| Budget Amount *help |
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
The fungus Ganoderma lucidum (Reishi, Mannentake, or Lingzhi) has been used for centuries in East Asia to treat various human diseases. We investigated anti-androgen effect and the inhibitory effects of osteoclastic differentiation of triterpenoids isolated from G lucidum in vitro. Ganoderic acid DM showed the strongest 512-reductase inhibiting effect among the other ten triterpenoids. Also, ganoderic acid DM inhibited the osteoclastic differentiation, which responding to receptor activator of NF-κB ligand (RANKL) and a tumor necrosis factor a (TNF-α). Ganoderic acid DM showed the dual functions such as anti-androgenic and anti-osteoclastic differentiation activities, which can be used to explain the multifunction of G. lucidum. The accumulation of the knowledge of biological activities of these kinds of triterpenoids leads us to give some hints in elucidating the unsolved function of G lucidum.
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