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Novel chaperonin-encapsulation system for aggregation-prone proteins.

Research Project

Project/Area Number 19687010
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Biophysics
Research InstitutionKyoto University

Principal Investigator

HOSHINO Masaru  Kyoto University, 薬学研究科, 准教授 (70304053)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2007: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
KeywordsNMR / 分子シャペロン / GroE / 会合・凝集 / 構造生物学 / CroE
Research Abstract

The protein has a central role in "vital activities", including digestion of foods, conversion of nutrients nto energy, and sensing external stimulations such as light or smell. These function of proteins depend n their specific tertiary structure, which could be visualized by nuclear magnetic resonance pectroscopy. A novel method which will allow the investigation of aggregation-prone proteins by NMR as developed.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009 2008 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results) Remarks (4 results)

  • [Journal Article] Chaperonin-encapsulation of proteins for NMR.2010

    • Author(s)
      S. Tanaka, Y. Kawata, G. Otting. N.E. Dixon, K. Matsuzaki, M. Hoshino
    • Journal Title

      Biochim. Biophys. Acta 1804

      Pages: 866-871

    • NAID

      120001981960

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chaperonin-encapsulation of proteins for NMR2010

    • Author(s)
      S.Tanaka, Y.Kawata, G.Otting, N.E.Dixon, K.Matsuzaki, M.Hoshino
    • Journal Title

      Biochimica et Biophysica Acta 1804

      Pages: 866-871

    • NAID

      120001981960

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 分子シャペロンカプセル化システムの構築2009

    • Author(s)
      増原泰英, 河田康志, 松崎勝巳, 星野大
    • Organizer
      第48回nmr討論会
    • Place of Presentation
      九州大学馬出病院キャンパス
    • Year and Date
      2009-11-10
    • Related Report
      2009 Final Research Report
  • [Presentation] 分子シャペロンカプセル化システムの構築2009

    • Author(s)
      増原泰英, 河田康志, 松崎勝巳, 星野大
    • Organizer
      第48回 NMR討論会
    • Place of Presentation
      九州大学馬出病院キャンパス
    • Year and Date
      2009-11-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 溶液nmrによる凝集性タンパク質の新規構造解析法2009

    • Author(s)
      田中慎治, 河田康志, 松崎勝巳, 星野大
    • Organizer
      日本薬学会第129回年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 溶液NMRによる凝集性タンパク質の新規構造解析法2009

    • Author(s)
      田中慎治, 河田康志, 松崎勝巳, 星野大
    • Organizer
      日本薬学会第129回年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 溶液高分解能nmrによる凝集性タンパク質の新規構造解析法の開発2008

    • Author(s)
      田中慎治, 河田康志, 松崎勝巳, 星野大
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-12-05
    • Related Report
      2009 Final Research Report
  • [Presentation] 溶液高分解能NMRによる凝集性タンパク質の新規構造解析法の開発2008

    • Author(s)
      田中慎治, 河田康志, 松崎勝巳, 星野大
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-12-05
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kyoto-u.ac.jp/yakkai/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.pharm.kyoto-u.ac.jp/yakkai/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kyoto-u.ac.jp/yakkai/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kyoto-u.ac.jp/yakkai/

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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