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Regulation of acquired immunity by thymus-specific proteasomes

Research Project

Project/Area Number 19687009
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Functional biochemistry
Research InstitutionThe University of Tokyo (2008-2009)
Tokyo Metropolitan Organization for Medical Research (2007)

Principal Investigator

MURATA Shigeo  The University of Tokyo, 大学院・薬学系研究科, 教授 (20344070)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords免疫 / 胸腺 / プロテアソーム / ペプチド / 正の選択 / T細胞 / タンパク質分解 / ユビキチン / シャペロン / 分子集合
Research Abstract

The acquired immune system, which can defend against all sorts of pathogens, is established by adequate selection of immature T cells in the thymus. We have discovered a new protease complex that we named "thymoproteasome" that is expressed exclusively in the cortical thymic epithelial cells, which mediate "positive selection," a process where useful T cells are selected and survive. We have demonstrated that the thymoproteasome regulate the positive selection by producing a unique peptide repertoire and presenting it to developing T cells.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (84 results)

All 2010 2009 2008 2007 Other

All Journal Article (48 results) (of which Peer Reviewed: 48 results) Presentation (32 results) Remarks (4 results)

  • [Journal Article] Genetic immunization based on the ubiquitin-fusion degradation pathway against Trypanosoma cruzi2010

    • Author(s)
      Chou B, Hiromatsu K, Hisaeda H, Duan X, Imai T, Murata S, Tanaka K, Himeno K
    • Journal Title

      Biochem Biophys Res Commun 392

      Pages: 277-282

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells2010

    • Author(s)
      Nitta T, Murata S, Sasaki K, Fujii H, Ripen AM, Ishimaru N, Koyasu S, Tanaka K, Takahama Y
    • Journal Title

      Immunity 32

      Pages: 29-40

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic immunization based on the ubiquitin-fusion degradation pathway against Trypanosoma cruzi2010

    • Author(s)
      Chou B
    • Journal Title

      Biochem Biophys Res Commun 392

      Pages: 277-282

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells2010

    • Author(s)
      Nitta T
    • Journal Title

      Immunity 32

      Pages: 29-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection.2009

    • Author(s)
      Tu L, Moriya C, Imai T, Ishida H, Tetsutani K, Duan X, Murata S, Tanaka K, Shimokawa C, Hisaeda H, et al.
    • Journal Title

      Eur J Immunol

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain2009

    • Author(s)
      Nishio K, Kim SW, Kawai K, Mizushima T, Yamane T, Hamazaki J, Murata S, Tanaka K, Morimoto Y
    • Journal Title

      Biochem Biophys Res Commun 390

      Pages: 855-860

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The 20S proteasome as an assembly platform for the 19S regulatory complex2009

    • Author(s)
      Hendil KB, Kriegenburg F, Tanaka K, Murata S, Lauridsen AM, Johnsen AH, Hartmann-Petersen R
    • Journal Title

      J Mol Biol 394

      Pages: 320-328

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones2009

    • Author(s)
      Kaneko T, Hamazaki J, Iemura S, Sasaki K, Furuyama K, Natsume T, Tanaka K, Murata S
    • Journal Title

      Cell 137

      Pages: 914-925

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis2009

    • Author(s)
      Kimura Y, Yashiroda H, Kudo T, Koitabashi S, Murata S, Kakizuka A, Tanaka K
    • Journal Title

      Cell 137

      Pages: 549-559

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exclusive expression of proteasome subunit {beta}5t in the human thymic cortex2009

    • Author(s)
      Tomaru U, Ishizu A, Murata S, Miyatake Y, Suzuki S, Takahashi S, Kazamaki T, Ohara J, Baba T, Iwasaki S, et al.
    • Journal Title

      Blood 113

      Pages: 5186-5191

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of proteasome assembly2009

    • Author(s)
      Murata S, Yashiroda H, Tanaka K
    • Journal Title

      Nat Rev Mol Cell Biol 10

      Pages: 104-115

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation2009

    • Author(s)
      Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, et al.
    • Journal Title

      Nat Cell Biol 11

      Pages: 123-132

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process2009

    • Author(s)
      Tonoki A, Kuranaga E, Tomioka T, Hamazaki J, Murata S, Tanaka K, Miura M
    • Journal Title

      Mol Cell Biol 29

      Pages: 1095-1106

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse2009

    • Author(s)
      Tokui K, Adachi H, Waza M, Katsuno M, Minamiyama M, Doi H, Tanaka K, Hamazaki J, Murata S, Tanaka F, et al.
    • Journal Title

      Hum Mol Genet 18

      Pages: 898-910

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection2009

    • Author(s)
      Tu L
    • Journal Title

      Eur J Immunol 39

      Pages: 3385-3394

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the de-ubiquitinating enzyme UCH37(human UCHL5)catalytic domain2009

    • Author(s)
      Nishio K
    • Journal Title

      Biochem Biophys Res Commun 390

      Pages: 855-860

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The 20S proteasome as an assembly platform for the 19S regulatory complex2009

    • Author(s)
      Hendil KB
    • Journal Title

      J Mol Biol 394

      Pages: 320-328

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assembly pathway of the mammalian proteasome base subcomplex is mediated by multiple specific chaperones2009

    • Author(s)
      Kaneko T
    • Journal Title

      Cell 137

      Pages: 914-925

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis2009

    • Author(s)
      Kimura Y
    • Journal Title

      Cell 137

      Pages: 549-559

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exclusive expression of proteasome subunit beta5t in the human thymic cortex2009

    • Author(s)
      Tomaru U
    • Journal Title

      Blood 113

      Pages: 5186-5191

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration throug2009

    • Author(s)
      Tokui, K.
    • Journal Title

      Human Molecular Genetics 29

      Pages: 898-910

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic evidence linking age-dependent attenuation of the 26S proteasome with aging p2009

    • Author(s)
      Tonoki, A.
    • Journal Title

      Molecular and Cellular Biology 29

      Pages: 1095-1106

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation2009

    • Author(s)
      Tokunaga, F.
    • Journal Title

      Nature Cell Biology 11

      Pages: 123-132

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of proteasome assembly2009

    • Author(s)
      Murata, S.
    • Journal Title

      Nature Reviews Molecular and Cellular Biology 10

      Pages: 104-115

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymic microenvironments for T-cell repertoire formation2008

    • Author(s)
      Nitta T, Murata S, Ueno T, Tanaka K, Takahama Y
    • Journal Title

      Adv Immunol 99

      Pages: 59-94

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hsp90-mediated assembly of the 26 S proteasome is involved in major histocompatibility complex class I antigen processing2008

    • Author(s)
      Yamano T, Mizukami S, Murata S, Chiba T, Tanaka K, Udono H
    • Journal Title

      J Biol Chem 283

      Pages: 28060-28065

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dissecting beta-ring assembly pathway of the mammalian 20S proteasome2008

    • Author(s)
      Hirano Y, Kaneko T, Okamoto K, Bai M, Yashiroda H, Furuyama K, Kato K, Tanaka K, Murata S
    • Journal Title

      EMBO J 27

      Pages: 2204-2213

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allele-selective effect of PA28 in MHC class I antigen processing2008

    • Author(s)
      Yamano T, Sugahara H, Mizukami S, Murata S, Chiba T, Tanaka K, Yui K, Udono H
    • Journal Title

      J Immunol 181

      Pages: 1655-1664

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modest cortex and promiscuous medulla for thymic repertoire formation2008

    • Author(s)
      Takahama Y, Tanaka K, Murata S
    • Journal Title

      Trends Immunol 29

      Pages: 251-255

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymoproteasome: probable role in generating positively selecting peptides2008

    • Author(s)
      Murata S, Takahama Y, Tanaka K
    • Journal Title

      Curr Opin Immunol 20

      Pages: 192-196

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical contribution of immunoproteasomes in the induction of protective immunity against Trypanosoma cruzi in mice vaccinated with a plasmid encoding a CTL epitope fused to green fluorescence protein2008

    • Author(s)
      Chou B, Hisaeda H, Shen J, Duan X, Imai T, Tu L, Murata S, Tanaka K, Himeno K
    • Journal Title

      Microbes Infect 10

      Pages: 241-250

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes2008

    • Author(s)
      Yashiroda H, Mizushima T, Okamoto K, Kameyama T, Hayashi H, Kishimoto T, Niwa S, Kasahara M, Kurimoto E, Sakata E, et al.
    • Journal Title

      Nat Struct Mol Biol 15

      Pages: 228-236

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymoproteasome : probable role in generating positively selecting peptides2008

    • Author(s)
      Murata, S.
    • Journal Title

      Current Opinion in Immunology 20

      Pages: 192-196

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modest cortex and promiscuous medulla for thymic repertoire formation2008

    • Author(s)
      Takahama, Y.
    • Journal Title

      Trends in Immunology 29

      Pages: 251-255

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dissecting beta-ring assembly pathway of the mammalian 20S proteasome2008

    • Author(s)
      Hirano, Y.
    • Journal Title

      The EMBO Journal 27

      Pages: 2204-2213

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allele-selective effect of PA28 in MHC class I antigen processing2008

    • Author(s)
      Yamano, T.
    • Journal Title

      Journal of Immunology 181

      Pages: 1655-1664

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hsp90-mediated assembly of the 26S proteasome is involved in major histocompatibility complex class I antigen2008

    • Author(s)
      Yamano, T.
    • Journal Title

      Journal of Biological Chemistry 283

      Pages: 28060-28065

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymic microenvironments for T-cell repertoire formation2008

    • Author(s)
      Nitta, T.
    • Journal Title

      Advances in Immunology 99

      Pages: 59-94

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes2008

    • Author(s)
      Yashiroda, H.
    • Journal Title

      Nat-Struct Mol Biol 15

      Pages: 228-236

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical contribution of immunoproteasomes in the induction of protective immunity against Trypansoma cruzi in mice vaccinated with a plasmid encoding a CTL epitope fused to green fluorescence protein2008

    • Author(s)
      Chou, B.
    • Journal Title

      Microbes Infect (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymoproteasome:probable role in generating positively selecting peptides2008

    • Author(s)
      Murata, S
    • Journal Title

      Curr Opin Immunol (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modest cortex and promiscuous medulla for thymic repertoire formation2008

    • Author(s)
      Takahama, Y.
    • Journal Title

      Trends Immunol (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice2007

    • Author(s)
      Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, et al.
    • Journal Title

      Cell 131

      Pages: 1149-1163

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development2007

    • Author(s)
      Hamazaki J, Sasaki K, Kawahara H, Hisanaga S, Tanaka K, Murata S
    • Journal Title

      Mol Cell Biol 27

      Pages: 6629-6638

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of CD8+ T cell development by thymus-specific proteasomes2007

    • Author(s)
      Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama Y, Tanaka K
    • Journal Title

      Science 316

      Pages: 1349-1353

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rpn 10-mediated degradation of ubiquitinated proteins is essential for mammalian development2007

    • Author(s)
      Hamazaki, J
    • Journal Title

      Mol Cell Biol 27

      Pages: 6629-6638

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of CD8+ T cell development by thymusspecific proteasomes2007

    • Author(s)
      Murata, S
    • Journal Title

      Science 316

      Pages: 1349-1353

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autoPhagv-deficient mice2007

    • Author(s)
      Komatsu, M.
    • Journal Title

      Cell 131

      Pages: 1149-1163

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] シャペロン依存的プロテアソーム形成機構と病態2009

    • Author(s)
      村田茂穂
    • Organizer
      日本生化学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Proteasome assembly in mammals2009

    • Author(s)
      Shigeo Murata
    • Organizer
      EMBO Ubiquitin Meeting
    • Place of Presentation
      イタリア
    • Year and Date
      2009-09-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Proteasome assembly in mammals2009

    • Author(s)
      村田茂穂
    • Organizer
      Ubiquitin and ubiquitin-like modifiers in health and disease
    • Place of Presentation
      IT-Riva del Garda Italia
    • Year and Date
      2009-09-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] プロテアソームの多様性による生命活動の制御とその分子基盤。2009

    • Author(s)
      村田茂穂
    • Organizer
      高遠シンポジウム
    • Place of Presentation
      長野
    • Year and Date
      2009-08-22
    • Related Report
      2009 Final Research Report
  • [Presentation] Mechanism of proteasome assembly in mammalian cells2009

    • Author(s)
      村田茂穂
    • Organizer
      The 66th KSBMB Annual Meeting
    • Place of Presentation
      韓国ソウル
    • Year and Date
      2009-05-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胸腺特異的プロテアソームによるT細胞の選別。2009

    • Author(s)
      村田茂穂
    • Organizer
      第28回日本胸腺研究会
    • Place of Presentation
      福岡
    • Year and Date
      2009-02-14
    • Related Report
      2009 Final Research Report
  • [Presentation] 胸腺特異的プロテアソームによるT細胞の選別2009

    • Author(s)
      村田茂穂
    • Organizer
      第28回日本胸腺研究会
    • Place of Presentation
      福岡
    • Year and Date
      2009-02-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Production of positively selecting peptides by thymus- specific proteasomes.2009

    • Author(s)
      Shigeo Murata
    • Organizer
      The 2nd international symposium of WPI-IFReC
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Production of positively selectingg peptides by thymus-specific proteasomes2009

    • Author(s)
      Murata, S.
    • Organizer
      The 2nd International Symposium of WPI-IFReC
    • Place of Presentation
      吹田
    • Year and Date
      2009-02-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dissecting the assembly pathway of the proteasome2009

    • Author(s)
      Shigeo Murata
    • Organizer
      The 32nd Annual Meeting of MBSJ
    • Place of Presentation
      Yokohama
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] シャペロン依存的プロテアソーム形成機構と病態。2009

    • Author(s)
      村田茂穂
    • Organizer
      日本生化学会年会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Mechanism of proteasome assembly in mammalian cells2009

    • Author(s)
      Shigeo Murata
    • Organizer
      The 66th KSBMB Annual Meeting
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2009 Final Research Report
  • [Presentation] プロテアソームの形成機構と病態。2008

    • Author(s)
      村田茂穂
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2009 Final Research Report
  • [Presentation] プロテアソームの形成機構と病態2008

    • Author(s)
      村田茂穂
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Production of positively selecting peptides by thymus- specific proteasomes.2008

    • Author(s)
      Shigeo Murata
    • Organizer
      Takeda Symposium
    • Place of Presentation
      東京
    • Year and Date
      2008-12-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Production of positively selectingg peptides by thymus-specific proteasomes2008

    • Author(s)
      Murata, S.
    • Organizer
      武田シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] プロテアソームの多様性による生命活動の制御とその分子基盤2008

    • Author(s)
      村田茂穂
    • Organizer
      高遠シンポジウム
    • Place of Presentation
      伊那
    • Year and Date
      2008-08-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Thymoproteasome regulate CD8+ T cell selection.2008

    • Author(s)
      Shigeo Murata
    • Organizer
      FASEB summer research conferences
    • Place of Presentation
      アメリカ
    • Year and Date
      2008-06-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Thymoproteasomes regulate CD8+ T cell selection2008

    • Author(s)
      Murata, S.
    • Organizer
      FASEB Summer Research conferences
    • Place of Presentation
      Vermont, USA
    • Year and Date
      2008-06-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 胸腺プロテアソームによる正の選択制御2008

    • Author(s)
      村田 茂穂
    • Organizer
      第17回東京免疫フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2008-03-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of positive selection of CD8 T cell bythymus-specific proteanomes2007

    • Author(s)
      村田 茂穂
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] プロテアソームによる適応免疫システム制御に関する研究2007

    • Author(s)
      村田 茂穂
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 哺乳類20Sプロテアソームの段階的な形成機構について2007

    • Author(s)
      平野 祐子
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] プロテアソーム分子集合因子PAC1欠損マウスの解析2007

    • Author(s)
      佐々木 克博
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] LUBACユビキチンリガーゼによるNEMOの直鎖型ポリユビキチン化修飾とNF-κB活性化2007

    • Author(s)
      徳永 文稔
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 26Sプロテアヅームにおけるp281Gankyrinの役割2007

    • Author(s)
      金子 岳海
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development2007

    • Author(s)
      濱崎 純
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] プロテアソームによる生体制御2007

    • Author(s)
      村田 茂穂
    • Organizer
      第2回臨床ストレス応答学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of positive selection of CDS T cell by thymusspecific proteanowes2007

    • Author(s)
      Murata, S.
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of positive selection of CD8 T cell by thymus-specific proteasowes2007

    • Author(s)
      Murata, S.
    • Organizer
      第7回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路島
    • Year and Date
      2007-09-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular basis for the diversity of mammalian proteasomes2007

    • Author(s)
      Murata, S
    • Organizer
      第59回日本細胞生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Thymoproteasomes regulate development of CD8+T cells in the thymus2007

    • Author(s)
      Murata, S
    • Organizer
      3rd Zeuthener see workshop 2007
    • Place of Presentation
      Berlin(Germany)
    • Year and Date
      2007-04-23
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.f.u-tokyo.ac.jp/~tanpaku/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.f.u-tokyo.ac.jp/~tanpaku/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.f.u-tokyo.ac.jp/~tanpaku/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.f.u-tokyo.ac.jp/~nbphome/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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