Clarification both of function and regulation of protein kinase NLK, that fine-tunes the activity of multiple intracellular signaling pathway.
| Project/Area Number |
19687013
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Kyushu University |
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Principal Investigator |
ISHITANI Tohru Kyushu University, 生体防御医学研究所, 特任准教授 (40448428)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | Nemo-like kinase / ゼブラフィッシュ / Wntシグナル / Notchシグナル / NLK / NGFシグナル / Notch シグナル |
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| Research Abstract |
Nemo-like kinase is a conserved protein kinase. In this study, we found that NLK promotes neurogenesis via phosphorylating Notch1 and that NLK contribute to neurite outgrowth via phosphorylating paxillin and MAP1B downstream of NGF signaling.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] NLK, an essential effector of anterior formation, functions downstream of p38 MAP kinase.2010
Author(s)
Ohnishi E, Goto T, Sato A, Kim MS, Iemura SI, Ishitani T, Natsume T, Ohnishi J, Shibuya H.
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Journal Title
Molecular and Cellular Biology. 30
Pages: 675-683
Related Report
Peer Reviewed
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[Presentation] Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.2010
Author(s)
Tohru Ishitani, Tomoko Hirao, Maho Suzuki, Miho Isoda, Shizuka Ishitani, Kenichi Harigaya, Motoo Kitagawa, Kunihiro Matsumoto, Motoyuki Itoh
Organizer
Keystone Symposia, Integration of Developmental Signaling Pathways
Place of Presentation
Victoria, Canada
Year and Date
2010-03-24
Related Report
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[Presentation] Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.2010
Author(s)
Tohru Ishitani, Tomoko Hirao, Maho Suzuki, Miho Isoda, Shizuka Ishitani, Kenichi Harigaya, Motoo Kitagawa, Kunihiro Matsumoto, Motoyuki Itoh
Organizer
Keystone Symposia, Integration of Developmental Signaling Pathways
Place of Presentation
Fairmont Empress Hotel, Victoria, Canada
Year and Date
2010-03-24
Related Report
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