Crystallographic analyses of functional mechanisms of sensory receptors
| Project/Area Number |
19687006
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YAMASHITA Atsuko The Institute of Physical and Chemical Research, 分子シグナリング研究チーム, チームリーダー (10321738)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2007: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Keywords | TRPチャネル / 機械刺激受容チャネル / 結晶構造 / タンパク質 / シグナル伝達 / 神経科学 / 構造生物学 / 感覚受容 |
|---|
| Research Abstract |
We identified a structurally-stable cytosolic domain of a mechanosensitive TRP channel, and found that the domain is a crucial region for its mechanosensitive channel activity. Structural analysis of the domain was performed by X-ray crystallography. A couple of regions in the domain were successfully crystallized and their X-ray diffraction data were collected. Among them, crystallographic structure of one region was determined.
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Report
(4 results)
Research Products
(2 results)
