| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
|
|---|
| Research Abstract |
The acquired immune system, which can defend against all sorts of pathogens, is established by adequate selection of immature T cells in the thymus. We have discovered a new protease complex that we named "thymoproteasome" that is expressed exclusively in the cortical thymic epithelial cells, which mediate "positive selection," a process where useful T cells are selected and survive. We have demonstrated that the thymoproteasome regulate the positive selection by producing a unique peptide repertoire and presenting it to developing T cells.
|
