伊藤維昭
  • Publisher: 羊土社
• [Book] Crystal structure of the DsbB-DsbA complex reveals a mechanism of disulfide bond generation. (2007)
  • Author(s): Inaba, K., Ito, K.
  • Publisher: Spring 8 Research Frontier 2006
• [Book] The Structural and Chemical Basis of Protein Disulfide Bond Formation in E.coli (2007)
  • Author(s): Inaba, K.
  • Publisher: KEK Highlight 2006
• [Book] 細胞内に張り巡らされた蛋白質ジスルフィドネットワーク (2007)
  • Author(s): 稲葉謙次, 伊藤維昭
  • Publisher: 羊土社
• [Remarks] ホームページ
  • URL: http://www.bioreg.kyushu-u.ac.jp/labo/pgpc/
• [Remarks]
  • URL: http://www.bioreg.kyushu-u.ac.jp/labo/pgpc/
• [Remarks] 2009年12月第7回日本分子生物学会三菱化学奨励賞研究題目:細胞品質管理に関わるタンパク質ジスルフィド結合形成・開裂因子の構造基盤の確立
• [Remarks] 2009年4月文部科学大臣表彰若手科学者賞研究題目:細胞における蛋白質ジスルフィド結合形成の分子機構の研究
• [Remarks] 研究室ホームページ
  • URL: http://www.bioreg.kyushu-u.ac.jp/labo/pgpc/
• [Remarks] 研究室ホームページ
  • URL: http://www.bioreg.kyushu-u.ac.jp/labo/pgpc/
• [Remarks] 研究室ホームページ
  • URL: http://www.bioreg.kyushu-u.ac.jp/labo/Pgpc/
• [Remarks]
  • URL: http://www.bioreg.kyushu-u.ac.jp/labo/pgpc/